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81. 发明授权

US06693077B1 Keratinocyte growth factor-2 失效
标题翻译：角质形成细胞生长因子-2
公开(公告)号：US06693077B1
公开(公告)日：2004-02-17
申请号：US09610651
申请日：2000-06-30
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K3818
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

82. 发明授权

US06639052B1 Human ADA2 polypeptides 失效
标题翻译：人ADA2多肽
公开(公告)号：US06639052B1
公开(公告)日：2003-10-28
申请号：US09417540
申请日：1999-10-14
申请人： Paul A. Moore
发明人： Paul A. Moore
IPC分类号： C12P2106
CPC分类号： C07K14/47 , A61K38/00
摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要翻译：公开了编码此类多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了将这些多肽用于治疗目的的方法。还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。还公开了用于检测利用序列和多肽的疾病的诊断方法。

83. 发明授权

US06627741B2 Antibodies to secreted protein HCEJQ69 有权
标题翻译：分泌蛋白HCEJQ69的抗体
公开(公告)号：US06627741B2
公开(公告)日：2003-09-30
申请号：US10012542
申请日：2001-12-12
申请人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. LaFleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
发明人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. LaFleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
IPC分类号： C07K1624
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

84. 发明授权

US06577855B1 Low IF receiver 有权
标题翻译：低IF接收机
公开(公告)号：US06577855B1
公开(公告)日：2003-06-10
申请号：US09377357
申请日：1999-08-19
申请人： Paul A. Moore , Michael E. Barnard , Astrid Paula Maria Schweer
发明人： Paul A. Moore , Michael E. Barnard , Astrid Paula Maria Schweer
IPC分类号： H04B126
CPC分类号： H04B1/1638 , H04B1/28
摘要： A low IF receiver suitable for use in cellular and cordless telephones and TV tuners, comprises input signal receiving means(10), quadrature related frequency down conversion means including first and second mixing means(14, 15) having first inputs(12, 13) coupled to the input signal receiving means and a local oscillator means(16) for generating a local oscillator signal having a frequency offset from a nominal centre frequency of the input signal coupled to second inputs(18, 19) of the first and second mixing means, a channel selectivity polyphase filtering means(20) for selecting a wanted channel signal from outputs of the first and second mixing means, means(26, 28, 30) for detecting when the quality of the frequency down converted signal becomes unacceptable due a large adjacent channel interfering component and means responsive to said detection for changing the local oscillator frequency by at least twice the low IF or one channel bandwidth to displace the large interfering component outside the bandwidth of the channel selectivity polyphase filtering means(20) and simultaneously changing the centre frequency of the polyphase filter.
摘要翻译：适用于蜂窝和无绳电话和电视调谐器的低IF接收机包括输入信号接收装置（10），正交相关频率下变频装置，包括具有第一输入端（12,13）的第一和第二混频装置（14,15）耦合到输入信号接收装置和本地振荡器装置（16），用于产生本地振荡器信号，该本地振荡器信号具有与耦合到第一和第二混合装置的第二输入端（18,19）的输入信号的标称中心频率的偏移，用于从所述第一和第二混合装置的输出中选择所需信道信号的信道选择性多相滤波装置（20），用于检测所述降频转换信号的质量何时被大量接收的装置（26,28,30）相邻信道干扰分量和响应于所述检测的装置，用于将本地振荡器频率改变至少两倍的低IF或一个信道带宽以置换大干扰化合物在通道选择性多相滤波装置（20）的带宽之外，同时改变多相滤波器的中心频率。

85. 发明授权

US06534631B1 Secreted protein HT5GJ57 有权
公开(公告)号：US06534631B1
公开(公告)日：2003-03-18
申请号：US09482273
申请日：2000-01-13
申请人： Steven M. Ruben , George Komatsoulis , Roxanne D. Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik Olsen , Laurie A. Brewer , Kimberly A. Florence , Paul Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
发明人： Steven M. Ruben , George Komatsoulis , Roxanne D. Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik Olsen , Laurie A. Brewer , Kimberly A. Florence , Paul Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
IPC分类号： C07K1100
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

