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81. 发明授权

US07910064B2 Nanowire-based sensor configurations 有权
标题翻译：基于纳米线的传感器配置
公开(公告)号：US07910064B2
公开(公告)日：2011-03-22
申请号：US11399218
申请日：2006-04-06
申请人： James M. Hamilton , Robert S. Dubrow , Calvin Y. H. Chow
发明人： James M. Hamilton , Robert S. Dubrow , Calvin Y. H. Chow
IPC分类号： G01N27/00
CPC分类号： G01N33/54313 , B82Y15/00 , G01N27/127 , G01N27/4146
摘要： This invention provides nanowire based molecular sensors and methods for detecting analytes in a microfluidic system. Methods for sensing analytes include detecting changed electrical parameters associated with contact of a nanowire with the analyte in a microfluidic system. Sensors of the invention include nanowires mounted in microchambers of a microfluidic system in electrical contact with the detector, whereby electrical parameter changes induced in the nanowire by the analyte can be monitored by the detector.
摘要翻译：本发明提供了基于纳米线的分子传感器和用于检测微流体系统中的分析物的方法。感测分析物的方法包括检测与微流体系统中的纳米线与分析物的接触相关联的改变的电参数。本发明的传感器包括安装在与检测器电接触的微流体系统的微室中的纳米线，由分析物在纳米线中诱发的电参数变化可由检测器监测。

82. 发明申请

US20100140160A1 Nanofiber surface for use in enhanced surfaces area appications 审中-公开
标题翻译：纳米纤维表面用于增强表面区域应用
公开(公告)号：US20100140160A1
公开(公告)日：2010-06-10
申请号：US12317797
申请日：2008-12-29
申请人： Robert S. Dubrow , Chunming Niu
发明人： Robert S. Dubrow , Chunming Niu
IPC分类号： B01D24/02
CPC分类号： B01J20/281 , A61L2400/12 , A61M1/1698 , B01J20/28007 , B01J20/28057 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3234 , B01J20/3236 , B01J20/3246 , B01J20/3265 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3289 , B01J20/3291 , B01L3/5027 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/161 , B01L2400/0406 , B82Y30/00 , F28D15/046 , F28F2245/02 , F28F2245/04 , G01N30/92 , G01N33/54346 , G01N33/54393 , H01J49/0418 , Y10S977/762 , Y10S977/764 , Y10S977/773 , Y10S977/813 , Y10S977/904 , Y10T428/29 , Y10T428/2913 , Y10T428/2915 , Y10T428/2918 , Y10T428/292 , Y10T428/2929 , Y10T428/298
摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates, as well as methods and uses for such substrates.
摘要翻译：本发明提供了新颖的纳米纤维增强表面积基底和包括这种基底的结构，以及这种基底的方法和用途。

83. 发明申请

US20090192429A1 RESORBABLE NANOENHANCED HEMOSTATIC STRUCTURES AND BANDAGE MATERIALS 有权
标题翻译：可再生的纳米化催化结构和粘合材料
公开(公告)号：US20090192429A1
公开(公告)日：2009-07-30
申请号：US12329431
申请日：2008-12-05
申请人： R. Hugh Daniels , Robert S. Dubrow , Robert Enzerink , Esther Li , Vijendra Sahi , Jay L. Goldman , J. Wallace Parce
发明人： R. Hugh Daniels , Robert S. Dubrow , Robert Enzerink , Esther Li , Vijendra Sahi , Jay L. Goldman , J. Wallace Parce
IPC分类号： A61F13/00 , A61B17/064
CPC分类号： A61F13/00034 , A61B17/0057 , A61B17/064 , A61B2017/00601 , A61B2017/00884 , A61B2017/00893 , A61F13/00008 , A61F13/00991 , A61F13/36 , A61F2013/00472 , A61F2013/0054 , A61F2013/00744 , A61F2013/00927 , A61F2013/00931 , A61L15/18 , A61L15/42 , A61L17/145 , A61L26/0004 , A61L26/0095 , A61L31/082 , A61L31/128 , A61L2400/04 , A61L2400/12 , D06M23/08
摘要： Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers and/or glass beads. The hemostatic materials and structures may be resorbable. Example embodiments include hemostatic bandages, hemostatic plugs, and hemostatic formulations.
摘要翻译：提供了纳米材料增强型止血医疗装置的方法，系统和装置。提供止血材料和结构，其在创伤，外科手术，溃疡或其他原因引起的伤口/开口处引起血液凝血。止血材料和结构可以结合纳米结构和/或其它止血元件，例如聚合物和/或玻璃珠。止血材料和结构可以是可再吸收的。示例性实施例包括止血绷带，止血塞和止血配方。

