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71. 发明申请

WO1993000981A1 METHOD AND APPARATUS FOR PURIFYING CONTAMINATED GASES 审中-公开
标题翻译：净化污染气体的方法和装置
公开(公告)号：WO1993000981A1
公开(公告)日：1993-01-21
申请号：PCT/US1992003200
申请日：1992-04-16
申请人： THE UNIVERSITY OF CONNECTICUT
发明人： THE UNIVERSITY OF CONNECTICUT , GRASSO, Domenic , HOAG, George, E.
IPC分类号： B01D53/14
CPC分类号： B01D53/1418 , B01D53/1487 , B01D53/1493 , Y02A50/235
摘要： A method for removing volatile organic compounds from a contaminated gas stream (2) includes contacting the contaminated gas stream (2) with a nonvolatile organic liquid absorbent stream (4) under conditions effective to allow absorption of the volatile organic compound from the gas stream (2) into the absorbent stream (4) and separation of the absorbed volatile organic compound from the absorbent in separation apparatus (12) to provide a recycled absorbent stream (14) and a reclaimed volatile organic compound stream (28). An apparatus for removing volatile organic compounds from a contaminated air stream includes means (6) for contacting the contaminated air stream with an absorbent to allow absorption of the volatile organic compound by the absorbent and means (12) for separating the absorbed volatile organic compound from the absorbent.
摘要翻译：从污染的气流（2）中除去挥发性有机化合物的方法包括在有效地允许从气流中吸收挥发性有机化合物的条件下使受污染气流（2）与非挥发性有机液体吸收剂流（4）接触 2）分离到吸收剂流（4）中，并将吸收的挥发性有机化合物与分离装置（12）中的吸收剂分离，以提供再循环吸收剂流（14）和回收的挥发性有机化合物流（28）。用于从受污染的空气流中除去挥发性有机化合物的装置包括用于使被污染空气流与吸收剂接触的装置（6），以允许吸收剂吸收挥发性有机化合物和用于将吸收的挥发性有机化合物从吸收剂。

72. 发明申请

WO1989004640A1 PASSIVE DENTAL APPLIANCES OF FIBER-REINFORCED COMPOSITES 审中-公开
标题翻译：纤维增强复合材料被动牙科器具
公开(公告)号：WO1989004640A1
公开(公告)日：1989-06-01
申请号：PCT/US1988004049
申请日：1988-11-14
申请人： THE UNIVERSITY OF CONNECTICUT
发明人： THE UNIVERSITY OF CONNECTICUT , GOLDBERG, A., Jon , BURSTONE, Charles, J.
IPC分类号： A61C13/00
CPC分类号： A61K6/083 , A61C5/007 , A61C13/0003
摘要： Nonforce-imparting or passive dental components and appliances are provided possessing not only greater stiffness and strength but also generally higher mechanical properties than those exhibited by the commonly used dental polymers. They also are more esthetic and easier to process, form and adjust than dental metallic alloys, thereby allowing for superior and unique designs. The passive dental appliances or structural components are fabricated from an effective fiber reinforced composite material comprised essentially of a polymeric matrix and a fiber component embedded within the matrix. The fiber component of the composite material constitutes greater than 20 percent by weight of the composite material and the modulus of elasticity of the composite is greater than 0.5 x 10 psi. The passive components are produced by initially compounding an effective fiber-reinforced composite material having the requisite stiffness and strength characteristics, fiber orientation and void free wetting of the fibers and thereafter forming the composite into the dental device to achieve improved aesthetics coupled with ease of processing and structural stability.
摘要翻译：提供非强制性或被动牙科部件和器具，不仅具有比通常使用的牙科聚合物所显示的那些更大的刚度和强度，而且通常具有更高的机械性能。它们还比牙科金属合金更美观，更容易加工，形成和调整，从而允许优异和独特的设计。被动牙科器具或结构部件由有效的纤维增强复合材料制成，该复合材料基本上由聚合物基质和嵌入基体内的纤维成分组成。复合材料的纤维组分构成复合材料的大于20重量％，复合材料的弹性模量大于0.5×10 6 psi。被动部件通过最初复合具有所需的刚度和强度特性，纤维取向和纤维无空隙润湿的有效的纤维增强复合材料制成，然后将复合材料形成牙科设备以实现改善的美观性以及加工容易性和结构稳定性。

