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71. 发明申请

WO2010129625A3 ENERGY STORAGE DEVICE WITH IMPROVED LEAD SULFATE SOLUBILITY 审中-公开
标题翻译：具有改善的铅硫酸溶解能力的储能装置
公开(公告)号：WO2010129625A3
公开(公告)日：2010-11-11
申请号：PCT/US2010/033647
申请日：2010-05-05
申请人： AXION POWER INTERNATIONAL, INC. , BUIEL, Edward , DICKINSON, Enders , WESTREICH, Philippe , SUN, Wei , ROMEO, Mike
发明人： BUIEL, Edward , DICKINSON, Enders , WESTREICH, Philippe , SUN, Wei , ROMEO, Mike
IPC分类号： H01M10/08 , H01M4/14 , H01M4/74 , B60L11/18 , H01M2/16
摘要： An energy storage device includes an electrode comprising lead, an electrode comprising lead dioxide, a separator between the lead and lead dioxide electrodes, and an aqueous solution electrolyte containing sulfuric acid. The sulfuric acid specific gravity when the energy device is fully charged is less than 1.25.
摘要翻译：能量存储装置包括包含铅的电极，包含二氧化铅的电极，铅和二氧化铅电极之间的隔离物以及包含硫酸的水溶液电解质。能量装置充满电时的硫酸比重小于1.25。

72. 发明申请

WO2010089900A1 METHOD, SYSTEM AND PROGRAM FOR DEADLINE CONSTRAINED TASK ADMISSION CONTROL AND SCHEDULING USING GENETIC APPROACH 审中-公开
标题翻译：方法，系统和程序，用于使用遗传方法进行约束任务控制和调度
公开(公告)号：WO2010089900A1
公开(公告)日：2010-08-12
申请号：PCT/JP2009/052355
申请日：2009-02-05
申请人： NEC CORPORATION , SUN, Wei
发明人： SUN, Wei
IPC分类号： G06F9/48 , G06N3/00
CPC分类号： G06F9/4881
摘要： Disclosed is an admission control and scheduling method of deadline constrained tasks. The method comprises: buffering new arriving tasks into a waiting queue; pre-scheduling a new task and a previously admitted task; producing multiple pre-schedules; using the most feasible pre-schedule as an executive schedule; and dispatching the tasks in the executive schedule. More tasks can be accepted in a short admission time, namely, a good trade off between high acceptance ratio and short admission time is obtained.
摘要翻译：公开了限期任务的准入控制和调度方法。该方法包括：将新的到达任务缓存到等待队列中; 预先安排新任务和以前承认的任务; 生产多个预先安排; 使用最可行的预先安排作为执行时间表; 并在执行时间表中分派任务。更多的任务可以在短时间内被接受，即获得高接受率和入场时间短的良好折衷。

73. 发明申请

WO2009023515A3 REACTORS AND METHODS FOR PROCESSING REACTANTS THEREIN 审中-公开
标题翻译：用于处理其中的反应物的反应器和方法
公开(公告)号：WO2009023515A3
公开(公告)日：2009-04-30
申请号：PCT/US2008072461
申请日：2008-08-07
申请人： LILLY CO ELI , BRADEN TIMOTHY MICHAEL , GONZALEZ MIGUEL ANGEL , JINES AMY REBECCA , JOHNSON MARTIN DAVID , SUN WEI-MING
发明人： BRADEN TIMOTHY MICHAEL , GONZALEZ MIGUEL ANGEL , JINES AMY REBECCA , JOHNSON MARTIN DAVID , SUN WEI-MING
IPC分类号： B01J19/00 , B01J8/00
CPC分类号： B01J19/1862 , B01J19/002 , B01J2219/00011 , B01J2219/0009 , B01J2219/00094 , B01J2219/00247 , B01J2219/00252 , B01J2219/0027
摘要： A reactor is provided and methods for its use provided to process reactants containing solids and/or reactants having an explosive potential. In order to prevent clogging, reactant feeds containing solids can be moved through the reactor without a mechanical pump and/or without forcing the slurry through a restricting orifice. An expansion chamber downstream from the reaction zone is provided to maintain a rapid gas expansion within the pressure limits of the reactor system. A variety of processes can be carried out in the preferred reactor. The processes include, but are not limited to reacting, polymerizing, crystallizing, re-crystallizing, mixing, emulsifying, isomerizing, purifying, digesting, and the like.
摘要翻译：提供反应器并提供其用于处理含有具有爆炸势的固体和/或反应物的反应物的方法。为了防止堵塞，含有固体的反应物进料可以在没有机械泵的情况下移动通过反应器和/或不迫使浆料通过限制孔。提供了从反应区下游的膨胀室，以保持在反应器系统的压力范围内的快速气体膨胀。可以在优选的反应器中进行各种方法。该方法包括但不限于反应，聚合，结晶，再结晶，混合，乳化，异构化，纯化，消化等。

