专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明申请

US20090326343A1 FLUID HANDLING CASSETTE HAVING A SPECTROSCOPIC SAMPLE CELL 有权
标题翻译：具有光谱样品池的流体处理箱
公开(公告)号：US20090326343A1
公开(公告)日：2009-12-31
申请号：US12359874
申请日：2009-01-26
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/15
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module includes a module housing and a first fluid passageway extending from the module housing. The first fluid passageway has a patient end remote from the housing. The first fluid passageway is configured to provide fluid communication with a bodily fluid in a patient. A fluid component separator is in fluid communication with the first fluid passageway. The fluid component separator is configured to separate at least one component from a portion of the bodily fluid drawn from the patient. A spectroscopic sample cell is configured to hold at least a portion of the first component.
摘要翻译：流体处理模块被配置为可移除地与可重复使用的主流体处理装置接合。模块包括模块壳体和从模块壳体延伸的第一流体通道。第一流体通道具有远离壳体的患者端。第一流体通道被配置为提供与患者体内的体液的流体连通。流体组分分离器与第一流体通道流体连通。流体部件分离器构造成将至少一个部件与从患者抽出的体液的一部分分离。光谱样品池被配置为保持第一组分的至少一部分。

82. 发明申请

US20080161723A1 INFUSION FLOW INTERRUPTION METHOD AND APPARATUS 审中-公开
标题翻译：输注流中断方法和装置
公开(公告)号：US20080161723A1
公开(公告)日：2008-07-03
申请号：US11850972
申请日：2007-09-06
申请人： Richard Keenan , Jeffrey Chiou , Peter Rule , James R. Braig
发明人： Richard Keenan , Jeffrey Chiou , Peter Rule , James R. Braig
IPC分类号： A61B5/00 , A61M5/142
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150267 , A61B5/150305 , A61B5/150755 , A61B5/150786 , A61B5/150824 , A61B5/150854 , A61B5/153 , A61B5/157 , A61M1/3609 , A61M5/14 , A61M5/1415 , A61M2005/1404 , A61M2005/1726 , A61M2230/201
摘要： Disclosed are systems, apparatus and methods for determining information related to analyte(s) (e.g., concentration) in a sample such as biological fluid. An analysis system for determining information relating to at least one analyte in a sample of biological fluid can be configured to: withdraw the sample of biological fluid from the source of biological fluid; interrupt the flow of infusion fluid while the sample of biological fluid is withdrawn; analyze the withdrawn biological fluid to determine information relating to at least one analyte; and resume the flow of infusion fluid after the sample of biological fluid is withdrawn. A method of interrupting flow of an infusion fluid without triggering an alarm can comprise, while the flow of the infusion fluid is interrupted, diverting the flow of the infusion fluid from a fluid passageway to an expandable volume at a rate that maintains constant flow from an infusion pump.
摘要翻译：公开了用于确定样品（例如生物流体）中与分析物（例如浓度）相关的信息的系统，装置和方法。用于确定与生物流体样品中的至少一种分析物相关的信息的分析系统可以被配置为：从生物流体源中抽出生物流体的样品; 中断生物流体样本取出时输液的流动; 分析所抽取的生物流体以确定与至少一种分析物有关的信息; 并在取出生物流体的样品后恢复输注液的流动。一种在不触发报警的情况下中断输注流体的流动的方法可以包括在输注流体的流动被中断的同时将输注流体的流动从流体通道转移到可膨胀体积，其速率保持恒定的流量输液泵。

83. 发明授权

US06989891B2 Device and method for in vitro determination of analyte concentrations within body fluids 失效
公开(公告)号：US06989891B2
公开(公告)日：2006-01-24
申请号：US10219625
申请日：2002-08-14
申请人： James R. Braig , Peter Rule , Philip C. Hartstein
发明人： James R. Braig , Peter Rule , Philip C. Hartstein
IPC分类号： G01N33/48
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

84. 发明授权

US06983177B2 Layered spectroscopic sample element with microporous membrane 失效
公开(公告)号：US06983177B2
公开(公告)日：2006-01-03
申请号：US10337226
申请日：2003-01-06
申请人： Peter Rule , James R. Braig , Philip C. Hartstein
发明人： Peter Rule , James R. Braig , Philip C. Hartstein
IPC分类号： A61B5/00
CPC分类号： B01L3/5023 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1491 , B01L3/5027 , B01L3/508 , B01L2200/027 , B01L2300/0654 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N21/03 , G01N21/8483 , G01N2021/0346
摘要： A spectroscopic sample holder comprises a microporous sheet. The microporous sheet has a top surface, a bottom surface substantially parallel to the top surface, and at least one side surface oriented substantially perpendicular to the top and bottom surfaces. The side surface forms an exposed transit opening configured to contact a material sample and distribute the contacted material sample into the microporous sheet. The spectroscopic sample holder further comprises a first planar support member positioned on, and substantially parallel to, the top surface of the microporous sheet. The spectroscopic sample holder further comprises a second planar support member positioned on the bottom surface of the microporous sheet, and oriented substantially parallel to the first planar support member.

