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81. 发明申请

US20050004606A1 Safety pacing in multi-site CRM devices 有权
标题翻译：多站点CRM设备中的安全起搏
公开(公告)号：US20050004606A1
公开(公告)日：2005-01-06
申请号：US10839268
申请日：2004-05-05
申请人： Jeffrey Stahmann , Andrew Kramer , Hugh Calkins
发明人： Jeffrey Stahmann , Andrew Kramer , Hugh Calkins
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： Safety pacing in multi-site cardiac rhythm management (CRM) devices is provided. According to various method embodiments, a first cardiac signal from a first cardiac region and a second cardiac signal from a second cardiac region are sensed. The first cardiac region is paced to maintain at least a minimum cardiac rate, and the second cardiac region is paced to maintain at least the minimum cardiac rate when a pace in the first cardiac region is inhibited. Other aspects and embodiments are provided herein.
摘要翻译：提供了多站点心律管理（CRM）设备中的安全起搏。根据各种方法实施例，感测来自第一心脏区域的第一心脏信号和来自第二心脏区域的第二心脏信号。第一心脏区域起搏以保持至少最小心率，并且当第一心脏区域中的步调被抑制时，第二心脏区域起搏以保持至少最小心率。本文提供了其它方面和实施例。

82. 发明授权

US08147415B2 System and method for detection of pulmonary embolism 有权
标题翻译：用于肺栓塞检测的系统和方法
公开(公告)号：US08147415B2
公开(公告)日：2012-04-03
申请号：US12414465
申请日：2009-03-30
申请人： Wangcai Liao , Jeffrey Stahmann , Bin Mi , Yunlong Zhang
发明人： Wangcai Liao , Jeffrey Stahmann , Bin Mi , Yunlong Zhang
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02007 , A61B5/02108 , A61B5/08 , A61B5/412 , A61B5/6846 , A61B5/7275
摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.
摘要翻译：系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。在患者体内设置动力以便于感测肺动脉压力并产生肺动脉压力测量。基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。响应于检测到肺栓塞，优选产生警报。

83. 发明授权

US08103343B2 Automatic modulation of pacing timing intervals using beat to beat measures 有权
标题翻译：使用节拍措施自动调节起搏定时间隔
公开(公告)号：US08103343B2
公开(公告)日：2012-01-24
申请号：US11799794
申请日：2007-05-03
申请人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
发明人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译：描述了调节起搏治疗时间间隔的方法和系统。对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。使用调制的定时间隔来提供起搏治疗。

84. 发明申请

US20080046017A1 Cardiac rhythm management system with staggered pulses for coordination therapy 审中-公开
标题翻译：用于协调治疗的具有交错脉冲的心律管理系统
公开(公告)号：US20080046017A1
公开(公告)日：2008-02-21
申请号：US11891896
申请日：2007-08-14
申请人： Jeffrey Stahmann , Andrew Kramer , Julio Spinelli
发明人： Jeffrey Stahmann , Andrew Kramer , Julio Spinelli
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3716
摘要： A cardiac rhythm management system for coordination therapy includes a pulse generator to generate pacing and discharging of recharge pulses. A pulse delivery controller coupled to the pulse generator, times the delivery of the pacing and discharging of recharge pulses in a desired sequence. A therapy circuit coupled to the pulse delivery controller, receives the timed pulses from the pulse delivery controller and delivers the timed pulses to one or more electrodes disposed in or around a heart to communicate the timed pacing and discharging of recharge pulses to different sites of a heart, to avoid any interactions resulting from the electric fields surrounding the electrodes during a multiple site pacing required by the coordination therapy.
摘要翻译：用于协调治疗的心律管理系统包括产生起搏和再充电脉冲放电的脉冲发生器。耦合到脉冲发生器的脉冲传送控制器以期望的顺序对起搏的递送和再充电脉冲的放电进行倍增。耦合到脉冲传送控制器的治疗电路接收来自脉冲传送控制器的定时脉冲，并将定时脉冲传送到设置在心脏中或周围的一个或多个电极，以将定时起搏和再充电脉冲的放电传达到不同部位心脏，以避免由协调治疗所需的多个位置起搏期间由电极周围的电场引起的任何相互作用。