74. 发明申请

WO2009023515A2 REACTORS AND METHODS FOR PROCESSING REACTANTS THEREIN 审中-公开
标题翻译：用于处理反应物的反应器和方法
公开(公告)号：WO2009023515A2
公开(公告)日：2009-02-19
申请号：PCT/US2008/072461
申请日：2008-08-07
申请人： ELI LILLY AND COMPANY , BRADEN, Timothy, Michael , GONZALEZ, Miguel, Angel , JINES, Amy, Rebecca , JOHNSON, Martin, David , SUN, Wei-Ming
发明人： BRADEN, Timothy, Michael , GONZALEZ, Miguel, Angel , JINES, Amy, Rebecca , JOHNSON, Martin, David , SUN, Wei-Ming
IPC分类号： B01J19/00 , B01J8/00
CPC分类号： B01J19/1862 , B01J19/002 , B01J2219/00011 , B01J2219/0009 , B01J2219/00094 , B01J2219/00247 , B01J2219/00252 , B01J2219/0027
摘要： A reactor is provided and methods for its use provided to process reactants containing solids and/or reactants having an explosive potential. In order to prevent clogging, reactant feeds containing solids can be moved through the reactor without a mechanical pump and/or without forcing the slurry through a restricting orifice. An expansion chamber downstream from the reaction zone is provided to maintain a rapid gas expansion within the pressure limits of the reactor system. A variety of processes can be carried out in the preferred reactor. The processes include, but are not limited to reacting, polymerizing, crystallizing, re-crystallizing, mixing, emulsifying, isomerizing, purifying, digesting, and the like.
摘要翻译：提供反应器及其使用方法以处理含有具有爆炸可能性的固体和/或反应物的反应物。为了防止堵塞，含有固体的反应物进料可以在没有机械泵的情况下移动通过反应器和/或不迫使浆液通过限制孔口。提供反应区下游的膨胀室以保持反应器系统压力极限内的快速气体膨胀。可以在优选的反应器中进行各种过程。该方法包括但不限于反应，聚合，结晶，重结晶，混合，乳化，异构化，纯化，消化等。

