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81. 发明申请

WO2010078198A1 SHORTENED ALK1 REGULATORY FRAGMENT 审中-公开
标题翻译：短暂的ALK1调节片段
公开(公告)号：WO2010078198A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069435
申请日：2009-12-23
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , SEKI, Tsugio
发明人： SEKI, Tsugio
IPC分类号： C12N15/00 , C07H21/04
CPC分类号： C07K14/71 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2830/008
摘要： Regulatory elements for controlling expression of transgenes in angiogenic tissue are provided. One embodiment provides an isolated nucleic acid having at least 80%, 85%, 90%, 95%, 97%, 99% or 100% sequence identity to SEQ ID NO: I, or a fragment thereof that causes expression of a transgene in angiogenic tissue. Vectors containing SEQ ID NO: 1 and one or more transgenes are also provided. A preferred vector is an adenovirus vector. The transgene can encode a cytotoxin, pro-apoptotic polypeptide, or a therapeutic polypeptide. SEQ ID NO:1 regulates the expression of the transgene such that the transgene is only expressed in angiogenic tissue including, but not limited to arteries feeding ischemic tissues. Methods of using vectors containing SEQ ID NO: 1 are also provided.
摘要翻译：提供了用于控制血管生成组织中转基因表达的调节元件。一个实施方案提供了与SEQ ID NO：1具有至少80％，85％，90％，95％，97％，99％或100％序列同一性的分离的核酸或其导致转基因表达的片段血管生成组织。还提供了含有SEQ ID NO：1的载体和一种或多种转基因。优选的载体是腺病毒载体。转基因可编码细胞毒素，促凋亡多肽或治疗性多肽。 SEQ ID NO：1调节转基因的表达，使得转基因仅在血管生成组织中表达，包括但不限于进食缺血组织的动脉。还提供了使用含有SEQ ID NO：1的载体的方法。

83. 发明申请

WO2008116216A1 COMPOSITIONS AND METHODS FOR INHIBITING CANCER METASTASIS 审中-公开
标题翻译：用于抑制癌症METASTASIS的组合物和方法
公开(公告)号：WO2008116216A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/058021
申请日：2008-03-24
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , BHALLA, Kapil , YANG, Yonghua
发明人： BHALLA, Kapil , YANG, Yonghua
IPC分类号： C07K16/30
CPC分类号： C07K16/30
摘要： It has been discovered that antagonists of acetylated heat shock proteins can inhibit or reduce tumor cell invasion or metastasis. Compositions and methods for inhibiting tumor cell invasion or metastasis are provided. One embodiment provides a pharmaceutical composition including a heat shock protein antagonist in an amount effective to inhibit or reduce tumor cell invasion or metastasis. Another embodiment provides a pharmaceutical composition including a heat shock protein deacetylase in an amount effective to inhibit or reduce secretion of heat shock proteins. Representative target heat shock proteins include, but are not limited to hsp90α and hsp70. Methods of treating cancer or inhibiting tumor cell invasion and metastasis are also provided.
摘要翻译：已经发现乙酰化热休克蛋白的拮抗剂可以抑制或减少肿瘤细胞侵袭或转移。提供了抑制肿瘤细胞侵袭或转移的组合物和方法。一个实施方案提供包含有效抑制或减少肿瘤细胞侵袭或转移的量的热休克蛋白拮抗剂的药物组合物。另一个实施方案提供包含热抑制蛋白脱乙酰酶的药物组合物，其量有效抑制或减少热休克蛋白的分泌。代表性的靶向热休克蛋白包括但不限于hsp90a和hsp70。还提供了治疗癌症或抑制肿瘤细胞侵袭和转移的方法。

84. 发明申请

WO2007021789A1 MODIFIED GREEN TEA POLYPHENOL FORMULATIONS 审中-公开
标题翻译：改性绿茶多酚配方
公开(公告)号：WO2007021789A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/031120
申请日：2006-08-10
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE , HSU, Stephen, D.
发明人： HSU, Stephen, D.
IPC分类号： A61K31/353 , A61P17/00
CPC分类号： A61K31/353 , A61K31/43 , A61K31/496 , A61K31/546 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K36/82 , A61K38/12
摘要： Modified green tea polyphenols and methods of their use are provided. One aspect provides compounds and compositions containing green tea polyphenols with one on more ester-linked fatty acids.
摘要翻译：提供了改良的绿茶多酚及其使用方法。一方面提供了含有多个酯连接的脂肪酸的绿茶多酚的化合物和组合物。

