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81. 发明授权

US06652902B2 Gels and multilayer surface structures from boronic acid containing polymers 有权
公开(公告)号：US06652902B2
公开(公告)日：2003-11-25
申请号：US10035625
申请日：2001-12-28
申请人： Jeffrey A. Hubbell , Donald L. Elbert , Natalie D. Winblade
发明人： Jeffrey A. Hubbell , Donald L. Elbert , Natalie D. Winblade
IPC分类号： B05D300
CPC分类号： A61L31/10 , A61L27/34 , A61L29/085 , C08L71/02
摘要： Boronic acid containing polymers are used to form bioinert gels and multilayer surface structures. These polymers form crosslinked hydrogels, which are highly swollen in water. The crosslinking can either be chemical or physical. Water soluble polymers containing boronic acid groups, such as phenylboronic acid (PBA), can be physically crosslinked by mixing the polymers in water with other polymers containing hydroxyls or carboxylic acids. Alternatively, surfaces can be treated by stepwise incubation with a solution of the boronic acid containing polymer, followed by incubation with a solution of a diol or carboxylic acid containing polymer. Many successive layers can be generated, increasing the thickness of the formed structure at each step. The bioinert gel or surface coating can be used for passivating the surfaces of medical implants (especially those based on transplanted tissue), or for passivating the surfaces of tissues in situ, decreasing the incidence or severity of such pathologic conditions as the formation of post-surgical adhesions, and thrombosis following angioplasty.

82. 发明授权

US06350527B1 Gels and multilayer surface structures from boronic acid containing polymers 有权
标题翻译：含有硼酸的聚合物的凝胶和多层表面结构
公开(公告)号：US06350527B1
公开(公告)日：2002-02-26
申请号：US09384888
申请日：1999-08-27
申请人： Jeffrey A. Hubbell , Donald L. Elbert , Natalie D. Winblade
发明人： Jeffrey A. Hubbell , Donald L. Elbert , Natalie D. Winblade
IPC分类号： B32B904
CPC分类号： A61L31/10 , A61L27/34 , A61L29/085 , C08L71/02
摘要： Boronic acid containing polymers are used to form bioinert gels and multilayer surface structures. These polymers form crosslinked hydrogels, which are highly swollen in water. The crosslinking can either be chemical or physical. Water soluble polymers containing boronic acid groups, such as phenylboronic acid (PBA), can be physically crosslinked by mixing the polymers in water with other polymers containing hydroxyls or carboxylic acids. Alternatively, surfaces can be treated by stepwise incubation with a solution of the boronic acid containing polymer, followed by incubation with a solution of a diol or carboxylic acid containing polymer. Many successive layers can be generated, increasing the thickness of the formed structure at each step. The bioinert gel or surface coating can be used for passivating the surfaces of medical implants (especially those based on transplanted tissue), or for passivating the surfaces of tissues in situ.
摘要翻译：含硼酸的聚合物用于形成生物凝胶和多层表面结构。这些聚合物形成在水中高度溶胀的交联水凝胶。交联可以是化学或物理的。含有硼酸基团的水溶性聚合物如苯基硼酸（PBA）可通过将水中的聚合物与含有羟基或羧酸的其它聚合物混合而物理交联。或者，可以通过与含硼酸的聚合物的溶液逐步温育，然后与含二醇或含羧酸的聚合物的溶液温育来处理表面。可以产生许多连续的层，从而在每个步骤增加形成的结构的厚度。生物测定凝胶或表面涂层可用于钝化医疗植入物（特别是基于移植组织的植入物）表面，或用于钝化组织表面的原位。