75. 发明申请

WO2008118752A3 SHORTENED PURIFICATION PROCESS FOR THE PRODUCTION OF CAPSULARSTREPTOCOCCUS PNEUMONIAE POLYSACCHARIDES 审中-公开
标题翻译：用于生产豌豆US US E E ES ES ES ES ES ES ES ES ES ES ES ES ES
公开(公告)号：WO2008118752A3
公开(公告)日：2008-11-20
申请号：PCT/US2008057688
申请日：2008-03-20
申请人： WYETH CORP , YUAN YONGHUI , RUPPEN MARK , SUN WEI-QIANG , CHU LING , SIMPSON JOHN , PATCH JAMES , FINK CHARBONNEAU PAMELA , MORAN JUSTIN K
发明人： YUAN YONGHUI , RUPPEN MARK , SUN WEI-QIANG , CHU LING , SIMPSON JOHN , PATCH JAMES , FINK CHARBONNEAU PAMELA , MORAN JUSTIN K
IPC分类号： C08B37/00 , A61K39/09 , A61K47/48
CPC分类号： A61K39/092 , A61K39/00 , A61K47/646 , A61K2039/6087 , A61K2039/62 , C07H1/08 , C08B37/00 , C08B37/0003 , C12P19/04
摘要： A shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular Streptococcus pneumoniae lysate broth is described. Ultrafiltering and diafiltering a clarified S. pneumoniae lysate followed by pH adjustment to less than 4.5, preferably about 3.5, precipitated at least 98% of the protein in the solution without seriously affecting polysaccharide yield. Furthermore, following ultrafiltration and diafiltration and acidification to a pH of less than 4.5, filtration using activated carbon precipitated at least 90% of remaining protein without seriously affecting polysaccharide yield. Exemplary, non-limiting S. pneumoniae serotypes that can be purified using the shortened process of the invention are 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In one embodiment, the Streptococcus pneumoniae cells are lysed using deoxycholate sodium (DOC), while in another embodiment the lytic agent is a non-animal derived lytic agent such as N-lauryl sarcosine sodium (NLS).
摘要翻译：描述了从细胞性肺炎链球菌裂解液肉汤制备含有基本上纯化的荚膜多糖的溶液的缩短方法。超滤并透析澄清的肺炎链球菌裂解物，然后pH调节至小于4.5，优选约3.5，在溶液中沉淀至少98％的蛋白质，而不会严重影响多糖产量。此外，在超滤和渗滤并酸化至pH小于4.5之后，使用活性炭过滤沉淀至少90％的剩余蛋白质，而不会严重影响多糖产率。可以使用本发明的缩短方法纯化的示例性非限制性肺炎链球菌血清型是1,4,5,6A，6B，7F，9V，14,18C，19A，19F和23F。在一个实施方案中，使用脱氧胆酸钠（DOC）裂解肺炎链球菌细胞，而在另一个实施方案中，溶解剂是非动物来源的溶解剂，例如N-月桂基肌氨酸钠（NLS）。

76. 发明申请

WO2008118752A2 SHORTENED PURIFICATION PROCESS FOR THE PRODUCTION OF CAPSULARSTREPTOCOCCUS PNEUMONIAE POLYSACCHARIDES 审中-公开
标题翻译：生产皮下白细胞肺炎多糖的缩短纯化工艺
公开(公告)号：WO2008118752A2
公开(公告)日：2008-10-02
申请号：PCT/US2008/057688
申请日：2008-03-20
申请人： WYETH , YUAN, Yonghui , RUPPEN, Mark , SUN, Wei-Qiang , CHU, Ling , SIMPSON, John , PATCH, James , FINK CHARBONNEAU, Pamela , MORAN, Justin, K.
发明人： YUAN, Yonghui , RUPPEN, Mark , SUN, Wei-Qiang , CHU, Ling , SIMPSON, John , PATCH, James , FINK CHARBONNEAU, Pamela , MORAN, Justin, K.
IPC分类号： C08B37/00 , A61K47/48 , A61K39/09
CPC分类号： A61K39/092 , A61K39/00 , A61K47/646 , A61K2039/6087 , A61K2039/62 , C07H1/08 , C08B37/00 , C08B37/0003 , C12P19/04
摘要： A shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular Streptococcus pneumoniae lysate broth is described. Ultrafiltering and diafiltering a clarified S. pneumoniae lysate followed by pH adjustment to less than 4.5, preferably about 3.5, precipitated at least 98% of the protein in the solution without seriously affecting polysaccharide yield. Furthermore, following ultrafiltration and diafiltration and acidification to a pH of less than 4.5, filtration using activated carbon precipitated at least 90% of remaining protein without seriously affecting polysaccharide yield. Exemplary, non-limiting S. pneumoniae serotypes that can be purified using the shortened process of the invention are 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In one embodiment, the Streptococcus pneumoniae cells are lysed using deoxycholate sodium (DOC), while in another embodiment the lytic agent is a non-animal derived lytic agent such as N-lauryl sarcosine sodium (NLS).
摘要翻译：描述了从细胞肺炎链球菌溶胞产物培养液制备含有基本上纯化的荚膜多糖的溶液的缩短方法。将澄清的肺炎链球菌裂解物超滤和渗滤，然后将pH调节至小于4.5，优选约3.5，在溶液中沉淀至少98％的蛋白质，而不会严重影响多糖产量。此外，在超滤和渗滤以及酸化至pH小于4.5之后，使用活性炭过滤沉淀至少90％的剩余蛋白质，而不会严重影响多糖产量。可以使用本发明的缩短的方法纯化的示例性，非限制性的肺炎链球菌血清型是1，图4，图5，图6A，6B，7F，9V，14，18C，19A，19F和23F。在一个实施方案中，肺炎链球菌细胞使用脱氧胆酸钠（DOC）裂解，而在另一实施例中的裂解剂为来源的溶解剂，例如N-月桂基肌氨酸钠（NLS）。非动物

