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71. 发明公开

EP2706117A1 Process for preparing sebacic acid 审中-公开
标题翻译： Verfahren zur Herstellung vonSebacinsäure
公开(公告)号：EP2706117A1
公开(公告)日：2014-03-12
申请号：EP12183534.2
申请日：2012-09-07
申请人： BASF SE
发明人： Piatesi, Andrea , Baldenius, Kai-Uwe , Ditrich, Klaus , Kindler, Alois , Zajaczkowski-Fischer, Marta , Böhling, Ralf , Rehfinger, Alwin
IPC分类号： C12P7/64 , C07C55/20 , C07C59/147
CPC分类号： C12P7/6427 , C07C51/235 , C07C51/373 , C12P7/6409 , C12Y402/01053 , C07C59/147 , C07C55/20
摘要： A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form10- hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step(iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.
摘要翻译：在第二步（ii）中热解10-羟基-12-十八碳烯酸的方法，通过在第一步骤（i）中将亚油酸与由油酸水合酶催化形成10-羟基-12-十八碳烯酸的水反应制备癸二酸酸至1-辛烯和10-氧代癸酸，并且在第三步（iii）中将10-氧代癸酸氧化成癸二酸。

72. 发明公开

EP2545027A1 KRISTALLINE SALZE UND/ODER COKRISTALLE VON O-DESMETHYLTRAMADOL 审中-公开
标题翻译： KRISTALLINE SALZE UND / ODER COKRISTALLE VON O-DESMETHYLTRAMADOL
公开(公告)号：EP2545027A1
公开(公告)日：2013-01-16
申请号：EP11707666.1
申请日：2011-03-09
申请人： Grünenthal GmbH
发明人： GRUß, Michael , ZIMMER, Oswald
IPC分类号： C07C215/64 , C07C53/126 , C07C55/20 , C07C57/15 , C07C57/44 , A61K31/135 , A61P25/00
CPC分类号： C07C215/64 , C07C53/126 , C07C55/20 , C07C57/15 , C07C57/44 , C07C2601/14
摘要： The present invention relates to salts present in crystalline form and/or to cocrystals of (+)- 3-[2-(dimethylamino)methyl-1-hydroxycyclohexyl]phenol or of (-)- 3-[2-(dimethylamino)methyl-1 -hydroxycyclohexyl]phenol containing cinnamic acid, C
8 - to C
10 -alkane monocarboxylic acids, C
6 - to C
10 -alkane dicarboxylic acids, C
15 - to C
17 -alkane monocarboxylic acids, fumaric acid, tartaric acid, mandelic acid, hippuric acid and/or embonic acid. It further relates to a method for the production thereof, to such salts and/or cocrystals for use as pharmaceuticals and to the use of salts and/or cocrystals for producing pharmaceuticals.
摘要翻译：（+） - 3- [2-（二甲基氨基） - 甲基-1-羟基环己基] - 酚或（ - ） - 3- [2-（二甲基氨基）甲基-1-羟基 - 环己基] - 苯酚的盐和/ ]酚，以肉桂酸，C 8〜C 10 - 烷烃 - 一元羧酸，C 6〜C 10 - 烷基二羧酸，C 15〜C 17 - 烷烃 - 一元羧酸，富马酸，酒石酸，扁桃酸，马尿酸酸和/或乌头酸，其生产方法，以及这些盐和/或共晶体作为药物的用途。

73. 发明授权

EP1295590B1 Zweikomponenten-Mittel mit zeitlichem pH-Gradienten und Verfahren zur Behandlung von Haaren 无效
标题翻译：颞pH梯度和用于治疗毛发的方法的双组分试剂
公开(公告)号：EP1295590B1
公开(公告)日：2007-01-03
申请号：EP02015153.6
申请日：2002-07-06
申请人： Wella Aktiengesellschaft
发明人： Kripp, Thomas, Dr. , Grasser, Beate , Koschik, Achim
IPC分类号： A61K8/362 , A61K8/41 , A61Q5/10 , A61Q5/04 , C07C51/41
CPC分类号： C07C51/412 , A61K8/19 , A61K8/362 , A61K8/41 , A61K2800/45 , A61K2800/88 , A61Q5/04 , A61Q5/10 , C07C55/02 , C07C55/20 , C07C55/21

