专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明申请

US20100278839A1 ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY 有权
标题翻译：抗生素稳定性增强的神经生长因子（NGF）抗体
公开(公告)号：US20100278839A1
公开(公告)日：2010-11-04
申请号：US12773488
申请日：2010-05-04
申请人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
发明人： John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
IPC分类号： A61K39/395 , C07K16/18 , C12N15/63 , C12N5/10 , A61P25/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/50 , C07K2317/53 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
摘要翻译：本发明提供含有包含稳定铰链区突变的IgG4恒定区的抗神经生长因子（NGF）抗体，其中抗体在食蟹猴中表现出意想不到的长的血清半衰期。还提供了包含抗NGF抗体的药物组合物，编码NGF抗体的核酸，用于表达NGF抗体的宿主细胞和使用该抗体治疗NGF相关疾病或病症的方法。

82. 发明授权

US07826939B2 Method, apparatus, signals, and medium for managing power in a hybrid vehicle 有权
标题翻译：用于管理混合动力车辆的动力的方法，装置，信号和介质
公开(公告)号：US07826939B2
公开(公告)日：2010-11-02
申请号：US11515175
申请日：2006-09-01
申请人： Wei Liu , Nicolas Louis Bouchon
发明人： Wei Liu , Nicolas Louis Bouchon
IPC分类号： H02J17/00
CPC分类号： B60W20/10 , B60K6/48 , B60L7/18 , B60L11/005 , B60L11/14 , B60L11/1861 , B60L15/20 , B60L15/2009 , B60L15/2045 , B60L2240/12 , B60L2240/14 , B60L2240/421 , B60L2240/423 , B60L2240/425 , B60L2240/427 , B60L2240/429 , B60L2240/441 , B60L2240/443 , B60L2240/445 , B60L2240/486 , B60L2240/507 , B60L2240/545 , B60L2240/547 , B60L2240/549 , B60W10/06 , B60W10/08 , B60W10/26 , B60W20/00 , B60W20/11 , B60W2510/0623 , B60W2510/244 , B60W2520/10 , B60W2520/105 , F02D29/02 , Y02T10/56 , Y02T10/6221 , Y02T10/6286 , Y02T10/645 , Y02T10/70 , Y02T10/7005 , Y02T10/7022 , Y02T10/7044 , Y02T10/705 , Y02T10/7077 , Y02T10/72 , Y02T10/7258 , Y02T10/7283 , Y02T10/84 , Y10S903/903
摘要： A method and apparatus for managing power in a hybrid vehicle is disclosed. The vehicle includes an engine, an electric motor, and an energy storage element coupled to the motor. The method involves receiving a request to supply operating power to drive the vehicle and responding to the request by selecting an apportionment of operating power between the engine and the motor from among a plurality of apportionments having respective operating costs such that the selected apportionment is associated with a minimum operating cost, the operating cost including at least an engine fuel consumption cost and a storage element lifetime cost. The method further involves causing power to be supplied by at least one of the engine and the motor in accordance with the selected apportionment.
摘要翻译：公开了一种用于管理混合动力车辆中的动力的方法和装置。车辆包括发动机，电动机和联接到电动机的能量存储元件。该方法涉及通过从具有各自的运营成本的多个分配中选择发动机和电动机之间的操作功率的分配来响应该请求来提供操作电力的请求以使得所选择的分配与最低运行成本，运行成本至少包括发动机燃料消耗成本和存储元件寿命成本。该方法还包括根据所选择的分配使发动机和电动机中的至少一个供电。

83. 发明申请

US20100241822A1 METHOD AND APPARATUS FOR MANAGING TLB 失效
标题翻译：管理TLB的方法和设备
公开(公告)号：US20100241822A1
公开(公告)日：2010-09-23
申请号：US12725513
申请日：2010-03-17
申请人： Xiao Tao Chang , Rui Hou , Wei Liu , Kun Wang
发明人： Xiao Tao Chang , Rui Hou , Wei Liu , Kun Wang
IPC分类号： G06F12/10 , G06F12/00 , G06F9/46
CPC分类号： G06F12/1036 , G06F12/109
摘要： An apparatus and method for managing a translation look-aside buffer (TLB). The TLB is shared by a plurality of jobs. The method including the steps of: obtaining at least one attribute of each job of the plurality of jobs; assigning a priority level to each job according to at least one attribute of each job; and managing the related TLB entries of each job according to the priority level of each job. The present invention also provides an apparatus for managing TLB corresponding to the above method. The method and apparatus according to the present invention provide an efficient use of the shared TLB.
摘要翻译：一种用于管理翻译后备缓冲器（TLB）的装置和方法。 TLB由多个作业共享。该方法包括以下步骤：获得多个作业的每个作业的至少一个属性; 根据每个作业的至少一个属性为每个作业分配优先级; 并根据每个作业的优先级来管理每个作业的相关TLB条目。本发明还提供了一种用于管理对应于上述方法的TLB的装置。根据本发明的方法和装置提供了共享TLB的有效使用。