77. 发明申请

WO2008098056A2 HIGH RELAXIVITY CHELATES 审中-公开
标题翻译：高度放松的螯合物
公开(公告)号：WO2008098056A2
公开(公告)日：2008-08-14
申请号：PCT/US2008053186
申请日：2008-02-06
申请人： EPIX PHARM INC , BAYER SCHERING PHARMA AG , CARAVAN PETER D , JACQUES VINCENT , DUMAS STEPHANE , SUN WEI-CHUAN , ZHOU KEVIN L , SCHMITT-WILLICH HERIBERT
发明人： CARAVAN PETER D , JACQUES VINCENT , DUMAS STEPHANE , SUN WEI-CHUAN , ZHOU KEVIN L , SCHMITT-WILLICH HERIBERT
CPC分类号： C07F9/6524 , A61K49/085 , A61K49/10 , A61K49/14 , C07D257/02 , C07F9/12 , C07F9/242 , C07F9/65583 , C07F9/6561
摘要： This disclosure relates to metal chelating ligands, and more particularly to metal chelating ligands having high relaxivity when in a metal chelate form.
摘要翻译：本公开涉及金属螯合配体，并且更具体地涉及当处于金属螯合物形式时具有高弛豫度的金属螯合配体。

78. 发明申请

WO2008057765A3 CELL ASSEMBLY FOR AN ENERGY STORAGE DEVICE USING PTFE BINDER IN ACTIVATED CARBON ELECTRODES 审中-公开
公开(公告)号：WO2008057765A3
公开(公告)日：2008-05-15
申请号：PCT/US2007/082347
申请日：2007-10-24
申请人： AXION POWER INTERNATIONAL, INC. , BUIEL, Edward , ESHKENAZI, Victor , RABINOVICH, Leonid , VICHNYAKOV, Vladimir , SWIECKI, Adam , SUN, Wei , COLE, Joseph
发明人： BUIEL, Edward , ESHKENAZI, Victor , RABINOVICH, Leonid , VICHNYAKOV, Vladimir , SWIECKI, Adam , SUN, Wei , COLE, Joseph
IPC分类号： H01M10/04 , H01G9/058
摘要： A hybrid supercapacitor energy storage device comprises at least one lead electrode, at least one carbon electrode, a separator, a casing, and an acid electrolyte. The lead electrode is enveloped in a common glass mat separator known in the lead-acid battery industry. The carbon electrode comprises a highly conductive current collector which is a sheet or other metal material sandwiched between two sheets of electronically conductive shield material. Activated carbon is manufactured using a binder such as polyethylene or PTFE adhered to and in electrical contact with the shield material of the current collector.