83. 发明授权

US5698189A Method for local application of polymeric material to tissue 失效
标题翻译：将聚合物材料局部应用于组织的方法
公开(公告)号：US5698189A
公开(公告)日：1997-12-16
申请号：US448573
申请日：1995-11-27
申请人： Stephen C. Rowe , Jeffrey A. Hubbell , Stephen J. Herman , Vae Sun , Michael F. Lang , George E. Selecman , Frederick F. Ahari
发明人： Stephen C. Rowe , Jeffrey A. Hubbell , Stephen J. Herman , Vae Sun , Michael F. Lang , George E. Selecman , Frederick F. Ahari
IPC分类号： A61B17/04 , A61B1/00 , A61B17/00 , A61C13/15 , A61F2/02 , A61M37/00 , B05C17/01 , A61K31/74 , A61N1/30 , A61K2/02
CPC分类号： B05C17/01 , A61B1/00165 , A61C19/004 , A61M37/00 , A61B17/00491
摘要： This invention relates to devices and techniques for applying therapeutic polymeric material to living tissue.
摘要翻译： PCT No.PCT / US94 / 03115 Sec。 371日期：1995年11月27日 102（e）日期1995年11月27日PCT 1994年3月23日PCT公布。出版物WO94 / 21324 日期1994年9月29日本发明涉及将活性组织施用治疗性聚合物材料的装置和技术。

84. 发明授权

US5462990A Multifunctional organic polymers 失效
标题翻译：多功能有机聚合物
公开(公告)号：US5462990A
公开(公告)日：1995-10-31
申请号：US132507
申请日：1993-10-05
申请人： Jeffrey A. Hubbell , Donald Elbert , Jennifer L. Hill-West , Paul D. Drumheller , Sanghamitra Chowdhury , Amarpreet Sawhney
发明人： Jeffrey A. Hubbell , Donald Elbert , Jennifer L. Hill-West , Paul D. Drumheller , Sanghamitra Chowdhury , Amarpreet Sawhney
IPC分类号： A61L27/00 , A61K9/50 , A61K47/48 , A61L31/06 , A61L33/00 , C08G63/91 , C08G73/00 , C08G81/00 , C08G81/02 , C08L77/00 , C08L79/00 , C08L101/00 , C09D187/00 , C08L1/00
CPC分类号： C08G81/00 , A61K47/48238 , A61K47/48315 , A61K9/5031 , A61K9/5073 , A61L31/06
摘要： Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.
摘要翻译：本文描述的是用于抑制细胞和细胞，细胞和组织以及组织和组织之间的粘附和免疫识别的多功能聚合物材料。聚合物材料的一个组分很好地吸附到细胞或组织上，而聚合物材料的其它组分不能很好地吸附到组织上。使用不带电荷的水溶性聚合物（多项式）作为非结合成分，使用在生理pH（聚阳离子）下带正电的水溶性聚合物作为组织结合成分。当双官能聚合物材料接触组织时，组织结合组分结合并因此固定所连接的非结合组分，其然后将一般远离组织表面延伸，并空间阻断其它组织的附着。该方法和组合物可用于抑制手术后粘连的形成，保护受损的血管免受血栓形成和再狭窄，并降低附着依赖性肿瘤细胞的转移程度。

85. 发明授权

US08309518B2 Drug delivery matrices to enhance wound healing 有权
标题翻译：药物递送基质以增强伤口愈合
公开(公告)号：US08309518B2
公开(公告)日：2012-11-13
申请号：US12845354
申请日：2010-07-28
申请人： Jason C. Schense , Hugo Schmoekel , Jeffrey A. Hubbell , Franz Weber
发明人： Jason C. Schense , Hugo Schmoekel , Jeffrey A. Hubbell , Franz Weber
IPC分类号： A61K38/18 , A61K38/36 , C07K14/495 , C07K14/51
CPC分类号： A61L31/046 , A61L24/0015 , A61L24/106 , A61L27/225 , A61L27/227 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/45
摘要： Bioactive molecules are entrapped within a matrix for the controlled delivery of these compounds for therapeutic healing applications. The matrix may be formed of natural or synthetic compounds. The primary method of entrapment of the bioactive molecule is through precipitation of the bioactive molecule during gelation of the matrix, either in vitro or in vivo. The bioactive molecule may be modified to reduce its effective solubility in the matrix to retain it more effectively within the matrix, such as through the deglycosylation of members within the cystine knot growth factor superfamily and particularly within the TGFβ superfamily. The matrix may be modified to include sites with binding affinity for different bioactive molecules, for example, for heparin binding.
摘要翻译：生物活性分子被包埋在基质内，用于受控递送这些化合物用于治疗性愈合应用。基质可以由天然或合成的化合物形成。捕获生物活性分子的主要方法是通过体外或体内在基质凝胶化过程中沉淀生物活性分子。生物活性分子可以被修饰以降低其在基质中的有效溶解度，以便在基质内更有效地保留生物活性分子，例如通过胱氨酸结生长因子超家族内，特别是在TGF-bgr内的成员的去糖基化; 超家族可以修饰基质以包括对不同生物活性分子具有结合亲和力的位点，例如用于肝素结合的位点。