84. 发明申请

US20090162643A1 Medical Device Applications of Nanostructured Surfaces 审中-公开
标题翻译：纳米结构表面的医疗器械应用
公开(公告)号：US20090162643A1
公开(公告)日：2009-06-25
申请号：US12393869
申请日：2009-02-26
申请人： Robert S. Dubrow , L. Douglas Sloan
发明人： Robert S. Dubrow , L. Douglas Sloan
IPC分类号： B32B5/16
CPC分类号： A61L31/14 , A61L2400/12 , A61L2400/18 , B82Y30/00 , Y10T428/259
摘要： This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices.
摘要翻译：本发明提供了新颖的纳米纤维增强表面积基材和包括用于各种医疗装置的这种基底的结构，以及用于这种基底和医疗装置的方法和用途。

85. 发明授权

US07466533B2 Nanofiber surface based capacitors 有权
标题翻译：纳米纤维表面电容器
公开(公告)号：US07466533B2
公开(公告)日：2008-12-16
申请号：US11840414
申请日：2007-08-17
申请人： Calvin Y.H. Chow , Robert S. Dubrow
发明人： Calvin Y.H. Chow , Robert S. Dubrow
IPC分类号： H01G4/005
CPC分类号： H01G4/008 , H01G4/005 , H01G4/06 , H01G4/203 , H01G4/33 , H01G9/04 , H01G11/36 , H01G11/46 , H01L28/82 , H05K1/162 , H05K2201/026 , Y02E60/13
摘要： This invention provides novel capacitors comprising nanofiber enhanced surface area substrates and structures comprising such capacitors, as well as methods and uses for such capacitors.
摘要翻译：本发明提供了包含纳米纤维增强表面积基板和包括这种电容器的结构的新型电容器，以及这种电容器的方法和用途。

86. 发明授权

US07391018B2 Nanostructured thin films and their uses 有权
标题翻译：纳米结构薄膜及其用途
公开(公告)号：US07391018B2
公开(公告)日：2008-06-24
申请号：US11226075
申请日：2005-09-14
申请人： Chunming Niu , Robert Hugh Daniels , Robert S. Dubrow , Jay L. Goldman
发明人： Chunming Niu , Robert Hugh Daniels , Robert S. Dubrow , Jay L. Goldman
IPC分类号： H01J49/04
CPC分类号： A61L27/303 , A61L31/122 , H01J49/0418 , Y10S977/701 , Y10T428/12736 , Y10T428/12743
摘要： The present invention generally discloses the use of a nanostructured non-silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.
摘要翻译：本发明一般公开了在支撑衬底上使用纳米结构非硅薄膜（例如氧化铝或铝薄膜），随后用诸如硅或钨的材料的活性层涂覆。底层的非硅材料产生增强的表面积，而活性层有助于在分析物的激光解吸附中用激光照射时，将能量并入和转移到吸附在活性层上的一种或多种分析物。本发明提供了可以通过相对直接和廉价的制造方法制造的衬底表面，其可用于各种应用，例如质谱，疏水或亲水涂层，医疗器械应用，电子学，催化，保护，数据存储，光学和传感器。

87. 发明申请

US20080073505A1 Nanostructured thin films and their uses 有权
公开(公告)号：US20080073505A1
公开(公告)日：2008-03-27
申请号：US11226075
申请日：2005-09-14
申请人： Chunming Niu , Robert Hugh Daniels , Robert S. Dubrow , Jay L. Goldman
发明人： Chunming Niu , Robert Hugh Daniels , Robert S. Dubrow , Jay L. Goldman
IPC分类号： H01J49/04
CPC分类号： A61L27/303 , A61L31/122 , H01J49/0418 , Y10S977/701 , Y10T428/12736 , Y10T428/12743
摘要： The present invention generally discloses the use of a nanostructured non-silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.

