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71. 发明申请

US20100152802A1 System and Method for Monitoring Patient Condition Using Atrial Timing Characteristics 有权
标题翻译：使用心房定时特征监测患者状况的系统和方法
公开(公告)号：US20100152802A1
公开(公告)日：2010-06-17
申请号：US12333176
申请日：2008-12-11
申请人： Xiaoyi Min
发明人： Xiaoyi Min
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/37 , A61B5/0452 , A61N1/3627 , A61N1/368
摘要： A system and method for using an implantable cardiac stimulation device to monitor a patient for the progress of an existing condition and/or early detection of an emerging condition based, at least in part, on measuring and evaluating the timing characteristics of the patient's atrial activity. The atrial timing characteristics are used as indicators or predictors of conditions of interest, such as heart failure (HF) and atrial fibrillation (AF). In certain implementations, the system can determine discriminating indicators of a predominant underlying cause of a condition, such as between vagal and non-vagal AF, as an indicator of a suggested therapy. The system can store data corresponding to the observed atrial timing for trending analysis as well as transmit data for offline analysis, such as via an external device.
摘要翻译：一种系统和方法，用于至少部分地基于测量和评估患者心房活动的时间特征来使用可植入心脏刺激装置来监测患者现有病症的进展和/或新出现的病症的早期检测。心房时间特征被用作心脏衰竭（HF）和房颤（AF）等感兴趣条件的指标或预测指标。在某些实施方案中，系统可以确定病症的主要潜在原因（例如迷走神经与非迷走神经AF之间）的鉴别指标，作为建议治疗的指标。系统可以存储对应于观察到的心房定时的数据，用于趋势分析，以及用于离线分析的传输数据，例如通过外部设备。

72. 发明申请

US20100121401A1 OPTIMIZATION OF CARDIAC PACING THERAPY BASED ON PACED PROPAGATION DELAY 有权
标题翻译：基于PACED传播延迟的心脏瓣膜治疗优化
公开(公告)号：US20100121401A1
公开(公告)日：2010-05-13
申请号：US12267390
申请日：2008-11-07
申请人： Xiaoyi Min , Stuart O. Schecter
发明人： Xiaoyi Min , Stuart O. Schecter
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/3702
摘要： An exemplary method includes delivering stimulation energy via a right ventricular site; sensing an evoked response caused by the delivered stimulation energy at the right ventricular site; calculating a paced propagation delay for the right ventricular site (PPDRV); delivering stimulation energy via a left ventricular site; sensing an evoked response caused by the delivered stimulation energy at the left ventricular site; calculating a paced propagation delay for the left ventricular site (PPDLV); and determining an interventricular delay time (VV) for delivery of a bi-ventricular pacing therapy based in part on the paced propagation delay for the right ventricular site (PPDRV) and the paced propagation delay for the left ventricular site (PPDLV). Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括经由右心室部位递送刺激能量; 感测由右心室位置传递的刺激能量引起的诱发反应; 计算右心室位点（PPDRV）的节奏传播延迟; 通过左心室部位传递刺激能量; 感测由左心室部位传递的刺激能量引起的诱发反应; 计算左心室位点（PPDLV）的节奏传播延迟; 以及部分地基于右心室部位（PPDRV）的节奏传播延迟和左心室部位（PPDLV）的起搏传播延迟来确定用于递送双心室起搏治疗的室间延迟时间（VV）。还公开了其它示例性方法，装置，系统等。

