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81. 发明申请

US20080200930A1 APPARATUS FOR MANIPULATING AND SECURING TISSUE 有权
标题翻译：用于操作和安全组织的装置
公开(公告)号：US20080200930A1
公开(公告)日：2008-08-21
申请号：US12107701
申请日：2008-04-22
申请人： VAHID SAADAT , RICHARD C. EWERS , CANG C. LAM , ROBERT A. VAUGHAN , CHRIS ROTHE , KENNETH J. MICHLITSCH
发明人： VAHID SAADAT , RICHARD C. EWERS , CANG C. LAM , ROBERT A. VAUGHAN , CHRIS ROTHE , KENNETH J. MICHLITSCH
IPC分类号： A61B17/10 , A61B17/08
CPC分类号： A61F5/0086 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B17/0487 , A61B17/06 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/12013 , A61B17/1285 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，组织稳定构件所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

82. 发明申请

US20080183036A1 SYSTEMS AND METHODS FOR UNOBSTRUCTED VISUALIZATION AND ABLATION 审中-公开
标题翻译：用于无障碍可视化和消除的系统和方法
公开(公告)号：US20080183036A1
公开(公告)日：2008-07-31
申请号：US11959158
申请日：2007-12-18
申请人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund Tam
发明人： Vahid Saadat , Chris A. Rothe , Ruey-Feng Peh , Edmund Tam
IPC分类号： A61B1/005 , A61B18/14
CPC分类号： A61B1/00089 , A61B1/00085 , A61B1/005 , A61B1/018 , A61B1/3137 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B17/12172 , A61B18/1492 , A61B2018/00357 , A61B2018/00577 , A61B2018/00982
摘要： Systems and methods for unobstructed, visualization and ablation, particularly of the pulmonary veins, are described herein. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration as well as one or more expandable anchors which are temporarily securable within a respective pulmonary vein while allowing blood flow to pass through the anchor unimpeded. With the one or more non-impeding anchors secured within a respective pulmonary vein, ablation of the tissue surrounding the ostium or several ostia may be effected with the catheter while the tissue is under direct visualization.
摘要翻译：本文描述了用于无障碍，可视化和消融，特别是肺静脉的系统和方法。这样的系统可以包括部署导管和可展开到扩展构型中的附接成像罩，以及一个或多个可扩展锚固件，其可临时固定在相应的肺静脉内，同时允许血液流动通过锚固体而不受阻碍。利用固定在相应的肺静脉内的一个或多个无阻塞的锚固件，可以在组织处于直接可视化的状态下用导管实现围绕口或组织的几个口的组织的消融。

83. 发明申请

US20080086155A1 APPARATUS AND METHODS FOR MANIPULATING AND SECURING TISSUE 有权
标题翻译：装置和方法用于操纵和保护组织
公开(公告)号：US20080086155A1
公开(公告)日：2008-04-10
申请号：US11951188
申请日：2007-12-05
申请人： Chris ROTHE , Richard EWERS , Cang LAM , Vahid SAADAT , Kenneth MICHLITSCH
发明人： Chris ROTHE , Richard EWERS , Cang LAM , Vahid SAADAT , Kenneth MICHLITSCH
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B1/0014 , A61B17/0401 , A61B17/06066 , A61B17/29 , A61B17/295 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/3488 , A61B2090/037
摘要： Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置和方法。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

84. 发明申请

US20080033290A1 DELIVERY OF BIOLOGICAL COMPOUNDS TO ISCHEMIC AND/OR INFARCTED TISSUE 有权
标题翻译：将生物化合物递送到化学和/或感染组织
公开(公告)号：US20080033290A1
公开(公告)日：2008-02-07
申请号：US11828267
申请日：2007-07-25
申请人： Vahid SAADAT , Sekhar Rao
发明人： Vahid SAADAT , Sekhar Rao
IPC分类号： A61B6/00 , A61M31/00
CPC分类号： A61B1/00165 , A61B1/00089 , A61B1/00096 , A61B1/00147 , A61B1/015 , A61B1/05 , A61B1/12 , A61B5/0084 , A61B5/6882 , A61B5/7282 , A61M25/0074 , A61M25/0082 , A61M25/0084
摘要： The delivery of biological compounds to ischemic and/or infarcted tissue are described herein where such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for performing any number of procedures on the tissue for identifying, locating, and/or accessing ischemic and/or infarcted tissue.
摘要翻译：在本文中描述了将生物化合物递送至缺血和/或梗死组织，其中这样的系统可以包括展开导管和可展开成扩展构型的附接成像罩。在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。此外，任何数量的治疗工具也可以通过展开导管并进入成像罩，以在组织上执行任何数量的程序，用于识别，定位和/或获取缺血和/或梗死组织。

