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81. 发明专利

GEP20063874B NEW BENZO[a]PYRANO[3,2-h]ACRIDIN- 7-ONE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：GEP20063874B
公开(公告)日：2006-07-10
申请号：GEAP2004005585
申请日：2004-06-24
申请人： SERVIER LAB
发明人： KOCH MICHEL , TILLEQUIN FRANCOIS , MICHEL SYLVIE , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE , PFEIFFER BRUNO , RENARD PIERRE
IPC分类号： C07D491/04 , C07D491/048 , A61K31/436 , A61K31/4741 , A61P35/00 , C07D491/052 , C07D491/14 , C07D491/153
摘要： A compound of formula is disclosed, Wherein the radicals values are defined in the specification. The compound is suitable for use in the treatment of cancer.

83. 发明专利

PL375956A1 NOVEL SUBSTITUTED[1,4]BENZODIOXINO[2,3-E]ISOINDOLE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 未知
公开(公告)号：PL375956A1
公开(公告)日：2005-12-12
申请号：PL37595603
申请日：2003-10-17
申请人： SERVIER LAB
发明人： COUDERT GERARD , AYERBE NATHALIE , LEPIFRE FRANCK , ROUTIER SYLVAIN , CAIGNARD DANIEL-HENRI , RENARD PIERRE , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE
IPC分类号： A61P35/00 , C07D471/14 , C07D487/04 , C07D491/14 , C07D491/147 , C07D491/22 , C07D498/14 , A61K31/5365
摘要： 1,4-benzodioxino(2,3-e)isoindole derivatives (I) are new. 1,4-benzodioxino(2,3-e)isoindole derivatives of formula (I) and their enantiomers, diastereoisomers, N-oxides and addition salts with acids and bases are new. A = atoms that complete groups of formula (a) or (b); W1 = atoms that complete a phenyl or pyridyl ring; Z' = H, halogen, 1-6C alkyl or alkoxy (both optionally substituted by aryl), nitro, cyano, hydroxy, aryl, or NR5R6; R5, R6 = H or 1-6C alkyl; R4 = H, 1-6C alkyl, aryl, aryl(1-6C)alkyl or COOR'5; R'5 = 1-6C alkyl, aryl or aryl(1-6C)alkyl; Y' = oxygen or methylene; R2 = H; and R3 = H, 1-6C alkyl, aryl, aryl(1-6C)alkyl or trifluoromethylsulfonyl; or R2+R3 = bond; R1 = H, 1-6C alkyl, aryl, aryl(1-6C)alkyl, or 1-6C alkylene, substituted by one or more of OR5 or NR5R6; Z1, Z2 = H or; Z1+Z2 = fused phenyl; and aryl = phenyl, naphthyl, di- or tetra-hydronaphthyl, indenyl or indanyl (all optionally substituted by one or more of halo, 1-6C (trihalo)alkyl or alkoxy, hydroxy, amino or mono- or di-1-6C alkylamino. Provided that if Z' is H, then R1 is not H. Independent claims are included for preparing (I).

