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1. 发明授权

US08562516B2 Methods and apparatus for obtaining endoluminal access 有权
标题翻译：用于获得腔内通路的方法和装置
公开(公告)号：US08562516B2
公开(公告)日：2013-10-22
申请号：US11036029
申请日：2005-01-14
申请人： Vahid Saadat , John A. Cox , Chris Rothe
发明人： Vahid Saadat , John A. Cox , Chris Rothe
IPC分类号： A61B1/00
CPC分类号： A61B17/3421 , A61B1/0008 , A61B1/00098 , A61B1/00183 , A61B1/00193 , A61B1/018 , A61B1/04 , A61B2017/00278 , A61B2017/3445 , A61B2017/3447
摘要： The present invention provides methods and apparatus for obtaining endoluminal access. An elongate body is configured for insertion within a body lumen, conduit, organ, orifice, passageway or cavity, the elongate body having a working axis and a distal region, and an articulating element disposed near the distal region, the articulating element configured to articulate off-axis from the working axis of the elongate body. The elongate may achieve access in an endoluminal or a laparoscopic fashion. Methods of using the apparatus are also provided.
摘要翻译：本发明提供了获得腔内通路的方法和装置。细长体构造成用于插入体腔，导管，器官，孔，通道或空腔中，细长体具有工作轴线和远端区域，以及设置在远侧区域附近的关节元件，所述关节元件构造成能够铰接离开细长体的工作轴线。细长可以实现腔内或腹腔镜的方式。还提供了使用该装置的方法。

2. 发明授权

US08277373B2 Methods and apparaus for off-axis visualization 有权
标题翻译：离轴可视化的方法和应用
公开(公告)号：US08277373B2
公开(公告)日：2012-10-02
申请号：US11365088
申请日：2006-02-28
申请人： Tracy D. Maahs , Richard C. Ewers , Arvin T. Chang , Chris Rothe , Eugene C. Chen , Marvin C. Elmer , Gilbert Madrid , Kabir Gambhir
发明人： Tracy D. Maahs , Richard C. Ewers , Arvin T. Chang , Chris Rothe , Eugene C. Chen , Marvin C. Elmer , Gilbert Madrid , Kabir Gambhir
IPC分类号： A61B1/00
CPC分类号： A61B1/00179 , A61B1/0008 , A61B1/00183 , A61B1/0051 , A61B1/018 , A61B1/04
摘要： Methods and apparatus for off-axis visualization are described herein. An endoluminal tissue manipulation assembly is disclosed which provides for a stable endoluminal platform and which also provides for effective triangulation of tools. Such an apparatus may comprise an optionally shape-lockable elongate body defining a longitudinal axis and adapted for endoluminal advancement in a patient body, at least one articulatable visualization lumen disposed near or at a distal region of the elongate body, the at least one articulating visualization lumen being adapted to articulate off-axis relative to a longitudinal axis of the elongate body, and at least one articulatable tool arm member disposed near or at the distal region of the elongate body, the at least one articulatable tool arm member being adapted to articulate off-axis and manipulate a tissue region of interest.
摘要翻译：本文描述了用于离轴可视化的方法和装置。公开了一种腔内组织操作组件，其提供稳定的内腔平台，并且还提供工具的有效三角测量。这种装置可以包括限定纵向轴线并且适于在患者体内进行腔内前进的可选形状可锁定细长体，至少一个可伸长的可视腔，其设置在细长体的远端区域附近或位于该远端区域处，该至少一个铰接可视化内腔适于相对于细长主体的纵向轴线偏轴关节，以及设置在细长主体的远侧区域附近或其附近的至少一个可铰接工具臂构件，所述至少一个可铰接工具臂构件适于铰接离轴并且操纵感兴趣的组织区域。

3. 发明授权

US08216253B2 Apparatus for manipulating and securing tissue 有权
标题翻译：用于操纵和固定组织的装置
公开(公告)号：US08216253B2
公开(公告)日：2012-07-10
申请号：US12107701
申请日：2008-04-22
申请人： Vahid Saadat , Richard C. Ewers , Cang C. Lam , Robert A. Vaughan , Chris Rothe , Kenneth J. Michlitsch
发明人： Vahid Saadat , Richard C. Ewers , Cang C. Lam , Robert A. Vaughan , Chris Rothe , Kenneth J. Michlitsch
IPC分类号： A61B17/00 , A61B17/10
CPC分类号： A61F5/0086 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B17/0487 , A61B17/06 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/12013 , A61B17/1285 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