73. 发明申请

US20100121179A1 Systems and Methods for Reducing RF Power or Adjusting Flip Angles During an MRI for Patients with Implantable Medical Devices 审中-公开
标题翻译：用于降低射频功率的系统和方法或在可植入医疗器械的患者的MRI期间调整翻转角度
公开(公告)号：US20100121179A1
公开(公告)日：2010-05-13
申请号：US12270768
申请日：2008-11-13
申请人： Xiaoyi Min
发明人： Xiaoyi Min
IPC分类号： A61B5/055
CPC分类号： G01R33/583 , G01R33/288
摘要： Techniques are provided for controlling magnetic resonance imaging (MRI) systems for imaging patients having implantable medical devices. In one example, a scaling factor is determined based on maximum local specific absorption rate (SAR) values for patients with implants and for patients without implants. The MRI determines the radio-frequency (RF) power and flip angle sequences to be used for a given patient, without regard to the presence of an implanted device. However, for patients with implanted devices, the MRI reduces its RF power or adjusts its flip angle sequences based on the scaling factor so as to ensure that the local SAR within the patient does not exceed acceptable levels. In other examples, rather than reducing the RF power of the MRI or adjusting the flip angles, blankets or pads formed of RF power attenuating materials, such as dielectrics, are positioned around the patient near the implantable device, to reduce the RF power incident tissues adjacent the device.
摘要翻译：提供了用于控制用于成像具有可植入医疗装置的患者的磁共振成像（MRI）系统的技术。在一个实例中，根据植入物患者和没有植入物的患者的最大局部比吸收率（SAR）值确定比例因子。 MRI确定用于给定患者的射频（RF）功率和翻转角序列，而不考虑植入装置的存在。然而，对于具有植入装置的患者，MRI降低其RF功率或基于比例因子来调整其翻转角序列，以确保患者内的局部SAR不超过可接受的水平。在其他示例中，不是降低MRI的RF功率或调整翻转角度，由RF功率衰减材料（例如电介质）形成的毯子或垫片位于可植入装置附近的患者周围，以减少RF功率入射组织相邻设备。

74. 发明申请

US20100113944A1 INTERPOLATING LEFT VENTRICULAR PRESSURES 有权
标题翻译：插入左心室压力
公开(公告)号：US20100113944A1
公开(公告)日：2010-05-06
申请号：US12266420
申请日：2008-11-06
申请人： Xiaoyi Min , Gene A. Bornzin
发明人： Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61B5/022 , A61B5/021 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/6846
摘要： Exemplary techniques and systems for interpolating left ventricular pressures are described. One technique interpolates pressures within the left ventricle from blood pressures gathered without directly sensing blood pressure in the left ventricle.
摘要翻译：描述用于内插左心室压力的示例性技术和系统。一种技术是从左心室内血压内插压力而不直接感测左心室的血压。

75. 发明申请

US20100106214A1 Systems and Methods for Exploiting the Tip or Ring Conductor of an Implantable Medical Device Lead During an MRI to Reduce Lead Heating and the Risks of MRI-Induced Stimulation 有权
标题翻译：在MRI中减少引线加热和MRI诱导刺激的风险的可植入医疗器械引线尖端或环形导体的系统和方法
公开(公告)号：US20100106214A1
公开(公告)日：2010-04-29
申请号：US12257263
申请日：2008-10-23
申请人： Xiaoyi Min
发明人： Xiaoyi Min
IPC分类号： A61N1/372 , A61N1/05
CPC分类号： A61N1/056 , A61N1/086 , A61N1/37 , A61N1/3718
摘要： Systems and methods are provided for reducing heating within pacing/sensing leads of a pacemaker or implantable cardioverter-defibrillator that occurs due to induced radio frequency (RF) currents during a magnetic resonance imaging (MRI) procedure, or in the presence of other sources of strong RF fields. For example, bipolar coaxial leads are described wherein the ring conductor of the lead is disconnected from the ring electrode via a switch in response to detection of MRI fields to convert the ring conductor into an RF shield for shielding the inner tip conductor of the lead so as to reduce the strength of RF currents induced therein and hence reduce tip heating. Other exemplary leads are described wherein a band stop filter is instead used to block RF signals to likewise convert the ring conductor into an RF shield. The switches and band stop filters also help to prevent MRI-induced stimulation.
摘要翻译：提供的系统和方法用于减少在磁共振成像（MRI）程序期间由于感应射频（RF）电流或存在其他来源的心脏起搏器或植入式心律转复除颤器的起搏/感测引线内的加热强射频场。例如，描述了双极同轴引线，其中响应于MRI场的检测，引线的环形导体经由开关与环形电极断开，以将环形导体转换成用于屏蔽引线的内部末端导体的RF屏蔽以降低在其中感应的RF电流的强度，从而减少尖端加热。描述了其它示例性引线，其中代替使用带阻滤波器来阻止RF信号以同样将环形导体转换成RF屏蔽。开关和带阻滤波器也有助于防止MRI诱发的刺激。

