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81. 发明授权

US07700586B2 Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders 失效
标题翻译：用作治疗炎症和免疫疾病的ccr3拮抗剂的芳基磺酰胺衍生物
公开(公告)号：US07700586B2
公开(公告)日：2010-04-20
申请号：US10489029
申请日：2002-09-04
申请人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/55 , A01N43/62 , A61K31/497 , C07D243/08 , C07D241/04 , C07D295/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译：本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。

82. 发明授权

US07517557B2 Oxide films, a method of producing the same and structures having the same 失效
标题翻译：氧化物膜，其制造方法和具有该氧化物膜的结构
公开(公告)号：US07517557B2
公开(公告)日：2009-04-14
申请号：US10792852
申请日：2004-03-05
申请人： Makoto Iwai , Makoto Ohmori , Takashi Yoshino , Minoru Imaeda
发明人： Makoto Iwai , Makoto Ohmori , Takashi Yoshino , Minoru Imaeda
IPC分类号： C23C16/00 , B01F3/02
CPC分类号： C30B25/14 , C23C16/40 , C30B25/02 , C30B29/30
摘要： An object of the present invention is to produce an oxide film having good surface morphology and crystal quality, by a metal organic chemical vapor deposition using two or more raw material gases of metal organic compounds and oxygen gas. It is used a film forming system having a first supply hole 11A, a second supply hole 11B, a third supply hole 11C and a film forming chamber 7. A first raw material gas “A” containing a first metal organic compound is supplied through the first supply hole 11A into the chamber 7. A second raw material gas “B” containing the second metal organic compound is supplied through the second supply hole 11B into the chamber 7, and oxygen gas “C” is supplied through the third supply hole 11C into the chamber 7. The oxygen gas “D” contacts the first raw material gas “E” before the oxygen gas is mixed with the second raw material gas “F” in the chamber 7.
摘要翻译：本发明的目的是通过使用两种或更多种金属有机化合物和氧气的原料气体的金属有机化学气相沉积来制造具有良好的表面形态和晶体质量的氧化膜。使用具有第一供给孔11A，第二供给孔11B，第三供给孔11C和成膜室7的成膜体系。通过第一供给孔11A，第二供给孔11B，第三供给孔11C和成膜室7配置含有第一金属有机化合物的第一原料气体“A” 第一供给孔11A插入到室7.包含第二金属有机化合物的第二原料气体“B”通过第二供给孔11B供给到室7中，并且通过第三供给孔11C供给氧气“C” 在氧气与第二原料气体“F”在室7中混合之前，氧气“D”接触第一原料气体“E”。

83. 发明申请

US20090074963A1 OXIDE FILMS, A METHOD OF PRODUCING THE SAME AND STRUCTURES HAVING THE SAME 失效
标题翻译：氧化膜，其制造方法和具有该氧化膜的结构
公开(公告)号：US20090074963A1
公开(公告)日：2009-03-19
申请号：US10792852
申请日：2004-03-05
申请人： Makoto Iwai , Makoto Ohmori , Takashi Yoshino , Minoru Imaeda
发明人： Makoto Iwai , Makoto Ohmori , Takashi Yoshino , Minoru Imaeda
IPC分类号： C23C16/06
CPC分类号： C30B25/14 , C23C16/40 , C30B25/02 , C30B29/30
摘要： An object of the present invention is to produce an oxide film having good surface morphology and crystal quality, by a metal organic chemical vapor deposition using two or more raw material gases of metal organic compounds and oxygen gas. It is used a film forming system having a first supply hole 11A, a second supply hole 11B, a third supply hole 11C and a film forming chamber 7. A first raw material gas “A” containing al first metal organic compound is supplied through the first supply hole 11A into the chamber 7. A second raw material gas “B” containing the second metal organic compound is supplied through the second supply hole 11B into the chamber 7, and oxygen gas “C” is supplied through the third supply hole 11C into the chamber 7. The oxygen gas “D” contacts the first raw material gas “E” before the oxygen gas is mixed with the second raw material gas “F” in the chamber 7.
摘要翻译：本发明的目的是通过使用两种或更多种金属有机化合物和氧气的原料气体的金属有机化学气相沉积来制造具有良好的表面形态和晶体质量的氧化膜。使用具有第一供给孔11A，第二供给孔11B，第三供给孔11C和成膜室7的成膜系统。含有第一金属有机化合物的第一原料气体“A”通过第一供给孔11A插入到室7.包含第二金属有机化合物的第二原料气体“B”通过第二供给孔11B供给到室7中，并且通过第三供给孔11C供给氧气“C” 在氧气与第二原料气体“F”在室7中混合之前，氧气“D”接触第一原料气体“E”。