84. 发明申请

US20100224857A1 FABRICATION OF PHOSPHOR FREE RED AND WHITE NITRIDE-BASED LEDs 有权
标题翻译：无磷红色和白色基于LED的制造
公开(公告)号：US20100224857A1
公开(公告)日：2010-09-09
申请号：US12682526
申请日：2007-10-12
申请人： Chew Beng Soh , Soo Jin Chua , Wei Liu , Jing Hua Teng
发明人： Chew Beng Soh , Soo Jin Chua , Wei Liu , Jing Hua Teng
IPC分类号： H01L33/06 , H01L21/20
CPC分类号： H01L33/06 , H01L27/153 , H01L33/08 , H01L33/32
摘要： A multiple quantum well (MQW) structure for a light emitting diode and a method for fabricating a MQW structure for a light emitting diode are provided. The MQW structure comprises a plurality of quantum well structures, each quantum well structure comprising: a barrier layer; and a well layer having quantum dot nanostructures embedded therein formed on the barrier layer, the barrier and the well layer comprising a first metal-nitride based material; wherein at least one of the quantum well structures further comprises a capping layer formed on the well layer, the capping layer comprising a second metal-nitride based material having a different metal element compared to the first metal-nitride based material.
摘要翻译：提供了用于发光二极管的多量子阱（MQW）结构和用于制造用于发光二极管的MQW结构的方法。 MQW结构包括多个量子阱结构，每个量子阱结构包括：阻挡层; 以及在所述阻挡层上形成有嵌入其中的量子点纳米结构的阱层，所述势垒层和所述阱层包含第一金属氮化物基材料; 其中所述量子阱结构中的至少一个还包括形成在所述阱层上的覆盖层，所述覆盖层包含与所述第一金属氮化物基材料相比具有不同金属元素的第二金属氮化物基材料。

85. 发明授权

US07788710B2 Architecture and design for central authentication and authorization in an on-demand utility environment using a secured global hashtable 有权
标题翻译：在使用安全的全球散列表的按需实用程序环境中进行中央身份验证和授权的架构和设计
公开(公告)号：US07788710B2
公开(公告)日：2010-08-31
申请号：US12147716
申请日：2008-06-27
申请人： Messaoud Benantar , Yen-Fu Chen , John W. Dunsmoir , Randolph Michael Forlenza , Wei Liu , Sandra Juni Schlosser
发明人： Messaoud Benantar , Yen-Fu Chen , John W. Dunsmoir , Randolph Michael Forlenza , Wei Liu , Sandra Juni Schlosser
IPC分类号： G06F7/04
CPC分类号： H04L63/0823 , H04L63/0407 , H04L63/14
摘要： A Centralized Authentication & Authorization (CAA) system that prevents unauthorized access to client data using a secure global hashtable residing in the application server in a web services environment. CAA comprises a Service Request Filter (SRF) and Security Program (SP). The SRF intercepts service requests, extracts the service client's identifier from a digital certificate attached to the request, and stores the identifier in memory accessible to service providers. The client identifier is secured by the SP using a key unique to the client identifier. When the web services manager requests the client identifier, the web services manager must present the key to the SP in order to access the client identifier. Thus, the present invention prevents a malicious user from attempting to obtain sensitive data within the application server once the malicious user has gained access past the firewall.
摘要翻译：集中式身份验证和授权（CAA）系统，可以防止使用位于Web服务环境中的应用程序服务器中的安全全局散列表来对客户端数据进行未经授权的访问。 CAA包括服务请求过滤器（SRF）和安全程序（SP）。 SRF拦截服务请求，从附加到请求的数字证书中提取服务客户端的标识符，并将该标识符存储在服务提供商可访问的存储器中。客户端标识符由SP使用客户端标识符唯一的密钥保护。当Web服务管理器请求客户端标识符时，Web服务管理器必须向SP呈现密钥以访问客户端标识符。因此，本发明防止恶意用户一旦恶意用户已经通过防火墙访问，就试图获取应用服务器内的敏感数据。