84. 发明专利

AT302183T 未知
公开(公告)号：AT302183T
公开(公告)日：2005-09-15
申请号：AT02291463
申请日：2002-06-12
申请人： SERVIER LAB
发明人： WIERZBICKI MICHEL , BOUSSARD MARIE-FRANCOISE , ROUSSEAU ANNE , ATASSI GHANEM , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE , GUILBAUD NICOLAS , KRAUS-BERTHIER LAURENCE
IPC分类号： C07D209/80 , A61K31/403 , A61K31/433 , A61K31/4439 , A61P35/00 , C07D209/94 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D491/04 , C07D491/056 , A61K31/407
摘要： Indenoindolone derivatives (I), their isomers and salts with acids and bases are new. Indenoindolone derivatives (I), their isomers and salts with acids and bases are new; R = H, alkyl (optionally substituted by carboxy, alkoxycarbonyl, or NR10R11), or alkenyl; R1-R8 = H, alkyl (optionally substituted by aryl, carboxy or alkoxycarbonyl), OH, acyloxy, NR12R13, carboxy, alkoxy (optionally substituted by aryl or NR14R15), alkenyloxy, or to adjacent groups R1-R8 = 1 or 2C alkylenedioxy; R9 = H, aryl, heteroaryl or alkyl (optionally containing one or more unsaturations and optionally substituted by one or more aryl, heteroaryl, 3-8C cycloalkyl, CN, or NR17R18 groups); X = O or NR16; R10, R11, R14, R15, R17, R18 = alkyl; NR10+R11, NR14+R15, NR17+R18 = nitrogen heterocycle; R12, R13 = H, alkyl, or NR14R15; R16 = H, alkyl, aryl, or aryl alkyl. Where alkyl, alkoxy, acyloxy, alkenyl and alkenyloxy groups have up to 6 C atoms, aryl is defined as phenyl, biphenyl, or naphthyl (optionally substituted by one or more halogen, alkyl, alkenyl, alkoxy, phenoxy, nitro, CN, amino, mono- and di-alkylamino or 1-2C alkylenedioxy groups) and heteroaryl groups may be mono- or bicyclic of 5-12 members with 1-3 heteroatoms (O, N, S) and optionally substituted by halogen, alkyl, OH, alkoxy, polyhaloalkyl, amino, mono- and di-alkylamino groups, and nitrogen heterocycles are monocyclic having 5-7 members including 1-3 heteroatoms, one of which is N and the others may be O, N, or S. An Independent claim is also included for the preparation of (I).

85. 发明专利

NO20050572L 未知
公开(公告)号：NO20050572L
公开(公告)日：2005-08-04
申请号：NO20050572
申请日：2005-02-02
申请人： SERVIER LAB
发明人： TILLEQUIN FRANCOIS , KOCH MICHEL , PIERRE ALAIN , RENARD PIERRE , MICHEL SYLVIE , HICKMAN JOHN , LEONCE STEPHANE , PFEIFFER BRUNO
IPC分类号： C07D491/147 , A61K31/4375 , A61K31/4985 , A61P35/00 , C07B61/00 , C07D491/14 , C07D491/22
