基本信息:
- 专利标题: USE OF A PEPTIDE AS A THERAPEUTIC AGENT
- 专利标题(中):使用作为治疗剂的肽
- 申请号:PCT/EP2008007668 申请日:2008-09-09
- 公开(公告)号:WO2009033731A2 公开(公告)日:2009-03-19
- 发明人: BEVEC DORIAN , CAVALLI FABIO , CAVALLI VERA , BACHER GERALD
- 申请人: MONDOBIOTECH LAB AG , BEVEC DORIAN , CAVALLI FABIO , CAVALLI VERA , BACHER GERALD
- 专利权人: MONDOBIOTECH LAB AG,BEVEC DORIAN,CAVALLI FABIO,CAVALLI VERA,BACHER GERALD
- 当前专利权人: MONDOBIOTECH LAB AG,BEVEC DORIAN,CAVALLI FABIO,CAVALLI VERA,BACHER GERALD
- 优先权: EP07017745 2007-09-11
- 主分类号: A61K38/08
- IPC分类号: A61K38/08 ; A61K38/39 ; A61P3/00 ; A61P9/00 ; A61P11/00 ; A61P25/28 ; A61P31/00 ; A61P35/00 ; A61P37/00
摘要:
The present invention is directed to the use of the peptide compound Cys-Ser-Arg-Ala- Arg-Lys-Gln-Ala-Ala-Ser-lle-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Cys-Ser-Arg-Ala-Arg-Lys-Gln-Ala-Ala-Ser- Ile-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要(中):
本发明涉及肽化合物Cys-Ser-Arg-Al-Arg-Lys-Gln-Ala-Ala-Ser-Lle-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg- OH作为预防和/或治疗癌症,自身免疫性疾病,纤维化疾病,炎性疾病,神经变性疾病,感染性疾病,肺部疾病,心脏和血管疾病和代谢疾病的治疗剂。 此外,本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有肽Cys-Ser-Arg-Ala-Arg-Lys-Gln-Ala-Ala-Ser- Ile-Lys-Val-Ala-Val-Ser-Ala-Asp-Arg-OH任选与至少一种药学上可接受的载体,冷冻保护剂,冻干保护剂,赋形剂和/或稀释剂一起。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K38/00 | 含肽的医药配制品 |
--------A61K38/04 | .在完全确定的序列中最多有20个氨基酸的肽;其衍生物 |
----------A61K38/08 | ..含有5~11个氨基酸的肽 |