84. 发明申请

US20080218847A1 WAVELENGTH CONVERSION DEVICES 有权
标题翻译：波长转换器件
公开(公告)号：US20080218847A1
公开(公告)日：2008-09-11
申请号：US12038208
申请日：2008-02-27
申请人： Takashi Yoshino
发明人： Takashi Yoshino
IPC分类号： G02F1/35
CPC分类号： G02F1/3775 , G02F2201/063
摘要： It is provided a wavelength conversion device 1 having a ridge optical waveguide 8 and a periodic domain inversion structure formed in the waveguide 8. The optical waveguide 8 has side wall faces 8c, a upper face and edge areas 8a formed between the upper face and the side wall faces 8, respectively. R-faces are formed on the edge areas 8a.
摘要翻译：提供了一种具有脊形光波导8和形成在波导8中的周期性畴反转结构的波长转换装置1。光波导8具有分别形成在上表面和侧壁面8之间的侧壁面8c，上表面和边缘区域8a。 R面形成在边缘区域8a上。

85. 发明授权

US07373065B2 Optical waveguide substrate and harmonics generating device 有权
标题翻译：光波导基板和谐波发生装置
公开(公告)号：US07373065B2
公开(公告)日：2008-05-13
申请号：US11725193
申请日：2007-03-16
申请人： Shoichiro Yamaguchi , Takashi Yoshino
发明人： Shoichiro Yamaguchi , Takashi Yoshino
IPC分类号： G02B6/10
CPC分类号： G02F1/3775 , G02B6/122 , G02B2006/1204 , G02B2006/12097 , G02B2006/12152 , G02F1/035 , G02F2201/063
摘要： It is provided a structure capable of reducing the loss of incident light propagating in a three-dimensional optical waveguide in a optical waveguide substrate having a ridge type optical waveguide. An optical waveguide substrate has a ferroelectric layer 3 made of a ferroelectric material, a ridge portion formed on a surface of the layer 3 and protrusions provided in both sides of the ridge portion. A three-dimensional optical waveguide is provided in the ridge portion. Alternatively, the substrate has a ridge portion 15 formed on a surface of the layer 3 and step portions provided in both sides of the ridge portion 15 and lower than the ridge portion 15. Grooves 16 are formed in the outsides of the step portions, respectively, and a three-dimensional optical waveguide is provided in the ridge portion 15.
摘要翻译：提供了一种能够减少在具有脊型光波导的光波导基板中在三维光波导中传播的入射光的损失的结构。光波导基板具有由铁电体材料制成的铁电体层3，形成在层3的表面上的脊部和设置在脊部两侧的突起。在脊部设置有三维光波导。或者，基板具有形成在层3的表面上的脊部15和设置在脊部15的两侧并且比脊部15低的台阶部。槽部16分别形成在台阶部的外侧并且在脊部15中设置有三维光波导。