86. 发明授权

US08119335B2 Methods and apparatus for selective, oxidative patterning of a surface 有权
标题翻译：用于表面选择性，氧化图案化的方法和装置
公开(公告)号：US08119335B2
公开(公告)日：2012-02-21
申请号：US11333090
申请日：2006-01-17
申请人： Jane P. Bearinger , Jeffrey A. Hubbell , Kenneth J. Michlitsch
发明人： Jane P. Bearinger , Jeffrey A. Hubbell , Kenneth J. Michlitsch
IPC分类号： C08F2/54 , C08F2/48 , G03F7/00
CPC分类号： B82Y10/00 , B82Y40/00 , G03F7/0002 , G03F7/2014 , G03F7/2043 , Y10S430/143 , Y10T428/24802
摘要： The present invention provides methods and apparatus for selectively patterning surfaces using radical species generated with a photocatalyst. The photocatalyst may comprise a photocatalytic semiconductor or a photosensitizer. The radical species are brought into contact with an oxidizable coating disposed on the surface, thereby locally oxidizing and selectively patterning the surface. The photocatalyst is preferably disposed on a delivery device, such as a stamp, mask, or scanning probe, that is brought into close proximity or contact with the coated surface. The photocatalyst is then excited in a manner capable of generating radical species, for example, oxygen-containing radical species, in appropriate media. It is expected that these radical species will be transferred to the coated surface along a substantially shortest distance path, thereby locally oxidizing and patterning the surface.
摘要翻译：本发明提供了使用由光催化剂生成的自由基物质来选择性地图案化表面的方法和装置。光催化剂可以包含光催化半导体或光敏剂。使自由基物质与设置在表面上的可氧化涂层接触，从而局部氧化并选择性地图案化该表面。光催化剂优选地设置在与涂覆表面紧密接触或接触的输送装置，例如印模，掩模或扫描探针上。然后在适当的介质中以能够产生自由基物质，例如含氧自由基物质的方式激发光催化剂。预期这些自由基物质将沿着基本上最短的距离路径转移到涂覆的表面，从而局部氧化和图案化表面。

87. 发明申请

US20110206759A1 CCR7 LIGAND DELIVERY AND CO-DELIVERY IN IMMUNOTHERAPY 有权
标题翻译： CCR7 LIGAND交付和交付在免疫学
公开(公告)号：US20110206759A1
公开(公告)日：2011-08-25
申请号：US13025009
申请日：2011-02-10
申请人： Melody A. Swartz , Jeffrey A. Hubbell , Alice A. Tomei , Jacqueline D. Shields , Iraklis Kourtis
发明人： Melody A. Swartz , Jeffrey A. Hubbell , Alice A. Tomei , Jacqueline D. Shields , Iraklis Kourtis
IPC分类号： A61K9/127 , A61K38/19 , A61K9/14 , A61K38/20 , C07K14/52 , C12N15/63 , C12N5/10 , A61P37/06
CPC分类号： A61L27/60 , A61K38/1841 , A61K38/195 , A61K38/20 , A61K38/2066 , A61K39/001 , A61K2039/55522 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/62 , C12N15/86 , C12N2740/15043 , C12N2740/15052 , A61K2300/00
摘要： Chemokines may be administered to a patient for immunotolerization. Chemokines include CCL19 and CCL21. Materials and methods for accomplishing tolerization and described.
摘要翻译：趋化因子可以被施用于患者用于免疫耐受。趋化因子包括CCL19和CCL21。材料和方法实现耐受性和描述。

