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81. 发明专利

JP2003302453A Method of exerting influence on uniform magnetostatic field in z-axis direction in nuclear magnetic resonance apparatus, and nuclear magnetic resonance resonator 有权
标题翻译：在核磁共振装置的Z轴方向上对均匀磁场的影响的方法和核磁共振谐振器
公开(公告)号：JP2003302453A
公开(公告)日：2003-10-24
申请号：JP2003020539
申请日：2003-01-29
申请人： Bruker Biospin Ag , ブルーカーバイオシュピンアー・ゲー
发明人： MAREK DANIEL
IPC分类号： G01R33/387 , G01R33/34 , H01F5/00
CPC分类号： G01R33/34069 , G01R33/34023 , G01R33/34061
摘要： PROBLEM TO BE SOLVED: To provide a method of correcting a disturbance disturbing a magnetostatic field generated by a superconducting RF coil in an NMR apparatus. SOLUTION: This method of exerting an influence in the Z-axis direction of the magnetostatic field B 0 in this NMR apparatus wherein a disturbance is generated due to superconducting components of the RF coil, is a method for exerting an influence on the magnetostatic field B 0 by elongating the superconducting components of the RF coil beyond an RF active region of a sample in the Z direction. The method is characterized in that the superconducting component of the RF coil is exposed to an additional magnetic field having sufficient intensity, and that all the superconducting structures of the superconducting components of the RF coil arranged near the RF active region of the sample are magnetized maximumly, and that the magnetization thereof in the perpendicular direction to B 0 along the Z-axis takes a value substantially constant and unequal to zero. This NMR resonator is adopted, wherein the superconductor structures of the NMR resonator are arranged at intervals in some radial direction from the measuring sample and the superconductor structures are elongated beyond the RF active region of the measuring sample in the Z direction. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种校正在NMR装置中由超导RF线圈产生的静磁场干扰的干扰的方法。解决方案：在该NMR装置中，由于RF线圈的超导分量产生干扰而在该静磁场B 0 的Z轴方向上施加影响的方法是通过将RF线圈的超导分量超过样品的RF有源区域在Z方向上延伸来对静磁场B 0 施加影响的方法。该方法的特征在于，RF线圈的超导部件暴露于具有足够强度的附加磁场，并且布置在样品的RF有源区附近的RF线圈的超导部件的所有超导结构被最大程度地磁化，并且沿着Z轴在垂直于B 0 SB的垂直方向的磁化取值基本上恒定且不等于零。采用这种NMR谐振器，其中NMR谐振器的超导体结构以一定的径向方向从测量样本排列，并且超导体结构在Z方向上延伸超出测量样品的RF有源区。版权所有（C）2004，JPO

82. 发明专利

JP2002311119A HIGH RESOLUTION MAGNETORESONANCE SPECTROSCOPIC MAGNET APPARATUS HAVING SUPERCONDUCTING MAGNET COIL SYSTEM AND MAGNETIC FIELD FORMING DEVICE AND METHOD OF DETERMINING MANUFACTURING ALLOWANCE THEREABOUT 审中-公开
公开(公告)号：JP2002311119A
公开(公告)日：2002-10-23
申请号：JP2002024124
申请日：2002-01-31
申请人： BRUKER BIOSPIN AG
发明人： SCHAUWECKER ROBERT , BOVIER PIERRE-ALAIN , AMANN ANDREAS , ECKERT DANIEL M
IPC分类号： G01R33/3815 , G01R33/3873 , G01R33/3875 , G01R33/421 , H01F7/20
摘要： PROBLEM TO BE SOLVED: To enough compensate the influence of the manufacturing allowance on a magnetic field forming in a work volume of a magnetic forming device composed of a magnetic substance having an adequate geographical shape in a high resolution resonance spectroscopic magnetic apparatus. SOLUTION: A superconducting magnet for generating a magnetic field in a direction of the (z) axis in a work volume (AV) disposed with center at z=0 on the (z) axis forms a magnetic coil system (C) in a work volume. Its magnetic field has at least one nonuniformly contributing component Hn .z (n>=2) to the total magnetic field strength on the (z) axis with center at z=0, varying exponentially as z and a magnetic field forming device (P) composed of a magnetic substance at least in cylindrical symmetric shape with respect to the (z) axis has at least one additional coil system (S) which has a radial distance of less than 80 mm from the x axis, compensates the one nonuniformly magnetic field contributing component Hn .z at least 50% in the magnet coil system (C), and acts as a seam device.