85. 发明申请

WO2005091751A2 NOVEL GENE ASSOCIATED WITH TYPE 1 DIABETES AND METHODS OF USE 审中-公开
标题翻译：与1型糖尿病相关的新基因和使用方法
公开(公告)号：WO2005091751A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/010079
申请日：2005-03-25
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE , SHE, Jin-Xiong , WANG, Cong-Yi
发明人： SHE, Jin-Xiong , WANG, Cong-Yi
IPC分类号： C07H21/04 , C07K14/47 , C12N9/64 , C12N15/09 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： Novel nucleic acids associated with Type 1 diabetes. Also provided are polypeptides encoded by the nucleic acids associated with T1D. The invention also provides methods for facilitating the diagnosis or pre-diagnosis of T1D through the use of such nucleic acids and polypeptides. This invention further provides compositions for the treatment of Type 1 diabetes.
摘要翻译：与1型糖尿病相关的新型核酸。还提供了由与T1D相关的核酸编码的多肽。本发明还提供了通过使用这种核酸和多肽促进T1D的诊断或预诊断的方法。本发明还提供了用于治疗1型糖尿病的组合物。

86. 发明申请

WO2005034787A2 COMBINATION INTERPROXIMAL DENTAL STRIPPER 审中-公开
标题翻译：组合性腹腔剥离器
公开(公告)号：WO2005034787A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/024238
申请日：2004-07-29
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE , STOCKSTILL, John W.
发明人： STOCKSTILL, John W.
IPC分类号： A61C
CPC分类号： A61C3/06
摘要： Interproximal reduction (IPR) is accomplished with use of a combination stripper having two distinct ends. The first end has a single abrasive side and the second distinct end is abrasive on both sides.
摘要翻译：使用具有两个不同端部的组合剥离器来实现间接还原（IPR）。第一端具有单个磨料侧，第二个不同的末端在两侧都是磨料。

87. 发明申请

WO2004024075A2 CHEMOKINE RECEPTOR ANTAGONISTS AS THERAPEUTIC AGENTS 审中-公开
标题翻译：化疗受体拮抗剂作为治疗药物
公开(公告)号：WO2004024075A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028349
申请日：2003-09-11
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , MUNN, David, H. , MELLOR, Andrew, L. , PEIPER, Stephen, C.
发明人： MUNN, David, H. , MELLOR, Andrew, L. , PEIPER, Stephen, C.
IPC分类号： A61K
CPC分类号： G01N33/6863 , C07K16/2866 , C07K16/40 , C07K2317/76 , G01N33/5047 , G01N2333/52
摘要： The present invention provides methods and compositions to reduce immune tolerance at specific sites. In one aspect, the present invention comprises methods and compositions to reduce tumorigenicity. In an embodiment, the present invention reduces recruitment of tolerance-inducing antigen presenting cells (APCs) or their precursors to a tumor and/or tumor draining lymph node by decreasing binding of at least one tumor-associated of at least one tumor-associated ligand to a chemokine receptor present on the tolerance-inducing APCs or APC precursors. In an embodiment, the chemokine receptor is CCR6 and the tumor-associated ligand is mip-3α. In another aspect, the present invention comprises methods and compositions to reduce immune tolerance to a virus. In an embodiment, the virus is HIV. The present invention further provides for the development of CCR6 antibodies and antagonists as therapeutic agents to prevent or reduce immune tolerance.
摘要翻译：本发明提供减少特定部位免疫耐受性的方法和组合物。一方面，本发明包括减少致瘤性的方法和组合物。在一个实施方案中，本发明通过减少至少一种与肿瘤相关联的至少一种肿瘤相关的配体的结合来减少对肿瘤和/或肿瘤引流淋巴结的耐受诱导抗原呈递细胞（APC）或其前体的募集涉及存在于耐受性APC或APC前体上的趋化因子受体。在一个实施方案中，趋化因子受体是CCR6，肿瘤相关配体是mip-3alpha。另一方面，本发明包括降低对病毒的免疫耐受性的方法和组合物。在一个实施方案中，病毒是HIV。本发明进一步提供CCR6抗体和拮抗剂作为治疗剂的发展，以预防或降低免疫耐受性。