85. 发明申请

US20080033241A1 LEFT ATRIAL APPENDAGE CLOSURE 审中-公开
标题翻译：左侧附件关闭
公开(公告)号：US20080033241A1
公开(公告)日：2008-02-07
申请号：US11828281
申请日：2007-07-25
申请人： Ruey-Feng Peh , Vahid Saadat
发明人： Ruey-Feng Peh , Vahid Saadat
IPC分类号： A61B1/00 , A61B17/128
CPC分类号： A61B1/3137 , A61B1/0008 , A61B1/00082 , A61B1/00089 , A61B1/00179 , A61B5/6882 , A61B17/0057 , A61B17/0469 , A61B17/0644 , A61B17/12122 , A61B2017/00345 , A61B2017/00575 , A61B2017/0409 , A61B2017/0443 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0649 , A61B2017/306
摘要： Methods and apparatus for intraluminally or transluminally closing a left atrial appendage while under direct visualization are described herein. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for performing any number of procedures on the tissue for accessing and closing the left atrial appendage.
摘要翻译：本文描述了在直接可视化期间内壁或平滑闭合左心耳的方法和装置。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。此外，任何数量的治疗工具也可以通过展开导管并进入成像罩，用于在组织上执行用于访问和关闭左心耳的任何数量的程序。

86. 发明申请

US20080009747A1 TRANSMURAL SUBSURFACE INTERROGATION AND ABLATION 审中-公开
标题翻译：传递式的表面介入和排除
公开(公告)号：US20080009747A1
公开(公告)日：2008-01-10
申请号：US11775837
申请日：2007-07-10
申请人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , David Miller , Chris Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , David Miller , Chris Rothe
IPC分类号： A61B8/14 , A61B1/04 , A61M31/00 , A61B18/04
CPC分类号： A61B1/005 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/02007 , A61B8/12 , A61B8/4472 , A61B18/1477 , A61B18/1492 , A61B2018/00214 , A61B2018/00702 , A61B2018/00791 , A61B2018/00809 , A61B2018/00875 , A61B2018/1425 , A61B2090/3614
摘要： Transmural subsurface interrogation and ablation apparatus and methods are described where tissue to be ablated is monitored while under direct visualization for tissue parameters (e.g., temperature and impedance) prior to, during, or after ablation. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid can be pumped into the imaging hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An ablation probe and one or more interrogation needles having sensors are advanced into the tissue to be ablated and monitored. Alternatively, a combined ablation and interrogation probe may be used.
摘要翻译：描述了跨壁地下询问和消融设备和方法，其中在消融之前，期间或之后的组织参数（例如，温度和阻抗）直接可视化的同时监测要消融的组织。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。在使用中，将成像罩放置在通常填充有不透明体液（例如血液）的体腔中的待成像组织上或邻近待成像的组织。半透明或透明流体可被泵送到成像罩中，直到流体移动通过部署导管中的成像元件离开要成像的组织的清晰区域的任何血液。消融探针和具有传感器的一个或多个询问针被推进到待烧蚀和监测的组织中。或者，可以使用组合消融和询问探针。

87. 发明申请

US20070225781A1 Apparatus and methods for altering temperature in a region within the body 审中-公开
标题翻译：用于改变体内区域温度的装置和方法
公开(公告)号：US20070225781A1
公开(公告)日：2007-09-27
申请号：US11386239
申请日：2006-03-21
申请人： Vahid Saadat , Lorns G. Eltherington
发明人： Vahid Saadat , Lorns G. Eltherington
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B2017/00084 , A61F2007/0056 , A61F2007/0076 , A61F2007/0094
摘要： Apparatus and methods for cooling and/or heating selected regions within a body are described herein. An implantable system is used to cool or heat nerve bodies down to about 15° C. to diminish nerve impulses. In one embodiment, the system can include an implantable unit containing a pumping mechanism and/or various control electronics. The system has a cooling element. The cooling element can be a Peltier junction or a catheter through which hot or cold fluid flows. The heated portion of the Peltier junction can be cooled by a liquid heat transfer medium which absorbs the heat from the junction and dissipates the heat elsewhere.
摘要翻译：本文描述了用于冷却和/或加热体内所选区域的装置和方法。使用可植入系统将神经体冷却或加热至约15℃，以减少神经冲动。在一个实施例中，系统可以包括含有泵送机构和/或各种控制电子装置的可植入单元。该系统具有冷却元件。冷却元件可以是热或冷流体流过的珀尔帖接头或导管。珀尔帖接头的加热部分可以通过液体传热介质进行冷却，液体传热介质吸收来自接头的热量，并将热量散发到别处。

