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71. 发明申请

WO01014390A3 METABOTROPIC GLUTAMATE RECEPTOR LIGAND DERIVATIVES AS NAALADase INHIBITORS 审中-公开
标题翻译：代谢谷氨酸受体配体衍生物作为NAALADase抑制剂
公开(公告)号：WO01014390A3
公开(公告)日：2001-09-27
申请号：PCT/US2000/022412
申请日：2000-08-16
IPC分类号： C07C229/14 , C07C229/16 , C07C229/46 , C07C259/08 , C07F9/30 , C07F9/38 , C07F9/572 , C07F9/6561 , C07F9/44 , C07C229/50 , C07F9/40
CPC分类号： C07F9/5727 , C07C229/14 , C07C229/16 , C07C229/46 , C07C259/08 , C07C2601/02 , C07F9/303 , C07F9/383 , C07F9/5722 , C07F9/6561
摘要： The present invention relates to metabotropic glutamate receptor ligand derivatives and methods of using the same to inhibit NAALADase enzyme activity, to effect neuronal activities, to inhibit angiogenesis, and to treat glutamate abnormalities, compulsive disorders, pain, diabetic neuropathy, and prostate diseases, as well as pharmaceutical compositions comprising the same.
摘要翻译：本发明涉及代谢型谷氨酸受体配体衍生物及其使用方法，以抑制NAALADase酶活性，影响神经元活性，抑制血管发生，以及治疗谷氨酸异常，强迫症，疼痛，糖尿病性神经病和前列腺疾病，如以及包含其的药物组合物。

72. 发明申请

WO01034612A2 CHIRAL PHOSPHINES, TRANSITION METAL COMPLEXES THEREOF AND USES THEREOF IN ASYMMETRIC REACTIONS 审中-公开
标题翻译：手性膦以及它们的过渡金属络合物和使用不对称反应复杂
公开(公告)号：WO01034612A2
公开(公告)日：2001-05-17
申请号：PCT/US2000/030889
申请日：2000-11-10
IPC分类号： B01J31/24 , C07B53/00 , C07C231/18 , C07C233/05 , C07C233/13 , C07C233/18 , C07F9/50 , C07F9/553 , C07F9/572 , C07F9/6506 , C07F9/655 , C07F9/6561 , C07F9/6596 , C07F
CPC分类号： B01J31/2409 , B01J31/1625 , B01J31/1658 , B01J31/24 , B01J31/2414 , B01J31/2457 , B01J31/249 , B01J2231/643 , B01J2231/645 , B01J2531/80 , B01J2531/822 , C07B53/00 , C07C231/18 , C07F9/5027 , C07F9/5537 , C07F9/5722 , C07F9/65062 , C07F9/65515 , C07F9/6552 , C07F9/65522 , C07F9/6561 , C07F9/6596 , C07C233/05 , C07C233/13 , C07C233/18
摘要： Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include (R,S,S,R)-DIOP*. The ruthenium complex reduces enamide to the corresponding amine with up to 99% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation, hydride transfer, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, hydrocarboxylation, isomerization, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.
摘要翻译：本发明涉及用这些手性配体形成的手性配体和过渡金属配合物，其可用于催化不对称反应。这些手性配体包括（R，S，S，R）-DIOP *。钌络合物将烯酰胺还原为相应的胺，对映选择性高达99％。这些手性配体的过渡金属配合物是在不对称反应如氢化，氢负离子转移，氢化硅烷化，硼氢化，所述hydrovinylation，加氢甲酰化，hydrocarboxylation，有用异构化，烯丙基烷基化，环丙烷化，Diels-Alder反应，Heck反应，异构化，醛醇缩合反应，迈克尔加成和不对称环氧化反应。

73. 发明申请

WO01004131A1 DIPHOSPHINE LIGANDS FOR METAL COMPLEXES 审中-公开
标题翻译：金属配合物的二氢吡啶配体
公开(公告)号：WO01004131A1
公开(公告)日：2001-01-18
申请号：PCT/EP2000/006658
申请日：2000-07-12
IPC分类号： B01J31/24 , C07B35/02 , C07B53/00 , C07B61/00 , C07C231/12 , C07C233/47 , C07F9/50 , C07F9/572 , C07F15/00 , C07F17/02
CPC分类号： C07F9/5027 , C07B35/02 , C07F9/5722 , C07F9/5726 , C07F15/008 , C07F17/02
摘要： Chiral or nonchiral ditertiary diphosphines having solubilizing substituents, for example -NH-C(O)-NH-C(CH2-O-CH2CH2CO2H)3, in the diphosphine framework are excellent ligands for d8 metal complexes which are soluble in polar media, for example water or alcohols, and which can be used as asymmetric or symmetric hydrogenation catalysts for compounds having carbon-carbon or carbon-heteroatom double bonds.
摘要翻译：在二膦框架中具有增溶取代基的手性或非手性二重二膦，例如-NH-C（O）-NH-C（CH 2 -O-CH 2 CH 2 CO 2 H）3是可溶于极性介质的d8金属络合物的优异配体，例如水或醇，并且其可以用作具有碳 - 碳或碳 - 杂原子双键的化合物的不对称或对称加氢催化剂。