4. 发明授权

US07955340B2 Apparatus and methods for forming and securing gastrointestinal tissue folds 有权
标题翻译：用于形成和固定胃肠组织褶皱的装置和方法
公开(公告)号：US07955340B2
公开(公告)日：2011-06-07
申请号：US10734562
申请日：2003-12-12
申请人： Kenneth J. Michlitsch , Vahid C. Saadat , Richard C. Ewers , Chris Rothe , Rodney Brenneman , Cang C. Lam , Eugene C. Chen
发明人： Kenneth J. Michlitsch , Vahid C. Saadat , Richard C. Ewers , Chris Rothe , Rodney Brenneman , Cang C. Lam , Eugene C. Chen
IPC分类号： A61B17/10 , A61B17/08 , A61B1/00
CPC分类号： A61B1/0055 , A61B1/00135 , A61B1/018 , A61B1/2736 , A61B1/31 , A61B17/00234 , A61B17/0218 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/062 , A61B17/0625 , A61B17/0644 , A61B17/29 , A61B17/3421 , A61B17/3468 , A61B17/3478 , A61B2017/00269 , A61B2017/003 , A61B2017/00353 , A61B2017/00827 , A61B2017/0404 , A61B2017/0417 , A61B2017/0419 , A61B2017/0443 , A61B2017/0451 , A61B2017/0454 , A61B2017/0458 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/061 , A61B2017/06176 , A61B2017/0649 , A61B2017/2905 , A61B2017/2927 , A61B2017/2943 , A61B2017/3445 , A61B2017/3488 , A61B2090/3614 , A61F5/0086
摘要： Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point and moving the first tissue contact point from a position initially distal to, or in line with, a second tissue contact point to a position proximal of the second contact point, thereby forming the tissue fold, and extending an anchor assembly through the tissue fold from a vicinity of the second tissue contact point. Adjustable anchor assemblies; as well as anchor delivery systems, shape-lockable guides and methods for endoluminally performing medical procedures, such as gastric reduction, treatment of gastroesophageal reflux disease, resection of lesions, and treatment of bleeding sites; are also provided.
摘要翻译：提供了设备和方法，用于通过在第一组织接触点处接合组织并使第一组织接触点从最初远端或与第二组织接触点一致的位置移动到位于第二组织接触点附近的位置来形成胃肠组织折叠第二接触点，从而形成组织折叠，并且从第二组织接触点的附近延伸锚固组件穿过组织折叠。可调锚固组件; 以及锚定递送系统，可锁定形状的导管和用于内窥镜执行医学程序的方法，例如胃减压，治疗胃食管反流疾病，切除病变和治疗出血部位; 也提供。

5. 发明授权

US07621925B2 Needle assembly for tissue manipulation 有权
标题翻译：用于组织操作的针组件
公开(公告)号：US07621925B2
公开(公告)日：2009-11-24
申请号：US10955243
申请日：2004-09-30
申请人： Vahid Saadat , Chris Rothe , Richard C. Ewers
发明人： Vahid Saadat , Chris Rothe , Richard C. Ewers
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Needle assemblies for tissue manipulation are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. A needle deployment assembly is deployable through the tissue manipulation assembly via a handle assembly, through the tubular member, and into or through tissue. An elongate pusher is translationally disposed within a sheath of the needle deployment assembly and can be urged distally for deploying an anchor assembly from the sheath distal end. The anchor assembly is positioned distally of the pusher within the sheath.
摘要翻译：用于组织操作的针组件在本文中描述。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，组织稳定构件所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。针部署组件可经由手柄组件穿过组织操纵组件展开，穿过管状构件，并且进入或穿过组织。细长的推动器平移地设置在针展开组件的护套内，并且可以向远侧推动以从护套远端展开锚固组件。锚固组件位于鞘内的推动器的远侧。

