专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明授权

US07745625B2 Prodrugs of piperazine and substituted piperidine antiviral agents 有权
标题翻译：哌嗪的前药和取代的哌啶抗病毒剂
公开(公告)号：US07745625B2
公开(公告)日：2010-06-29
申请号：US11066745
申请日：2005-02-25
申请人： Yasutsugu Ueda , Timothy P. Connolly , John F. Kadow , Nicholas A. Meanwell , Tao Wang , Chung-Pin H. Chen , Kap-Sun Yeung , Zhongxing Zhang , David Kenneth Leahy , Shawn K. Pack , Nachimuthu Soundararajan , Pierre Sirard , Kathia Levesque , Dominique Thoraval
发明人： Yasutsugu Ueda , Timothy P. Connolly , John F. Kadow , Nicholas A. Meanwell , Tao Wang , Chung-Pin H. Chen , Kap-Sun Yeung , Zhongxing Zhang , David Kenneth Leahy , Shawn K. Pack , Nachimuthu Soundararajan , Pierre Sirard , Kathia Levesque , Dominique Thoraval
IPC分类号： C07D401/00
CPC分类号： A61K31/675 , A61K31/497 , A61K45/06 , C07D471/04 , C07F9/062 , C07F9/5728 , C07F9/65515 , C07F9/65586 , C07F9/6561
摘要： This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
摘要翻译：本发明提供前药化合物I，其药物组合物及其在治疗HIV感染中的用途。其中：X为C或N，条件是当X为N时，R1不存在; W为C或N，条件是当W为N时，R2不存在; V是C; E是氢或其药学上可接受的盐; 并且Y选自本发明另外，本发明提供了可用于制备前药化合物I的中间体化合物II。其中：L和M独立地选自C 1 -C 6烷基，苯基，苄基，三烷基甲硅烷基， 2,2,2-三氯乙氧基和2-三甲基甲硅烷基乙氧基。

82. 发明授权

US07745463B2 Alkene piperidine derivatives as antiviral agents 有权
标题翻译：烯酸哌啶衍生物作为抗病毒剂
公开(公告)号：US07745463B2
公开(公告)日：2010-06-29
申请号：US12484407
申请日：2009-06-15
申请人： Tao Wang , Ying Han , John F. Kadow , Zhongxing Zhang , Nicholas A. Meanwell
发明人： Tao Wang , Ying Han , John F. Kadow , Zhongxing Zhang , Nicholas A. Meanwell
IPC分类号： A61K31/445 , A61K31/4545 , A61P31/12 , C07D215/20 , C07D295/00
CPC分类号： A61K31/445 , A61K31/4545 , A61K45/06 , C07D211/70 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D413/14 , A61K2300/00
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
摘要翻译：本公开提供了具有药物和生物影响性质的化合物，其药物组合物和使用方法。特别地，本公开涉及具有独特抗病毒活性的烯烃哌啶衍生物。更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。

83. 发明申请

US20100138729A1 Pseudorandom binary sequence checker with control circuitry for end-of-test check 有权
标题翻译：具有用于测试结束检查的控制电路的伪随机二进制序列检查器
公开(公告)号：US20100138729A1
公开(公告)日：2010-06-03
申请号：US12324920
申请日：2008-11-28
申请人： Si Ruo Chen , Hao Li , Jin Song Liu , Tao Wang
发明人： Si Ruo Chen , Hao Li , Jin Song Liu , Tao Wang
IPC分类号： G06F11/07
CPC分类号： H04L1/244 , G06F2217/14
摘要： Control circuitry is coupled between an error event output and a data input of a pseudorandom binary sequence (PRBS) checker. The control circuitry is configured to switch between a first operating state in which a received PRBS signal is applied to the data input of the PRBS checker and a second operating state in which an error signal is applied to the data input of the PRBS checker, responsive to detection of a designated condition of the PRBS checker. In an illustrative embodiment, the designated condition is an end-of-test condition indicating that the PRBS checker has completed a test involving the received PRBS signal.
摘要翻译：控制电路耦合在错误事件输出和伪随机二进制序列（PRBS）检查器的数据输入之间。控制电路被配置为在其中接收的PRBS信号被施加到PRBS检查器的数据输入的第一操作状态和其中错误信号被施加到PRBS检查器的数据输入的第二操作状态之间切换，响应检测PRBS检查器的指定条件。在说明性实施例中，指定条件是指示PRBS检查器已经完成涉及所接收的PRBS信号的测试的测试结束条件。

