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81. 发明申请

US20110238151A1 SURFACE TREATED BIOERODIBLE METAL ENDOPROSTHESES 失效
标题翻译：表面处理的生物可降解金属内切酶
公开(公告)号：US20110238151A1
公开(公告)日：2011-09-29
申请号：US13053791
申请日：2011-03-22
申请人： Torsten Scheuermann , Jan Weber , Charles Deng , Jonathan S. Stinson , Steven R. Larsen , Dennis A. Boismier , Jacob D. Edick
发明人： Torsten Scheuermann , Jan Weber , Charles Deng , Jonathan S. Stinson , Steven R. Larsen , Dennis A. Boismier , Jacob D. Edick
IPC分类号： A61F2/82
CPC分类号： A61L31/148 , A61F2/91 , A61F2210/0004 , A61L31/022 , A61L31/088
摘要： An endoprosthesis includes an expandable tubular body defined by a plurality of struts. In some embodiments, the expandable tubular body includes a bioerodible metal that has at least a first surface region and a second surface region. The first and second surface regions can have different surface oxide compositions. In some embodiments, the first portion has a thermally altered microstructure and the second portion has a wrought microstructure. The thermally altered microstructure can be a cast microstructure comprising dendritic grains. The first portion forms at least a portion of an outer surface of the expandable tubular body. In some embodiments, the expandable tubular body includes iron or a bioerodible iron alloy and at least one surface of the expandable tubular body includes a substantially uniform coating of iron(III) oxide.
摘要翻译：内假体包括由多个支柱限定的可扩张管状体。在一些实施例中，可扩张管状体包括具有至少第一表面区域和第二表面区域的生物浸渍金属。第一和第二表面区域可以具有不同的表面氧化物组成。在一些实施例中，第一部分具有热改变的微结构，第二部分具有锻造微结构。热改变的微结构可以是包含树枝状晶粒的铸造微结构。第一部分形成可扩张管状体的外表面的至少一部分。在一些实施例中，可膨胀管状体包括铁或生物腐蚀性铁合金，并且可膨胀管体的至少一个表面包括基本均匀的氧化铁（III）涂层。

82. 发明授权

US07972350B2 Catheter tip 有权
标题翻译：导管尖
公开(公告)号：US07972350B2
公开(公告)日：2011-07-05
申请号：US10767675
申请日：2004-01-29
申请人： Thomas McHale , Jan Weber
发明人： Thomas McHale , Jan Weber
IPC分类号： A61M25/10
CPC分类号： A61M25/0068 , A61F2/958 , A61F2002/9583 , A61F2250/0098 , A61M25/001 , A61M25/0052 , A61M25/0054 , A61M25/0069 , A61M25/008 , A61M25/0108 , A61M25/0127 , A61M25/1027 , A61M2025/1079 , A61M2025/1093 , A61M2205/32
摘要： A catheter tip may be coupled to a catheter shaft. The catheter tip may include markers, such as radiopaque markers and MRI markers, securement hubs, recessed portions, a radiused tip, and varying axial flexibility. The catheter tip may be a molded tip, and the markers may be insert molded. Recessed portions and raised securement hubs may be formed during the molding process. The raised hubs may be integrally formed and made from the same material as the catheter tip.
摘要翻译：导管尖端可以联接到导管轴。导管尖端可以包括标记，例如不透射线标记和MRI标记，固定轮毂，凹陷部分，圆角末端和变化的轴向柔性。导管尖端可以是模制尖端，并且标记可以是嵌入模制的。嵌入部分和凸起的固定轮毂可以在模制过程中形成。凸起的轮毂可以由与导管尖端相同的材料一体地形成并制成。