86. 发明授权

US06420526B1 186 human secreted proteins 失效
标题翻译： 186人分泌蛋白
公开(公告)号：US06420526B1
公开(公告)日：2002-07-16
申请号：US09149476
申请日：1998-09-08
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel P. Soppet , Kenneth C. Carter , Daniel R. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. Lafleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel P. Soppet , Kenneth C. Carter , Daniel R. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. Lafleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： C12Q168
CPC分类号： G01N33/68 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

87. 发明授权

US06278870B1 Phasing receivers 有权
标题翻译：定相接收器
公开(公告)号：US06278870B1
公开(公告)日：2001-08-21
申请号：US09159285
申请日：1998-09-23
申请人： Alan J. Davie , Paul A. Moore
发明人： Alan J. Davie , Paul A. Moore
IPC分类号： H04B110
CPC分类号： H03D3/007 , H03D7/165 , H03D2200/0017 , H04B1/26
摘要： A phasing receiver includes a quadrature mixing arrangement for frequency converting an input or high IF information signal to a pair of quadrature related low IF signals. The low IF signals are applied to a polyphase filter which functions as a low pass and adjacent channel rejection filter. One or more elements effecting a fine adjustment of relative phase away from quadrature and/or relative amplitude away from equality of the low IF signals are incorporated in information or oscillator signal paths in or about the mixing arrangement or a superhet stage preceding the quadrature mixing arrangement. These elements effect a predistortion of relative phase and/or relative amplitude of the low IF signals in order to compensate for mismatches in an input stage of the filter, and thereby improve image rejection by the filter.
摘要翻译：定相接收机包括用于将输入或高IF信息信号频率转换成一对正交相关低IF信号的正交混频装置。低IF信号被施加到用作低通和相邻信道抑制滤波器的多相滤波器。影响相对相位的精细调整的一个或多个元素远离正交和/或相对幅度远离低IF信号的相等，被并入混合装置中或周围的信息或振荡器信号路径中，或者在正交混频装置之前的监控级。这些元件影响低IF信号的相对相位和/或相对幅度的预失真，以补偿滤波器的输入级中的失配，从而改善滤波器的图像抑制。

88. 发明授权

US6035186A Integrated receiver 失效
标题翻译：集成接收机
公开(公告)号：US6035186A
公开(公告)日：2000-03-07
申请号：US815099
申请日：1997-03-11
申请人： Paul A. Moore , Michael E. Barnard
发明人： Paul A. Moore , Michael E. Barnard
IPC分类号： H03D1/22 , H03D3/00 , H03H7/21 , H03H11/04 , H03H11/08 , H04B1/16 , H04B1/30 , H04B1/26
CPC分类号： H03H7/21 , H03D3/008 , H03D3/009 , H04B1/30 , H03H2007/0192
摘要： An integrated receiver in which in order to permit ac-coupling between stages and to remove the effects of strong directly detected amplitude modulated interfering signals lying within the input band of the receiver, the input signal is frequency down converted using a local oscillator signal which provides an intermediate frequency (F.sub.if) which lies above the frequency of the directly detected interferer (F.sub.AMP). The outputs from the frequency down converters (14, 16, 18, 20) are ac coupled to filtering means the outputs of which are applied to an equalizer (52). The filtering means may comprise a polyphase filter (50), the frequency response of which is distorted by the ac coupling capacitors (54, 56). By applying the outputs of the filtering means to the equalizer (52) substantially all the distortion introduced by the ac coupling capacitors (54, 56) on the filter response is removed to provide an acceptable signal for detection and recovery of the modulating signal.
摘要翻译：一种集成接收机，其中为了允许级之间的交流耦合并且消除位于接收机的输入频带内的强直接检测的调幅干扰信号的影响，输入信号使用提供的本地振荡器信号进行降频转换位于直接检测到的干扰源（FAMP）的频率之上的中频（Fif）。来自降频转换器（14,16,18,20）的输出被耦合到滤波装置，其输出被施加到均衡器（52）。滤波装置可以包括多相滤波器（50），其频率响应由交流耦合电容器（54,56）变形。通过将滤波装置的输出施加到均衡器（52），消除了由交流耦合电容器（54,56）引入的滤波器响应所引起的所有失真，以提供用于调制信号的检测和恢复的可接受的信号。