74. 发明申请

WO00037477A1 ORGANO-PHOSPHORUS COMPOUNDS AND THEIR UTILIZATION 审中-公开
标题翻译：磷光体有机物及其用途
公开(公告)号：WO00037477A1
公开(公告)日：2000-06-29
申请号：PCT/EP1999/010274
申请日：1999-12-22
IPC分类号： A61K31/675 , A01N57/24 , A61P31/00 , A61P31/04 , A61P31/12 , C07F9/553 , C07F9/572 , C07F9/58 , C07F9/59 , C07F9/62 , C07F9/6561 , A61P33/00
CPC分类号： C07F9/62 , C07F9/5537 , C07F9/5722 , C07F9/592 , C07F9/65616
摘要： The invention relates to organo-phosphorus compounds of formula (I), wherein A is selected from the group consisting of a (C1-9) alkylene radical, -C-O-C- and -C-N-C- or A corresponds to formula (II), wherein one or more carbon atoms selected from the group consisting of C3, C4, C5 and their substituents can also be absent and at least one of the substituents of B1 to B10 is a C3-8-cycloalkyl-(C0-9)-alkyl group in which R1 is selected from the group consisting of five and six membered heterocycles having at least one nitrogen atom in the ring or polycyclic carbon atoms containing one of said heterocycles, wherein at least one of said nitrogen atoms belongs to a hydroxamic acid group or a hydroxamic acid ester group. The invention also relates to the utilization of the above-mentioned compounds in the therapeutic and prophylactic treatment of infections in human beings and animals caused by virus, bacteria, fungi and parasites and as fungicides, bactericides and herbicides in plants.
摘要翻译：其中选自（C 1-9）亚烷基的基团，和-COC-选择-CNC- A中的通式（I）的有机磷化合物，或其中A是式（II），其特征在于，一个或多个选自C3，C4，C5，与他们的取代基一起也可以省略选择的碳原子数，和B1中的至少一个取代基的至B10呈现C 3-8 - 环烷基 - （C0-9） - 烷基，其中R1 由具有该组中的环或含有这些杂环中的至少一个的多环烃的至少一个氮原子，包括5-和6-元杂环，选自其中这些氮原子的异羟肟酸基团中的至少一个或Hydroxamsäureestergruppe所属以及其使用的治疗性和预防性治疗人类和动物中引起的感染病毒，细菌，真菌和寄生虫，和杀真菌剂，杀菌剂和除草剂植物。

75. 发明申请

WO00001688A1 FIVE-MEMBERED HETEROARYL COMPOUNDS 审中-公开
标题翻译：五分共振化合物
公开(公告)号：WO00001688A1
公开(公告)日：2000-01-13
申请号：PCT/JP1999/003549
申请日：1999-07-01
IPC分类号： C07F9/572 , C07D401/04 , A61K31/44 , A61K31/445 , A61K31/505 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07F9/6558
CPC分类号： C07F9/5722
摘要： [Problem] Provision of compounds exhibiting an excellent inhibitory activity against the production of inflammatory cytokines. [Means for solution] Compounds represented by general formula (I); or pharmacologically acceptable salts, esters or other derivatives thereof, wherein A is a five-membered heteroaryl ring; Ar and Ar are each optionally substituted aryl or the like; Q is optionally substituted arylene or the like; R is H, optionally substituted arkyl or the like; R is H, optionally substituted alkyl or the like; and R is -WR , -S(O)mWR , -N(WR )R , -PO(OR )(OR ) or the like (wherein m is 0 to 2; W is alkylene or the like; R is azido, C(=NOR )R or the like; R , R and R are each H, alkyl or the like; and R and R are each H, alkyl or the like).
摘要翻译： [问题]提供对产生炎性细胞因子具有优异抑制活性的化合物。 [溶解方法]通式（I）表示的化合物; 或其药理学上可接受的盐，酯或其它衍生物，其中A是五元杂芳基环; Ar 1和Ar 2各自为任选取代的芳基等; Q是任选取代的亚芳基等; R 1是H，任选取代的烷基等; R 2是H，任选取代的烷基等; 和R 3是-WR 4，-S（O）m W R 4，-N（WR 4）R 5，-PO（OR 6）（OR 7））等（其中m为0〜2; W为亚烷基等; R 4为叠氮基，C（= NOR 8）R 9等; R 5，R 8 >和R 9各自为H，烷基等; R 6和R 7各自为H，烷基等。

