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81. 发明授权

US08097742B2 Water-soluble, surface-functionalized nanoparticle for bioconjugation via universal silane coupling 失效
标题翻译：用于通过通用硅烷偶联生物缀合的水溶性表面官能化纳米颗粒
公开(公告)号：US08097742B2
公开(公告)日：2012-01-17
申请号：US11795639
申请日：2005-01-20
申请人： Jackie Y. Ying , Nikhil R. Jana , Yuangang Zheng
发明人： Jackie Y. Ying , Nikhil R. Jana , Yuangang Zheng
IPC分类号： C07F7/08
CPC分类号： C07K17/14 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C07B2200/11 , C07F7/1804 , C07F9/4012
摘要： The invention provides a process for the preparation of a surface-functionalized nanoparticle comprising: (a) reacting a nanoparticle with a functionalized silane and a base in a substantially non-aqueous solvent to obtain a partially conjugated silanated nanoparticle, wherein the functionalized silane and the base are present in relative amounts such that said functionalized silane undergoes substantially only a single hydrolysis reaction; (b) reacting the partially conjugated silanated nanoparticle formed in step (a) with a base in a solvent in which the partially conjugated silanated nanoparticle is substantially insoluble and in which the base is substantially soluble. The invention also provides a surface-functionalized nanoparticle prepared therefrom and a bioconjugate comprising said a surface-functionalized nanoparticle.
摘要翻译：本发明提供了制备表面官能化纳米颗粒的方法，其包括：（a）使纳米颗粒与官能化的硅烷和碱在基本上非水溶剂中反应，得到部分共轭的硅烷化纳米颗粒，其中官能化的硅烷和碱以相对量存在，使得所述官能化硅烷基本上仅经历单一水解反应; （b）使步骤（a）中形成的部分共轭的硅烷化纳米颗粒与碱在溶剂中反应，其中部分共轭的硅烷化纳米颗粒基本上不溶，其中碱基本上是可溶的。本发明还提供由其制备的表面官能化纳米颗粒和包含所述表面官能化纳米颗粒的生物共轭物。

82. 发明申请

US20120004430A1 PRODUCTION OF HYDROXYMETHYLFURFURAL 有权
标题翻译：生产羟基甲基纤维素
公开(公告)号：US20120004430A1
公开(公告)日：2012-01-05
申请号：US12999610
申请日：2008-06-18
申请人： Yugen Zhang , Jackie Y. Ying
发明人： Yugen Zhang , Jackie Y. Ying
IPC分类号： C07D307/48
CPC分类号： C07D307/50 , B01J31/2269 , B01J31/2273 , B01J2231/70 , B01J2531/62 , C10G2300/1011 , C10G2300/1014 , C10G2300/44 , Y02P20/582 , Y02P30/20
摘要： The invention provides a process for making hydroxymethylfurfural comprising exposing a saccharide, e.g. glucose or fructose, to a metal complex of an N-heterocyclic carbene.
摘要翻译：本发明提供了一种制备羟甲基糠醛的方法，包括将糖，例如葡萄糖或果糖，涉及N-杂环卡宾的金属络合物。

83. 发明授权

US08003380B2 High throughput cell-based assays fabricated with integrated silicon and cell culture technologies 有权
标题翻译：采用集成硅和细胞培养技术制造的高通量基于细胞的测定
公开(公告)号：US08003380B2
公开(公告)日：2011-08-23
申请号：US11325609
申请日：2006-01-04
申请人： Shyi Herng Kan , Jackie Y. Ying , Hanry Yu , Karl Schumacher , Susanne San San Ng , Wanxin Sun
发明人： Shyi Herng Kan , Jackie Y. Ying , Hanry Yu , Karl Schumacher , Susanne San San Ng , Wanxin Sun
IPC分类号： C12M1/12
CPC分类号： C12N5/0068 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0887 , C12M23/20 , C12M23/34 , C12M25/02 , C12N2533/10 , C12N2533/54 , C12N2535/10
摘要： The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface. The porous material may be capable of attaching species with control over the positioning and spatial distribution of the species across the surface of the material. Such articles and methods may be useful in, for example, biological assays, biological sensors, or in the culturing of biological cells.
摘要翻译：本发明涉及涉及可与物种如生物分子，细胞等相互作用的多孔材料（例如膜）的制品和方法，由此该物质可能相对于多孔材料的表面粘附或变得固定或涂覆多孔表面的粘附层。多孔材料可以能够附着物质以控制物质在材料表面上的定位和空间分布。这样的制品和方法可用于例如生物测定，生物传感器或生物细胞的培养。

