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81. 发明申请

WO2015066329A1 ENCLOSURE WITH INTERGRATED INDIVIDUAL ONU-TO-DSL CONVERSION MODULES 审中-公开
标题翻译：具有互联的个人ONU到DSL转换模块的外壳
公开(公告)号：WO2015066329A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063157
申请日：2014-10-30
申请人： TYCO ELECTRONICS UK LTD , TYCO ELECTRONICS CORPORATION , TYCO ELECTRONICS RAYCHEM BVBA , BROWN, David , MATHER, David , SHADDOCK, Robert Neil , WEEKS, William Atley , FRANCKX, Joris , ERREYGERS, Jan Jozef Julia Maria
发明人： BROWN, David , MATHER, David , SHADDOCK, Robert Neil , WEEKS, William Atley , FRANCKX, Joris , ERREYGERS, Jan Jozef Julia Maria
IPC分类号： H04B10/29 , H04B10/25
CPC分类号： H04B10/25 , H04B10/29 , H04Q11/0067
摘要： A re-entrant enclosure for use in a passive fiber optic network comprises a plurality of single line converter modules; and a housing configured to enclose the plurality of single line converter modules. Each of the single line converter modules comprises a fiber optic connector configured to be optically coupled to a service terminal via a respective optical fiber for receiving downstream optical frames; a single electrical connector coupled over a respective metallic medium to a respective network terminal providing a service to respective customer premise equipment (CPE); and an optical-to-electrical (O/E) converter located in the housing and configured to convert the downstream optical frames to an electrical signal for transmission over the respective metallic medium to the respective network terminal. The housing of the re-entrant enclosure further comprises a seal around each of the plurality of optical fibers coupled to a respective one of the plurality of single line converter modules.
摘要翻译：在无源光纤网络中使用的重入封装包括多个单线转换器模块; 以及壳体，其被构造成围绕所述多个单线转换器模块。每个单线转换器模块包括光纤连接器，其被配置为通过相应的光纤光学地耦合到服务终端以接收下游光学帧; 通过相应的金属介质耦合到相应的网络终端的单个电连接器，以向相应的客户驻地设备（CPE）提供服务; 以及位于所述壳体中并被配置为将所述下游光学镜架转换为电信号的光学到电气（O / E）转换器，以在相应的金属介质上传输到相应的网络终端。入口外壳的壳体还包括围绕耦合到多个单线转换器模块中的相应一个的多个光纤中的每一个的密封。

82. 发明申请

WO2012109525A2 REFILLABLE CONTAINER WITH A ZERO WASTE DISPENSING SYSTEM 审中-公开
标题翻译：具有零废料分配系统的可再生容器
公开(公告)号：WO2012109525A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024620
申请日：2012-02-10
申请人： DERBY, Stephen , MCFADDEN, John , BROWN, David , ECKERT, Eugene
发明人： DERBY, Stephen , MCFADDEN, John , BROWN, David , ECKERT, Eugene
IPC分类号： B65D77/04 , B65D25/18 , B65D30/20 , B65D8/04 , B65D69/00 , B65D83/76
CPC分类号： B65D35/30 , B65D21/08 , B65D25/48 , B65D71/70 , B65D77/06 , Y10T29/49826
摘要： The refillable container (20) includes a semi-rigid outer shell (22) that defines an interior void (24) and includes a detachable pour spout (26). The container (20) may be refilled with a plurality of collapsible inserts (32). Instead of rigid beverage bottles and other flowable substance containers, the collapsible inserts (32) may be transported from a manufacturing to a filling facility in a collapsed state (76), and do not have to include semi-rigid materials thereby minimizing disposal requirements. A tilt-pouring embodiment (2:0), a helical track embodiment (100), a helical axle embodiment (240) and an air-bladder embodiment (300) o f refillable containers having common components permit dispensing of products from the containers (20, 100, 240, 300) to achieve virtually zero waste of the products.
摘要翻译：可再填充容器（20）包括限定内部空隙（24）并包括可拆卸倾倒口（26）的半刚性外壳（22）。容器（20）可以用多个可折叠插入件（32）重新填充。代替刚性饮料瓶和其它可流动物质容器，可折叠插入物（32）可以在制造过程中以塌缩状态（76）运输到填充设施，并且不必包括半刚性材料，从而最小化排放要求。倾斜倾倒实施例（2：0），螺旋轨道实施例（100），螺旋轴实施例（240）和具有共同部件的可再填充容器的气囊实施例（300）允许从容器（20 ，100,240,300），以实现产品几乎零浪费。