83. 发明专利

JP2002311118A APPARATUS FOR TRANSPORTING AND ACCURATELY POSITIONING SAMPLE TUBE IN HIGH RESOLUTION NMR SPECTROMETER 审中-公开
公开(公告)号：JP2002311118A
公开(公告)日：2002-10-23
申请号：JP2002066018
申请日：2002-03-11
申请人： BRUKER BIOSPIN AG
发明人： TSCHIRKY HANSJOERG , WARDEN MICHAEL , SEYDOUX ROBERTO , MAREK DANIEL
IPC分类号： G01R33/32 , G01R33/30
摘要： PROBLEM TO BE SOLVED: To improve an apparatus for transporting an NMR measuring capillary so that danger is eliminated and glass is protected, using a simple technique. SOLUTION: The apparatus has a spinner having a through-hole into which a sample tube is inserted, carried into a measuring chamber 2 on an air cushion and can be positioned with the vertical axis of an NMR receiving coil system 9 therein, and comprises a mounting sleeve 17 disposed radially around the sample tube 8 like a flange impossible to shift. At an operating position of the sample tube 8 in the measuring chamber 22, a horizontal end face of the sleeve 17 flatly contacts a horizontal stop face 18 of at least two-stepped axial hole 20 of the spinner in its inside bottom region.

84. 发明申请

WO2014053531A1 METHOD FOR HYPERPOLARIZATION TRANSFER IN THE LIQUID STATE 审中-公开
标题翻译：在液体状态下超高效转移的方法
公开(公告)号：WO2014053531A1
公开(公告)日：2014-04-10
申请号：PCT/EP2013/070522
申请日：2013-10-02
申请人： BRUKER BIOSPIN AG , ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： JANNIN, Sami , LOHMAN, Joost , BODENHAUSEN, Geoffrey , GOLMAN, Klaes
IPC分类号： G01R33/28 , G01R33/30 , G01R33/381 , G01R33/46
CPC分类号： G01R33/282 , G01R33/307 , G01R33/381 , G01R33/4608
摘要： A method for producing a hyperpolarized sample for use in a magnetic resonance investigation, with the following steps: a) providing a solid sample (50), containing long T1 nuclei and short T1 nuclei in the same molecules (51); b) hyperpolarizing the short T1 nuclei in the solid sample (50), c) transforming the solid sample (50) into a liquid sample (52), d) transferring the polarization of the short T1 nuclei to the long T1 nuclei within the molecules in the liquid sample (52) by Cross Polarization. The invention provides a method which can provide samples with hyperpolarized long T1 nuclei, in particular 13 C or 15 N, in a simple and efficient way.
摘要翻译：一种用于生产用于磁共振研究的超极化样品的方法，具有以下步骤：a）提供在相同分子（51）中含有长T1核和短T1核的固体样品（50）; b）将固体样品（50）中的短T1核超极化，c）将固体样品（50）转化为液体样品（52），d）将短T1核的极化转移到分子内的长T1核在液体样品（52）中通过交叉极化。本发明提供了一种以简单有效的方式提供具有超极化长T1核，特别是13C或15N的样品的方法。