摘要： Benzo[b]chromeno[g]naphthyridone or pyrano[2',3':7,8]quinolino[2,3-b]quinoxalinone derivatives (I) are new. Benzo[b]chromeno[g]naphthyridone or pyrano[2',3':7,8]quinolino[2,3-b]quinoxalinone derivatives of formula (I) and their isomers, N-oxides and salts are new: B 1, B 2C or N, at least one being N; X, Y : H, halo, OH, 1-6C alkoxy, NO 2, CN, 1-6C alkyl, 2-6C alkenyl, 1-6C polyhaloalkyl or NR aR b; R a, R bH, COCF 3, CONH 2 or 1-6C alkyl optionally substituted with NR' aR' b or NR aR b is a 5- to 7-membered ring optionally containing another heteroatom (O or N); R' a, R' bH or 1-6C alkyl, or NR' aR' b is a 5- to 7-membered ring optionally containing another heteroatom (O or N); X 1, Y 1X and Y or are absent when B 1, B 2 is N; R 1H or 1-6C alkyl; R 2H, 1-6C alkyl, OR" a, NR' aR' b, OT aOR" a, NR" aT aNR' aR' b, NR" aCOT aH, OCOT aH, OT aNR' aR' b, NR" aT aOR" a, NR" aT aCOOR" a or NR" aCOT aNR' aR' b; T a1-6C alkylene; R" aH or 1-6C alkyl; R 3, R 4H or 1-6C alkyl or together form a 3- to 6-membered ring; A : CHR 5CHR 6, CH=CR 7, CR 7=CH, COCHR 8 or CHR 8CO; R 5, R 6H, OR c, NR cR d, SR c, W 1C(W 2)U'V', W 1C(W 2)W 3T 1, W 1SO nW 3T 1, W 1SO nT 1 or C(W 2)T 1, or together form OC(Z)O, NHC(Z)O, OC(Z)NH, NHC(Z)NH, O(CH 2) mO, OCOB'COO, NHCOB'COO or OCOB'CONH, or CR 5R 6 is an oxirane or optionally N-substituted aziridine group; R c, R dH, 1-6C alkyl, aryl, aryl(1-6C)alkyl or COR e; R eH, aryl or NR"' aR"' b; R"' a, R"' bH or NR"' aR"' b is a 5- to 7-membered ring optionally containing another heteroatom (O or N); W 1O, S or NR c; W 2O or S; U' : 1-8C alkylene or 2-8C alkenylene, or is a bond when W 2 is not O and V' is not H, aryl or NH 2; V' : H, aryl, OR c, COOR c, COR c, CONR' aR' b, NR cR d, N(R c)COOR' c or N(R c)COR' c; R' c1-6C alkyl, aryl or aryl(1-6C)alkyl; W 3O, S or NR c; T 1H, 1-6C alkyl, 2-6C alkenyl, aryl, aryl(1-6C)alkyl, or 1-6C alkyl or 2-6C alkenyl substituted with OR c or NR' aR' b; n : 1 or 2; Z : O or S; m : 1-4; B' : bond, 1-6C alkylene or 2-6C alkenylene; R 7H, OR" a, W 1C(W 2)U'V', W 1C(W 2)W 3T 1, W 1SO nW 3T 1, W 1SO nT 1 or C(W 2)T 1; and R 8H, 2-7C alkanoyloxy or OR" a. An independent claim is also included for the preparation of (I). [Image] ACTIVITY : Cytostatic. cis-1,2-Acetoxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7H-benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one had IC50 values of 0.32 mu M against L1210 murine leukemia cells and 0.037 mu M against KB-3-1 human epidermoid carcinoma cells. MECHANISM OF ACTION : Cell cycle blocker.