73. 发明公开

EP3191121A1 IDENTIFICATION OF IMMUNOLOGICALLY PROTECTIVE NEO-EPITOPES FOR THE TREATMENT OF CANCERS 审中-公开
标题翻译：鉴定免疫保护性近表位用于治疗癌症
公开(公告)号：EP3191121A1
公开(公告)日：2017-07-19
申请号：EP15839204.3
申请日：2015-09-03
申请人： The University of Connecticut , University of Notre Dame du Lac
发明人： SRIVASTAVA, Pramod K. , BAKER, Brian M.
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K39/39533 , A61K2039/5158 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/574 , G01N33/6878 , G01N2333/70539 , G01N2500/04 , A61K2300/00
摘要： Described herein are methods of identifying immunologically protective neo-epitopes from the cancer tissue DNA of cancer patients using biophysical principles as well as bioinformatics techniques. The identification of immunologically protective neo-epitopes provides pharmaceutical compositions with a limited number of tumor-specific peptides suitable for personalized genomics-driven immunotherapy of human cancer. Specifically disclosed herein is a method of using the conformational stability of an epitope in an MHC protein-binding groove to predict immunogenicity of peptides in a putative neo-peptide set from a tumor from a cancer patient. Pharmaceutical compositions and methods of administration are also included.
摘要翻译：本文描述了使用生物物理原理以及生物信息学技术从癌症患者的癌症组织DNA鉴定免疫保护性新表位的方法。免疫保护性新表位的鉴定提供了药物组合物，所述药物组合物具有适用于个性化基因组学驱动的人类癌症免疫治疗的有限数量的肿瘤特异性肽。本文具体公开了使用MHC蛋白结合沟中的表位的构象稳定性来预测来自癌症患者的肿瘤的推定的新肽组中肽的免疫原性的方法。药物组合物和给药方法也包括在内。

74. 发明公开

EP3177394A1 ARTICLE WITH CONTROLLABLE WETTABILITY 有权转让
标题翻译：具有可控的可湿性的物品
公开(公告)号：EP3177394A1
公开(公告)日：2017-06-14
申请号：EP15830434.5
申请日：2015-08-07
申请人： United Technologies Corporation , The University of Connecticut
发明人： FURRER, David Ulrich , BURLATSKY, Sergei F. , ELLIOTT, Paul , STAGON, Stephen P. , HUANG, Hanchen
IPC分类号： B01J19/08 , B05D7/00 , B82B1/00 , B82Y30/00
CPC分类号： B63B1/34 , B05D3/061 , B05D3/14 , B05D3/145 , B05D5/00 , B05D5/08 , B63B1/32 , B64D15/00 , B64D15/12 , B64D2033/0233 , B81B1/00 , B81B2201/058 , B81C1/00206 , B82Y30/00 , F15D1/0065 , F15D1/0075 , F15D1/0085 , Y02T70/12
摘要： An article with controllable wettability includes a substrate and a layer of a composite material supported on the substrate. The layer has an exposed surface and the composite material includes particles that have controllable polarization embedded fully or partially in a matrix. A controller is operable to selectively apply a controlled variable activation energy to the layer. The controllable polarization of the particles varies responsive to the controlled variable activation energy such that a wettability of the exposed surface also varies responsive to the controlled variable activation energy.
摘要翻译：具有可控润湿性的制品包括基材和支撑在基材上的复合材料层。该层具有暴露的表面，并且复合材料包括具有完全或部分嵌入基体中的具有可控极化的颗粒。控制器可操作以选择性地向层施加受控变量激活能量。颗粒的可控极化响应于受控变量活化能而变化，使得暴露表面的润湿性也响应于受控变量活化能而变化。