85. 发明申请

WO2019016035A1 TRANSPORTEINRICHTUNG FÜR EINEN NMR MAS ROTOR IN EINEN PROBENKOPF ("MAS SHUTTLE") 审中-公开
公开(公告)号：WO2019016035A1
公开(公告)日：2019-01-24
申请号：PCT/EP2018/068679
申请日：2018-07-10
申请人： BRUKER BIOSPIN AG
发明人： DE VRIES, Jonathan , SIEBER, Sven , MEISTER, Roger
IPC分类号： G01R33/30
摘要： Eine Transporteinrichtung zum Transport einer NMR-Probe zum NMR MAS- Probenkopf (16), mit einem Transportbehälter (15) und einer Verriegelungsvorrichtung (3) für den Rotor (5), die durch Lösen den Rotor freigibt, sowie mit einer Detektionsvorrichtung zur Anwesenheitserkennung des Rotors im Transportbehälter ist dadurch gekennzeichnet, dass der Probenkopf eine Positioniervorrichtung (2) aufweist, die ihn in einer Messposition relativ zum Transportbehälter in einer definierten Lage hält, und dass die Detektionsvorrichtung eine Sensorleitung umfasst, die ein von der aktuellen Relativposition des Transportbehälters zum Probenkopf abhängiges Signal aus dem Probenkopf zum Transportbehälters leiten kann. Damit sind keine mechanischen Verschiebungen und auch keine zusätzlichen bewegten Bauteile für eine berührungsfreie, sichere Erkennung der aktuellen Bestückung des Rotors im Transportbehälter mehr erforderlich.

86. 发明申请

WO2017114998A8 TOPOLOGÍA DE RED DE LECTURA 审中-公开
公开(公告)号：WO2017114998A8
公开(公告)日：2017-07-06
申请号：PCT/ES2016/070950
申请日：2016-12-30
申请人： GENERAL EQUIPMENT FOR MEDICAL IMAGING, S.A. , CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) , UNIVERSITAT POLITÈCNICA DE VALÈNCIA , BRUKER BIOSPIN AG
发明人： HERNÁNDEZ HERNÁNDEZ, Liczandro , GONZÁLEZ MARTÍNEZ, Antonio Javier , AGUILAR TALENS, Albert , BENLLOCH BAVIERA, José María , PAVÓN HERNÁNDEZ, Noriel
IPC分类号： G01T1/208
摘要： Topología de red de lectura para dispositivo de salida matricial con un número de salidas dadas por la combinación cruzada de "m" filas y columnas "n", que comprende un bloque de filtrado básico, replicado para todas las salidas, y asignado por separado a cada una; cada bloque de filtrado contiene dos circuitos de filtrado que tienen una conexión de entrada común a su salida matricial asignada y que proporcionan dos salidas separadas, simétricas y filtradas; todas las salidas de Fila (i) procedentes de la misma fila "i", pero de diferentes columnas están conectadas entre sí a una entrada de un amplificador vinculado a la fila "i", y todas las salidas de Columna (j) procedentes de la misma columna "j", pero diferentes filas, están conectadas juntas a una entrada de un amplificador vinculado a la columna "j", la topología completa aparece revelada expandiendo "i" y "j" en sus respectivos intervalos.

87. 发明申请

WO2013153101A1 METHOD AND DEVICE FOR RAPID DNP 审中-公开
标题翻译：用于快速DNP的方法和装置
公开(公告)号：WO2013153101A1
公开(公告)日：2013-10-17
申请号：PCT/EP2013/057467
申请日：2013-04-10
申请人： BRUKER BIOSPIN AG , ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： JANNIN, Sami , GIANOTTI, Antonio Giuseppe , LOHMAN, Joost , ENGELKE, Frank , MELZI, Roberto , BORNET, Aurélien , BODENHAUSEN, Geoffrey
IPC分类号： G01R33/28 , G01R33/62
CPC分类号： G01R33/282 , G01R33/4608 , G01R33/5605 , G01R33/62
摘要： A method for producing hyperpolarized sample material for use in magnetic resonance investigations, with a) preparing a target material, containing high γ nuclei with a short T1, - a polarizing agent with a broad EPR line, and low γ nuclei with a long T1, b) irradiating the polarizing agent in the target material with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B 0 ≥ 4.0 T, thus polarizing the high γ nuclei by DNP, c) transferring the polarization from the high γ nuclei to the low γ nuclei by Cross Polarization, d) preparing a dissolved sample material containing the hyperpolarized low y nuclei from the target material. With the inventive method, nuclei with a long longitudinal relaxation time T1 can be quickly hyperpolarized to a high polarization level.
摘要翻译：一种生产用于磁共振研究的超极化样品材料的方法，其中a）制备包含具有短T1的高γ核的目标材料，具有宽EPR线的偏振剂和具有长T1的低γ核， b）用微波辐射照射目标材料中的偏振剂，其中目标材料处于低温并暴露于静态磁场B0> = 4.0T，从而通过DNP使高γ核偏振，c）转移极化通过交叉极化从高γ核到低γ核，d）从目标材料制备含有超极化低Y核的溶解样品材料。利用本发明的方法，具有长纵向弛豫时间T1的核可以快速超极化到高极化水平。