86. 发明授权

US07748133B2 Workpiece inspecting device 失效
标题翻译：工件检查装置
公开(公告)号：US07748133B2
公开(公告)日：2010-07-06
申请号：US12324856
申请日：2008-11-27
申请人： Wei Liu
发明人： Wei Liu
IPC分类号： G01B5/02
CPC分类号： G01B3/14 , G01B3/30 , G01B3/32 , G01B5/02 , G01B5/06 , Y10S33/01
摘要： An exemplary workpiece inspecting device includes a base, a slider, a handle, a number of magnets, a number of probes and a measuring block. The slider is slidably mounted on the base and supports the handle thereon. The magnets are respectively embedded into the base for attracting and fixing a workpiece on the base. The probes are separately disposed on both the base and the slider for inspecting the perforations defined on a workpiece. The measuring block is attached on the slider for sliding and inspecting a thickness of the workpiece during the movement of the slider.
摘要翻译：示例性的工件检查装置包括基座，滑块，手柄，多个磁体，多个探针和测量块。滑块可滑动地安装在基座上并在其上支撑手柄。磁体分别嵌入基座中，用于在基座上吸引和固定工件。探针分别设置在基座和滑块上，用于检查在工件上限定的穿孔。测量块安装在滑块上，用于在滑块移动期间滑动和检查工件的厚度。

87. 发明授权

US07745164B2 Methods of modulating apoptosis using inhibitors of brain-localized protein kinases homologous to homeodomain-interacting protein kinases 失效
标题翻译：使用与同源结构域相互作用蛋白激酶同源的脑定位蛋白激酶抑制剂调节凋亡的方法
公开(公告)号：US07745164B2
公开(公告)日：2010-06-29
申请号：US11645056
申请日：2006-12-26
申请人： Wei Liu , Bradley A. Ozenberger , Leeying Wu , Ching-Hsiung Frederick Lo , Steven A. Haney , Hemchand Sookdeo , Jee Hyung Lee
发明人： Wei Liu , Bradley A. Ozenberger , Leeying Wu , Ching-Hsiung Frederick Lo , Steven A. Haney , Hemchand Sookdeo , Jee Hyung Lee
IPC分类号： C12Q1/48
CPC分类号： C12N9/1205
摘要： The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), isolated nucleic acid molecules that encode these polypeptides, inhibitors, and methods related thereto. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention, as well as inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention. The invention further provides uses of HIPK4 and its inhibitors, e.g., mutants of HIPK4 lacking protein kinase activity, for modulation of apoptosis, as well as the prevention and treatment of neurological disorders and cancers.
摘要翻译：本发明提供与与已知同源结构域相互作用蛋白激酶（HIPK）同源的新型脑定位蛋白激酶相关的分离的蛋白激酶多肽，编码这些多肽的分离的核酸分子，抑制剂及其相关方法。本发明的新型多肽和核酸分子称为HIPK4。本发明还提供了遗传工程改造的表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。本发明还向本发明的核酸分子以及能够结合本发明的蛋白激酶多肽的抑制剂，激活剂和抗体提供反义和RNAi分子。本发明还提供了HIPK4及其抑制剂（例如缺乏蛋白激酶活性的HIPK4的突变体）用于调节凋亡以及预防和治疗神经障碍和癌症的用途。

88. 发明申请

US20100137438A1 ISOVALINE FOR TREATMENT OF PAIN 有权
标题翻译：用于治疗疼痛的ISOVALINE
公开(公告)号：US20100137438A1
公开(公告)日：2010-06-03
申请号：US12441054
申请日：2007-09-12
申请人： Ernest Puil , Bernard Ansel MacLeod , Thomas Michael Stokes , Wei Liu
发明人： Ernest Puil , Bernard Ansel MacLeod , Thomas Michael Stokes , Wei Liu
IPC分类号： A61K31/197 , A61P25/02
CPC分类号： A61K31/198
摘要： The invention provides for the use of isovaline or a pharmaceutically acceptable salt thereof for the treatment of Pain in a mammalian subject in some preferred embodiments, the invention provides for the treatment of acute and chronic Pain syndromes where other drug therapies have limited efficacy or unacceptable toxicity in said subject.
摘要翻译：本发明在一些优选实施方案中提供异缬氨酸或其药学上可接受的盐在哺乳动物受试者中用于治疗疼痛的用途，本发明提供治疗急性和慢性疼痛综合征，其中其它药物疗法具有有限的功效或不可接受的毒性在所述主题。