86. 发明专利

NO20050572A 未知
公开(公告)号：NO20050572A
公开(公告)日：2005-08-04
申请号：NO20050572
申请日：2005-02-02
申请人： SERVIER LAB
发明人： TILLEQUIN FRANCOIS , KOCH MICHEL , PIERRE ALAIN , RENARD PIERRE , MICHEL SYLVIE , HICKMAN JOHN , LEONCE STEPHANE , PFEIFFER BRUNO
IPC分类号： C07D491/147 , A61K31/4375 , A61K31/4985 , A61P35/00 , C07B61/00 , C07D491/14 , C07D491/22
CPC分类号： C07D491/14

87. 发明专利

BRPI0402500A 未知
公开(公告)号：BRPI0402500A
公开(公告)日：2005-06-14
申请号：BRPI0402500
申请日：2004-06-23
申请人： SERVIER LAB
发明人： KOCH MICHEL , TILLEQUIN FRANCOIS , MICHEL SYLVIE , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE , PFEIFFER BRUNO , RENARD PIERRE
IPC分类号： C07D491/048 , A61K31/4741 , A61P35/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/153 , C07D491/056 , C07D491/147 , A61K31/4748 , A61P35/04
摘要： 1,2,3,14-Tetrahydro- or 3,14-dihydro-7H-benzo-(a)-pyrano-(3,2-h)-acridin-7-one derivatives (I) are new. Pentacyclic acridone derivatives of formula (I) and their enantiomers, diastereomers, N-oxides and acid or base addition salts are new. [Image] X, Y : H, halo, OH, alkoxy, NO 2, CN, alkyl, 2-6C alkenyl, polyhaloalkyl or NR aR b; R a, R bH, COCF 3, CONH 2 or alkyl (optionally substituted (os) by NR' aR' b); or NR aR b = Het; R' a, R' bH, alkyl or aralkyl; or NR' aR' bHet; R 1H or alkyl; R 2H, alkyl, OR'' a, NR' aR' b, -O-T a-OR'' a, -NR'' a-T a-NR' aR' b, -NR'' a-CO-Ta-H, -O-CO-T a-H, -O-T a-NR' aR' b, -NR'' a-T a-OR'' a, -NR'' a-T a-COOR'' a or -NR'' a-CO-T a-NR' aR' b; T a1-6C alkylene; R'' aH or alkyl; R 3, R 4H or alkyl; or CR 3R 43-6 membered monocyclic ring (e.g. cycloalkyl); A : -CHR 5-CHR 6-, -CH=C(R 7)-, -C(R 7)=CH-, -CO-CH(R 8)- or -CH(R 8)-CO-; R 5, R 6H, OR c, NR cR d, SR c, -W 1-C(W 2)-U-V, -W 1-C(W 2)-W 3-T 1, -W 1-S(O) n-W 3-T 1, -W 1-S(O) n-U'-V' or -C(W 2)-T 1; or R 5 + R 6-O-C(Z)-O-, -NH-C(Z)-O-, -O-C(Z)-NH-, -NH-C(Z)-NH-, -O-(CH 2) m-O-, -O-C(O)-B-CO-O-, -NH-C(O)-B-CO-O-, -O-C(O)-B-CO-NH-, O, NH or N(alkyl); R c, R dH, alkyl, aryl, aralkyl or -CO-R e; R eH, aryl or NR''' aR''' b; R''' a, R''' bH or alkyl; or NR''' aR''' bHet; W 1O, S or NR c; W 2, Z : O or S; U : 1-8C alkylene or 2-8C alkenylene; or may also be a direct bond if W 2 is S and V is other than H, aryl or NH 2; V : H, aryl, OR c, COOR c, CONR' aR' b, NR' aR' b, N(R c)COOR' c or N(R c)COR' c; R' cH, alkyl, aryl or aralkyl; W 3O, S or NR c; T 1H, aryl or aralkyl; or alkyl or 2-6C alkenyl (both os by OR c or NR' aR' b); n : 1 or 2; U' : 1-8C alkylene or 2-8C alkenylene; V : H, aryl, OR c, COOR c, COR c, CONR' aR' b, NR' aR' b, N(R c)COOR' c or N(R c)COR' c; m : 1-4; B : direct bond, 1-6C alkylene or 2-6C alkenylene; R 7H, OR'' a, -W 1-C(W 2)-U-V, -W 1-C(W 2)-W 3-T 1, -W 1-S(O) n-W 3-T 1, -W 1-S(O) n-U'-V' or -C(W 2)-T 1; R 8H, alkylcarbonyloxy or OR'' a; aryl moieties : phenyl or naphthyl (both os by one or more of OH, halo, COOH, NO 2, NH 2, mono- or dialkylamino, aloxy, 1-6C acyl and/or alkylcarbonyloxy); Het : 5-7 membered monocyclic heterocycle (optionally containing a second O or N heteroatom), e.g. pyrrolidinyl, isoxazolidinyl, oxazolidinyl, pyrazolidinyl, imidazolidinyl, piperidinyl, oxazinanyl, morphol;inyl, hexahydropyridazinyl, hexahydropyrimidinyl, piperazinyl, azepanyl, oxazepanyl or diazepanyl; alkyl moieties have 1-6C unless specified otherwise. Independent claims are included for the preparation of (I). ACTIVITY : Cytostatic. In tests in mice with transplanted C38 colon adenocarcinoma, ()-cis-1,2-diacetoxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7H-benzo-(a)-pyrano-(3,2-h)-acridin-7-one (Ia) at the optimum dose of 4 mg/kg i.v. (administered twice on days 12 and 22) inhibited tumor growth by 95% (T/C = 5%). For comparison, acronycin at the optimum dose of 100 mg/kg gave a T/C value of 27%. MECHANISM OF ACTION : Specific cell cycle blocker.