88. 发明申请

WO2003090747A1 TOPICAL TREATMENT OF ERECTILE DYSFUNCTION 审中-公开
标题翻译：精神功能障碍的局部治疗
公开(公告)号：WO2003090747A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/013084
申请日：2003-04-25
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , MILLS, Thomas, M. , WINGARD, Christopher, J. , WEBB, R., Clinton , LEWIS, Ronald, W. , CHITALEY, Kanchan, A.
发明人： MILLS, Thomas, M. , WINGARD, Christopher, J. , WEBB, R., Clinton , LEWIS, Ronald, W. , CHITALEY, Kanchan, A.
IPC分类号： A61K31/44
CPC分类号： A61K31/44
摘要： The invention relates to the treatment of sexual dysfunction using compounds suitable for topical administration. In one embodiment, the invention comprises methods for treating male and female sexual dysfunction which comprises topical administration to an individual in need of such treatment of a composition comprising a compound which attenuates Rho-kinase activity in an organ subject to sexual stimulation and a pharmaceutically acceptable carrier. In one embodiment, the compound comprises an inhibitor of the enzyme Rho-kinase. In other embodiments, compounds targeted to other enzymes involved in the Rho-kinase pathway are used. Also described are compositions and kits for performing the methods of the invention.
摘要翻译：本发明涉及使用适用于局部给药的化合物治疗性功能障碍。在一个实施方案中，本发明包括治疗男性和女性性功能障碍的方法，其包括对需要这种治疗的个体局部施用组合物，所述组合物包含减弱受性刺激的器官中的Rho激酶活性的化合物和药学上可接受的载体。在一个实施方案中，该化合物包含酶Rho-激酶的抑制剂。在其它实施方案中，使用靶向涉及Rho激酶途径的其它酶的化合物。还描述了用于实施本发明方法的组合物和试剂盒。

89. 发明申请

WO2002069995A2 TREATMENT OF PROSTATE CANCER 审中-公开
标题翻译：治疗前列腺癌
公开(公告)号：WO2002069995A2
公开(公告)日：2002-09-12
申请号：PCT/US2002/004712
申请日：2002-02-15
申请人： MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. , KUMAR, M., Vijay
发明人： KUMAR, M., Vijay
IPC分类号： A61K38/00
CPC分类号： A61K45/06 , A61K31/573 , A61K38/177 , A61K2300/00
摘要： The present invention provides methods and compositions for treating cancer, and even more preferably, prostate cancer. In one aspect, the present invention comprises a method for inducing cell death in cancer cells comprising treating at least a portion of the cancer cells with an effective amount of TRAIL and an effective amount of an antiprogestin sufficient to induce apoptosis in at least a portion of the treated cancer cells. In another aspect, the present invention comprises a composition for treating cancer by inducing cell death in cancer cells comprising a pharmaceutical composition comprising an effective amount of TRAIL and an effective amount of an antiprogestin sufficient to induce apoptosis in at least a portion of the cancer cells exposed to the composition. In an embodiment, the antiprogestin is Mifepristone.
摘要翻译：本发明提供了用于治疗癌症，甚至更优选前列腺癌的方法和组合物。一方面，本发明包括在癌细胞中诱导细胞死亡的方法，包括用有效量的TRAIL和有效量的抗孕激素治疗至少一部分癌细胞，所述有效量的抗孕激素足以在至少一部分治疗的癌细胞。在另一方面，本发明包括通过在癌细胞中诱导细胞死亡来治疗癌症的组合物，其包含药物组合物，所述药物组合物包含有效量的TRAIL和有效量的抗孕激素，其足以在至少一部分癌细胞中诱导凋亡暴露于组合物。在一个实施方案中，抗孕激素是米非司酮。

90. 发明申请

WO2010099062A1 ORAL CARE COMPOSITIONS FOR TREATING XEROSTOMIA 审中-公开
标题翻译：口腔护理组合物治疗XEROSTOMIA
公开(公告)号：WO2010099062A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/024906
申请日：2010-02-22
申请人： MEDICAL COLLEGE OF GEORGIA , HSU, Stephen
发明人： HSU, Stephen
IPC分类号： A01N43/16 , A61K31/35
CPC分类号： A01N43/16 , A61K31/35
摘要： Disclosed herein are oral care compositions for promoting salivary flow. Thus, also disclosed are methods of treating and preventing xerostomia. The oral care compositions can contain all-natural ingredients, including, for example, green tea polyphenols and jaborandi extract.
摘要翻译：本文公开了用于促进唾液流的口腔护理组合物。因此，还公开了治疗和预防口腔干燥症的方法。口腔护理组合物可以含有全天然成分，包括例如绿茶多酚和苦瓜提取物。

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