75. 发明公开

EP0970032A4 METHOD FOR PREPARING CLEAVED PRODUCTS FROM CASTOR OIL OR DERIVATIVES THEREOF 失效
标题翻译：方法裂变产物由蓖麻油或其衍生物生产
公开(公告)号：EP0970032A4
公开(公告)日：2001-03-28
申请号：EP98906246
申请日：1998-02-11
申请人： CASCHEM INC
发明人： RIES CHARLES D , TOTAH THOMAS S
IPC分类号： C07C27/00 , C07C29/00 , C07C31/125 , C07C45/00 , C07C45/27 , C07C45/78 , C07C49/04 , C07C51/16 , C07C51/295 , C07C55/20
CPC分类号： C07C45/78 , C07C45/27 , C07C51/295 , C07C55/20
摘要： A process for producing a cleaved product from castor oil, or derrivatives thereof, by high temperature caustic oxidation reaction accomplished by combining at least one chemically inert diluent, a catalyst, and an alkali in aqueous solution to form a first mixture wherein the diluent is present in an amount sufficient to reduce foaming and solidification of the mixture while increasing the yield and improving the purity and adding a ricinic compound to the first mixture to form a second mixture. The temperature of the second mixture is raised to a level sufficient to conduct pyrolysis, and the cleaved product produced thereby is recovered by adding an acid to the reaction mixture in an amount sufficient to acidify the reaction mixture down below a pH of about 6. The invention further relates to the reaction mixture used to produce the cleaved products. The present invention provides higher product yields and purer cleaved products produced by the oxidation of castor oil or its derivatives than conventionally obtained.

76. 发明公开

EP0484372A1 USE OF SEBACIC ACID AND DERIVATIVES THEREOF IN ENTERAL AND PARENTERAL NUTRITION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS 失效转让
标题翻译：癸二中的应用及其衍生物对药物组合物的肠内和肠外营养的生产。
公开(公告)号：EP0484372A1
公开(公告)日：1992-05-13
申请号：EP90910871.0
申请日：1990-07-30
申请人： SIGMA TAU Industrie Farmaceutiche Riunite S.p.A.
发明人： MINGRONE, Geltrude
IPC分类号： A61K31 , A61P3 , C07C55 , C07C69
CPC分类号： A61K31/23 , A61K31/20 , C07C55/20
摘要： L'acide sébacique et ses dérivés pharmacologiquement acceptables, tels que les nouveaux composés sébacate de sodium et sébacate de potassium, le triglycéride de l'acide sébacique, et les sels de sodium et de potassium du triglycéride, sont employés dans la fabrication de compositions pharmaceutiques adaptées à la nutrition entérale et parentérale.

77. 发明申请

US20170113992A1 METHODS AND MATERIALS FOR HYDROLYZING POLYESTERS 审中-公开
公开(公告)号：US20170113992A1
公开(公告)日：2017-04-27
申请号：US15301715
申请日：2014-04-02
申请人： East China University of Science and Technology
发明人： Guiping CAO , Xuekun LI , Kaiyue HAN , Chen MENG
IPC分类号： C07C51/09 , C07C29/80 , C07C51/44 , B01J27/053 , B01J23/22 , B01J37/02 , B01J21/06 , B01J23/26 , B01J23/10 , B01J21/04 , B01J23/30 , B01J21/12 , C07C29/09 , B01J23/14
CPC分类号： C07C51/09 , B01J21/04 , B01J21/063 , B01J21/066 , B01J21/12 , B01J23/02 , B01J23/10 , B01J23/14 , B01J23/22 , B01J23/26 , B01J23/30 , B01J23/745 , B01J27/053 , B01J37/0036 , B01J37/0201 , B01J37/0209 , C07C29/095 , C07C29/80 , C07C51/44 , Y02P20/52 , C07C63/26 , C07C31/202 , C07C31/207 , C07C31/20 , C07C55/20 , C07C63/38 , C07C31/276 , C07C55/14 , C07C31/205
摘要： The present application relates to methods of hydrolyzing a polyester by contacting the polyester with a solid acid catalyst. Also disclosed are solid acid catalysts that are useful for hydrolyzing a polyester and methods of making the solid acid catalysts. Furthermore, compositions including one or both of a dicarboxylic acid and a diol, and at least one solid acid catalyst are also disclosed.

78. 发明申请

US20150361028A1 PROCESS FOR PREPARING A DIAMINE/DICARBOXYLIC ACID SALT 有权
标题翻译：制备二胺/二羧酸盐的方法
公开(公告)号：US20150361028A1
公开(公告)日：2015-12-17
申请号：US14234248
申请日：2012-07-26
申请人： Eric Grolman , Rudy Rulkens
发明人： Eric Grolman , Rudy Rulkens
IPC分类号： C07C209/68 , C07C51/41 , C07C211/12 , C07C55/20 , C07C211/09 , C07C63/28 , C07C55/14
CPC分类号： C07C209/68 , C07B2200/13 , C07C51/412 , C07C55/14 , C07C55/20 , C07C63/28 , C07C211/09 , C07C211/12 , C08G69/04 , C08G69/265 , C07C63/24 , C07C63/26 , C07C63/36
摘要： The present invention also relates to a process for preparing a diamine/dicarboxylic acid salt wherein the dicarboxylic acid comprises an aromatic dicarboxylic acid and is provided in a powder form; the diamine is provided in a liquid form gradually dosed to the dicarboxylic acid powder, while keeping the dicarboxylic acid powder in constant movement; the processing temperature is above 0° C. and below the boiling temperature of the diamine and the melting temperature of the acid and the salt, and the reaction mixture comprises at most 5 wt. % of water. The present invention also relates to an anhydrous diamine/dicarboxylic acid salt obtainable by the process according to invention, or any embodiment thereof as described above.
摘要翻译：本发明还涉及一种制备二胺/二羧酸盐的方法，其中二羧酸包括芳族二羧酸并以粉末形式提供; 二胺以逐渐递送到二羧酸粉末的液体形式提供，同时保持二羧酸粉末恒定运动; 处理温度高于0℃，低于二胺的沸点温度和酸和盐的熔融温度，反应混合物至多为5重量％。％的水。本发明还涉及通过本发明的方法获得的无水二胺/二羧酸盐或其如上所述的任何实施方案。