79. 发明申请

WO2008005865A1 ORTHOSIS AND METHOD OF USE FOR TREATMENT AND REHABILITATION OF DROPFOOT 审中-公开
标题翻译：用于治疗和康复DROPFOOT的治疗方法和方法
公开(公告)号：WO2008005865A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/072535
申请日：2007-06-29
申请人： DREXEL UNIVERSITY , SIEGLER, Sorin , HRABAN, Brett, W. , LA MONTAGNE, Elizabeth , MELES, Joshua , SUN, Wei
发明人： SIEGLER, Sorin , HRABAN, Brett, W. , LA MONTAGNE, Elizabeth , MELES, Joshua , SUN, Wei
IPC分类号： A61F2/72 , A61F2/68 , A61F2/66
CPC分类号： A61F5/0127 , A61B5/1036 , A61B5/4519 , A61B5/4528 , A61H3/00 , A61N1/36003
摘要： A functional electrical stimulation brace responsive to various positions of an intended wearer's foot. The device includes a plurality of sensors positioned at different locations under the intended wearer's foot to detect the current position of the foot. Outputs from the sensors are fed to a controller that uses logic to activate an electrical stimulation unit that stimulates the peroneal muscles of a patient at the appropriate times during the patient's gait. The device may also employ mechanical stabilization of the ankle in addition to the functional electrical stimulation by means of an ankle foot orthosis with a variable resistance hinge. The electrodes are embedded in fixed locations in the brace upper portion so that optimal location of the electrodes relative to the peroneal muscles is maintained every time the device is applied. Also provided is a method for assistance and rehabilitation for a patient by electrical stimulation of the peroneal muscles. In the method, the position of the foot is detected and the peroneal muscles are stimulated responsive to particular positions of the patient's foot in order to activate the muscles at the appropriate times during the patient's gait. The device also provides lateral and torsional stability by means of the ankle-foot orthosis.
摘要翻译：一种功能性电刺激支架，其响应于预期佩戴者的脚的各种位置。该装置包括位于目标佩戴者脚下的不同位置处的多个传感器，以检测脚的当前位置。来自传感器的输出被馈送到控制器，该控制器使用逻辑来激活在患者的步态中适当的时间刺激患者的腓骨肌肉的电刺激单元。除了通过具有可变电阻铰链的踝足矫形器的功能性电刺激之外，该装置还可以采用脚踝的机械稳定。电极被嵌入在支架上部中的固定位置，使得每次施加装置时都保持电极相对于腓骨肌肉的最佳位置。还提供了一种通过电刺激腓骨肌肉来为患者进行辅助和康复的方法。在该方法中，检测脚的位置，并且响应于患者脚的特定位置刺激腓骨肌肉，以便在患者的步态期间适当的时间激活肌肉。该装置还通过踝足矫形器提供横向和扭转稳定性。

80. 发明申请

WO2005005651A2 T CELL RECEPTOR SEQUENCE AND METHOD FOR DETECTING AND TREATING RHEUMATOID ARTHRITIS 审中-公开
标题翻译： T细胞受体序列和检测和治疗类风湿性关节炎的方法
公开(公告)号：WO2005005651A2
公开(公告)日：2005-01-20
申请号：PCT/US2004/021096
申请日：2004-06-30
申请人： MAXX GENETECH CO., LTD. , ZHANG, Jingwu, Z. , HO, Walter, Kowk, Keung , ZHANG, Dongqing , SUN, Wei
发明人： ZHANG, Jingwu, Z. , HO, Walter, Kowk, Keung , ZHANG, Dongqing , SUN, Wei
IPC分类号： C12Q
CPC分类号： C07K14/7051 , A61K39/0008 , A61K2039/53 , A61K2039/54 , C07H21/04
摘要： A substantially pure and isolated DNA fragment having a nucleic acid sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2, and a substantially pure peptide having an amino acid sequence selected from the group consisting of SEQ ID NO. 3, SLS, SEQ ID NO. 4, SQD, SLL, SEQ ID NO. 5, SEQ ID NO. 169 and SEQ ID NO. 170 are provided. Also provided are vaccines, antibodies and pharmaceutical compositions generated from at least one of the DNA fragments and/or peptides. Further provided are methods for detecting and/or treating rheumatoid arthritis.
摘要翻译：具有如SEQ ID NO.2所示的核酸序列的基本上纯的且分离的DNA片段。 1或SEQ ID NO。 2和具有选自SEQ ID NO.2的氨基酸序列的基本上纯的肽。 3，SLS，SEQ ID NO。 4，SQD，SLL，SEQ ID NO。 5，SEQ ID NO。 169和SEQ ID NO。 170提供。还提供了由至少一种DNA片段和/或肽产生的疫苗，抗体和药物组合物。还提供了用于检测和/或治疗类风湿性关节炎的方法。

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