89. 发明申请

US20090297418A1 Composite Catalyst Materials And Method For The Selective Reduction Of Nitrogen Oxides 审中-公开
标题翻译：复合催化剂材料和氮氧化物选择性还原的方法
公开(公告)号：US20090297418A1
公开(公告)日：2009-12-03
申请号：US12473577
申请日：2009-05-28
申请人： Wei Liu
发明人： Wei Liu
IPC分类号： B01D53/56 , B01J23/10
CPC分类号： B01J23/8892 , B01D53/8628 , B01D2251/204 , B01D2251/206 , B01D2251/208 , B01D2255/1021 , B01D2255/2045 , B01D2255/2047 , B01D2255/206 , B01D2255/2073 , B01D2255/20738 , B01D2255/20761 , B01D2255/9202 , B01J23/10 , B01J23/63 , B01J23/83 , B01J23/8946 , B01J29/146 , B01J29/166 , B01J29/46 , B01J29/48
摘要： Composite catalyst materials that may be used to reduce nitrogen oxides to nitrogen gas in the presence of other gasses without significant poisoning of the composite catalyst materials or reaction with the other gasses. The composite catalyst materials are formed of a matrix material comprised of cerium oxide doped with alkaline earth metal oxides, rare earth metal oxides, and combinations thereof wherein the cerium oxide comprises more than 50 atomic percent of the matrix material, and nanoparticles comprising transition metal oxides wherein the transition metal oxides comprise less than 20 atomic percent of the composite catalyst material. The composite catalyst materials may further contain noble metals dispersed in the matrix material.
摘要翻译：可用于在其他气体存在下将氮氧化物还原成氮气的复合催化剂材料，而不会复合催化剂材料的显着中毒或与其它气体的反应。复合催化剂材料由掺杂有碱土金属氧化物的氧化铈，稀土金属氧化物及其组合构成的基质材料形成，其中氧化铈包含基体材料的50原子％以上，纳米颗粒包含过渡金属氧化物其中所述过渡金属氧化物包含小于20原子％的所述复合催化剂材料。复合催化剂材料还可以含有分散在基体材料中的贵金属。

90. 发明授权

US07627392B2 Automated process control using parameters determined with approximation and fine diffraction models 失效
$Automated process control using parameters determined with approximation and fine diffraction models$
标题翻译：使用近似和精细衍射模型确定的参数进行自动过程控制
公开(公告)号：US07627392B2
公开(公告)日：2009-12-01
申请号：US11848214
申请日：2007-08-30
申请人： Wei Liu , Shifang Li , Weidung Yang , Manuel Madriaga
发明人： Wei Liu , Shifang Li , Weidung Yang , Manuel Madriaga
IPC分类号： G06F19/00
CPC分类号： G05B19/41875 , G01N21/4788 , G03F7/70625 , G05B2219/32182 , G05B2219/32186 , G05B2219/32188 , G05B2219/37224
摘要： Provided is a method of controlling a fabrication cluster using a machine learning system, the machine learning system trained developed using an optical metrology model. A simulated approximation diffraction signal is generated based on an approximation diffraction model of the structure. A set of difference diffraction signal is obtained by subtracting the simulated approximation diffraction signal from each of simulated fine diffraction signals and paired with the corresponding profile parameters. A first machine learning system is trained using the pairs of difference diffraction signal and corresponding profile parameters. A library of simulated fine diffraction signals and profile parameters is generated using the trained first machine learning system and using ranges and corresponding resolutions of the profile parameters. A measured diffraction signal is input into the trained second machine learning system to determine at least one profile parameter. The at least one profile parameter is used to adjust at least one process parameter or equipment setting of the fabrication cluster.
摘要翻译：提供了一种使用机器学习系统来控制制造集群的方法，使用光学计量学模型训练的机器学习系统。基于结构的近似衍射模型生成模拟近似衍射信号。通过从每个模拟的细衍射信号中减去模拟近似衍射信号并与相应的轮廓参数配对来获得差分衍射信号。使用差分衍射信号和相应的轮廓参数对来训练第一机器学习系统。使用训练有素的第一机器学习系统并使用轮廓参数的范围和相应的分辨率来生成模拟的细衍射信号和轮廓参数的库。测量的衍射信号被输入到训练有素的第二机器学习系统中以确定至少一个轮廓参数。至少一个轮廓参数用于调整至少一个制造集群的过程参数或设备设置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式