76. 发明申请

WO2016138457A1 PHENYLETHYNYLNAPHTHALENE DYES AND METHODS FOR THEIR USE 审中-公开
标题翻译：苯乙烯基苯乙烯染料及其使用方法
公开(公告)号：WO2016138457A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019903
申请日：2016-02-26
申请人： SONY CORPORATION , SONY CORPORATION OF AMERICA
发明人： BATTRELL, C., Frederick , MATRAY, Tracy , SHERIF, Hesham , VANBRUNT, Michael
IPC分类号： C07C15/62 , C09B57/00 , G03C1/00 , G03F7/038 , G03F7/004 , G11B7/00
CPC分类号： C09B57/00 , C07C215/68 , C07F9/094 , C07F9/2429 , C07F9/5722 , C09B23/141 , C09B69/101 , C09B69/109 , G01N33/52 , G03C1/00
摘要： Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I), including salts thereof, wherein R 1a , R 1b , R 1c , R 1d , R 1e , R 1f , R 2a , R 2b , R 2c , R 2d , R 2e , R 2f , R 2g , R 2h , R 2i , R 2j , x and y are as defined herein. Methods associated with preparation and use of such compounds are also provided.
摘要翻译：公开了可用作荧光或着色染料的化合物。该化合物具有下列结构（I），包括其盐，其中R1a，R1b，R1c，R1d，R1e，R1f，R2a，R2b，R2c，R2d，R2e，R2f，R2g，R2h，R2i，R2j，x和y 如本文所定义。还提供了与这些化合物的制备和使用有关的方法。

77. 发明申请

WO2015009731A3 AZACYCLIC CONSTRAINED ANALOGS OF FTY720 审中-公开
标题翻译： AZYYCLIC约束类似FTY720
公开(公告)号：WO2015009731A3
公开(公告)日：2015-03-19
申请号：PCT/US2014046711
申请日：2014-07-15
申请人： UNIV CALIFORNIA
发明人： EDINGER AIMEE , HANESSIAN STEPHEN
IPC分类号： C07D207/08
CPC分类号： C07D207/12 , C07F9/572 , C07F9/5722
摘要： Small molecules comprised of azacyclic constrained analogs of FTY720 are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, leukemia, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.
摘要翻译：提供由FTY720的氮杂环受约束类似物组成的小分子。还提供了涉及疾病治疗的制剂和药物，例如白血病和其他疾病。还提供治疗剂，其含有治疗有效剂量的一种或多种小分子化合物，以药学上有效的盐或以纯的形式存在，包括但不限于用于口服，静脉内或肌内给药的制剂。

78. 发明申请

WO2015009731A2 AZACYCLIC CONSTRAINED ANALOGS OF FTY720 审中-公开
标题翻译： FTY720的AZACYCLIC约束模拟
公开(公告)号：WO2015009731A2
公开(公告)日：2015-01-22
申请号：PCT/US2014/046711
申请日：2014-07-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： EDINGER, Aimee , HANESSIAN, Stephen
IPC分类号： A61K31/4015
CPC分类号： C07D207/12 , C07F9/572 , C07F9/5722
摘要： Small molecules comprised of azacyclic constrained analogs of FTY720 are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, leukemia, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.
摘要翻译：提供了由FTY720的氮杂受限类似物组成的小分子。还提供了用于治疗疾病，例如白血病和其他疾病的制剂和药物。还提供治疗剂，其含有治疗有效剂量的一种或多种小分子化合物，其以药物有效盐或纯形式存在，包括但不限于用于口服，静脉内或肌内给药的制剂。

79. 发明申请

WO2014195702A1 NOVEL PYRROLE DERIVATIVES 审中-公开
标题翻译：新颖的红宝石衍生物
公开(公告)号：WO2014195702A1
公开(公告)日：2014-12-11
申请号：PCT/GB2014/051725
申请日：2014-06-04
申请人： UNIVERSITY OF LEICESTER
发明人： ANDREW, Peter, William , DAMASO, Mafalda, Pires , DAVIES, Mark, William , LONNEN, Rana , HAMZA, Daniel , HIRST, Simon, Christopher
IPC分类号： C07D207/36 , C07F9/09
CPC分类号： A61K31/496 , A61K45/06 , C07D207/36 , C07F9/5722
摘要： There isprovided inter alianovel N-phenyl substituted pyrrole derivativesand theiruse in therapy, especially in the treatment of bacterial (e.g. pneumococcal) infections.
摘要翻译：提供了亚硝酰基N-苯基取代的吡咯衍生物及其在治疗中的用途，特别是在细菌（例如肺炎球菌）感染的治疗中。

80. 发明申请

WO2009118712A3 NOVEL DIHYDROXYPYRROLIDINE DERIVATIVES AS ANTI-CANCER AGENTS 审中-公开
标题翻译：新型二羟基吡咯烷酮衍生物作为抗癌剂
公开(公告)号：WO2009118712A3
公开(公告)日：2010-01-07
申请号：PCT/IB2009051295
申请日：2009-03-27
申请人： ECOLE POLYTECH , BELLO CLAUDIA , VOGEL PIERRE
发明人： BELLO CLAUDIA , VOGEL PIERRE
IPC分类号： C07D207/12 , A61K31/4015 , A61P35/00 , C07D291/06 , C07D513/04
CPC分类号： C07D307/33 , C07D207/12 , C07D291/06 , C07D513/04 , C07F9/5722 , C07F9/6561
摘要： The present invention provides new dihydroxypyrrolidine derivatives for use as medicaments. The compounds are useful in the treatment in cancer, in particular non-solid neoplasms.
摘要翻译：本发明提供用作药物的新型二羟基吡咯烷衍生物。这些化合物可用于治疗癌症，特别是非固体肿瘤。

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