88. 发明专利

AU781768B2 New indenoindolone compounds, a process for their preparation and pharmaceutical compositions containing them 未知
公开(公告)号：AU781768B2
公开(公告)日：2005-06-09
申请号：AU4590302
申请日：2002-06-11
申请人： SERVIER LAB
发明人： WIERZBICKI MICHEL , BOUSSARD MARIE-FRANCOISE , ROUSSEAU ANNE , ATASSI GHANEM , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE , GUILBAUD NICOLAS , KRAUS-BERTHIER LAURENCE
IPC分类号： C07D209/80 , A61K31/403 , A61K31/433 , A61K31/4439 , A61P35/00 , C07D209/94 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D491/04 , C07D491/056 , A61K31/404 , C07D209/88
摘要： Indenoindolone derivatives (I), their isomers and salts with acids and bases are new. Indenoindolone derivatives (I), their isomers and salts with acids and bases are new; R = H, alkyl (optionally substituted by carboxy, alkoxycarbonyl, or NR10R11), or alkenyl; R1-R8 = H, alkyl (optionally substituted by aryl, carboxy or alkoxycarbonyl), OH, acyloxy, NR12R13, carboxy, alkoxy (optionally substituted by aryl or NR14R15), alkenyloxy, or to adjacent groups R1-R8 = 1 or 2C alkylenedioxy; R9 = H, aryl, heteroaryl or alkyl (optionally containing one or more unsaturations and optionally substituted by one or more aryl, heteroaryl, 3-8C cycloalkyl, CN, or NR17R18 groups); X = O or NR16; R10, R11, R14, R15, R17, R18 = alkyl; NR10+R11, NR14+R15, NR17+R18 = nitrogen heterocycle; R12, R13 = H, alkyl, or NR14R15; R16 = H, alkyl, aryl, or aryl alkyl. Where alkyl, alkoxy, acyloxy, alkenyl and alkenyloxy groups have up to 6 C atoms, aryl is defined as phenyl, biphenyl, or naphthyl (optionally substituted by one or more halogen, alkyl, alkenyl, alkoxy, phenoxy, nitro, CN, amino, mono- and di-alkylamino or 1-2C alkylenedioxy groups) and heteroaryl groups may be mono- or bicyclic of 5-12 members with 1-3 heteroatoms (O, N, S) and optionally substituted by halogen, alkyl, OH, alkoxy, polyhaloalkyl, amino, mono- and di-alkylamino groups, and nitrogen heterocycles are monocyclic having 5-7 members including 1-3 heteroatoms, one of which is N and the others may be O, N, or S. An Independent claim is also included for the preparation of (I).

89. 发明专利

MA27340A1 NOUVEAUX DERIVES DE [1,4]BENZODIOXINO[2,3-e]ISOINDOLE SUBSTITUES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT . 未知
公开(公告)号：MA27340A1
公开(公告)日：2005-05-02
申请号：MA28179
申请日：2005-03-30
申请人： SERVIER LAB
发明人： COUDERT GERARD , AYERBE NATHALIE , LEPIFRE FRANCK , ROUTIER SYLVAIN , CAIGNARD DANIEL-HENRI , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE , RENARD PIERRE
IPC分类号： A61P35/00 , C07D471/14 , C07D487/04 , C07D491/14 , C07D491/147 , C07D491/22 , C07D498/14 , A61K31/5365
摘要： NOUVEAUX DERIVES DE [l,4]BENZODIOXINO[2,3-e]ISOINDOLE SUBSTITUES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT Composés de formule (1) : dans laquelle : A est tel que définis dans la description, Y représente un groupement choisi parmi atome d'oxygène ou groupement méthylène, R2 représente un atome d'hydrogène, et dans ce cas : R3 représente un groupement choisi parmi atome d'hydrogène, groupement alkyle (C1-C6) linéaire eu ramifié, aryle, arylalkyle (C1-C6,) linéaire ou ramifié, ou SO2CF3, ou bien R2 et R3 forment une liaison, R1 représente un groupement choisi parmi atome d'hydrogène, groupement alkyle (C1-C6) linéaire ou ramifié, aryle, arylalkyle (C1-C6) linéaire ou ramifié, ou une chaîne alkylène (C1-C6) linéaire ou ramifié, Z1 et Z2 représentent chacun un atome d'hydrogène ou, Z1 et Z2 forment ensemble, avec les atomes de carbone qui les portent, un groupement phényle, Médicaments.