83. 发明申请

WO2012021495A3 AUTOMATED PRODUCT ENGAGER, TRANSPORTER AND PATTERNED DEPOSITOR SYSTEM 审中-公开
公开(公告)号：WO2012021495A3
公开(公告)日：2012-02-16
申请号：PCT/US2011/047051
申请日：2011-08-09
申请人： DERBY, Stephen , MCFADDEN, John , BROWN, David , ECKERT, Eugene
发明人： DERBY, Stephen , MCFADDEN, John , BROWN, David , ECKERT, Eugene
IPC分类号： B65B35/50 , B65B43/54 , B65B35/44 , B65B35/24
摘要： The system (30) includes a product engager (32), a transporter (34) and a patterned depositor (36) for engaging products (38) and transporting the products (38) from the product engager (32) to the patterned depositor (36), such as between a product bagging machine (56) that forms and fills a bag (24), a conveyor that transports the bags as the products (38) and delivers them to a case packing machine as the patterned depositor (36). The product engager (32) and the patterned depositor (36) include first and second drivers (46, 48) and the transporter (34) includes an adjustable-length buffer (50) to compensate for any temporary difference between a first product delivery rate of the product engager (32) and a rate of movement of the products (38) passing from the product engager (32) along the transporter (34) to the patterned depositor (36).

84. 发明申请

WO2010135692A2 MIRNA BIOMARKERS OF PROSTATE DISEASE 审中-公开
标题翻译：前列腺疾病的MIRNA生物标志物
公开(公告)号：WO2010135692A2
公开(公告)日：2010-11-25
申请号：PCT/US2010/035839
申请日：2010-05-21
申请人： ASURAGEN, INC. , SHELTON, Jeffrey , KELNAR, Kevin , VOLZ, Stephanie , ADAI, Alex , BROWN, David
发明人： SHELTON, Jeffrey , KELNAR, Kevin , VOLZ, Stephanie , ADAI, Alex , BROWN, David
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178
摘要： This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing prostate disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as prostate cancer.
摘要翻译：该应用描述了可用作血清或血浆生物标志物的miRNA，用于表征患者中的前列腺疾病。这些miRNA生物标志物可以单独使用或与其它标志物组合使用，用于诊断，预后或监测前列腺癌等疾病。