79. 发明申请

US20150191409A1 Process 审中-公开
标题翻译：处理
公开(公告)号：US20150191409A1
公开(公告)日：2015-07-09
申请号：US14148974
申请日：2014-01-07
申请人： NATURALLY SCIENTIFIC TECHNOLOGIES LIMITED
发明人： Glenn RICHARDS
IPC分类号： C07C51/00 , C07C67/03 , B01F5/00 , C07C29/09
CPC分类号： C07C67/03 , C07C29/00 , C07C29/1285 , C07C51/295 , Y02E50/13 , C07C31/125 , C07C31/225 , C07C69/52 , C07C55/20
摘要： The present invention relates to a process, which is particularly suitable for the production of sebacic acid and/or 2-octanol, and also for the production of biodiesel, wherein the process is a process for the reaction of a fatty acid ester (such as castor oil, or canola or rapeseed oil) and/or a fatty acid (such as riconleic acid) with an inorganic base (such as sodium hydroxide), the process comprising the following steps: (i) providing a pressurised and heated stream of fatty acid ester and/or fatty acid; (ii) providing an inorganic base; (iii) combining the stream obtained from step (i) with the inorganic base obtained in step (ii), in the presence of water, in a reaction vessel, by injection, thereby to produce reaction mixture in the form of a pressurised and heated stream; (iv) optionally maintaining the stream obtained in step (iii) at a selected temperature and pressure; and (v) thereby obtaining a reaction product.
摘要翻译：本发明涉及一种特别适用于生产癸二酸和/或2-辛醇以及生产生物柴油的方法，其中该方法是一种脂肪酸酯（如蓖麻油或油菜籽油或菜籽油）和/或与无机碱（如氢氧化钠）的脂肪酸（如微康酸），该方法包括以下步骤：（i）提供加压和加热的脂肪酸酯和/或脂肪酸; （ii）提供无机碱; （iii）将由步骤（ⅰ）获得的物流与步骤（ⅱ）中获得的无机碱在水存在下，在反应容器中通过注射混合，由此产生加压和加热的形式的反应混合物流; （iv）任选地将步骤（iii）中获得的物流保持在选定的温度和压力下; 和（v），从而得到反应产物。

80. 发明申请

US20140249330A1 METHOD FOR THE PRODUCTION OF AN AQUEOUS SOLUTION OF SALTS 有权
标题翻译：生产水溶液的方法
公开(公告)号：US20140249330A1
公开(公告)日：2014-09-04
申请号：US14131855
申请日：2012-06-05
申请人： Ekkehard Siebecke , Mirko Bär , Eberhard Raue
发明人： Ekkehard Siebecke , Mirko Bär , Eberhard Raue
IPC分类号： C07C209/68
CPC分类号： C07C209/68 , B01J8/20 , B01J2208/00592 , B01J2208/00628 , B01J2219/0004 , C07C51/412 , C07C55/14 , C07C55/18 , C07C55/20 , C07C55/16 , C07C55/21
摘要： The invention relates to a method for the continuous production of a solution of salts, in particular for the production of hexamethylenediamine adipate and a device for implementing such a method. According to the invention, it is proposed to convert, in a first step, a substoichiometric quantity of alkane diamine in a ratio to the alkane dicarboxylic acid in water and, in a subsequent second step, to implement making-up with alkane diamine, adjustment of the stoichiometric ratios being effected via a pH value measurement at a constant temperature.
摘要翻译：本发明涉及连续生产盐溶液的方法，特别是用于生产己二酸己二胺的六亚甲基二胺和用于实施这种方法的装置。根据本发明，提出了在第一步中将亚烷基二胺的亚化学计量量与水中的烷烃二羧酸成比例的转化，并且在随后的第二步中，用烷基二胺进行化妆，调整的化学计量比通过在恒定温度下的pH值测量来实现。

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