84. 发明申请

US20100067863A1 VIDEO EDITING METHODS AND SYSTEMS 有权
标题翻译：视频编辑方法和系统
公开(公告)号：US20100067863A1
公开(公告)日：2010-03-18
申请号：US12211883
申请日：2008-09-17
申请人： Patricia P. Wang , Yimin Zhang , Tao Wang , Jianguo Li
发明人： Patricia P. Wang , Yimin Zhang , Tao Wang , Jianguo Li
IPC分类号： G11B27/00 , H04N9/00
CPC分类号： G11B27/034
摘要： Video editing methods and systems, including methods and systems to identify video clips having similar visual characteristics. Video clips may correspond to first and second videos, which may include a professional music video and a personal video, respectively. Identified video clips of the personal video may be combined into a new video clip, and music corresponding to visually similar video clips of the music video may be associated with the corresponding video clips of the new video. Video frames of the video clips may be characterized with respect to one or more visual features, which may include one or more of facial and/or body features, salient objects, camera motion, and image quality. Characterizations may be compared between video clips on an incremental basis. Characterization of a music video may implicitly model an underlying correlation between music rhythm and changes in visual appearance.
摘要翻译：视频编辑方法和系统，包括识别具有相似视觉特征的视频剪辑的方法和系统。视频剪辑可以分别对应于第一和第二视频，其可以分别包括专业音乐视频和个人视频。识别的个人视频的视频剪辑可以被组合成新的视频剪辑，并且对应于音乐视频的视觉上相似的视频剪辑的音乐可以与新视频的相应视频剪辑相关联。视频剪辑的视频帧可以相对于一个或多个视觉特征来表征，其可以包括面部和/或身体特征，显着对象，照相机运动和图像质量中的一个或多个。可以在增量的基础上比较视频片段之间的特征。音乐视频的表征可以隐含地模拟音乐节奏和视觉外观变化之间的底层相关性。

85. 发明申请

US20100062495A1 Homologous recombination-based DNA cloning methods and compositions 审中-公开
公开(公告)号：US20100062495A1
公开(公告)日：2010-03-11
申请号：US12584684
申请日：2009-09-10
申请人： Weiqiang Liu , Ping Yang , Tao Wang , Ping Yang , Zhuying Wang , Wenzhu Chen , Fang Liang Zhang
发明人： Weiqiang Liu , Ping Yang , Tao Wang , Ping Yang , Zhuying Wang , Wenzhu Chen , Fang Liang Zhang
IPC分类号： C12N15/64 , C12N9/16
CPC分类号： C12N15/66
摘要： Methods and compositions for cloning a donor DNA molecule into an acceptor vector at a predetermined location are described. The methods are based on homologous recombination mediated by in vitro treatment of the donor DNA and the acceptor vector with an enzyme cocktail containing an exonuclease and a single-stranded DNA binding protein.

86. 发明申请

US20100009993A1 Diketo Fused Azolopiperidines and Azolopiperazines as Anti-HIV Agents 有权
公开(公告)号：US20100009993A1
公开(公告)日：2010-01-14
申请号：US12490714
申请日：2009-06-24
申请人： Tao Wang , Yasutsugu Ueda , Lawrence G. Hamann , Zhongxing Zhang , Zhiwei Yin , Alicia Regueiro-Ren , David J. Carini , Jacob Swidorski , Zheng Liu , Nicholas A. Meanwell , John F. Kadow , Barry L. Johnson
发明人： Tao Wang , Yasutsugu Ueda , Lawrence G. Hamann , Zhongxing Zhang , Zhiwei Yin , Alicia Regueiro-Ren , David J. Carini , Jacob Swidorski , Zheng Liu , Nicholas A. Meanwell , John F. Kadow , Barry L. Johnson
IPC分类号： A61K31/495 , A61K31/437 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives that possess unique antiviral activity are provided. These compounds are useful for the treatment of HIV and AIDS.
摘要翻译：阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。特别地，提供具有独特抗病毒活性的二酮稠合偶氮哌啶和偶氮哌嗪衍生物。这些化合物可用于治疗艾滋病毒和艾滋病。