86. 发明申请

US20070200459A1 PIEZOELECTRIC THIN FILM DEVICE 审中-公开
标题翻译：压电薄膜器件
公开(公告)号：US20070200459A1
公开(公告)日：2007-08-30
申请号：US11675682
申请日：2007-02-16
申请人： Takashi Yoshino , Shoichiro Yamaguchi , Yuichi Iwata , Akira Hamajima , Kengo Suzuki
发明人： Takashi Yoshino , Shoichiro Yamaguchi , Yuichi Iwata , Akira Hamajima , Kengo Suzuki
IPC分类号： H01L41/08
CPC分类号： H03H3/02 , H03H9/02023 , H03H9/02031 , H03H9/02039 , H03H9/02055 , H03H9/02133 , H03H9/173 , H03H9/564 , H03H2003/021
摘要： The present invention is directed to preventing characteristic variations and damage caused by a difference in thermal expansion coefficient. A piezoelectric thin film filter, including four film bulk acoustic resonators, has a configuration where a filter section for providing a filter function of the piezoelectric thin film filter is bonded with a flat base substrate mechanically supporting the filter section via an adhesive layer. In manufacturing of the piezoelectric thin film filter, a piezoelectric thin film is obtained by performing removal processing on a piezoelectric substrate that can individually stand up under its own weight, but substrates made of one kind of single crystal material are adopted as the base substrate and the piezoelectric substrate, to make the respective thermal expansion coefficients of the piezoelectric thin film and the base substrate coincident with each other.
摘要翻译：本发明旨在防止由热膨胀系数差引起的特性变化和损坏。包括四个膜体声波谐振器的压电薄膜滤波器具有其中用于提供压电薄膜滤波器的滤波器功能的滤波器部分通过经由粘合剂层机械地支撑滤波器部分的平坦基底基板结合的构造。在压电薄膜滤波器的制造中，通过在能够单独自重地承受其自重的压电基板上进行去除处理而获得压电薄膜，但采用由一种单晶材料制成的基板作为基底，压电基板，以使压电薄膜和基底基板的各自的热膨胀系数相互一致。

87. 发明申请

US20070200458A1 PIEZOELECTRIC THIN FILM DEVICE 审中-公开
标题翻译：压电薄膜器件
公开(公告)号：US20070200458A1
公开(公告)日：2007-08-30
申请号：US11675671
申请日：2007-02-16
申请人： Takashi Yoshino , Shoichiro Yamaguchi , Yuichi Iwata , Akira Hamajima , Kengo Suzuki
发明人： Takashi Yoshino , Shoichiro Yamaguchi , Yuichi Iwata , Akira Hamajima , Kengo Suzuki
IPC分类号： H01L41/08
CPC分类号： H03H3/02 , H03H9/02023 , H03H9/02031 , H03H9/02039 , H03H9/02055 , H03H9/02133 , H03H9/173 , H03H9/564 , H03H2003/021
摘要： The present invention is directed to improving characteristics of a piezoelectric thin film device. A piezoelectric thin film filter including four film bulk acoustic resonators has a configuration where a filter section and a base substrate are bonded to each other via an adhesive layer, the filter section including a piezoelectric thin film which cannot stand up individually under its own weight, the flat base substrate mechanically supporting the filter section. As a piezoelectric material constructing the piezoelectric thin film, it is desirable to use a single-crystal material including no grain boundary, selected from crystal, lithium niobate, lithium tantalite, lithium tetraborate, zinc oxide, potassium niobate, and langasite.
摘要翻译：本发明旨在改善压电薄膜器件的特性。包括四个膜体声波谐振器的压电薄膜滤波器具有滤波器部分和基底基板经由粘合剂层彼此接合的构造，该滤波器部分包括不能在其自重下单独承受的压电薄膜，平底基底机械地支撑过滤器部分。作为构成压电薄膜的压电材料，优选使用选自晶体，铌酸锂，钽酸锂，四硼酸锂，氧化锌，铌酸钾，镧系元素等不含晶界的单晶材料。