75. 发明公开

EP2875033A1 ELECTROCHROMIC COPOLYMERS FROM PRECURSORS, METHOD OF MAKING, AND USE THEREOF 有权
标题翻译：电致变色共聚物由前体，方法的生产和使用
公开(公告)号：EP2875033A1
公开(公告)日：2015-05-27
申请号：EP13823696.3
申请日：2013-07-23
申请人： The University of Connecticut Helth Center
发明人： SOTZING, Gregory Allen
IPC分类号： C07F7/18 , C07F7/10
CPC分类号： C08G75/06 , B05D5/06 , C07F7/0838 , C07F7/2208 , C08G61/12 , C08G61/123 , C08G77/50 , C08G2261/124 , C08G2261/1424 , C08G2261/3223 , C08G2261/3246 , C08G2261/344 , C08G2261/414 , C08G2261/54 , C09D5/24 , C09D181/02 , H01B1/124
摘要： This invention relates to electrochromic copolymers having a specific color transition prepared from precursors containing Si, Ge, Sn, or Pb, methods of producing such copolymers and precursors, and applications utilizing the copolymers to prepare electrochromic devices.

76. 发明公开

EP2841210A1 METHOD OF FORMING THERMAL BARRIER COATING, THERMAL BARRIER COATING FORMED THEREBY, AND ARTICLE COMPRISING SAME 审中-公开
标题翻译：法形成在这个过程中形绝缘层与物品相关的绝缘层的
公开(公告)号：EP2841210A1
公开(公告)日：2015-03-04
申请号：EP13781072.7
申请日：2013-04-22
申请人： The University of Connecticut
发明人： GELL, Maurice , JORDAN, Eric , ROTH, Jeffrey D.
IPC分类号： B05D1/08 , C23C28/00 , C23C4/02
CPC分类号： C04B35/44 , C23C4/02 , C23C4/10 , C23C4/11 , C23C4/134 , C23C28/3215 , C23C28/3455 , C23C28/36 , F01D5/288 , F02C7/24 , F05D2300/2112 , Y10T428/24471 , Y10T428/24997
摘要： A thermal barrier coating that includes a YAG-based ceramic is prepared by a solution precursor plasma spray method that includes injecting a precursor solution into a thermal jet, evaporating solvent from the precursor solution droplets, and pyrolyzing the resulting solid to form a YAG-based ceramic that is melted and deposited on a substrate. The thermal barrier coating can include through coating-thickness cracks that improve the strain tolerance of the coating.

77. 发明公开

EP2620209A1 Methods and apparatus for the activation of a chemical compound 审中-公开
标题翻译： Verfahren und Vorrichtungfürdie Aktivierung einer chemische Verbindung
公开(公告)号：EP2620209A1
公开(公告)日：2013-07-31
申请号：EP13163256.4
申请日：2008-09-19
申请人： Catelectric Corp. , The University of Connecticut
发明人： Stancovski, Victor , Suib, Steven Lawrence , Hu, Boxun
IPC分类号： B01D53/86 , B01J29/00 , C07C37/00 , C07C45/53 , C07C49/403 , B01J19/08 , B01J23/00 , B01J8/02 , B01J23/06 , B01J23/04 , B01J23/42
CPC分类号： B01J8/0221 , B01J19/087 , B01J23/002 , B01J23/06 , B01J23/34 , B01J23/42 , B01J2208/00061 , B01J2208/00168 , B01J2219/0809 , B01J2523/00 , C07C45/53 , C07C49/403 , B01J2523/23 , B01J2523/48
摘要： A method for activation of a chemical compound is provided, comprising:
introducing the chemical compound to a catalyst;
providing an oxidizing agent or a reducing agent to the catalyst and the chemical compound;
applying an alternating current to said catalyst to produce an activation reaction in the chemical compound;
wherein the activation reaction produces a useful product.
摘要翻译：提供了一种激活化合物的方法，包括：将化学化合物引入催化剂; 向催化剂和化合物提供氧化剂或还原剂; 向所述催化剂施加交流电以在所述化合物中产生活化反应; 其中所述活化反应产生有用的产物。

