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81. 发明授权

US08541460B2 PDK-1/Akt signaling inhibitors 有权
标题翻译： PDK-1 / Akt信号传导抑制剂
公开(公告)号：US08541460B2
公开(公告)日：2013-09-24
申请号：US12118788
申请日：2008-05-12
申请人： Ching-Shih Chen
发明人： Ching-Shih Chen
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/12
摘要： Use of a new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I for inducing apoptosis in unwanted rapidly proliferating cells, for treating, inhibiting, or delaying the onset of cancer, and for preventing restenosis in a subject that has undergone an angioplasty or stent: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, akylaryl, haloaryl, haloalkylaryl, and combinations thereof; and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea.
摘要翻译：使用新一类式I的磷酸肌醇依赖性激酶-1（PDK-1）抑制剂用于诱导不期望的快速增殖细胞中的凋亡，用于治疗，抑制或延迟癌症的发作，以及用于预防受试者的再狭窄已经经历了血管成形术或支架：其中X选自烷基和卤代烷基; Ar是选自苯基，联苯基，萘基，蒽基，菲基和芴基的芳基; 并且其中Ar任选被一个或多个选自卤素，C 1 -C 4烷基，C 1 -C 4卤代烷基，叠氮基，C 1 -C 4叠氮基烷基，芳基，烷基芳基，卤代芳基，卤代烷基芳基及其组合的基团取代。并且R选自腈，乙腈，乙腈，丙腈，甲酰胺，脒，四唑，肟，腙，乙脒，氨基乙酰胺，胍和脲。

82. 发明授权

US08478368B2 Portable electronic device 有权
标题翻译：便携式电子设备
公开(公告)号：US08478368B2
公开(公告)日：2013-07-02
申请号：US12120259
申请日：2008-05-14
申请人： Chang-Hwang Chiou , Ching-Shih Chen , Yun-Long Tun
发明人： Chang-Hwang Chiou , Ching-Shih Chen , Yun-Long Tun
IPC分类号： H04M1/00
CPC分类号： H04M1/0237 , H04M1/0227 , Y10T16/52 , Y10T16/5323 , Y10T16/54026 , Y10T16/54048 , Y10T16/5409 , Y10T70/7136
摘要： A portable electronic device includes a main body, a cap body and a hinge assembly. The cap body is movably attached to the main body, and the hinge assembly is disposed between the main body and the cap body. The hinge assembly includes a sliding portion and a rotating portion connected to each other. When the cap body and the main body are totally overlapped, the cap body is selectively to rotate or to slide with respect to the main body over the hinge assembly.
摘要翻译：便携式电子设备包括主体，盖体和铰链组件。盖主体可移动地附接到主体，并且铰链组件设置在主体和盖体之间。铰链组件包括彼此连接的滑动部分和旋转部分。当盖主体和主体完全重叠时，盖主体选择性地旋转或相对于主体在铰链组件上滑动。

83. 发明授权

US08318808B2 Zn2+chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors 有权
标题翻译： Zn2 +螯合基序 - 束缚短链脂肪酸作为新一类组蛋白脱乙酰酶抑制剂
公开(公告)号：US08318808B2
公开(公告)日：2012-11-27
申请号：US12361626
申请日：2009-01-29
申请人： Ching-Shih Chen
发明人： Ching-Shih Chen
IPC分类号： A61K31/19 , C07C223/00
CPC分类号： C07D213/81 , A61K31/167 , A61K31/19 , A61K31/4402 , C07B2200/07 , C07C237/22 , C07C237/42 , C07C259/06 , C07C259/10
摘要： Zn2+-chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests.
摘要翻译： Zn2 +螯合基序 - 拴系脂肪酸作为组蛋白脱乙酰酶（HDAC）抑制剂。化合物在体外和体内测试中表现良好。