88. 发明授权

US10655783B2 Cryogen-free magnet system comprising a heat sink connected to the gas circuit of a cryocooler 有权
公开(公告)号：US10655783B2
公开(公告)日：2020-05-19
申请号：US15680313
申请日：2017-08-18
申请人： Bruker BioSpin AG
发明人： Patrick Wikus , Joerg Hinderer
IPC分类号： F17C3/08 , F25B9/14 , H01F6/04 , F25D19/00 , G01R33/38 , G01R33/3815
摘要： A cryostat arrangement includes a superconducting magnet to be cooled by an active cryocooler. The cryocooler includes a coolant circuit with a compressor, a cold head, and a cold finger in thermal contact with the magnet. A volumetric vessel containing cryogenic fluid is thermally coupled to the magnet. The volumetric vessel is connected to the coolant circuit by a pressure-resistant line. A fluidic component influences the flow rate through the line in a defined manner such that the cryogenic fluid flows between the volumetric vessel and the coolant circuit with a time constant of at least 15 minutes. The cryostat can be operated in a “cryogen-free” manner and permits a sufficiently long time to quench in the event of operational malfunctions.

89. 发明授权

US10261143B2 Probehead with adjustable angle for NMR-MAS apparatus 有权
公开(公告)号：US10261143B2
公开(公告)日：2019-04-16
申请号：US15355290
申请日：2016-11-18
申请人： Bruker BioSpin AG
发明人： Nicolas Freytag , Fabian Kuehler
IPC分类号： G01R33/30 , G01R33/46
摘要： A probehead of an NMR-MAS apparatus includes a sample which has a rotation axis tilted by an angle θ>0 with respect to the z-axis. The angle θ can be adjusted about a target angle θtarget by tilting around a tilt axis. The rotation axis has a fixed angle with respect to the probehead, and the NMR-MAS apparatus tilts at least part of the probehead to adjust the angle θ. The probehead has an outer contour K between an upper end and a lower end. For all z between the upper end and the lower end, a cross-section S(z) of the contour K exists parallel to the xy-plane with a width Q(z) in the x-direction. The width Q(z) is smaller at points away from z=0, such that Q(z1) 0.

90. 发明授权

US10228471B2 Hybrid scintillation module 有权
公开(公告)号：US10228471B2
公开(公告)日：2019-03-12
申请号：US15586908
申请日：2017-05-04
申请人： General Equipment for Medical Imaging S.A. , West Virginia University , Consejo Superior de Investigaciones Cientificas (CSIC) , Universitat Politecnica de Valencia , BRUKER BIOSPIN AG
发明人： Jose Maria Benlloch Baviera , Antonio Javier Gonzalez Martinez , Stan Majewski
IPC分类号： G01T1/20 , G01T1/29 , G01T1/164
摘要： This disclosure describes an imaging radiation detection module with novel configuration of the scintillator sensor allowing for simultaneous optimization of the two key parameters: detection efficiency and spatial resolution, that typically cannot be achieved. The disclosed device is also improving response uniformity across the whole detector module, and especially in the edge regions. This is achieved by constructing the scintillation modules as hybrid structures with continuous (also referred to as monolithic) scintillator plate(s) and pixelated scintillator array(s) that are optically coupled to each other and to the photodetector. There are two basic embodiments of the novel hybrid structure: (1) the monolithic scintillator plate is at the entrance for the incoming radiation, preferably gamma rays, and the pixelated array placed behind the plate, all in optical contact with the photodetector, (2) the order of the scintillator components is reversed with the pixelated scintillation plate placed in front of the monolithic plate.

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