85. 发明授权

US06884222B1 Method and apparatus for estimation of resting respiratory quotient 失效
公开(公告)号：US06884222B1
公开(公告)日：2005-04-26
申请号：US10718075
申请日：2003-11-20
申请人： James R. Braig
发明人： James R. Braig
IPC分类号： A61B5/083 , A61B5/08
CPC分类号： A61B5/083
摘要： A method and apparatus for determining a user's Respiratory Quotient (RQ) using just measured O2 and CO2 concentrations without use of a flow meter. The RQ is determined by measuring the user's real-time inspired O2 concentration (INS O2) and end tidal O2 concentration (ETO2) and measuring the user's real-time inspired CO2 concentration (INS CO2) and end tidal CO2 concentration (ETCO2), and then determining the user's RQ from the measured INS O2, ETO2, INS CO2, and ETCO2 values in accordance with the following equation: RQ=(ETCO2−INS CO2)/(INS O2−ETO2). In order to avoid error introduced by the flow rate, the measurement steps are preferably performed while the user is in a resting condition. Also, ETCO2 is preferably measured as the maximum CO2 value in a breath cycle of the user, while INS CO2 is preferably measured as the minimum CO2 value in a breath cycle of the user. Similarly, ETO2 is preferably measured as the minimum O2 value within a breath cycle of the user, while INS O2 is measured as the maximum O2 value within a breath cycle of the user. On the other hand, the values of INS CO2 and ETCO2 also may be determined in accordance with the invention by analysis of a CO2 waveform of a breath cycle of the user and the values of INS O2 and ETO2 determined by synchronizing timing of the O2 waveform of a breath cycle of the user with the CO2 waveform and sampling INS O2 and ETO2 values simultaneously with sampling of complementary CO2 values determined by analysis of the CO2 wavefomm. The RQ measuring device may include the oxygen and CO2 sensors in a mainstream or sidestream configuration.

86. 发明授权

US06731961B2 Method for transforming phase spectra to absorption spectra 失效
公开(公告)号：US06731961B2
公开(公告)日：2004-05-04
申请号：US10291912
申请日：2002-11-08
申请人： James R. Braig , W. Dale Hall , Casper W. Barnes , Peng Zheng , Jennifer H. Gable
发明人： James R. Braig , W. Dale Hall , Casper W. Barnes , Peng Zheng , Jennifer H. Gable
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/1491 , G01N21/1717 , G01N21/35 , G01N21/3577 , G01N21/71
摘要： A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. One embodiment provides a transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation. Phase and magnitude differences in the transfer function are detected in the presence of the sought-after analyte. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. Another embodiment provides a method for transforming thermal phase spectra to absorption spectra for consistent determination of analyte concentration within the sample.

87. 发明授权

US09561001B2 Fluid handling cassette system for body fluid analyzer 有权
标题翻译：流体处理盒系统用于体液分析仪
公开(公告)号：US09561001B2
公开(公告)日：2017-02-07
申请号：US12986112
申请日：2011-01-06
申请人： Richard Keenan , Jeff Chiou , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James R. Braig
发明人： Richard Keenan , Jeff Chiou , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James R. Braig
IPC分类号： G01N33/50 , A61B5/157
CPC分类号： A61B5/157 , G01N33/50
摘要： A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module configured to interface with a main instrument. The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.
摘要翻译：用于体液分析的流体处理系统。该系统包括被配置为与主仪器接口的第一流体处理模块。第一流体处理模块具有第一流体处理网络，并且第一流体处理网络包括适于在输注通道内移动流体的输注通道和输液流体压力构件。流体处理系统还具有与第一模块分离的第二流体处理模块，第一模块被配置为与主仪器相接触。第二流体处理模块具有第二流体处理网络和可经由第二流体处理网络访问的至少一个样品分析单元。第一和第二模块被配置为在第一和第二流体处理网络和样品池之间互连并提供流体连通。

88. 发明授权

US09091676B2 Systems and methods for measuring multiple analytes in a sample 有权
标题翻译：用于测量样品中多种分析物的系统和方法
公开(公告)号：US09091676B2
公开(公告)日：2015-07-28
申请号：US13156295
申请日：2011-06-08
申请人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
发明人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
IPC分类号： G01N33/49 , A61B5/155 , A61B5/145 , A61B5/1455 , A61B5/1495 , A61B5/15 , A61B5/153 , A61B5/00 , G01N21/31 , G01N21/35
CPC分类号： G01N33/491 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150801 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/7275 , A61B2560/0223 , A61B2560/0233 , A61B2560/0437 , A61B2560/0443 , A61B2562/0238 , A61B2562/08 , G01N21/35 , G01N2021/3174 , G01N2201/1215 , G01N2201/1293 , G06F19/00
摘要： Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.
摘要翻译：提供了用于分析流体样品的多个组分的系统和方法。在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分的样品分离后。

89. 发明授权

US08786838B2 Analyte monitoring systems and methods 有权
标题翻译：分析物监测系统和方法
公开(公告)号：US08786838B2
公开(公告)日：2014-07-22
申请号：US13423029
申请日：2012-03-16
申请人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
发明人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
IPC分类号： G01N33/48
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

90. 发明授权

US08449524B2 Fluid component analysis systems and methods for glucose monitoring and control 有权
标题翻译：用于葡萄糖监测和控制的流体成分分析系统和方法
公开(公告)号：US08449524B2
公开(公告)日：2013-05-28
申请号：US13174610
申请日：2011-06-30
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/168
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式