83. 发明申请

US20110160839A1 Endoprosthesis 审中-公开
标题翻译：内假体
公开(公告)号：US20110160839A1
公开(公告)日：2011-06-30
申请号：US12649007
申请日：2009-12-29
申请人： Jan Weber , Liliana Atanasoska , Rajesh Radhakrishnan
发明人： Jan Weber , Liliana Atanasoska , Rajesh Radhakrishnan
IPC分类号： A61F2/82 , B05D3/00
CPC分类号： A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067
摘要： An endoprosthesis, e.g., a bioerodable stent, that is treated by plasma immersion ion implantation on the surface and optionally in the bulk. Releasable therapeutic agent, drug, or pharmaceutically active compound may be incorporated into the treated surface of the endoprosthesis to provide desired medical benefits.
摘要翻译：内表假体，例如生物可蚀塑的支架，其通过等离子体浸没离子注入在表面上和任选地在本体中进行处理。可释放的治疗剂，药物或药物活性化合物可以并入内用假体的经处理的表面以提供所需的医疗益处。

84. 发明申请

US20110130829A1 Medical Devices Containing Therapeutic Agents 审中-公开
标题翻译：包含治疗药物的医疗器械
公开(公告)号：US20110130829A1
公开(公告)日：2011-06-02
申请号：US13000594
申请日：2009-06-19
申请人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
发明人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
IPC分类号： A61F2/82 , A61L29/08 , A61L29/16 , A61L27/28 , A61L27/54
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0014 , A61F2250/0025 , A61F2250/0026 , A61F2250/0037 , A61F2250/0067 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/146 , A61L2300/416 , A61L2300/63
摘要： The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译：本发明涉及可植入或可插入的医疗装置，其包括基质和含有一种或多种治疗剂的一种或多种含治疗剂的区域。在本发明的各个方面，控制这种含治疗剂的区域的一个或多个特征。本发明的其它方面涉及形成这种装置的方法以及使用这种装置的方法。

85. 发明申请

US20110071559A1 Cutting Member for Bifurcation Catheter Assembly 审中-公开
标题翻译：分叉导管组件切割成员
公开(公告)号：US20110071559A1
公开(公告)日：2011-03-24
申请号：US12955578
申请日：2010-11-29
申请人： Thomas J. Holman , Jan Weber
发明人： Thomas J. Holman , Jan Weber
IPC分类号： A61B17/22 , A61M29/00
CPC分类号： A61B17/320725 , A61B2017/22061 , A61M25/1002 , A61M25/1011 , A61M2025/0058 , A61M2025/1045 , A61M2025/1081 , A61M2025/1086
摘要： A catheter assembly for deployment in a vessel includes a catheter shaft extending from a proximal end portion to a distal end portion. A balloon is operatively coupled to the distal end portion of the catheter shaft. At least one cutting member is coupled to the catheter assembly. As the balloon is inflated, the cutting member is moved to a position to cut a portion of the vessel.
摘要翻译：用于展开在容器中的导管组件包括从近端部分延伸到远端部分的导管轴。气囊可操作地联接到导管轴的远端部分。至少一个切割构件联接到导管组件。当气囊膨胀时，切割构件移动到切割容器的一部分的位置。

86. 发明授权

US07850645B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US07850645B2
公开(公告)日：2010-12-14
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

87. 发明申请

US20100297334A1 Variable Stiffness Catheter Assembly 有权
标题翻译：可变刚度导管组件
公开(公告)号：US20100297334A1
公开(公告)日：2010-11-25
申请号：US12847703
申请日：2010-07-30
申请人： Jan Weber
发明人： Jan Weber
IPC分类号： A61L33/00 , B23P17/04
CPC分类号： A61M25/0054 , A61M25/0009 , A61M25/0045 , A61M25/0053 , A61M25/0138 , A61M25/0158 , A61M25/09 , A61M25/1006 , A61M2025/0024 , A61M2025/0035 , A61M2025/0039 , A61M2025/0058 , A61M2025/0063 , A61M2025/0915 , A61M2025/09175 , Y10T29/49826
摘要： A catheter comprising an outer shaft comprising a first section of electroactive polymer. The first section of electroactive polymer affecting either the flexibility of the catheter or the steerability of the catheter.
摘要翻译：一种导管，其包括包含电活性聚合物的第一部分的外轴。电活性聚合物的第一部分影响导管的柔性或导管的可操纵性。