84. 发明申请

US20110189071A1 MESOPOROUS NANOSTRUCTURES 审中-公开
标题翻译：多孔纳米结构
公开(公告)号：US20110189071A1
公开(公告)日：2011-08-04
申请号：US12811783
申请日：2009-01-05
申请人： Jackie Y. Ying , Yu Han , Leng Leng Chng , Lan Zhao
发明人： Jackie Y. Ying , Yu Han , Leng Leng Chng , Lan Zhao
IPC分类号： C01B33/12 , B82Y30/00
CPC分类号： C01B37/00 , C01B37/02
摘要： The invention provides a process for making a particulate mesoporous material. A solution comprising a surfactant and a base is combined with a hydrolysable precursor without agitating said solution. The resulting mixture is then allowed to stand without externally applied agitation for sufficient time for hydrolysis of the precursor to form the particulate mesoporous material.
摘要翻译：本发明提供一种制备颗粒介孔材料的方法。将包含表面活性剂和碱的溶液与可水解的前体组合而不搅拌所述溶液。然后将所得混合物在不经外部搅拌的情况下静置足够的时间用于水解前体以形成颗粒介孔材料。

85. 发明授权

US07976696B2 Mesostructured zeolitic materials and methods of making and using the same 有权
标题翻译：中间结构沸石材料及其制造和使用方法
公开(公告)号：US07976696B2
公开(公告)日：2011-07-12
申请号：US12133879
申请日：2008-06-05
申请人： Jackie Y. Ying , Javier García-Martínez
发明人： Jackie Y. Ying , Javier García-Martínez
IPC分类号： C10G11/00 , C10G11/05
CPC分类号： B01J29/40 , B01J20/18 , B01J20/186 , B01J29/005 , B01J29/0308 , B01J29/041 , B01J29/084 , B01J29/106 , B01J29/18 , B01J29/80 , B01J2229/62 , B82Y30/00 , C01B39/02 , C01B39/023 , C01B39/026 , C01B39/04 , C10G1/086 , C10G11/02 , C10G11/05 , C10G11/18 , C10G45/04 , C10G47/02 , C10G2300/1033 , C10G2300/1074 , C10G2300/1096 , C10G2400/02 , C10G2400/20 , Y10T428/26
摘要： One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for organic compounds and degradation catalysts for polymers.
摘要翻译：本发明的一个方面涉及介孔结构的沸石。本发明还涉及一种制备介孔结构的沸石的方法，以及它们用作有机化合物的裂化催化剂和聚合物的降解催化剂。

86. 发明申请

US20110146449A1 METHODS AND COMPOSITIONS COMPRISING POLYOXOMETALATES 审中-公开
标题翻译：包含聚羟基乙酸酯的方法和组合物
公开(公告)号：US20110146449A1
公开(公告)日：2011-06-23
申请号：US13060184
申请日：2009-08-21
申请人： Jackie Y. Ying , Jie Zhang , Boon Ping Ting
发明人： Jackie Y. Ying , Jie Zhang , Boon Ping Ting
IPC分类号： B22F9/18 , C01B33/20 , B82Y40/00
CPC分类号： B22F9/24 , B22F2998/00 , C22B11/00 , C22B23/00 , B22F1/0018
摘要： The present invention generally relates to compositions and methods comprising polyoxometalates (POMs). In some cases, a reduced form of a POM may be formed via electrolysis in the presence of essentially no supporting electrolyte. The reduced POMs may be used for various applications, for example, for the formation of metallic nanoparticles. Some embodiments of the present invention provide compositions and methods comprising reduced forms of the polyoxometalate, [alpha-SiW12O40]4−.
摘要翻译：本发明一般涉及包含多金属氧酸盐（POM）的组合物和方法。在一些情况下，在基本不存在支持电解质的情况下，可通过电解形成还原形式的POM。还原的POM可用于各种应用，例如用于形成金属纳米颗粒。本发明的一些实施方案提供了组合物和方法，其包括多金属氧酸盐还原形式，[α-SiW12O40] 4-。

87. 发明申请

US20110124755A1 Polyisocyanurates 有权
标题翻译：聚异氰脲酸酯
公开(公告)号：US20110124755A1
公开(公告)日：2011-05-26
申请号：US12988246
申请日：2009-04-09
申请人： Yugen Zhang , Jackie Y. Ying , Siti Nurhanna Binte Riduan
发明人： Yugen Zhang , Jackie Y. Ying , Siti Nurhanna Binte Riduan
IPC分类号： C08G18/02 , C07C2/02 , C07D213/06 , C07C45/00 , C08J9/00 , B01J31/06 , B82Y30/00
CPC分类号： C08G18/022 , B01J23/42 , B01J23/44 , B01J31/063 , B01J35/10 , C08G18/71 , C08G18/76 , C08G18/7614 , C08G18/7671 , C08G18/77
摘要： The invention relates to a polyisocyanurate comprising isocyanurate rings linked by linker groups coupled to the nitrogen atoms of said rings. The polyisocyanurate may be microporous or mesoporous or both microporous and mesoporous.
摘要翻译：本发明涉及包含通过与所述环的氮原子连接的连接基团连接的异氰脲酸酯环的聚异氰脲酸酯。聚异氰脲酸酯可以是微孔或中孔或微孔和介孔两者。