88. 发明授权

US07303727B1 Microfluidic sample delivery devices, systems, and methods 有权
标题翻译：微流体样品输送装置，系统和方法
公开(公告)号：US07303727B1
公开(公告)日：2007-12-04
申请号：US10369325
申请日：2003-02-19
申请人： Robert S. Dubrow , Michael Greenstein , Luc J. Bousse , Khushroo Gandhi
发明人： Robert S. Dubrow , Michael Greenstein , Luc J. Bousse , Khushroo Gandhi
IPC分类号： B01L3/02 , B32B5/02 , B32B27/04 , B32B27/12 , G01N15/06
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2200/12 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/027 , B01L2400/0415 , B01L2400/0487 , G01N30/6095 , G01N30/84 , G01N35/1095 , G01N2030/847 , G01N2030/8488 , G01N2035/1039 , Y10T436/11 , Y10T436/118339 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： Methods and apparatus for delivering fluidic materials to sample destinations, including mass spectrometers for analysis are provided. In preferred embodiments, sample aliquots are electrosprayed from tapered spray tips of capillary elements into the orifices of mass spectrometric inlet systems. In certain embodiments, fluidic samples are orthogonally sprayed from capillary elements or other fluid conduits, whereas in other embodiments samples are sprayed after devices are rotated or otherwise translocated from sample sources to sample destinations. In still other embodiments, samples are sprayed from flexed or deflected capillary elements at selected sample destinations.
摘要翻译：提供了将流体材料输送到样品目的地的方法和设备，包括用于分析的质谱仪。在优选的实施方案中，将样品等分试样从毛细管元件的锥形喷嘴电喷雾到质谱入口系统的孔中。在某些实施方案中，流体样品从毛细管元件或其他流体导管正交喷射，而在其它实施方案中，在将装置旋转或以其他方式从样品源转移到样品目的地之后，将样品喷雾。在其它实施例中，样品在选定的样品目的地从挠曲或偏转的毛细管元件喷射。

89. 发明授权

US06592821B1 Focusing of microparticles in microfluidic systems 有权
标题翻译：将微粒聚焦在微流体系统中
公开(公告)号：US06592821B1
公开(公告)日：2003-07-15
申请号：US09853887
申请日：2001-05-10
申请人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow , Yevgeny Yurkovetsky , Javier Anibal Farinas
发明人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow , Yevgeny Yurkovetsky , Javier Anibal Farinas
IPC分类号： G01N3348
CPC分类号： B01F13/0062 , B01J19/0093 , B01L3/502776 , B01L2200/0636 , B01L2400/0406 , B01L2400/0487 , G01N15/1404 , G01N27/44704 , G01N27/44791 , G01N2015/1409 , G01N2015/149 , G01N2333/4718 , Y10T436/11
摘要： Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
摘要翻译：提供了粒子聚焦的方法和系统，以增加微量体系中的分析产量和灵敏度。本发明包括为微流体装置中的流动颗粒提供基本均匀的流速的方法。还提供了分选颗粒群体成员的方法，例如细胞和各种亚细胞组分。另外包括其中聚焦和/或分选颗粒的集成系统。

90. 发明授权

US06475364B1 Methods, devices and systems for characterizing proteins 有权
标题翻译：表征蛋白质的方法，装置和系统
公开(公告)号：US06475364B1
公开(公告)日：2002-11-05
申请号：US09496849
申请日：2000-02-02
申请人： Robert S. Dubrow , Christopher Bloxsom , Calvin Y. H. Chow , J. Wallace Parce
发明人： Robert S. Dubrow , Christopher Bloxsom , Calvin Y. H. Chow , J. Wallace Parce
IPC分类号： G01N2726
CPC分类号： G01N27/44747 , G01N27/44791
摘要： A method of characterizing a polypeptide, comprising providing a first capillary channel having a separation buffer disposed within, wherein the separation buffer comprises a non-crosslinked polymer solution, a buffering agent, a detergent, and a lipophilic dye. The separation buffer is provided such that, at the time of detection, the detergent concentration in the buffer is not above the critical micelle concentration. The polypeptide is introduced into one end of the capillary channel. An electric field is applied across a length of the capillary channel, which transports polypeptides of different sizes through the polymer solution at different rates. The polypeptide is then detected as it passes a point along the length of the capillary channel.
摘要翻译：一种表征多肽的方法，包括提供其中设置有分离缓冲液的第一毛细通道，其中所述分离缓冲液包含非交联聚合物溶液，缓冲剂，洗涤剂和亲脂性染料。提供分离缓冲液，使得在检测时，缓冲液中的洗涤剂浓度不高于临界胶束浓度。将多肽引入毛细管通道的一端。在毛细通道的一段长度上施加电场，毛细通道以不同的速率输送不同尺寸的多肽通过聚合物溶液。然后当毛细通道沿着毛细通道的长度通过点时，检测该多肽。

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