85. 发明申请

US20080045852A1 DETECTION OF CONGESTION FROM MONITORING PATIENT RESPONSE TO A RECUMBENT POSITION 有权
标题翻译：检测患者对重要位置的反应
公开(公告)号：US20080045852A1
公开(公告)日：2008-02-21
申请号：US11926425
申请日：2007-10-29
申请人： John Hatlestsad , Qingsheng Zhu , Jeffrey Stahmann
发明人： John Hatlestsad , Qingsheng Zhu , Jeffrey Stahmann
IPC分类号： A61B5/08
CPC分类号： A61B5/0809 , A61B5/0816 , A61B5/1071 , A61B5/1116 , A61B5/1135 , A61B5/4806 , A61B5/6831 , A61B5/6846 , A61B5/686 , A61N1/36542
摘要： Systems and methods obtain information that allows detection of whether a patient suffers from congestion by monitoring a response of the patient to a recumbent position of the patient's body. The patient may be monitored to determine a respiration pattern for a non-recumbent position such as standing and a respiration pattern for a recumbent position such as lying down. The two patterns may be compared, either by a processing device or a physician, to determine a difference in the two respiration patterns. Furthermore, the congestion may be inferred from detecting an amount of time that the patient spends in a recumbent position or from detecting the recumbent angle that the patient obtains, either of which is presumed to indicate whether a recumbent position presents discomfort to the patient due to the presence of congestion.
摘要翻译：系统和方法获得允许通过监视患者对患者身体的卧位的反应来检测患者是否患有拥塞的信息。可以监测患者以确定用于躺卧位置的无卧位的呼吸模式，例如躺卧和躺卧位置的呼吸模式。可以通过处理装置或医师来比较两种模式，以确定两种呼吸模式的差异。此外，可以通过检测患者在躺卧位置中花费的时间量或从检测患者获得的躺卧角度来推断拥塞，其中任何一个被推定为指示躺卧位置是否由于患者的不适而给患者带来不适拥堵的存在。

86. 发明申请

US20070250125A1 EXPERT SYSTEM AND METHOD 有权
标题翻译：专家系统和方法
公开(公告)号：US20070250125A1
公开(公告)日：2007-10-25
申请号：US11624035
申请日：2007-01-17
申请人： Par Lindh , James Kalgren , Jeffrey Stahmann , Rene Wentkowski
发明人： Par Lindh , James Kalgren , Jeffrey Stahmann , Rene Wentkowski
IPC分类号： A61N1/36
CPC分类号： A61N1/37247 , A61N1/3627 , A61N1/37235
摘要： A medical device programmer and a method of operation in which a first data value is received and used in the execution of one or more algorithms. One or more suggested pulse generator settings are calculated from the one or more algorithms based on the first data value, and the one or more suggested pulse generator settings are displayed on an interactive display screen of the medical device programmer. In one embodiment, the first data value is a duration interval of a QRS complex. From the duration interval, suggestions are made as to one or more ventricular chambers in which to provide pacing pulses. Additionally, pacing intervals for an AV delay are suggested based on measured P-R intervals, or pacing intervals for an LV offset are suggested based on a measured duration interval of a V-V-interval between a right ventricular event and a left ventricular event.
摘要翻译：一种医疗设备编程器和操作方法，其中在执行一个或多个算法时接收并使用第一数据值。基于第一数据值从一个或多个算法计算一个或多个建议的脉冲发生器设置，并且一个或多个建议的脉冲发生器设置显示在医疗设备编程器的交互式显示屏幕上。在一个实施例中，第一数据值是QRS复数的持续时间间隔。从持续时间间隔，建议一个或多个心室，其中提供起搏脉冲。另外，基于测量的P-R间隔建议AV延迟的起搏间隔，或者基于右心室事件和左心室事件之间的V-V间隔的测量持续时间间隔来建议LV偏移的起搏间隔。