85. 发明申请

WO2009150424A1 ANTI-MICROBIAL POLYMERIC FILM AND METHOD OF MANUFACTURE OF SAID FILM 审中-公开
标题翻译：抗微生物聚合物薄膜和制作薄膜的方法
公开(公告)号：WO2009150424A1
公开(公告)日：2009-12-17
申请号：PCT/GB2009/001459
申请日：2009-06-10
申请人： DUPONT TEIJIN FILMS U.S. LIMITED PARTNERSHIP , ROBINSON, Julian, Neal , EVESON, Robert, W. , RAKOS, Karl , BROWN, David , SYMONDS, Jackie , STEPHENSON, Debbie, A.
发明人： EVESON, Robert, W. , RAKOS, Karl , BROWN, David , SYMONDS, Jackie , STEPHENSON, Debbie, A.
IPC分类号： B29C55/02 , B29C71/00 , B65D81/28
CPC分类号： B29C55/026 , B29C55/023 , B29C71/0009 , Y10T428/24942
摘要： A method of manufacture of an anti-microbial polymeric film comprising coextruding a polymeric substrate layer comprising a first layer of a first polymeric material and a second layer of a second polymeric material wherein the crystalline melting temperature (TM2) of said second polymeric material is lower than the crystalline melting temperature (TM1) of the first polymeric material; stretching the coextruded substrate in a first direction; optionally stretching the substrate layer in a second, orthogonal direction; disposing on the surface of the polymeric second layer a composition comprising a particulate antimicrobial compound and a liquid vehicle, and preferably also a surfactant; and heat-setting the stretched film at a temperature above the crystalline melting temperature (TM2) of the second polymeric material but below the crystalline melting temperature (TMI) of the first polymeric material; wherein the composition is applied to the polymeric second layer after the coextrusion step but before the heat-setting step; such that in the final film said second layer comprises said anti-microbial compound in an amount of from about 1 to about 80 % by weight of said polymeric material of the second layer is described. Anti-microbial films are also described.
摘要翻译：一种制造抗微生物聚合物膜的方法，包括将包含第一聚合物材料的第一层和第二聚合物材料的第二层的聚合物基底层共挤出，其中所述第二聚合物材料的结晶熔融温度（TM2）较低比第一聚合物材料的结晶熔融温度（TM1）高; 在第一方向上拉伸所述共挤出的基材; 任选地在第二正交方向上拉伸基底层; 在聚合物第二层的表面上设置包含颗粒状抗微生物化合物和液体载体的组合物，优选还包括表面活性剂; 以及在高于第二聚合物材料的结晶熔融温度（TM2）但低于第一聚合物材料的结晶熔化温度（TMI）的温度下热定型拉伸膜; 其中所述组合物在共挤出步骤之后但在热定形步骤之前施加到聚合物第二层; 使得在最终膜中所述第二层包含所述抗微生物化合物的量为所述第二层聚合物材料的约1至约80重量％。还描述了抗微生物膜。

86. 发明申请

WO2009149418A2 NOVEL COMPOSITIONS FOR THE IN VIVO DELIVERY OF RNAI AGENTS 审中-公开
标题翻译： RNAi代谢产物的新型组合物
公开(公告)号：WO2009149418A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046505
申请日：2009-06-05
申请人： ASURAGEN, INC. , BIOO SCIENTIFIC CORPORATION , FORD, Lance , BROWN, David , BADER, Andreas, G.
发明人： FORD, Lance , BROWN, David , BADER, Andreas, G.
IPC分类号： A61K9/107 , A61K9/127 , A61K48/00 , A61P35/00
CPC分类号： A61K9/1075 , A61K9/0019 , A61K9/127 , A61K9/19 , A61K47/24 , A61K47/26 , A61K47/44 , A61K47/46
摘要： This application describes emulsion formulations containing neutral phospholipids for delivering RNAi, anti-miRNA, or aptamer agents in vivo . The application also relates to methods of making the formulations, and uses of the formulations as delivery agents.
摘要翻译：本申请描述了含有用于在体内递送RNAi，抗miRNA或适体试剂的中性磷脂的乳剂制剂。本申请还涉及制备制剂的方法和制剂作为递送剂的用途。

87. 发明申请

WO2009137807A3 COMPOSITIONS AND METHODS RELATED TO MIRNA MODULATION OF NEOVASCULARIZATION OR ANGIOGENESIS 审中-公开
公开(公告)号：WO2009137807A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/043361
申请日：2009-05-08
申请人： ASURAGEN, INC. , SHEN, Jikui , KELNAR, Kevin , SHELTON, Jeffrey , BROWN, David , CAMPOCHIARO, Peter
发明人： SHEN, Jikui , KELNAR, Kevin , SHELTON, Jeffrey , BROWN, David , CAMPOCHIARO, Peter
IPC分类号： C12N15/11 , C12Q1/68
摘要： The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.