84. 发明授权

US08306584B2 Portable electronic device 有权
标题翻译：便携式电子设备
公开(公告)号：US08306584B2
公开(公告)日：2012-11-06
申请号：US12419279
申请日：2009-04-06
申请人： Chih-Shan Yeh , Ching-Shih Chen
发明人： Chih-Shan Yeh , Ching-Shih Chen
IPC分类号： H04M1/00
CPC分类号： H04M1/0237 , H04M1/022
摘要： A portable electronic device having a first body, a second body, and a moving mechanism is provided. The moving mechanism is disposed between the first body and the second body such that the second body is moveable between a first position and a second position. In the first position, the second body is stacked on the first body. In the second position, top surfaces of the first body and second body are substantially coplanar.
摘要翻译：提供具有第一主体，第二主体和移动机构的便携式电子装置。移动机构设置在第一主体和第二主体之间，使得第二主体能够在第一位置和第二位置之间移动。在第一位置，第二主体被堆叠在第一主体上。在第二位置，第一主体和第二主体的顶表面基本上共面。

85. 发明授权

US07973062B2 Androgen receptor-ablative agents 有权
标题翻译：雄激素受体消融剂
公开(公告)号：US07973062B2
公开(公告)日：2011-07-05
申请号：US12389759
申请日：2009-02-20
申请人： Ching-Shih Chen , Dasheng Wang , Jian Yang
发明人： Ching-Shih Chen , Dasheng Wang , Jian Yang
IPC分类号： A61K31/426 , C07D277/34
CPC分类号： C07D277/34 , C07D417/06 , C07D417/12
摘要： Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating or preventing cancer by administering a therapeutically effective amount of one of the androgen receptor ablative agents to a subject in need of such treatment.
摘要翻译：噻唑烷二酮家族的化合物被提供并显示为有效的雄激素受体消融剂，其可用于治疗或预防癌症或癌前病，包括前列腺癌的方法。还提供了通过向需要这种治疗的受试者施用治疗有效量的一种雄激素受体消融剂来治疗或预防癌症的方法。

86. 发明授权

US07928145B2 Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors 有权
公开(公告)号：US07928145B2
公开(公告)日：2011-04-19
申请号：US10597022
申请日：2004-12-01
申请人： Ching-Shih Chen , Lu Qiang
发明人： Ching-Shih Chen , Lu Qiang
IPC分类号： A61K31/19 , C07C233/00
摘要： Zn2+-chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests.

87. 发明申请

US20100273871A1 ANTICANCER TOCOPHERYL SUCCINATE DERIVATIVES 审中-公开
公开(公告)号：US20100273871A1
公开(公告)日：2010-10-28
申请号：US12768392
申请日：2010-04-27
申请人： Ching-Shih Chen , Dasheng Wang
发明人： Ching-Shih Chen , Dasheng Wang
IPC分类号： A61K31/355 , C07D311/72 , A61P35/00
CPC分类号： C07D311/72
摘要： Compounds of formula I: wherein X is selected from oxygen, nitrogen and sulfur; n is 0 or 1; R1 is selected from alkyl, carboxylic acid, carboxylate, carboxamide, ester and combinations thereof; R2 is selected from alkyl, substituted alkyl, carboxylic acid, carboxylate, carboxamide, sulfonyl, sulfonamide and combinations thereof; and derivatives and metabolites thereof. Further provided are methods of using a compound of formula I to prevent and/or treat a subject having a condition characterized by unwanted cell proliferation. Also provided are pharmaceutical compounds comprising one or more compounds of formula I, or derivatives or pharmaceutically acceptable salts thereof.
摘要翻译：式I化合物：其中X选自氧，氮和硫; n为0或1; R1选自烷基，羧酸，羧酸酯，羧酰胺，酯及其组合; R 2选自烷基，取代的烷基，羧酸，羧酸酯，羧酰胺，磺酰基，磺酰胺及其组合; 及其衍生物和代谢物。还提供了使用式I化合物预防和/或治疗具有不想要的细胞增殖特征的病症的受试者的方法。还提供了包含一种或多种式I化合物或其衍生物或药学上可接受的盐的药物化合物。