88. 发明申请

US20100055189A1 Nanoparticles for immunotherapy 有权
标题翻译：用于免疫治疗的纳米颗粒
公开(公告)号：US20100055189A1
公开(公告)日：2010-03-04
申请号：US12231310
申请日：2008-08-29
申请人： Jeffrey A. Hubbell , Conlin P. O'Neil , Sai T. Reddy , Melody A. Swartz , Diana Velluto , Andre van Der Vlies , Eleonora Simeoni
发明人： Jeffrey A. Hubbell , Conlin P. O'Neil , Sai T. Reddy , Melody A. Swartz , Diana Velluto , Andre van Der Vlies , Eleonora Simeoni
IPC分类号： A61K9/14 , A61K31/74
CPC分类号： A61K9/5146 , A61K9/0034 , A61K9/006 , A61K38/19 , A61K39/0011 , A61K47/6907 , A61K47/6935 , A61K2039/6093 , B82Y5/00
摘要： Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.
摘要翻译：描述了在不存在生物分子的情况下激活补体的纳米颗粒。显示了纳米颗粒特异性靶向抗原呈递细胞，特别是在淋巴结中，而不用生物分子进行靶向。这些颗粒是用于递送免疫治疗剂的有用载体。描述了纳米颗粒的表面化学和化学配方。

89. 发明授权

US07670605B2 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 有权
标题翻译：药物活性化合物受控输送的共轭加成反应
公开(公告)号：US07670605B2
公开(公告)日：2010-03-02
申请号：US12192655
申请日：2008-08-15
申请人： Jeffrey A. Hubbell , Donald L. Elbert , Ronald Schoenmakers
发明人： Jeffrey A. Hubbell , Donald L. Elbert , Ronald Schoenmakers
IPC分类号： A61K39/00 , C12Q1/68 , C12N9/96 , C07H21/04
CPC分类号： A61L27/52 , A61K47/60 , A61K47/6903 , C07H21/04 , C08G65/329 , C08G65/3322 , C12N5/0068 , C12N2501/585 , C12N2533/30
摘要： The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
摘要翻译：本发明的特征在于通过对共轭不饱和基团的亲核加成反应形成的聚合物生物材料。这些生物材料可用于医疗治疗。

90. 发明申请

US20100003338A1 Micelles for delivery of nitric oxide 有权
标题翻译：胶束用于输送一氧化氮
公开(公告)号：US20100003338A1
公开(公告)日：2010-01-07
申请号：US12217507
申请日：2008-07-03
申请人： Jeffrey A. Hubbell , Yun Suk Jo , Andre J. Van der Vlies
发明人： Jeffrey A. Hubbell , Yun Suk Jo , Andre J. Van der Vlies
IPC分类号： A61K9/14 , A61K31/80 , A61K31/787 , A61K31/77
CPC分类号： A61K31/77 , A61K9/1075 , A61K9/1273 , A61K31/787 , A61K31/80 , A61K47/48176 , A61K47/488 , A61K47/58 , A61K47/6907 , Y10S977/906
摘要： Embodiments include a vehicle for delivery of nitric oxide comprising: a collection of micelles having an internal micelle core that comprises a polymer with N-diazeniumdiolate comprising NO complexed with secondary amines of the polymer. Embodiments include a method of making a nitric oxide vehicle comprising dissolving a polymer that comprises secondary amines in an aqueous solution and combining the polymer with nitric oxide in the solution to form a N-diazeniumdiolate comprising the nitric oxide complexed with the secondary amines, with the formation of the N-diazeniumdiolate causing the polymer to be at least partially insoluble in the solution and to form a collection of micelles that have an internal core that comprises N-diazeniumdiolate.
摘要翻译：实施方案包括用于递送一氧化氮的载体，其包含：具有内部胶束芯的胶束的集合，所述胶束芯包含与包含与所述聚合物的仲胺络合的NO的具有N二氮烯鎓二醇的聚合物。实施方案包括制备一氧化氮载体的方法，其包括将包含仲胺的聚合物溶解在水溶液中，并将该聚合物与一氧化氮混合在溶液中以形成包含与仲胺络合的一氧化氮的N-二氮烯鎓二醇，形成N-二氮烯鎓二硫酸盐，导致聚合物至少部分不溶于溶液中，并形成具有内核的包含N-二氮茚鎓二醇的胶束的集合。

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