78. 发明授权

EP1414775B1 BICYCLIC CANNABINOID 有权
标题翻译：双环大麻素
公开(公告)号：EP1414775B1
公开(公告)日：2012-12-19
申请号：EP02749947.4
申请日：2002-07-11
申请人： The University of Connecticut
发明人： MAKRIYANNIS, Alexandros , NIKAS, Spyridon, P. , KHANOLKAR, Atmaram, D.
IPC分类号： C07C49/747 , A61K31/122 , A61P25/00
CPC分类号： C07D409/04 , C07C37/055 , C07C39/23 , C07C45/54 , C07C49/747 , C07C2601/08 , C07D311/80 , C07D339/06 , C07D409/06 , C07C39/17 , C07C39/18

79. 发明公开

EP2201046A1 METHODS AND APPARATUS FOR THE SYNTHESIS OF USEFUL COMPOUNDS 审中-公开
标题翻译：方法和设备合成中是有用的链接
公开(公告)号：EP2201046A1
公开(公告)日：2010-06-30
申请号：EP08831850.6
申请日：2008-09-19
申请人： Catelectric Corp. , The University of Connecticut
发明人： STANCOVSKI, Victor , SUIB, Steven, Lawrence , HU, Boxum
IPC分类号： C08F10/00
CPC分类号： B01J8/0221 , B01J19/087 , B01J23/002 , B01J23/06 , B01J23/34 , B01J23/42 , B01J2208/00061 , B01J2208/00168 , B01J2219/0809 , B01J2523/00 , C07C45/53 , C07C49/403 , B01J2523/23 , B01J2523/48
摘要： The present invention relates to methods and apparatus for activation of a low reactivity, non-polar chemical compound. In one example embodiment, the method comprise introducing the low reactivity chemical compound to a catalyst. At least one of (a) an oxidizing agent or a reducing agent and (b) a polar compound is provided to the catalyst and the chemical compound. An alternating current is applied to the catalyst to produce an activation reaction in the chemical compound. This activation reaction produces a useful product.

80. 发明公开

EP2129517A1 ELECTROSPUN APATITE/POLYMER NANO-COMPOSITE SCAFFOLDS 审中-公开
标题翻译： ELEKTROGESPONNENE APATIT- /POLYMERNANOVERBUNDGERÜSTE
公开(公告)号：EP2129517A1
公开(公告)日：2009-12-09
申请号：EP08732834.0
申请日：2008-03-26
申请人： The University of Connecticut
发明人： PENG, Fei , XU, Zhi-Kang , WEI, Mei
IPC分类号： B32B5/00 , B82B1/00
CPC分类号： A61F2/02 , A61L27/46 , A61L27/48 , Y10T428/24124 , Y10T428/2924 , Y10T428/2927 , C08L67/04
摘要： An artificial bone composite structure is provided. This structure includes a fibrous matrix that itself includes a plurality of fibers. Also, the structure includes a plurality of hydroxyapatite (HA) particles. These particles are dispersed within the fibrous matrix. Also, the HA particles have controlled size and aspect ratios and are aligned along long axes of the fibers. In some instances, the fibers include poly-(L-lactic acid) (PLLA).
摘要翻译：提供人造骨复合结构。该结构包括本身包括多根纤维的纤维基质。此外，该结构包括多个羟基磷灰石（HA）颗粒。这些颗粒分散在纤维基质内。此外，HA颗粒具有受控的尺寸和纵横比并且沿着纤维的长轴对准。在一些情况下，纤维包括聚（L-乳酸）（PLLA）。

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