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71. 发明申请

WO1994015215A1 TEST STRIP FOR IMMUNOASSAYS 审中-公开
标题翻译：免疫测试条
公开(公告)号：WO1994015215A1
公开(公告)日：1994-07-07
申请号：PCT/FI1993000569
申请日：1993-12-29
申请人： OY MEDIX BIOCHEMICA AB , KOUVONEN, Ilkka, Sakari , SVENS, Eivor, Helena , TIKANOJA, Sari, Hannele , TURUNEN, Pekka, Antero , SIVONEN, Lauri, Markus
发明人： OY MEDIX BIOCHEMICA AB
IPC分类号： G01N33/543
CPC分类号： G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/971 , Y10S435/973 , Y10S436/805 , Y10S436/81 , Y10S436/818
摘要： A test strip for a rapid immunoassay containing specific immunochemical reagent zones (7, 8, 9) is described. The test strip (10) has a backing sheet (1) and attached thereto a receiving end pad (3) and at a distance therefrom a finishing end pad (5). A test membrane (2) is provided between said pads (3, 5). Said membrane (2) is positioned in parallel relationship to said backing (1) at a distance therefrom so that said backing (1) and said membrane (2) limit between themselves an air gap (4) which is open at its edges. Said gap (4) functions as a sheltered reaction chamber for the immunological reaction taking place as a liquid is made to flow through said membrane (2). The test strip is simple to manufacture by lamination and easy to use and it is suitable for both diagnostic and environmental immunoassays.
摘要翻译：描述了含有特异性免疫化学试剂区域的快速免疫测定试纸（7,8,9）。测试条（10）具有背衬片（1）并且附接到接收端垫（3）并且与其成一定距离的终端垫（5）。在所述垫（3,5）之间设置测试膜（2）。所述膜（2）与所述背衬（1）平行地定位在与其背离的距离处，使得所述背衬（1）和所述膜（2）在它们之间限制在其边缘处敞开的气隙（4）。所述间隙（4）用作防护反应室，用于当使液体流过所述膜（2）时发生免疫反应。测试条通过层压和易于使用而易于制造，并且适用于诊断和环境免疫测定。

72. 发明申请

WO1994003805A1 DOWN SYNDROME SCREENING METHOD UTILIZING DRIED BLOOD SAMPLES 审中-公开
标题翻译：使用干燥血液样品的下行综合征筛选方法
公开(公告)号：WO1994003805A1
公开(公告)日：1994-02-17
申请号：PCT/US1993007507
申请日：1993-08-06
申请人： MACRI, James, N.
IPC分类号： G01N33/49
CPC分类号： G01N33/76 , Y10S436/817 , Y10S436/818
摘要： The present invention relates to a method for detecting fetal Down syndrome (Trisomy 21), trisomy 13, trisomy 18 and other chromosomal anomalies during prenatal screening by analyzing a dried blood sample from a pregnant woman. More particularly the present invention relates to a method for improving detection efficiency in screening for the anomalies by measuring the amount of the free beta human chorionic gonadotropin (HCG) and nicked or fragmented or aberrant forms of free beta (HCG), all of which are referenced throughout this application as free beta (HCG) in dried blood samples from pregnant women.
摘要翻译：本发明涉及通过分析来自孕妇的干血样品来检测产前筛查中的胎儿唐氏综合征（三体21），三体13，三体性18和其他染色体异常的方法。更具体地说，本发明涉及通过测量游离β人绒毛膜促性腺激素（HCG）的量和游离β（HCG）的切口或断裂或异常形式来改善筛查异常的检测效率的方法，所有这些都是在本申请中引用作为来自孕妇的干血样品中的游离β（HCG）。