87. 发明申请

US20070135853A1 APPARATUS AND METHOD FOR VENTRICULAR RATE REGULARIZATION 有权
标题翻译：装置和方法进行正常速率正则化
公开(公告)号：US20070135853A1
公开(公告)日：2007-06-14
申请号：US11673098
申请日：2007-02-09
申请人： Andrew Kramer , Jeffrey Stahmann
发明人： Andrew Kramer , Jeffrey Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/362 , A61N1/3621 , A61N1/3622 , A61N1/365 , A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3688 , A61N1/3702 , A61N1/395 , A61N1/3962 , A61N1/3987
摘要： A cardiac rhythm management device which employs pacing therapy to regularize the ventricular rhythm. Such ventricular rate regularization may be employed within bradycardia pacemakers, ventricular resynchronization devices, or implantable cardioverter/defibrillators.
摘要翻译：一种心律管理装置，其采用起搏治疗来使心室节律正常化。心动过速起搏器，心室再同步装置或植入式心律转复器/去纤颤器中可采用这种心室率正常化。

88. 发明申请

US20070016260A1 Reduction of left-ventricular offset interaction with tachyarrhythmia detection 有权
标题翻译：减慢与心律失常检测的左心室偏移相互作用
公开(公告)号：US20070016260A1
公开(公告)日：2007-01-18
申请号：US11522691
申请日：2006-09-18
申请人： Kenneth Baker , David Perschbacher , Andrew Kramer , Jeffrey Stahmann
发明人： Kenneth Baker , David Perschbacher , Andrew Kramer , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A device and method for improving tachyarrhythmia detection when the ventricles are resynchronized by delivering paces to both ventricles separated by a specified offset interval. Timing of escape intervals and tachyarrhythmia detection is based upon senses from one of the ventricles designated as a rate ventricle. A reversion pacing mode is provided in order to prevent tachyarrhythmia detection from being compromised when the rate ventricle is paced after the other ventricle.
摘要翻译：通过向两个心室分配指定的偏移间隔来逐步重新同步心室，从而改善快速性心律失常检测的装置和方法。逃避间隔和快速性心律失常检测的时间是基于指定为速率心室的心室之一的感觉。提供回波起搏模式，以便当速率心室在另一脑室之后起搏时，防止快速性心律失常检测受到损害。

89. 发明申请

US20060259083A1 System and method to deliver therapy in presence of another therapy 有权
公开(公告)号：US20060259083A1
公开(公告)日：2006-11-16
申请号：US11125503
申请日：2005-05-10
申请人： Imad Libbus , Andrew Kramer , William Linder , Jeffrey Stahmann
发明人： Imad Libbus , Andrew Kramer , William Linder , Jeffrey Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/37 , A61N1/36114 , A61N1/36125 , A61N1/362 , A61N1/36514 , A61N1/36564 , A61N1/36592 , A61N1/3987
摘要： Various aspects relate to a method. In various embodiments, a therapy of a first therapy type is delivered, and it is identified whether a therapy of a second therapy type is present to affect the therapy of the first therapy type. Delivery of the therapy is controlled based on the presence of the therapy of the second therapy type. Some embodiments deliver the therapy of the first type using one set of parameters in the presence of a therapy of a second type, and deliver the therapy of the first type using another set of parameters when the therapy of the second type is not present. In various embodiments, one of the therapy types includes a cardiac rhythm management therapy, and the other includes a neural stimulation therapy. Other aspects and embodiments are provided herein.

90. 发明申请

US20060253162A1 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US20060253162A1
公开(公告)日：2006-11-09
申请号：US11125068
申请日：2005-05-09
申请人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey Stahmann , Carlos Ricci , Scott Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey Stahmann , Carlos Ricci , Scott Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

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