6. 发明授权

US07347863B2 Apparatus and methods for manipulating and securing tissue 有权
标题翻译：用于操纵和固定组织的装置和方法
公开(公告)号：US07347863B2
公开(公告)日：2008-03-25
申请号：US10955245
申请日：2004-09-29
申请人： Chris Rothe , Richard C. Ewers , Cang C. Lam , Vahid Saadat , Kenneth J. Michlitsch
发明人： Chris Rothe , Richard C. Ewers , Cang C. Lam , Vahid Saadat , Kenneth J. Michlitsch
IPC分类号： A61B17/10 , A61B17/00 , A61B17/08
CPC分类号： A61B1/0014 , A61B17/0401 , A61B17/06066 , A61B17/29 , A61B17/295 , A61B2017/00867 , A61B2017/00876 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/3488 , A61B2090/037
摘要： Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
摘要翻译：本文描述了用于操纵和固定组织的装置和方法。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。稳定构件可以适于相对于细长管状构件的纵向轴线成角度。此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

7. 发明申请

US20080058650A1 CORONARY SINUS CANNULATION 有权
标题翻译：冠状动脉瘤
公开(公告)号：US20080058650A1
公开(公告)日：2008-03-06
申请号：US11848207
申请日：2007-08-30
申请人： Vahid SAADAT , Chris Rothe , Ruey-Feng Peh , Edmund Tam
发明人： Vahid SAADAT , Chris Rothe , Ruey-Feng Peh , Edmund Tam
IPC分类号： A61B6/00 , A61B5/103 , A61M25/09
CPC分类号： A61B1/042 , A61B1/00089 , A61B1/0051 , A61B1/0676 , A61B1/0684 , A61B5/0084 , A61B5/6853 , A61B17/0057 , A61B17/0401 , A61B17/0487 , A61B17/12045 , A61B17/221 , A61B17/3417 , A61B2017/00221 , A61B2017/00243 , A61B2017/00278 , A61B2017/00296 , A61B2017/00575 , A61B2017/00778 , A61B2017/00884 , A61B2017/00893 , A61B2017/00907 , A61B2017/00986 , A61B2017/12127 , A61B2017/3484 , A61B2017/3488 , A61B2090/373 , A61M25/007 , A61M25/1002 , A61M2025/0058
摘要： Coronary sinus cannulation apparatus and methods relating to tissue visualization catheters that can locate and/or cannulate a morphological feature within a body lumen, such as the coronary sinus, are described. Such devices can also perform a variety of therapeutic tissue treatments under direct in vivo visualization thereafter. Moreover, such apparatus and methods may also be utilized with guidewires to facilitate delivery into the coronary sinus to eliminate repositioning of the device and/or repeating an entire sequence of operations, consequently improving procedure effectiveness and reducing procedure time.
摘要翻译：描述了可以定位和/或插入体腔内的形态特征（例如冠状窦）的冠状窦插管装置和与组织可视化导管相关的方法。这样的装置还可以在其后直接体内可视化下执行各种治疗组织处理。此外，这种装置和方法还可以与引导线一起使用以便于递送到冠状窦以消除装置的重新定位和/或重复整个操作序列，从而提高手术有效性并缩短手术时间。

8. 发明申请

US20080058591A1 TISSUE VISUALIZATION DEVICE AND METHOD VARIATIONS 有权
标题翻译：组织可视化设备和方法变体
公开(公告)号：US20080058591A1
公开(公告)日：2008-03-06
申请号：US11848202
申请日：2007-08-30
申请人： Vahid Saadat , Chris Rothe , Edmund Tam , Ruey-Feng Peh
发明人： Vahid Saadat , Chris Rothe , Edmund Tam , Ruey-Feng Peh
IPC分类号： A61B1/01
CPC分类号： A61B1/00085 , A61B1/0008 , A61B1/00082 , A61B1/00089 , A61B1/00091 , A61B1/00177 , A61B1/005 , A61B1/012 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/02007 , A61B5/6882 , A61B8/12 , A61B17/00234 , A61B17/0057 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/22012 , A61B18/24 , A61B2017/048 , A61B2017/0496
摘要： Tissue visualization devices and variations thereof are described herein where such devices may utilize a variety of methods for facilitating clearing of the device of opaque bodily fluids and sealing between the device and the underlying tissue surface. Additionally, methods and devices for enhancing navigation of the device through a patient body are also described.
摘要翻译：本文描述了组织可视化装置及其变型，其中这样的装置可以利用各种方法来促进不透明体液的装置的清除和装置与下面的组织表面之间的密封。此外，还描述了用于增强穿过患者身体的装置导航的方法和装置。

