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71. 发明申请

US20040126751A1 Method of prolonging the life-span of living cells using NADH, NADPH and ADP-ribose 审中-公开
标题翻译：使用NADH，NADPH和ADP-核糖延长活细胞寿命的方法
公开(公告)号：US20040126751A1
公开(公告)日：2004-07-01
申请号：US10330973
申请日：2002-12-27
发明人： Jorg G.D. Birkmayer , Karl Nadlinger , Seth Hallstrom , Wilhelm Westerthaler
IPC分类号： A01N001/02
CPC分类号： A01N1/02 , A01N1/0226 , A61K35/15 , A61K35/18 , A61K35/19 , A61K35/34
摘要： A method for increasing and/or enhancing the production of intracellular energy in living cells. By incubating living cells with an intracellular-energy-increasing substance, such as NADH, NADPH and/or ADP-ribose, the living cells increase their levels of intracellular energy thereby resulting in more vital, longer-living cells. Specifically, the life span and vitality of blood cells, transplantable organs and tissues, and living organisms can thereby be prolonged.
摘要翻译：增加和/或增强活细胞内细胞内能量生成的方法。通过将活细胞与诸如NADH，NADPH和/或ADP-核糖的细胞内能量增加物质一起孵育，活细胞增加其细胞内能量的水平，从而导致更重要的更长寿命的细胞。具体来说，可以延长血细胞，可移植器官和组织以及活体的寿命和寿命。

72. 发明申请

US20040121302A1 Monochromatic fluid treatment systems 失效
标题翻译：单色液体处理系统
公开(公告)号：US20040121302A1
公开(公告)日：2004-06-24
申请号：US10660930
申请日：2003-09-12
发明人： John Coogan
IPC分类号： A01N001/02 , H01K001/50
CPC分类号： H01J61/125 , A61M1/3681 , A61M1/3683 , C12N13/00
摘要： Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(s) to generate monochromatic light energy, preferably in the range of 260 nm to 310 nm, for fluid treatment. Advantageous processing regimens and/or adjunct additives and/or agents may also be used to achieve desired and/or enhanced results, e.g., inactivation of pathogens, bacteria and/or viruses, modulation of immune response, and/or leukoreduction. Particularly preferred embodiments include specific wavelengths, novel temperature control systems and geometric/structural arrangements that provide enhanced processing results and/or efficiencies. The disclosed methods, systems and apparatus achieve desirable results in a broad range of diagnostic, therapeutic and treatment applications, and generally provide enhanced operating efficiencies and/or processing results in application modalities that employ a broad range of photo-activated and/or photo-responsive materials and/or compounds.
摘要翻译：提供了用于流体，特别是复杂流体如血液制品，药物，注射剂和疫苗的光加工的方法，系统和装置。所公开的方法和系统使用非激光光源来产生单色光能，优选在260nm至310nm的范围内用于流体处理。还可以使用有利的加工方案和/或辅助添加剂和/或试剂来实现期望和/或增强的结果，例如病原体，细菌和/或病毒的失活，免疫应答的调节和/或白细胞减退。特别优选的实施方案包括特定的波长，新的温度控制系统和提供增强的处理结果和/或效率的几何/结构布置。公开的方法，系统和装置在广泛的诊断，治疗和治疗应用中实现期望的结果，并且通常在应用模式中提供增强的操作效率和/或处理结果，其应用范围广泛的光激活和/ 响应材料和/或化合物。

73. 发明申请

US20040115612A1 Monochromatic fluid treatment systems 失效
公开(公告)号：US20040115612A1
公开(公告)日：2004-06-17
申请号：US10661262
申请日：2003-09-12
发明人： John Coogan , Barry Ressler
IPC分类号： A01N001/02 , A61N001/30
CPC分类号： H01J61/125 , A61M1/3681 , A61M1/3683 , C12N13/00
摘要： Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(s) to generate monochromatic light energy, preferably in the range of 260 nm to 310 nm, for fluid treatment. Advantageous processing regimens and/or adjunct additives and/or agents may also be used to achieve desired and/or enhanced results, e.g., inactivation of pathogens, bacteria and/or viruses, modulation of immune response, and/or leukoreduction. Particularly preferred embodiments include specific wavelengths, novel temperature control systems and geometric/structural arrangements that provide enhanced processing results and/or efficiencies. The disclosed methods, systems and apparatus achieve desirable results in a broad range of diagnostic, therapeutic and treatment applications, and generally provide enhanced operating efficiencies and/or processing results in application modalities that employ a broad range of photo-activated and/or photo-responsive materials and/or compounds.

