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    • 76. 发明申请
    • NOVEL CHEMICAL INTERMEDIATES BEARING A TRIFLUOROMETHYL GROUP
    • 新型化学中间体承载三氟甲磺酸组
    • WO99037610A1
    • 1999-07-29
    • PCT/US1999/001684
    • 1999-01-27
    • C07C45/68C07C49/227C07C211/24C07C251/12C07C319/14
    • C07C319/14C07C45/68C07C49/227C07C211/24C07C251/12
    • Novel trifluoromethylated intermediates are provided which are useful in synthesizing trifluoromethylated organic compounds. Specifically, compounds of the formula CF3CR are provided, wherein R is (C1)=CHCH2SO2Ph, (C1)=CHCH2CH2C(=O)CH3, (C1)=CHCH2CH(COCH3)2, (C1)=CHCH2NR'R'' or H=CHCH=NR'; R' and R'' are the same or different and are selected from the group consisting of hydrogen, unsubstituted or substituted C1 to C6 straight chain or branched alkyl, unsubstituted or substituted C3 to C7 cycloalkyl, unsubstituted or substituted C2 to C12 alkenyl, a benzyl group unsubstituted or substituted with R''', or a phenyl group unsubstituted or substituted with R'''; or R' and R'' taken together form a five- or six-membered ring; and R''' is an unsubstituted or substituted C1 to C6 straight chain or branched alkyl, an unsubstituted or substituted C1 to C6 alkoxy, an unsubstituted or substituted C1 to C6 thioakyl, a cyano, a halogen, or a C1 to C2 dialkylamino group; with the proviso that when the alkyl, cycloalkyl oralkenyl or R' or R'' or the alkyl, alkoxy or thioalkyl of R''' is substituted it may be substituted with any group compatible with amine functionality. The novel compounds are versatile intermediates for the synthesis of a wide variety of trifluoromethylated organic compounds, which have found great utility as pharmaceuticals, agricultural chemicals, and materials such as liquid crystals.
    • 提供了可用于合成三氟甲基化有机化合物的新型三氟甲基化中间体。 具体地,提供式CF3CR的化合物,其中R是(C1)= CHCH2SO2Ph,(C1)= CHCH2CH2C(= O)CH3,(C1)= CHCH2CH(COCH3)2,(C1)= CHCH2NR'R“ H = CHCH = NR'; R'和R“相同或不同,并且选自氢,未取代或取代的C1至C6直链或支链烷基,未取代或取代的C3至C7环烷基,未取代或取代的C2至C12链烯基, 未被取代或被R“取代的苄基,或未取代或被R”取代的苯基; 或R'和R“一起形成五元或六元环; 未取代或取代的C1至C6直链或支链烷基,未取代或取代的C1至C6烷氧基,未取代或取代的C1至C6硫代烷基,氰基,卤素或C1至C2二烷基氨基 ; 条件是当R“'的烷基,环烷基或链烯基或R'或R”或烷基,烷氧基或硫代烷基被取代时,其可以被与胺官能团相容的任何基团取代。 新型化合物是用于合成各种三氟甲基化有机化合物的多功能中间体,其已经发现作为药物,农药和液晶等材料具有很大的用途。