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    • 82. 发明申请
    • USE OF A PEPTIDE AS A THERAPEUTIC AGENT
    • 使用作为治疗剂的肽
    • WO2009039982A2
    • 2009-04-02
    • PCT/EP2008007530
    • 2008-09-09
    • MONDOBIOTECH LAB AGBEVEC DORIANCAVALLI FABIOCAVALLI VERABACHER GERALD
    • BEVEC DORIANCAVALLI FABIOCAVALLI VERABACHER GERALD
    • A61K38/22A61K38/33A61P3/00A61P9/00A61P11/00A61P25/28A61P31/00A61P35/00A61P37/00
    • A61K38/2242A23C9/1526A23L33/18A23L33/40A61K38/44C12Y114/18001A61K2300/00
    • The present invention is directed to the use of the peptide compound Tyr-Ala-Glu-Gly- Thr-Phe-lle-Ser-Asp-Tyr-Ser-lle-Ala-Met-Asp-Lys-lle-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-lle-Thr-Gln-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Tyr-Ala-Glu-Gly-Thr-Phe-lle-Ser-Asp-Tyr-Ser-lle-Ala-Met-Asp-Lys-lle-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-lle-Thr-Gln-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
    • 本发明涉及肽化合物Tyr-Ala-Glu-Gly-Thr-Phe-1le-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln- Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Lle-Thr-Gln-OH 用于预防和/或治疗癌症,自身免疫性疾病,纤维化疾病,炎性疾病,神经变性疾病,感染性疾病,肺部疾病,心脏和血管疾病和代谢疾病的药物。 此外,本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有Tyr-Ala-Glu-Gly-Thr-Phe-Lle-Ser-Asp-Tyr- SER-LLE-ALA-Met的 - 天冬氨酸 - 赖氨酸 - LLE-HIS-GLN-GLN-ASP-PHE-VAL-ASN-TRP-LEU-LEU-丙氨酸 - 谷氨酰胺 - 赖氨酸 - 甘氨酸 - 赖氨酸 - 赖氨酸 - 天冬酰胺 - Asp-的 Trp-Lys-His-Asn-Lle-Thr-Gln-OH任选与至少一种药学上可接受的载体,冷冻保护剂,冻干保护剂,赋形剂和/或稀释剂一起。
    • 90. 发明申请
    • USE OF A PEPTIDE AS A THERAPEUTIC AGENT
    • 使用作为治疗剂的肽
    • WO2009033666A2
    • 2009-03-19
    • PCT/EP2008007453
    • 2008-09-09
    • MONDOBIOTECH LAB AGBEVEC DORIANCAVALLI FABIOCAVALLI VERABACHER GERALD
    • BEVEC DORIANCAVALLI FABIOCAVALLI VERABACHER GERALD
    • A61K38/29A61P3/00A61P9/00A61P11/00A61P25/28A61P31/00A61P31/18A61P31/20A61P35/00A61P37/00
    • A61K38/10
    • The present invention is directed to the use of the peptide compound Ser-Val-Ser-Glu- Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu- Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ser-Val-Ser-Glu-lle-Gln-Leu-Met-His-Asn- Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp- Val-His-Asn-Phe optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
    • 本发明涉及肽化合物Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu- Arg-Val-Glu-Trp-Leu- Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe作为预防和/或治疗癌症,自身免疫疾病,纤维化疾病,炎症 疾病,神经退行性疾病,传染病,肺部疾病,心血管疾病和代谢疾病。 此外,本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn- Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe 至少一种药学上可接受的载体,低温保护剂,冻干保护剂,赋形剂和/或稀释剂。