74. 发明申请

US20040082057A1 Organ preservation apparatus and methods 有权
标题翻译：器官保存仪器及方法
公开(公告)号：US20040082057A1
公开(公告)日：2004-04-29
申请号：US10692394
申请日：2003-10-23
发明人： Martin L. Alford , Robert M. Dowben
IPC分类号： A01N001/02
CPC分类号： A01N1/0247 , A01N1/02 , A01N1/0273
摘要： This invention is a transportable organ preservation system that substantially increases the time during which the organ can be maintained viable for successful implantation into a human recipient. A chilled oxygenated nutrient solution is pumped through the vascular bed of the organ after excision of the organ from the donor and during transport. The device of the present invention uses flexible permeable tubing to oxygenate the perfusion fluid while the CO2 produced by the organ diffuses out of the perfusion fluid. One pressurized two liter nullCnull cylinder that contains 255 liters of oxygen at standard temperature and pressure can supply oxygen for up to 34 hours of perfusion time. The device uses a simple electric pump driven by a storage battery to circulate the perfusion fluid through the organ being transported. The vessel containing the organ to be transported is held at 4null C. by coolant blocks.
摘要翻译：本发明是一种可运输的器官保存系统，其大大增加了器官可以维持生存以便成功植入人类接受者的时间。将冷冻的含氧营养液从供体切除并在运输过程中抽出器官的血管床。本发明的装置使用柔性可渗透管来对灌注流体进行氧化，同时由器官产生的CO 2从灌注液中扩散出来。在标准温度和压力下包含255升氧气的一个加压的两升“C”气瓶可以供给氧气长达34小时的灌注时间。该装置使用由蓄电池驱动的简单的电动泵来使灌注流体循环通过被运送的器官。装有运输器官的容器由冷却剂块保持在4℃。

75. 发明申请

US20040076945A1 Compositions comprising reproductive cell media and methods for using such compositions 审中-公开
标题翻译：包含生殖细胞培养基的组合物和使用这种组合物的方法
公开(公告)号：US20040076945A1
公开(公告)日：2004-04-22
申请号：US10685953
申请日：2003-10-15
申请人： Minitube of America, Inc.
发明人： Kevin J. Rozeboom , Mark E. Wilson
IPC分类号： A01N001/02 , C12N015/00
CPC分类号： A61K35/52 , A01N1/021 , A01N1/0226 , C12N5/061
摘要： Disclosed are compositions for mammalian, avian or piscian reproductive cells and methods for the collection, holding, processing, in vitro fertilization, sexing culturing, or storing (including long-term cryopreservation) of mammalian, avian, or piscian reproductive sperm cells. The compositions comprise a suitable reproductive cell media and a transforming growth factor, an insulin-like growth factor, or zinc, and, optionally, inositol, transferrin, or fructose, or combinations thereof.
摘要翻译：公开了用于哺乳动物，禽或生殖精子细胞的收集，保持，加工，体外受精，性别培养或储存（包括长期冷冻保存）的哺乳动物，禽类或者piscian生殖细胞的组合物。组合物包含合适的生殖细胞培养基和转化生长因子，胰岛素样生长因子或锌，以及任选的肌醇，转铁蛋白或果糖或其组合。

76. 发明申请

US20040076657A1 Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced 有权
标题翻译：软组织工程医用植入物脱细胞化方法和脱细胞化软组织医用植入物的制备方法
公开(公告)号：US20040076657A1
公开(公告)日：2004-04-22
申请号：US10624534
申请日：2003-07-23
申请人： LifeNet.
发明人： Lloyd Wolfinbarger JR. , Perry Lange , Alyce Linhurst , Eric Moore , Barry Nolf
IPC分类号： A01N001/02 , A61F002/00
CPC分类号： A61L27/3625 , A61K35/12 , A61K35/32 , A61K35/36 , A61K35/44 , A61L27/3604 , A61L27/3633 , A61L27/3687 , A61L2430/40
摘要： The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.
摘要翻译：本发明提供用于生产少量和可商业化量的无细胞软组织植入物的方法和装置。这种软组织植入物包括血管移植物替代物。通过使组织样品经受诱导压力介导的提取溶液流，然后诱导压力介导的处理溶液流，然后洗涤经处理的组织以产生无细胞移植物来产生无细胞移植物。所生产的无细胞移植物是均匀的和非免疫原性的。本发明的方法允许生产多个脱细胞的软组织植入物，其中处理时间显着小于现有技术的方法，并且每天生产的植入物的数量比现有技术方法增加。在临床应用中，所生产的脱细胞移植物在长期耐久性和功能上显示出显着改善。

77. 发明申请

US20040072138A1 Attenuation of ischemia/reperfusion injury 审中-公开
标题翻译：缺血/再灌注损伤的衰减
公开(公告)号：US20040072138A1
公开(公告)日：2004-04-15
申请号：US10429231
申请日：2003-05-02
申请人： Medical University of South Carolina
发明人： Inderjit Singh
IPC分类号： A01N001/00 , A01N001/02 , A61K031/7056 , A61K031/198
CPC分类号： A61K31/197 , A61K31/00 , A61K31/137 , A61K31/145 , A61K31/175 , A61K31/192 , A61K31/198 , A61K31/20 , A61K31/275 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/366 , A61K31/40 , A61K31/4015 , A61K31/4196 , A61K31/472 , A61K31/522 , A61K31/661 , A61K31/7052 , A61K31/7056 , A61K31/7076 , C12N9/99 , A61K2300/00
摘要： This current invention includes compositions and methods of nitric oxide synthase inhibitors to treat or reduce ischemia/reperfusion injury in a patient. More specifically, the invention relates to a combinational therapy of 5-Aminoimidazole-4-carboxamide-1-B-D-ribonucleoside (AICAR) and N-acetyl cysteine (NAC) to attenuate ischemia/reperfusion injury to a transplanted organ.
摘要翻译：本发明包括用于治疗或减少患者的缺血/再灌注损伤的一氧化氮合酶抑制剂的组合物和方法。更具体地，本发明涉及5-氨基咪唑-4-甲酰胺-1-B-D-核糖核苷（AICAR）和N-乙酰半胱氨酸（NAC）的组合疗法，以减少移植器官的缺血/再灌注损伤。

