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71. 发明专利

MX351228B METODOS DE DIAGNOSTICO Y TRATAMIENTO UTILIZANDO UNA GENOTECA DE LIGANDOS. 未知
公开(公告)号：MX351228B
公开(公告)日：2017-09-06
申请号：MX2013010999
申请日：2012-03-23
申请人： OPKO PHARMACEUTICALS LLC
发明人： MURALIDHAR REDDY MOOLA , JESSICA SCHILKE
IPC分类号： C07K7/06 , C40B20/08 , C40B30/04 , C40B40/10 , G01N33/543 , G01N33/574
摘要： La presente invención se refiere a métodos de diagnóstico y tratamiento que utilizan una genoteca de ligandos. Específicamente, la invención se refiere a la utilización de una genoteca de ligandos para diagnosticar o detectar una respuesta inducida por fármaco, incluyendo una reacción adversa al fármaco, efectos secundarios, resistencia al fármaco, y eficacia terapéutica. La invención se refiere además a la identificación de biomarcadores asociados con una respuesta inducida por fármaco y a la proporción de un tratamiento médico personalizado.

72. 发明专利

FR3011932B1 DISPOSITIF ET PROCEDE DE MESURE DE FLUORESCENCE RESOLUE EN TEMPS POUR LE CRIBLAGE A HAUT DEBIT D'ECHANTILLONS 未知
公开(公告)号：FR3011932B1
公开(公告)日：2017-03-24
申请号：FR1359860
申请日：2013-10-10
申请人： UNIV STRASBOURG , CENTRE NAT DE LA RECH SCIENT (CNRS)
发明人： LEONARD JEREMIE , UHRING WILFRIED , DUMAS NORBERT , HAACKE STEFAN , MAILLOT SACHA
IPC分类号： G01N21/64 , C12Q1/00 , C40B20/08 , C40B30/10 , G01N33/483 , G01N33/533

73. 发明专利

EA201391382A1 СПОСОБЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ С ПРИМЕНЕНИЕМ БИБЛИОТЕКИ ЛИГАНДОВ 未知
公开(公告)号：EA201391382A1
公开(公告)日：2014-09-30
申请号：EA201391382
申请日：2012-03-23
IPC分类号： C40B20/08 , C07K7/06 , C40B30/04 , C40B40/10 , G01N33/543 , G01N33/574
摘要： Настоящееизобретениеотноситсяк способамдиагностикии леченияс применениембиблиотекилигандов. Вчастности, настоящееизобретениеотноситсяк применениюбиблиотекилигандовдлядиагностикиилидетектированияреакции, вызваннойлекарственнымсредством, включаянежелательныереакцииналекарство, побочныеэффекты, устойчивостьк лекарствуи терапевтическуюэффективность. Настоящееизобретениетакжеотноситсяк идентификациибиомаркеров, ассоциированныхс вызваннойлекарственнымсредствомреакцией, иобеспечениюперсонализированноголечения.

74. 发明专利

CA2526690C STRUCTURE BASED AND COMBINATORIALLY SELECTED OLIGONUCLEOSIDE PHOSPHOROTHIOATE AND PHOSPHORODITHIOATE APTAMER TARGETING AP-1 TRANSCRIPTION FACTORS 未知
公开(公告)号：CA2526690C
公开(公告)日：2014-01-14
申请号：CA2526690
申请日：2004-05-20
申请人： UNIV TEXAS
发明人： GORENSTEIN DAVID G , LUXON BRUCE A , LEARY JAMES
IPC分类号： C40B30/04 , A61K20060101 , C12N15/10 , C12Q1/68 , C40B20/08 , G01N33/53 , G01N33/543 , G01N33/558 , G01N33/68
摘要： The present invention includes composition and methods for making and using a combinatorial library to identify modified thioptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL-6, NF-KB, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.

75. 发明专利

AU2012230880A1 Biomarker discovery in complex biological fluid using bead or particle based libraries and diagnostic kits and therapeutics 未知
公开(公告)号：AU2012230880A1
公开(公告)日：2013-10-24
申请号：AU2012230880
申请日：2012-03-22
申请人： OPKO PHARMACEUTICALS LLC
发明人： MOOLA MURALIDHAR REDDY , SCHILKE JESSICA
IPC分类号： C40B20/08 , C07K7/06 , C40B30/04 , C40B40/10 , G01N33/543 , G01N33/574
摘要： The present invention is useful in screening for biomarkers associated with any other disease or condition. Such diseases and conditions range from the neurological diseases, autoimmune diseases and cancers identified above as well as any other disease or condition that has a biomarker such as an antibody or other characterizing protein or biomolecule associated with the disease or progression of the disease. The large ligand libraries of the invention can be used directly in biological fluid, under the appropriate experimental conditions and according to the processes recited herein, to screen for such markers and without the need to use fewer support members or without the need to transfer such peptoids or ligands to a micro array before screening the biological fluid. In addition, the ligand libraries may also be used to screen for cell based receptors that specifically relate to a particular cell surface marker.