88. 发明申请

US20100267673A1 PROTEIN PHOSPHATASE 2A-ACTIVATING AGENTS 有权
标题翻译：蛋白磷酸酶2A激活剂
公开(公告)号：US20100267673A1
公开(公告)日：2010-10-21
申请号：US12758858
申请日：2010-04-13
申请人： Ching-Shih Chen , Dasheng Wang , Samuel K. Kulp
发明人： Ching-Shih Chen , Dasheng Wang , Samuel K. Kulp
IPC分类号： A61K31/352 , C07D311/04 , C07F9/06 , A61P35/00
CPC分类号： C07D311/72 , A61K31/353 , A61K31/355 , A61K31/662 , C07F9/65522
摘要： Tocopheryl succinate derivatives according to formula I: are described. These compounds increase the activity of protein phosphatase 2A, can be included in pharmaceutical compositions, and can be used for the treatment of androgen receptor-dependent cancers such as prostate cancer.
摘要翻译：描述了式I的生育酚琥珀酸衍生物：这些化合物增加蛋白磷酸酶2A的活性，可以包括在药物组合物中，并且可以用于治疗依赖于雄激素受体的癌症如前列腺癌。

89. 发明授权

US07807705B2 Potent indole-3-carbinol-derived antitumor agents 失效
标题翻译：强力吲哚-3-甲醇衍生的抗肿瘤剂
公开(公告)号：US07807705B2
公开(公告)日：2010-10-05
申请号：US12118591
申请日：2008-05-09
申请人： Ching-Shih Chen , Dasheng Wang , Jing-Ru Weng
发明人： Ching-Shih Chen , Dasheng Wang , Jing-Ru Weng
IPC分类号： A61K31/404 , A61P35/00 , C07D209/14
CPC分类号： C07D209/12 , C07D209/14
摘要： Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I: wherein X is hydroxyl or amino; Y is carboxyl or sulfonyl; R1, R2, R3, and R4 can be the same or different and are selected from hydrogen, halogen, methoxy, trifluoromethyl, hydroxyl and combinations thereof, R5, R6, and R7 may be the same or different and are selected from hydrogen, chloro, bromo, nitro, phenyl, amino, methoxy, and combinations thereof, and derivatives or metabolites thereof.
摘要翻译：用于治疗癌症并诱导不需要的快速增殖细胞凋亡的化合物和方法。化合物示于式I中：其中X是羟基或氨基; Y是羧基或磺酰基; R 1，R 2，R 3和R 4可以相同或不同，并且选自氢，卤素，甲氧基，三氟甲基，羟基及其组合，R 5，R 6和R 7可以相同或不同，并且选自氢，氯，溴，硝基，苯基，氨基，甲氧基及其组合，及其衍生物或代谢物。

90. 发明申请

US20090281328A1 PDK-1/AKT SIGNALING INHIBITORS 有权
标题翻译： PDK-1 / AKT信号抑制剂
公开(公告)号：US20090281328A1
公开(公告)日：2009-11-12
申请号：US12476772
申请日：2009-06-02
申请人： Ching-Shih Chen
发明人： Ching-Shih Chen
IPC分类号： C07D403/12 , C07D231/12
CPC分类号： C07D231/12
摘要： A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, alkylaryl, haloaryl, haloalkylaryl, and combinations thereof; and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea. Also provided are methods of using the compounds for the treatment and prevention of cancer in humans.
摘要翻译：新型的式I的磷酸肌醇依赖性激酶-1（PDK-1）抑制剂：其中X选自烷基和卤代烷基; Ar是选自苯基，联苯基，萘基，蒽基，菲基和芴基的芳基; 并且其中Ar任选被一个或多个选自卤素，C 1 -C 4烷基，C 1 -C 4卤代烷基，叠氮基，C 1 -C 4叠氮基烷基，芳基，烷基芳基，卤代芳基，卤代烷基芳基及其组合的基团取代。并且R选自腈，乙腈，乙腈，丙腈，甲酰胺，脒，四唑，肟，腙，乙脒，氨基乙酰胺，胍和脲。还提供了使用该化合物治疗和预防人类癌症的方法。

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