73. 发明申请

WO1983004312A1 MONOCLONAL ANTIBODY MIXTURES AND USE THEREOF FOR ENHANCED SENSITIVITY IMMUNOASSAYS 审中-公开
标题翻译：单克隆抗体混合物及其用于增强敏感性免疫球蛋白
公开(公告)号：WO1983004312A1
公开(公告)日：1983-12-08
申请号：PCT/US1983000751
申请日：1983-05-17
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY
发明人： THE TRUSTEES OF COLUMBIA UNIVERSITY , CANFIELD, Robert, E. , EHRLICH, Paul, H. , MOYLE, William, R.
IPC分类号： G01N33/54
CPC分类号： G01N33/577 , G01N33/5306 , G01N33/54393 , G01N33/74 , G01N33/76 , Y10S435/962 , Y10S435/965 , Y10S436/804 , Y10S436/817 , Y10S436/818
摘要： Mixtures of monoclonal antibodies which contain effective assaying amounts of each of at least two monoclonal antibodies that bind to different antigenic sites on the antigen and are capable under appropriate conditions of binding simultaneously to an antigen are useful in enhanced sensitivity assays for the antigen. By utilizing such mixtures in diagnostic assays for important antigens such as the polypeptide human chorionic gonadotropin enhanced sensitivity can be achieved as compared with assays employing individual monoclonal antibodies.

74. 发明授权

EP2336772B1 METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY HCG ASSAY 有权
标题翻译： HCG分析预测受试者妊娠结局的方法
公开(公告)号：EP2336772B1
公开(公告)日：2017-06-28
申请号：EP10184567.5
申请日：1999-02-03
申请人： The Trustees of Columbia University in the City of New York
发明人： O'Connor, John F. , Kovalevskaya, Galina I. , Birken, Steven
IPC分类号： G01N33/53
CPC分类号： G01N33/76 , C07K14/59 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , Y10S435/971 , Y10S436/811 , Y10S436/814 , Y10S436/818

75. 发明授权

EP1183390B1 METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY hCG ASSAY 有权
标题翻译：通过hCG测定法预测受试者妊娠结局的方法
公开(公告)号：EP1183390B1
公开(公告)日：2006-01-04
申请号：EP00935949.8
申请日：2000-05-12
申请人： The Trustees of Columbia University in the City of New York
发明人： O'CONNOR, John , BIRKEN, Steven , KOVALEVSKAYA, Galina
IPC分类号： C12Q1/68 , C12Q1/70 , G01N21/64 , G01N33/00 , G01N33/53 , G01N33/531 , G01N33/533 , G01N33/543 , C07H21/02 , C07H21/04 , C12N15/00 , B05D1/18 , B01J13/00
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
摘要翻译：本发明提供了通过确定样品中hCG的早孕相关分子同种型的量来预测受试者的妊娠结果的方法。本发明进一步提供了用于确定样品中人绒毛膜促性腺激素（hCG）的早孕相关分子同种型的量的方法。本发明还提供了用于确定样品中早期妊娠相关hCG量的诊断试剂盒。本发明另外提供了特异性结合人早孕相关的人绒毛膜促性腺激素分子同种型的抗体。最后，本发明提供了检测样品中滋养层或非滋养层恶性肿瘤的方法。

76. 发明公开

EP1057000A4 METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY hCG ASSAY 审中-公开
标题翻译： FOR VOHERSAGE妊娠结果的方式等在实验中使用的人一HCG试验
公开(公告)号：EP1057000A4
公开(公告)日：2003-06-11
申请号：EP99925541
申请日：1999-02-03
申请人： UNIV COLUMBIA
发明人： O'CONNOR JOHN F , KOVALEVSKAYA GALINA I , BIRKEN STEVEN
IPC分类号： G01N33/53 , C12N15/02 , G01N33/577 , G01N33/76
CPC分类号： G01N33/76 , C07K14/59 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , Y10S435/971 , Y10S436/811 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.