88. 发明申请

WO2008109741A1 MULTI-SERVICE CELLULAR PHONE NETWORK ACCESS DEVICE 审中-公开
标题翻译：多功能蜂窝电话网络接入设备
公开(公告)号：WO2008109741A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/056036
申请日：2008-03-06
申请人： TRINITY COVERGENCE LIMITED , BROWN, David , PENDSE, Ajit, B.
发明人： BROWN, David , PENDSE, Ajit, B.
IPC分类号： H04L12/28 , H04Q7/34 , H04B7/26
CPC分类号： H04W4/16 , H04L12/5692
摘要： An access device is described herein for determining and selecting, for a cellular call received by a cellular transceiver of the access device, one of a plurality of networks to route the call to. In some embodiments, the determining and selecting may be based at least on a type of each of a plurality of network interfaces of the access device and availability of each corresponding network, the network interfaces including at least two of a cellular retransmitter, an IP networking interface, or a PSTN interface. In various embodiments, if a cellular network is determined and selected, the access device may relay the call. Also, if an IP or PSTN network is determined and selected, the access device may establish on behalf of the call an outgoing call through the IP or PSTN network and translate signals of the cellular call to signals for the IP or PSTN network.
摘要翻译：本文描述了一种接入设备，用于确定和选择由接入设备的蜂窝收发器接收的蜂窝呼叫，将多个网络之一路由到呼叫。在一些实施例中，确定和选择可以至少基于接入设备的多个网络接口中的每一个的类型和每个相应网络的可用性，网络接口包括蜂窝转发器，IP网络中的至少两个接口或PSTN接口。在各种实施例中，如果蜂窝网络被确定和选择，则接入设备可以中继该呼叫。此外，如果确定并选择了IP或PSTN网络，则接入设备可以通过IP或PSTN网络代表呼叫建立呼出呼叫，并将蜂窝呼叫的信号转换为IP或PSTN网络的信号。

89. 发明申请

WO2008073922A2 FUNCTIONS AND TARGETS OF LET-7 MICRO RNAS 审中-公开
标题翻译： LET-7微RNA的功能和目标
公开(公告)号：WO2008073922A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/087037
申请日：2007-12-10
申请人： ASURAGEN, INC. , JOHNSON, Charles, D. , BYROM, Mike , BADER, Andreas, G. , SLACK, Frank, J. , BROWN, David , OVCHARENKO, Dmitriy , KELNAR, Kevin
发明人： JOHNSON, Charles, D. , BYROM, Mike , BADER, Andreas, G. , SLACK, Frank, J. , BROWN, David , OVCHARENKO, Dmitriy , KELNAR, Kevin
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/141 , C12N2330/10
摘要： The present invention concerns methods and compositions for treating or assessing treatment of diseases related to mis-expression of genes or genetic pathways that can be modulated by let-7. Methods may include evaluating patients for genes or genetic pathways modulated by let-7, and/or using an expression profile to assess the condition of a patient or treating the patient with an appropriate miRNA.
摘要翻译：本发明涉及用于治疗或评估与由let-7调节的基因或遗传途径的错误表达有关的疾病的治疗方法和组合物。方法可以包括评价患者的由let-7调节的基因或遗传途径，和/或使用表达谱来评估患者的状况或用合适的miRNA治疗患者。

90. 发明申请

WO2008073921A2 MIR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 审中-公开
标题翻译： MIR-126调节基因和途径作为治疗性干预的目标
公开(公告)号：WO2008073921A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/087033
申请日：2007-12-10
申请人： ASURAGEN, INC. , BADER, Andreas, G. , BYROM, Mike , JOHNSON, Charles, D. , BROWN, David
发明人： BADER, Andreas, G. , BYROM, Mike , JOHNSON, Charles, D. , BROWN, David
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/14
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-126, using miR-126 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译：本发明涉及用于鉴定miR-126调节的基因或遗传途径的方法和组合物，其使用miR-126调节基因或基因途径，在评估患者状况和/或用合适的患者治疗患者时使用该分布 miRNA的。

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