89. 发明授权

US5697093A Zero IF receivers 失效
标题翻译：零中频接收机
公开(公告)号：US5697093A
公开(公告)日：1997-12-09
申请号：US506138
申请日：1995-07-24
申请人： Anthony Richard Cusdin, deceased , Alan J. Davie , Paul A. Moore
发明人： Anthony Richard Cusdin, deceased , Alan J. Davie , Paul A. Moore
IPC分类号： H03G3/20 , H03G3/30 , H04B1/16 , H04B1/30
CPC分类号： H03G3/3052
摘要： An automatic gain control strategy for zero IF receivers in which the gain of low pass filters (20,22) is altered whilst keeping their bandwidths substantially constant. The low pass filters (20,22) are implemented as gyrator filters, each of which comprise at least one pair of transconductors, the ratio of the transconductances of which are adjustable in such a manner as to maintain the product of their transconductances constant. An electronic signal for adjusting the ratio of the transconductances is derived from an estimate of the instantaneous signal amplitude of the received signal.
摘要翻译：一种零中频接收机的自动增益控制策略，其中低通滤波器（20,22）的增益被改变，同时保持其带宽基本恒定。低通滤波器（20,22）被实现为回转器滤波器，每个反射器滤波器包括至少一对跨导体，其跨导的比例可以以使其跨导的乘积保持恒定的方式可调。用于调整跨导比的电子信号是从接收信号的瞬时信号幅度的估计得出的。

90. 发明授权

US5023568A Combined current differencing and operational amplifier circuit 失效
标题翻译：组合电流差分和运算放大器电路
公开(公告)号：US5023568A
公开(公告)日：1991-06-11
申请号：US540017
申请日：1990-06-18
申请人： Paul A. Moore , Colin L. Perry , Johannes O. Voorman
发明人： Paul A. Moore , Colin L. Perry , Johannes O. Voorman
IPC分类号： H03F3/34 , H03F1/48 , H03F3/343 , H03F3/45 , H03H11/12
CPC分类号： H03F1/48 , H03F3/3432 , H03F3/45071 , H03F3/45479
摘要： A combined current difference and operational amplifier circuit (10) for use either as or in a filter embodied in an integrated receiver includes inputs (I.sub.A and I.sub.B) for oppositely phased current signals which are applied to a current mirror circuit formed by first and second NPN transistors (Q1,Q2) having their bases connected to a junction (20). Equal value resistors (R1,R2) are serially connected in the emitter circuits of the first and second transistors, respectively and the current inputs are coupled to the free ends of the resistors. The base-collector path of a third NPN transistor (Q3) is connected between the free end of one of the resistors (R1) and the junction (20). A current difference signal (i.sub.b -i.sub.a) derived from the free end of the other one of the resistors is applied to the virtual ground input of an operational amplifier formed by a common emitter stage (Q4) coupled to an emitter follower (Q5). The operational amplifier has a capacitive (C1) feedback between its output and virtual ground input so that the d.c. potential at said input has no effect on the d.c. operating point of the output.As an alternative, resistive (Rf) feedback may be used instead of the capacitive feedback.Another embodiment (FIG. 2) enables the input and output voltage swings to be increased without unduly degrading the bandwidth.
摘要翻译：用于集成接收机中实现的或在滤波器中使用的组合电流差和运算放大器电路（10）包括用于相反相位电流信号的输入（IA和IB），其被施加到由第一和第二NPN形成的电流镜电路其基极连接到结（20）的晶体管（Q1，Q2）。等电阻电阻（R1，R2）分别串联连接在第一和第二晶体管的发射极电路中，电流输入耦合到电阻器的自由端。第三NPN晶体管（Q3）的基极 - 集电极路径连接在电阻器（R1）中的一个的自由端和结（20）之间。从另一个电阻器的自由端导出的电流差信号（ib-ia）被施加到由耦合到射极跟随器（Q5）的公共发射极级（Q4）形成的运算放大器的虚拟接地输入。运算放大器在其输出和虚拟接地输入之间具有电容（C1）反馈，使得直流所述输入的电位对直流电压没有影响。输出的工作点。作为替代，可以使用电阻（Rf）反馈来代替电容反馈。另一实施例（图2）能够增加输入和输出电压摆幅，而不会过度地降低带宽。

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