87. 发明授权

US07626045B2 Synthesis of himbacine analogs 有权
标题翻译：烟草类似物的合成
公开(公告)号：US07626045B2
公开(公告)日：2009-12-01
申请号：US12428773
申请日：2009-04-23
申请人： Tiruvettipuram K. Thiruvengadam , Tao Wang , Jing Liao , John S. Chiu , David J. S. Tsai , Hong-Chang Lee , Wenxue Wu , Xiaoyong Fu
发明人： Tiruvettipuram K. Thiruvengadam , Tao Wang , Jing Liao , John S. Chiu , David J. S. Tsai , Hong-Chang Lee , Wenxue Wu , Xiaoyong Fu
IPC分类号： C07D307/92
CPC分类号： C07D405/06
摘要： The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer.An example of a step in the synthesis of such a himbacine analog is as follows:
摘要翻译：本发明涉及一种制备烟肼类似物的改进方法。该化合物可用作凝血酶受体拮抗剂。改进的方法可以允许至少一种通过结晶进行更容易的纯化，更容易的伸缩性和提高所需对映异构体的方法产率。合成这种甜菜碱类似物的步骤的一个例子如下：

88. 发明授权

US07622465B2 Costunolide derivatives 失效
标题翻译： Costunolide衍生物
公开(公告)号：US07622465B2
公开(公告)日：2009-11-24
申请号：US12335902
申请日：2008-12-16
申请人： Wei-Guo Su , Hong Jia , Xiaoqiang Yan , Jifeng Duan , Tao Wang , Yu Cai , Weihan Zhang
发明人： Wei-Guo Su , Hong Jia , Xiaoqiang Yan , Jifeng Duan , Tao Wang , Yu Cai , Weihan Zhang
IPC分类号： A61K31/535 , A61K31/34 , A61K31/445
CPC分类号： C07D307/93 , C07D405/06 , C07D413/06
摘要： Disclosed are methods for inhibiting TNFα expression, IL-1β expression, iNOS expression, and NF-κB activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a compound of the following formula:
摘要翻译：公开了用下列化学式抑制TNFα表达，IL-1β表达，iNOS表达和NF-κB活性的方法和用于治疗自身免疫性疾病，癌症或动脉粥样硬化的方法：

89. 发明申请

US20090281321A1 EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS 有权
标题翻译：乙酰胺类似物的外 - 和二选择性合成
公开(公告)号：US20090281321A1
公开(公告)日：2009-11-12
申请号：US12505079
申请日：2009-07-17
申请人： George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
发明人： George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
IPC分类号： C07C69/608 , C07D405/08 , C07F9/40 , C07D307/92 , C07D417/08 , C07D277/64
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

90. 发明申请

US20090203936A1 SYNTHESIS OF 3-(5-NITROCYCLOHEX-1-ENYL) ACRYLIC ACID AND ESTERS THEREOF 失效
标题翻译： 3-（5-硝基环己基-1-环己基）丙烯酸及其酯的合成
公开(公告)号：US20090203936A1
公开(公告)日：2009-08-13
申请号：US12274075
申请日：2008-11-19
申请人： Tiruvettipuram K. Thiruvengadam , Tao Wang , John S. Chiu , Jing Liao
发明人： Tiruvettipuram K. Thiruvengadam , Tao Wang , John S. Chiu , Jing Liao
IPC分类号： C07C51/16
CPC分类号： C07C251/44 , C07C201/06 , C07C249/08 , C07C2601/16 , C07C205/56 , C07C251/42
摘要： This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one step) oxidation of an oxime functional group mediated by a molybdenum VI/VII peroxo complex, the process comprising: (a) providing a substrate of Formula I containing an oxime functional group; wherein R1 and R2 are selected independently from linear, branched or cyclic alkyl and linear, branched or cyclic alkenyl groups, optionally substituted, with the proviso that at least one of R1 or R2 contains a carbon/carbon double bond; and (b) contacting said substrate of Formula I with a molybdenum oxidation complex, thereby oxidizing said oxime functional group to a nitro functional group to yield the structure of Formula III. Where R1 and R2 are as defined above.
摘要翻译：本申请公开提供了一种通过由钼VI / VII过氧配合物介导的肟官能团的直接（一步）氧化将硝基官能团引入到还含有不饱和位和/或氧官能团位点的化合物的方法该方法包括：（a）提供含有肟官能团的式I的底物; 其中R 1和R 2独立地选自直链，支链或环状的烷基和直链，支链或环状烯基，任选被取代，条件是R 1或R 2中的至少一个含有碳/碳双键; 和（b）使式I的底物与钼氧化络合物接触，从而将所述肟官能团氧化为硝基官能团，得到式III的结构。其中R1和R2如上所定义。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式