88. 发明申请

US20070213733A1 Mechanical tissue modification devices and methods 有权
标题翻译：机械组织修饰装置及方法
公开(公告)号：US20070213733A1
公开(公告)日：2007-09-13
申请号：US11405848
申请日：2006-04-17
申请人： Jeffery Bleich , Vahid Saadat , Roy Leguidleguid , Jeffery Bleam
发明人： Jeffery Bleich , Vahid Saadat , Roy Leguidleguid , Jeffery Bleam
IPC分类号： A61B17/16
CPC分类号： A61B17/1659 , A61B17/00234 , A61B17/02 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/32002 , A61B17/3421 , A61B2017/00261 , A61B2017/00867 , A61B2017/32006 , A61B2017/3488 , A61B2090/08021
摘要： A device for modifying one or more tissues in a patient's spine may include: an elongate, at least partially flexible body having a proximal portion and a distal portion, wherein at least the distal portion has dimensions that allow it to be passed into an epidural space and between target and non-target tissues of the spine; at least one movable blade disposed along one side of the elongate body; at least one actuator coupled with the at least one blade and disposed at or near the proximal or distal portion of the body for moving the blade(s) to modify one or more target tissues, wherein the at least one actuator is configured to move the blade(s) without significantly translating the elongate body proximally or distally; and means at or near the proximal and distal portions of the elongate body for facilitating application of at least one of anchoring force and tensioning force to the body to urge the at least one blade against the target tissue.
摘要翻译：用于修改患者脊柱中的一个或多个组织的装置可以包括：细长的至少部分柔性的身体，其具有近端部分和远端部分，其中至少远端部分具有允许其进入硬膜外腔的尺寸和脊柱的靶和非靶组织之间; 沿着所述细长体的一侧设置的至少一个可动刀片; 至少一个致动器，其与所述至少一个叶片耦合并且设置在所述主体的近端或远端部分处或附近，用于移动所述叶片以修改一个或多个目标组织，其中所述至少一个致动器被配置成使所述至少一个致动器移动刀片不在近侧或远端显着地平移细长体; 以及在所述细长体的近端部分和远端部分附近的装置，用于便于将至少一个锚定力和张紧力施加到身体以将至少一个刀片推向靶组织。

89. 发明申请

US20070167828A1 TISSUE IMAGING SYSTEM VARIATIONS 有权
标题翻译：组织成像系统变化
公开(公告)号：US20070167828A1
公开(公告)日：2007-07-19
申请号：US11560742
申请日：2006-11-16
申请人： Vahid Saadat
发明人： Vahid Saadat
IPC分类号： A61B8/14
CPC分类号： A61B1/005 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/0031 , A61B5/02007 , A61B5/6882 , A61B8/12 , A61B2018/0212
摘要： Tissue imaging system variations are described herein. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, the system can be deployed in a number of various ways such as clearing blood clots, emboli, and other debris which may be present in a body lumen. Other variations may also be used for facilitating trans-septal access across tissue regions as well as for balancing body fluids during a procedure.
摘要翻译：本文描述了组织成像系统的变化。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。在使用中，成像罩被放置在通常填充有不透明体液如血液的体腔中的待成像组织区域附近或邻近。半透明或透明的液体（例如盐水）可被泵送到成像罩中，直到流体移动任何血液，从而留下通过展开导管中的成像元件成像的组织的清晰区域。此外，该系统可以以多种各种方式进行部署，例如清除血液凝块，栓塞以及可能存在于体腔内的其它碎片。也可以使用其它变化来促进跨组织区域的间隔隔离以及用于在手术过程中平衡体液。

90. 发明授权

US07186262B2 Apparatus and methods for treating tissue 有权
标题翻译：用于治疗组织的装置和方法
公开(公告)号：US07186262B2
公开(公告)日：2007-03-06
申请号：US10188509
申请日：2002-07-03
申请人： Vahid Saadat
发明人： Vahid Saadat
IPC分类号： A61B17/04 , A61F2/06
CPC分类号： A61B18/00 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/122 , A61B17/1285 , A61B17/29 , A61B18/1442 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/39 , A61B2017/00084 , A61B2017/00243 , A61B2017/00867 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0427 , A61B2017/0437 , A61B2017/044 , A61B2017/0451 , A61B2017/0454 , A61B2017/0458 , A61B2017/0461 , A61B2017/0464 , A61B2017/0496 , A61B2017/2945 , A61B2018/00023 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00232 , A61B2018/00273 , A61B2018/00369 , A61B2018/00791 , A61B2018/00797 , A61B2018/1253 , A61B2018/126 , A61B2018/1432 , A61B2018/1435 , A61B2090/064 , A61F2/2445 , A61F2/2451 , A61F2/2454 , A61N7/00 , A61N7/02
摘要： Apparatus and methods are provided for thermally and/or mechanically treating tissue, such as valvular structures, to reconfigure or shrink the tissue in a controlled manner. Mechanical clips are implanted over the leaflets of a valve, e.g., in the heart, either alone or after thermal treatment to cause the valve to close more tightly. The clips are delivered by a catheter and may be configured to traverse directly over the valve itself or to lie partially over the periphery of the valve to prevent obstruction of the valve channel. The clips can be coated with drugs or a radiopaque coating. Alternatively, individual anchors with a tensioning element, like a suture, may be used to approximate the valves towards each other. The catheter can also incorporate sensors or energy delivery devices, e.g., transducers, on its distal end.
摘要翻译：提供了用于热和/或机械处理组织（例如瓣结构）的设备和方法，以受控的方式重新配置或收缩组织。将机械夹子单独地或在热处理之后植入例如心脏的瓣膜的小叶上，以使阀门更紧密地闭合。夹子由导管递送，并且可以被配置成直接在阀本身上移动或部分地位于阀的周边上以防止阀通道的阻塞。夹子可以涂上药物或不透射线的涂层。或者，可以使用具有诸如缝合线的张紧元件的单个锚定件来朝向彼此近似阀。导管还可以在其远端上并入传感器或能量输送装置，例如换能器。

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