9. 发明申请

US20080015445A1 TISSUE VISUALIZATION DEVICE AND METHOD VARIATIONS 有权
标题翻译：组织可视化设备和方法变体
公开(公告)号：US20080015445A1
公开(公告)日：2008-01-17
申请号：US11775771
申请日：2007-07-10
申请人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Amir Abolfathi , Chris Rothe
发明人： Vahid Saadat , Ruey-Feng Peh , Edmund Tam , Amir Abolfathi , Chris Rothe
IPC分类号： A61B8/12
CPC分类号： A61B1/005 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00089 , A61B1/015 , A61B1/018 , A61B1/04 , A61B5/0031 , A61B5/02007 , A61B5/6882 , A61B8/12 , A61B2018/0212
摘要： Tissue visualization device and method variations are described herein where an imaging hood is temporarily sealed against a region of tissue to be treated while under direct visualization. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. The imaging hood is placed against or adjacent to the tissue to be imaged in a body linen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid is pumped into the hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via all imaging element. Temporary sealing against the tissue can be achieved in a number of ways such as circumferential balloons inflatable within the hood or other sealing techniques. A field of view of the imaging element can be expanded by inflating the balloon beyond the imaging hood.
摘要翻译：本文描述了组织可视化装置和方法变化，其中成像罩在直接可视化期间临时密封待处理组织的区域。这样的系统可以包括部署导管和可展开成扩展配置的附接成像罩。成像罩被放置在通常用不透明的体液如血液填充的身体亚麻织物中或邻近要成像的组织上。半透明或透明流体被泵送到罩中，直到流体移动通过所有成像元件离开要成像的组织的清晰区域的任何血液。可以以多种方式实现对组织的临时密封，例如在罩内充气的周向气囊或其他密封技术。成像元件的视野可以通过使气囊膨胀超过成像罩而扩大。

10. 发明申请

US20060058582A1 Disposable shapelocking system 审中-公开
标题翻译：一次性形状锁定系统
公开(公告)号：US20060058582A1
公开(公告)日：2006-03-16
申请号：US11238298
申请日：2005-09-28
申请人： Tracy Maahs , Vahid Saadat , Chris Rothe , Tung Le
发明人： Tracy Maahs , Vahid Saadat , Chris Rothe , Tung Le
IPC分类号： A61B1/00
CPC分类号： A61B1/00154 , A61B1/0055 , A61B17/3421 , A61B2017/00314 , A61B2017/345
摘要： Disposable shapelocking systems are disclosed herein. A shapelock assembly generally comprises an elongate body defining at least one lumen therethrough for advancement of an endoscope or other endoscopic instruments therethrough. A handle assembly can be actuated to compress nested links against one another to transition the elongate body from a flexible state to a rigid shape-locked state. One or more of the nested links can be made from a particular thermoplastic either alone or in combination with one or more reinforcing structures. Such structures can include a reinforcing ring integrated with the link on an inner, outer, or lower surface of the link. Alternatively, the link can be coated or layered to enhance its strength. Additionally, different portions of the shapelock body can be made from different types of links depending upon the loads imparted upon the various portions of the shapelock body.
摘要翻译：本文公开了一次性形状锁定系统。形状锁定组件通常包括限定穿过其中的至少一个内腔的细长主体，用于使内窥镜或其它内窥镜器械从其中前进。手柄组件可以被致动以将嵌套的链节相互压缩以将细长主体从柔性状态转换到刚性形状锁定状态。嵌套链接中的一个或多个可以单独地或与一个或多个加强结构组合地由特定的热塑性材料制成。这种结构可以包括与连杆的内，外或下表面上的连杆成一体的加强环。或者，链接可以被涂覆或分层以提高其强度。此外，形状锁体的不同部分可以根据施加在形状锁体的各个部分上的载荷从不同类型的连杆制成。

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