90. 发明专利

NO20050572D0 未知
公开(公告)号：NO20050572D0
公开(公告)日：2005-02-02
申请号：NO20050572
申请日：2005-02-02
申请人： SERVIER LAB
发明人： TILLEQUIN FRANCOIS , KOCH MICHEL , PIERRE ALAIN , RENARD PIERRE , MICHEL SYLVIE , HICKMAN JOHN , LEONCE STEPHANE , PFEIFFER BRUNO
IPC分类号： C07D491/147 , A61K31/4375 , A61K31/4985 , A61P35/00 , C07B61/00 , C07D491/14 , C07D491/22 , C07D
摘要： Benzo[b]chromeno[g]naphthyridone or pyrano[2',3':7,8]quinolino[2,3-b]quinoxalinone derivatives (I) are new. Benzo[b]chromeno[g]naphthyridone or pyrano[2',3':7,8]quinolino[2,3-b]quinoxalinone derivatives of formula (I) and their isomers, N-oxides and salts are new: B 1, B 2C or N, at least one being N; X, Y : H, halo, OH, 1-6C alkoxy, NO 2, CN, 1-6C alkyl, 2-6C alkenyl, 1-6C polyhaloalkyl or NR aR b; R a, R bH, COCF 3, CONH 2 or 1-6C alkyl optionally substituted with NR' aR' b or NR aR b is a 5- to 7-membered ring optionally containing another heteroatom (O or N); R' a, R' bH or 1-6C alkyl, or NR' aR' b is a 5- to 7-membered ring optionally containing another heteroatom (O or N); X 1, Y 1X and Y or are absent when B 1, B 2 is N; R 1H or 1-6C alkyl; R 2H, 1-6C alkyl, OR" a, NR' aR' b, OT aOR" a, NR" aT aNR' aR' b, NR" aCOT aH, OCOT aH, OT aNR' aR' b, NR" aT aOR" a, NR" aT aCOOR" a or NR" aCOT aNR' aR' b; T a1-6C alkylene; R" aH or 1-6C alkyl; R 3, R 4H or 1-6C alkyl or together form a 3- to 6-membered ring; A : CHR 5CHR 6, CH=CR 7, CR 7=CH, COCHR 8 or CHR 8CO; R 5, R 6H, OR c, NR cR d, SR c, W 1C(W 2)U'V', W 1C(W 2)W 3T 1, W 1SO nW 3T 1, W 1SO nT 1 or C(W 2)T 1, or together form OC(Z)O, NHC(Z)O, OC(Z)NH, NHC(Z)NH, O(CH 2) mO, OCOB'COO, NHCOB'COO or OCOB'CONH, or CR 5R 6 is an oxirane or optionally N-substituted aziridine group; R c, R dH, 1-6C alkyl, aryl, aryl(1-6C)alkyl or COR e; R eH, aryl or NR"' aR"' b; R"' a, R"' bH or NR"' aR"' b is a 5- to 7-membered ring optionally containing another heteroatom (O or N); W 1O, S or NR c; W 2O or S; U' : 1-8C alkylene or 2-8C alkenylene, or is a bond when W 2 is not O and V' is not H, aryl or NH 2; V' : H, aryl, OR c, COOR c, COR c, CONR' aR' b, NR cR d, N(R c)COOR' c or N(R c)COR' c; R' c1-6C alkyl, aryl or aryl(1-6C)alkyl; W 3O, S or NR c; T 1H, 1-6C alkyl, 2-6C alkenyl, aryl, aryl(1-6C)alkyl, or 1-6C alkyl or 2-6C alkenyl substituted with OR c or NR' aR' b; n : 1 or 2; Z : O or S; m : 1-4; B' : bond, 1-6C alkylene or 2-6C alkenylene; R 7H, OR" a, W 1C(W 2)U'V', W 1C(W 2)W 3T 1, W 1SO nW 3T 1, W 1SO nT 1 or C(W 2)T 1; and R 8H, 2-7C alkanoyloxy or OR" a. An independent claim is also included for the preparation of (I). [Image] ACTIVITY : Cytostatic. cis-1,2-Acetoxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7H-benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one had IC50 values of 0.32 mu M against L1210 murine leukemia cells and 0.037 mu M against KB-3-1 human epidermoid carcinoma cells. MECHANISM OF ACTION : Cell cycle blocker.

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