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    • 86. 发明申请
    • AGENT FOR PROMOTING HEPATIC CELL REPLICATION AND AGENT FOR IMPROVING INSULIN RESISTANCE
    • 促进细胞再生的代理和改善胰岛素抵抗的药剂
    • US20090081787A1
    • 2009-03-26
    • US11912424
    • 2006-04-24
    • Hiroyuki YoneyamaTakafumi IchidaShosaku Narumi
    • Hiroyuki YoneyamaTakafumi IchidaShosaku Narumi
    • C12N5/06C07K16/28
    • C07K16/24A61K2039/505
    • The present invention aims at providing a medicament and a method for promoting replication of hepatocytes and a medicament and a method for ameliorating insulin resistance. An effective amount of a neutralizing agent for CXCL10 belonging to a subfamily of chemokines which are heparin-binding proteins is administered to the hepatocytes to promote the replication of the hepatocytes. As the neutralizing agent for CXCL10, a factor which is specifically bound to CXCL10 and inhibits an activity of CXCL10 or a factor which inhibits CXCL10 expression is suitably used. By administering the neutralizing agent to impaired hepatic tissue, it is possible to restore and regenerate the hepatic tissue. Meanwhile, by administering an effective amount of the neutralizing agent for CXCL10 to the hepatocytes, the insulin resistance in type II diabetes and metabolic syndrome is ameliorated.
    • 本发明的目的在于提供促进肝细胞复制的药物和方法,以及用于改善胰岛素抵抗的药物和方法。 向肝细胞施用有效量的属于肝素结合蛋白的趋化因子亚类的CXCL10的中和剂,以促进肝细胞的复制。 作为CXCL10的中和剂,适当使用与CXCL10特异性结合并抑制CXCL10活性或抑制CXCL10表达的因子的因子。 通过将中和剂施用于肝组织损伤,可以恢复和再生肝组织。 同时,通过向肝细胞施用有效量的CXCL10中和剂,可以改善II型糖尿病和代谢综合征中的胰岛素抵抗。