77. 发明公开

EP1307134A1 DIAGNOSTIC DEVICE FOR DISTINGUISHING BETWEEN NORMAL AND ECTOPIC PREGNANCY AND METHOD FOR PREPARING THE SAME 有权
标题翻译：诊断仪之间的正常妊娠和异位DISTINCTION
公开(公告)号：EP1307134A1
公开(公告)日：2003-05-07
申请号：EP01957025.8
申请日：2001-08-10
申请人： Humasis Co.,Ltd.
发明人： CHANG, Jin-Dong , CHA, Jung-Hak , NAM, Jung-Hyun
IPC分类号： A61B5/00 , G01N33/53
CPC分类号： G01N33/76 , A61B8/0866 , A61B10/0012 , G01N33/558 , G01N33/689 , G01N2800/368 , Y10S436/818
摘要： The present invention provides one-step pregnancy diagnosis devices which can simultaneously detect and distinguish between normal pregnancy and ectopic pregnancy and methods of preparing the devices. According to the present invention, normal pregnancy and ectopic pregnancy can be rapidly and accurately determined at an early stage by immunologically detecting the morphological differences between human chorionic gonadotropin (hCG) and modified forms thereof which are secreted into the body fluid of a pregnant female.

78. 发明公开

EP1183390A1 METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY hCG ASSAY 有权
标题翻译： FOR VOHERSAGE妊娠结果的方式等在实验中使用的人一HCG试验
公开(公告)号：EP1183390A1
公开(公告)日：2002-03-06
申请号：EP00935949.8
申请日：2000-05-12
申请人： The Trustees of Columbia University in the City of New York
发明人： O'CONNOR, John , BIRKEN, Steven , KOVALEVSKAYA, Galina
IPC分类号： C12Q1/68 , C12Q1/70 , G01N21/64 , G01N33/00 , G01N33/53 , G01N33/531 , G01N33/533 , G01N33/543 , C07H21/02 , C07H21/04 , C12N15/00 , B05D1/18 , B01J13/00
CPC分类号： G01N33/76 , C07K16/26 , G01N33/57434 , G01N33/57449 , G01N2333/59 , G01N2800/368 , Y10S436/814 , Y10S436/818
摘要： The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.

79. 发明公开

EP1141703A1 METHODS OF DETERMINING AN INCREASED RISK OF A WOMAN CARRYING A DOWNS SYNDROME 有权
标题翻译：一种用于确定女性的甲风险增加，随着“唐氏综合征” A胎儿WEAR
公开(公告)号：EP1141703A1
公开(公告)日：2001-10-10
申请号：EP00904286.2
申请日：2000-01-10
申请人： Quest Diagnostics Investments Incorporated
发明人： PANDIAN, M., R.
IPC分类号： G01N33/48 , G01N33/00 , G01N33/53 , G01N33/573 , C12Q1/00
CPC分类号： G01N33/74 , Y10S436/814 , Y10S436/817 , Y10S436/818
摘要： There are provided methods for assaying biological specimens for one or more of leptin, prorenin or renin in order to provide predictive information about the likelihood of a woman carrying a Downs Syndrome affected fetus.

80. 发明授权

EP0627082B1 ANTENATAL SCREENING FOR CHROMOSOMAL ABNORMALITIES 失效
标题翻译：测试之前出生染色体异常
公开(公告)号：EP0627082B1
公开(公告)日：2000-03-22
申请号：EP94901864.2
申请日：1993-11-24
申请人： KODAK LIMITED , Johnson & Johnson Clinical Diagnostics, Inc.
发明人： DAVIES, Christopher John
IPC分类号： G01N33/76 , G01N33/68 , G01N33/74
CPC分类号： G01N33/74 , G01N33/689 , G01N33/743 , G01N33/76 , G01N2800/368 , G01N2800/387 , G06F19/00 , G06Q50/22 , Y10S436/811 , Y10S436/817 , Y10S436/818
摘要： A method for antenatal screening for chromosomal abnormalities in which maternal blood from a pregnant woman is measured for levels of free beta hCG and at least a second serum marker and/or precursors and metabolites of these markers and the measured levels of these markers together with the gestational age of the pregnant woman are compared to reference values at various gestational ages of the levels for free beta hCG and the second serum marker in (a) pregnant women carrying foetuses having the abnormalitie(s) subject to the screen and (b) pregnant women carrying normal foetuses, the comparison being indicative of the risk of the pregnant woman carrying a foetus with an abnormality subject to the screen characterised in that the second serum marker is pregnancy associated plasma protein A (PAPPA) and the screen is carried out by the end of the thirteenth (13th) completed week of pregnancy.

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