78. 发明申请

US20040053207A1 Preservation of cells 审中-公开
标题翻译：保存细胞
公开(公告)号：US20040053207A1
公开(公告)日：2004-03-18
申请号：US10451272
申请日：2003-10-14
发明人： Benjamin J. N. Griffiths , Peter John Evans
IPC分类号： A01N001/02
CPC分类号： A01N1/02 , A01N1/0231
摘要： The present invention relates to methods for preserving cells, in particular primary cells such as hepatocytes. In particular, the present invention relates to preserving cells within a gel comprising a hydrolysed gelatin and culturing the cells at a temperature between 0 and 15null C.
摘要翻译：本发明涉及保存细胞，特别是原代细胞如肝细胞的方法。特别地，本发明涉及在包含水解明胶的凝胶内保存细胞，并在0至15℃的温度下培养细胞。

79. 发明申请

US20040033551A1 Assay for low molecular weight heparin 有权
标题翻译：测定低分子量肝素
公开(公告)号：US20040033551A1
公开(公告)日：2004-02-19
申请号：US10222345
申请日：2002-08-16
发明人： Ted C. K. Lee , Amanda B. McBride , Frank M. LaDuca
IPC分类号： A01N001/02 , C12Q001/56
CPC分类号： C12Q1/56 , G01N33/86 , G01N2405/04
摘要： A prothrombin time reagent for determination of low molecular weight heparin in fresh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture includes a phosphatidylalcohol. A formulation buffer which includes a sensitivity adjuster is used in formulating the reagent. The recombinant animal tissue factor includes rabbit brain. The synthetic phospholipids of the mixture include palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylserine (POPS), and a phosphatidylalcohol. The phosphatidyl alcohol includes dioleoylphosphatidylethanol, dioleoylphosphatidylmethanol, dioleoylphosphatidylpropanol, dioleoylphosphatidylbutanol, and dioleoylphosphatidylinositol. The sensitivity adjuster included in the formulation buffer is null-Cyclodextrin. The formulated reagent is air-dried and remains stable for at least 3 weeks at 37null C.
摘要翻译：提供了一种用于测定新鲜全血和抗凝血剂处理血液中低分子量肝素的凝血酶原时间试剂。试剂由重组动物组织因子和合成磷脂的混合物组成，该混合物包含磷脂酰醇。在配制试剂时使用包含灵敏度调节剂的制剂缓冲液。重组动物组织因子包括兔脑。该混合物的合成磷脂包括棕榈酰胆碱磷脂酰胆碱（POPC），棕榈酰叶酰磷脂酰丝氨酸（POPS）和磷脂酰醇。磷脂酰胆固醇包括二油酰磷脂酰乙醇，二油酰磷脂酰基甲醇，二油酰磷脂酰丙醇，二油酰磷脂酰丁醇和二油酰磷脂酰肌醇。制剂缓冲液中的灵敏度调节剂是γ-环糊精。将配制的试剂空气干燥，并在37℃下保持稳定至少3周。

80. 发明申请

US20040029097A1 Addition of glycolysis inhibitor to a pathogen reduction and storage solution 审中-公开
标题翻译：将糖酵解抑制剂添加到病原体还原和储存溶液中
公开(公告)号：US20040029097A1
公开(公告)日：2004-02-12
申请号：US10417925
申请日：2003-04-16
申请人： Gambro, Inc.
发明人： Laura Goodrich , Raymond P. Goodrich
IPC分类号： A01N001/02 , A61K031/70
CPC分类号： A61L2/08 , A61L2/0011 , A61L2/0082 , A61L2/10 , A61L2/16 , A61M1/0272 , A61M1/3681 , A61M1/3683 , A61M2202/0275
摘要： This invention relates to the addition of glycolytic inhibitors to solutions used in the pathogen reduction and subsequent storage of platelets. More particularly, the invention relates to the addition of 2-deoxy-D-glucose and sodium succinate to a platelet pathogen reduction and storage solution.
摘要翻译：本发明涉及将糖酵解抑制剂加入用于减少血小板的病原体和随后储存的溶液中。更具体地，本发明涉及向血小板病原体还原和储存溶液中加入2-脱氧-D-葡萄糖和琥珀酸钠。

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