88. 发明授权

US07838806B2 Resonator with adjustable capacitor for medical device 失效
标题翻译：谐振器用于医疗设备的可调电容器
公开(公告)号：US07838806B2
公开(公告)日：2010-11-23
申请号：US11982548
申请日：2007-11-02
申请人： Jan Weber
发明人： Jan Weber
IPC分类号： H05B6/36
CPC分类号： G01R33/286 , A61B5/055 , A61F2/82 , G01R33/3628 , Y10T29/49117
摘要： An apparatus, system and method of a resonator device with an adjustable capacitor for allowing the resonance frequency (F) of the resonator device to continue to be matched to the Larmor frequency of the MRI system. The resonator device includes an inductor coil, a conductive member, a sleeve having first and second sockets that receive at least portions of the inductor coil and the conductive member as electrodes to provide a capacitor structure. Dielectric material can be positioned between at least the first and second sockets, where changes in the cross sectional area defined by the induction coil cause changes in the capacitance value (C) as one or more of the electrodes move within the socket. Changes in the inductance and the capacitance values allow for the resonance frequency (F) of the resonator device to continue to be matched to the Larmor frequency of the MRI system.
摘要翻译：具有可调电容器的谐振器装置的装置，系统和方法，用于允许谐振器装置的谐振频率（F）继续与MRI系统的拉莫尔频率匹配。谐振器装置包括电感线圈，导电构件，具有第一和第二插座的套筒，该套管至少容纳电感器线圈和导电构件的至少一部分作为电极以提供电容器结构。介电材料可以位于至少第一和第二插座之间，其中由感应线圈限定的横截面积的变化引起电容值（C）的变化，因为一个或多个电极在插座内移动。电感和电容值的变化允许谐振器装置的谐振频率（F）继续与MRI系统的拉莫尔频率匹配。

89. 发明申请

US20100286678A1 Medical Devices 有权
标题翻译：医疗设备
公开(公告)号：US20100286678A1
公开(公告)日：2010-11-11
申请号：US12838980
申请日：2010-07-19
申请人： Jan Weber , John M. Hokanson , John H. Chen
发明人： Jan Weber , John M. Hokanson , John H. Chen
IPC分类号： A61B18/02 , A61B18/04 , A61M25/10
CPC分类号： A61M25/104 , A61F7/123 , A61L29/126 , A61M25/10 , B82Y5/00 , B82Y30/00
摘要： Medical systems and methods including balloons having nanotubes are disclosed. In some embodiments, a medical system includes an elongated shaft, and an expandable balloon carried by the shaft and including nanotubes. The medical system is capable of cooling the balloon to less than about 37° C. In some embodiments, a method includes providing a medical device having an elongated shaft, and an expandable balloon carried by the elongated shaft and including nanotubes; and cooling the balloon to less than about 37° C.
摘要翻译：公开了包括具有纳米管的气囊的医疗系统和方法。在一些实施例中，医疗系统包括细长轴和由轴承载并包括纳米管的可膨胀气囊。医疗系统能够将球囊冷却到小于约37℃。在一些实施例中，一种方法包括提供具有细长轴的医疗装置和由细长轴承载并包括纳米管的可膨胀气囊; 并将气球冷却至小于约37℃。

90. 发明申请

US20100280452A1 MEDICAL DEVICES HAVING MULTIPLE LAYERS 有权
公开(公告)号：US20100280452A1
公开(公告)日：2010-11-04
申请号：US12835157
申请日：2010-07-13
申请人： John Jianhua Chen , Jan Weber
发明人： John Jianhua Chen , Jan Weber
IPC分类号： A61M25/10 , A61K9/14 , A61K31/19 , A61K31/662 , A61K31/255 , A61K31/135 , A61K31/13 , A61K31/713 , A61K38/00 , A61P29/00 , A61P35/00 , A61P23/00 , A61P7/02 , A61P3/06
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/608 , A61L2300/624
摘要： Described herein are medical devices which are configured for implantation or insertion into a subject, preferably a mammalian subject. The medical devices contain one or more multilayer regions, which contain: (a) one or more (typically a plurality of) charged nanoparticle layers and (b) one or more (typically a plurality of) charged polyelectroyte layers. Such multilayers have a number of desirable attributes, including high strength, non-compliance, and flexibility. Also described herein are methods of making such devices.

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