88. 发明申请

US20070199186A1 PIEZOELECTRIC THIN FILM DEVICE AND METHOD FOR MANUFACTURING THE SAME 有权
标题翻译：压电薄膜装置及其制造方法
公开(公告)号：US20070199186A1
公开(公告)日：2007-08-30
申请号：US11675677
申请日：2007-02-16
申请人： Takashi Yoshino , Shoichiro Yamaguchi , Yuichi Iwata , Akira Hamajima , Kengo Suzuki
发明人： Takashi Yoshino , Shoichiro Yamaguchi , Yuichi Iwata , Akira Hamajima , Kengo Suzuki
IPC分类号： H04R17/00
CPC分类号： H03H3/02 , H03H9/02023 , H03H9/02031 , H03H9/02039 , H03H9/02055 , H03H9/02133 , H03H9/173 , H03H9/564 , H03H9/568 , H03H2003/021 , Y10T29/42 , Y10T29/435 , Y10T29/49005
摘要： In a piezoelectric thin film device of the present invention, the degree of flexibility is enhanced in selection of a piezoelectric material constituting a piezoelectric thin film and the crystal orientation in the piezoelectric thin film. A piezoelectric thin film filter, including four film bulk acoustic resonators, has a configuration where a filter section for providing a filter function of the piezoelectric thin film filter is bonded with a flat base substrate mechanically supporting the filter section via an adhesive layer. In manufacturing of the piezoelectric thin film filter, a piezoelectric thin film is obtained by performing removal processing on a piezoelectric substrate, but the piezoelectric thin film obtained by removal processing cannot independently stand up under its own weight. For this reason, a prescribed member including the piezoelectric substrate is previously bonded to the base substrate as a support prior to the removal processing.
摘要翻译：在本发明的压电薄膜器件中，在构成压电薄膜的压电材料和压电薄膜中的晶体取向的选择方面，柔性程度提高。包括四个膜体声波谐振器的压电薄膜滤波器具有其中用于提供压电薄膜滤波器的滤波器功能的滤波器部分通过经由粘合剂层机械地支撑滤波器部分的平坦基底基板结合的构造。在压电薄膜滤波器的制造中，通过对压电基板进行去除处理，获得了压电薄膜，但是通过去除处理获得的压电薄膜不能独立地在其自重下立起。因此，在去除处理之前，预先将包括压电基板的规定构件作为支撑体接合到基底基板。

89. 发明申请

US20070129355A1 Pyrimidine derivatives useful for the treatment of diseases mediated by crth2 有权
标题翻译：可用于治疗由crth2介导的疾病的嘧啶衍生物
公开(公告)号：US20070129355A1
公开(公告)日：2007-06-07
申请号：US10554668
申请日：2004-04-14
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/506 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译：本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

90. 发明授权

US06984649B1 Pyridine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US06984649B1
公开(公告)日：2006-01-10
申请号：US10402500
申请日：2003-03-28
申请人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
发明人： Toshiki Murata , Masaomi Umeda , Sachiko Sakakibara , Takashi Yoshino , Hiroki Sato , Tsutomu Masuda , Yuji Koriyama , Mitsuyuki Shimada , Takuya Shintani , Hiroshi Kadono , Timothy B. Lowinger , Karl B. Ziegelbauer , Kinji Fuchikami , Hiroshi Komura
IPC分类号： A61K31/4545 , C07D409/14 , C07D211/68 , C07D213/73
CPC分类号： C07D213/08 , C07D213/10 , C07D213/73 , C07D213/80 , C07D213/85 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/08 , C07D513/04 , C07D515/04
摘要： Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents 1.2.3.6-tetrahydro-pyridine, or —CR31R32R33 wherein R31 represents H or C1-6 alkyl and R32 and R33 are joined to form a 5-8 membered saturated ring optionally containing up to three heteroatoms; R4 is carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.
摘要翻译：吡啶化合物，其通式如下：其中R 1表示其中R 11为氢，C 1-6烷基，卤素，羟基，C 1-12烷氧基，硝基，氨基，C 1-6烷基磺酰基氨基，C 1-6烷氧基羰基，C 1-6烷基，（C 1-6烷基）氨基，C 1-6烷酰基氨基，苯基C 1-6烷基氨基，苯基磺酰基氨基，C 1 -C 6烷基氨基，，或-O-（CH 2）n - n - R 111; R 2表示氢或卤素; R 3表示1.2.3.6-四氢 - 吡啶或-CR 31，其中R 1，R 2，R 3， SUP> 31表示H或C 1-6烷基，R 32和R 33连接形成5-8 任选地含有至多三个杂原子的饱和环; R 4是氨基甲酰基，CN，羧基等; R 5是氨基，C 1-6烷基氨基，C 1-6烷基氨基等，或其盐。该化合物具有优异的抗炎活性和其他生物活性。

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