76. 发明专利

CA2616439C METHODS AND SYSTEMS FOR MONITORING MULTIPLE OPTICAL SIGNALS FROM A SINGLE SOURCE 未知
公开(公告)号：CA2616439C
公开(公告)日：2012-03-20
申请号：CA2616439
申请日：2006-08-10
申请人： PACIFIC BIOSCIENCES CALIFORNIA
发明人： LUNDQUIST PAUL , TURNER STEPHEN , ZACCARIN DENIS
IPC分类号： G01D5/28 , C40B20/08 , C40B30/10 , G01N21/75 , G01N33/58 , G02B26/08 , G02B27/10
摘要： Methods and systems for monitoring a plurality of different optical signals from a single source of such signals, where each such different optical signal is spatially separated from other such signals and directed to different detectors or locations upon a single detector, which direction is generally accomplished through the use of a small number of optical components and/or manipulations.

77. 发明专利

AT516263T 未知
公开(公告)号：AT516263T
公开(公告)日：2011-07-15
申请号：AT03736639
申请日：2003-05-15
申请人： SUNOVION PHARMACEUTICALS INC
发明人： AQUILA BRIAN , HOPKINS SETH , LOCKSHIN CURTIS , WANG FENGJIANG
IPC分类号： A61P1/04 , C07C217/58 , A61K31/137 , A61P1/08 , A61P1/14 , A61P3/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P15/00 , A61P19/02 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/22 , A61P25/28 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/18 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07B61/00 , C07C217/62 , C07C229/34 , C07D307/14 , C40B20/08 , C40B30/04 , C40B40/04 , C40B50/14
摘要： One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries.

78. 发明专利

AU2009202965A1 Methods for ligand discovery 未知
公开(公告)号：AU2009202965A1
公开(公告)日：2009-08-13
申请号：AU2009202965
申请日：2009-07-22
申请人： SUNESIS PHARMACEUTICALS INC
发明人： WELLS JAMES , ERLANSON DANIEL A , BRAISTED ANDREW A
IPC分类号： G01N33/531 , C07B61/00 , C07C323/39 , C07C335/04 , C07D207/46 , C07D333/38 , C07D333/70 , C07D401/04 , C07D405/12 , C07K14/00 , C07K14/435 , C12Q1/00 , C12Q1/68 , C12Q1/70 , C40B20/08 , C40B30/04 , C40B40/04 , G01N33/00 , G01N33/53
摘要： The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed "tethering" where potential ligands are covalently bonded or "tethered" to a target and subsequently identified.

79. 发明专利

GB2428676B Library of compounds labelled with radioisotope 未知
公开(公告)号：GB2428676B
公开(公告)日：2007-06-06
申请号：GB0622381
申请日：2004-02-27
申请人： XCELERON LTD
发明人： GARNER RONALD COLIN , LAPPIN GRAHAM JOHN
IPC分类号： C40B40/04 , C40B20/08 , C40B70/00 , G01N33/60
摘要： Library of compounds or their pharmaceutically acceptable salts, each compound being associated with information on its chemical identity and structure, wherein at least two of the compounds is labelled with radioisotope characterised in that the radioisotope is an AMS active radioisotope; A solid support having a compound or its pharmaceutically acceptable salt as hereindefined bound thereto, the compound being associated with information on its chemical identity and structure and comprising a radioisotope, characterised in that the radioisotope is an AMS active radioisotope as hereinbefore defined; Process for the preparation of a library of compounds as claimed in any of claims 1 to 19 comprising radioisotope labelling a plurality of compounds, each compound being associated with information on its chemical identity and structure characterised in that labelling is with an AMS active radioisotope; A kit therefor; Method for selecting one or more candidate compounds comprising screening a library of the invention comprising AMS active radioisotope labelled compounds as hereinbefore defined and obtaining a sample from the screen or submitting a compound identified for metabolic studies and obtaining a sample therefrom, and performing AMS detection of the sample; and Use of the library, a solid support comprising radioisotope labelled compound or a method as hereinbefore defined in (bio)medical, agrochemical, environmental and like screening for further study by AMS detection.

80. 发明专利

CA2521142A1 LIGAND-RECEPTOR TRACKING ASSAYS 未知
公开(公告)号：CA2521142A1
公开(公告)日：2006-04-25
申请号：CA2521142
申请日：2005-10-24
申请人： HOFFMANN LA ROCHE
发明人： ZOFFMANN SANNAH JENSEN , ENDERLE THILO , APFEL CHRISTIAN , MOSER MIREILLE
IPC分类号： G01N33/569 , C40B20/08 , C40B30/04 , G01N21/64 , G01N33/53 , G01N33/566 , G01N33/58
摘要： The present invention provides an image-based method of screening for compounds based on the measurement of internalization of a fluorescently labeled ligan d. It further provides a multiplex method for high content screening of compounds wherein at least one cellular parameter is measured.

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