88. 发明申请

US20110124049A1 INTEGRATED MICROFLUIDIC DEVICE FOR GENE SYNTHESIS 审中-公开
标题翻译：用于基因合成的集成微流体装置
公开(公告)号：US20110124049A1
公开(公告)日：2011-05-26
申请号：US12672673
申请日：2008-07-31
申请人： Mo-Huang Li , Jackie Y. Ying , Mo-Chao Huang , Sean Pin Ng
发明人： Mo-Huang Li , Jackie Y. Ying , Mo-Chao Huang , Sean Pin Ng
IPC分类号： C12P19/34
CPC分类号： C12N15/1093 , C12N15/1031
摘要： We report making an integrated micro-fluidic device for synthesizing double stranded DNA from short oligo-nucleotides. We demonstrate successful synthesis of a 760 bp gene segment from a pool of 39 oligonucleotides on a micro-fluidic device using both the one-step and two-step synthesis processes. We also describe purifying the double stranded DNA PCR product and filtering out sequence errors in the double stranded DNA product, all on the same device.
摘要翻译：我们报告制备用于从短寡核苷酸合成双链DNA的整合微流体装置。我们证明使用一步法和两步合成法在微流体装置上从39个寡核苷酸库中成功地合成了一个760bp的基因区段。我们还描述了纯化双链DNA PCR产物并滤出双链DNA产物中的序列错误，全部在同一器件上。

89. 发明申请

US20100285585A1 METHOD FOR EXTRACELLULAR MATRIX MEDIATED DIFFERENTIATION AND PROLIFERATION OF STEM CELLS 失效
标题翻译：超细胞基质介导的分化和干细胞增殖的方法
公开(公告)号：US20100285585A1
公开(公告)日：2010-11-11
申请号：US12746512
申请日：2008-12-05
申请人： Jackie Y. Ying , Andrew Chwee Aun Wan , Karthikeyan Narayanan , Karl M. Schumacher
发明人： Jackie Y. Ying , Andrew Chwee Aun Wan , Karthikeyan Narayanan , Karl M. Schumacher
IPC分类号： C12N5/0775
CPC分类号： C12N5/0606 , C12N5/0663 , C12N2502/13 , C12N2502/22 , C12N2502/256 , C12N2533/90
摘要： There is provided a method of culturing a stem cell on extracellular matrix extracted from support cells and in a stem cell culture medium comprising medium conditioned by the support cells
摘要翻译：提供了一种培养从支持细胞提取的细胞外基质上的干细胞的方法，以及包含由支持细胞调节的培养基的干细胞培养基

90. 再颁专利

USRE41584E1 Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production 有权
标题翻译：纳米晶体磷灰石和复合材料，并入其中的假体及其生产方法
公开(公告)号：USRE41584E1
公开(公告)日：2010-08-24
申请号：US10863863
申请日：2004-06-07
申请人： Jackie Y. Ying , Edward S. Ahn , Atsushi Nakahira
发明人： Jackie Y. Ying , Edward S. Ahn , Atsushi Nakahira
IPC分类号： C01B15/16 , C04B35/01
CPC分类号： A61L27/12 , A61F2/30767 , A61F2310/00239 , A61F2310/00293 , A61F2310/00796 , A61L27/32 , A61L2400/12 , B82Y30/00 , C01B25/32 , C03C4/0007 , C03C14/00 , C04B35/117 , C04B35/447 , C04B35/46 , C04B35/488 , C04B35/6262 , C04B35/62675 , C04B35/645 , C04B2235/3212 , C04B2235/3217 , C04B2235/3225 , C04B2235/3232 , C04B2235/3244 , C04B2235/3246 , C04B2235/5409 , C04B2235/5445 , C04B2235/5454 , C04B2235/549 , C04B2235/608 , C04B2235/656 , C04B2235/6562 , C04B2235/6567 , C04B2235/668 , C04B2235/77 , C04B2235/785 , C04B2235/80 , C04B2235/96 , C04B2235/9653 , F16C2240/64 , Y10S977/776
摘要： Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having average crystal size of less than 150 nm are provided. Products also can have a surface area of at least 40 m2/g and can be of high density.Hydroxyapatite material is investigated in particular detail. Compositions of the invention can be used as prosthetic implants and coatings for prosthetic implants.
摘要翻译：提出了纳米晶磷灰石的合成方法，以及一系列具体的反应参数，可以根据具体方式调整回收产物的特性。提供平均晶体尺寸小于150nm的颗粒状磷灰石组合物。产品还可以具有至少40m 2 / g的表面积，并且可以具有高密度。详细研究了羟基磷灰石材料。本发明的组合物可以用作假体植入物和用于假体植入物的涂层。

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