76. 发明申请

US20100069768A1 USE OF CARDIOHEMIC VIBRATION FOR PACING THERAPIES 有权
标题翻译：用于治疗的心脏震颤的使用
公开(公告)号：US20100069768A1
公开(公告)日：2010-03-18
申请号：US12211760
申请日：2008-09-16
申请人： Xiaoyi Min , Gene A. Bornzin , Jay Snell , Josh Reiss
发明人： Xiaoyi Min , Gene A. Bornzin , Jay Snell , Josh Reiss
IPC分类号： A61B5/02
CPC分类号： A61N1/365 , A61B5/0215 , A61B5/026 , A61B7/023 , A61B8/08 , A61B2562/0219 , A61N1/3627 , A61N1/36578
摘要： An exemplary method includes receiving a signal from an intrathoracic vibration sensor, analyzing the signal for vibration associated with deceleration of blood flow into the left ventricle, based at least in part on the analyzing, deciding whether to call for adjustment to one or more parameters of a bi-ventricular pacing therapy. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括从胸腔内振动传感器接收信号，至少部分地基于分析来分析与进入左心室的血流减速相关的振动信号，决定是否要调整一个或多个参数双心室起搏治疗。还公开了其它示例性方法，装置，系统等。

77. 发明授权

US07668593B1 System and method to accelerate individualized gain adjustment in implantable medical device systems 有权
标题翻译：用于加速植入式医疗设备系统中个体化增益调整的系统和方法
公开(公告)号：US07668593B1
公开(公告)日：2010-02-23
申请号：US11694534
申请日：2007-03-30
申请人： Xing Pei , Xiaoyi Min
发明人： Xing Pei , Xiaoyi Min
IPC分类号： A61N1/36
CPC分类号： A61N1/3704 , A61B5/0452 , A61N1/3622 , A61N1/368
摘要： A system and method for increasing the speed of individualizing amplifier gain optimization in implantable medical devices. A variable amplifier gain is initially set at a relatively high level such that the amplifier experiences at least intervals of saturation. A saturation indicator is determined which is indicative of the relative degree of saturation. The gain is then adjusted as a function of the saturation indicator. Relative larger degrees of saturation result in more aggressive gain adjustment. This increases the speed of adjustment with reduced likelihood of loss of sensing. In one implementation, one or more discrete amplifier gain adjustment steps are made in a single adjustment to effectively skip over intermediate adjustments. In another implementation, an estimate is made of a signal peak during a saturating interval. The gain is adjusted directly based on the estimated peak with appropriate sensing safety margins. The method can be implemented with a system including a programmer in communication with an implantable device.
摘要翻译：一种用于提高可植入医疗设备中个性化放大器增益优化的速度的系统和方法。可变放大器增益最初设置在相对高的电平，使得放大器经历至少饱和的间隔。确定饱和指示符，其表示相对饱和度。然后根据饱和指标调整增益。相对较大的饱和度导致更积极的增益调整。这增加了调节速度，减少了感测丢失的可能性。在一个实现中，在单个调整中进行一个或多个离散放大器增益调整步骤以有效跳过中间调整。在另一实现中，在饱和间隔期间估计信号峰值。基于具有适当感应安全裕度的估计峰值直接调整增益。该方法可以利用包括与可植入装置通信的编程器的系统来实现。

78. 发明授权

US07437192B2 System and method for detecting heart failure and pulmonary edema based on ventricular end-diastolic pressure using an implantable medical device 有权
标题翻译：基于使用可植入医疗装置的心室舒张末期压力来检测心力衰竭和肺水肿的系统和方法
公开(公告)号：US07437192B2
公开(公告)日：2008-10-14
申请号：US11100008
申请日：2005-04-05
申请人： Jong Gill , Xiaoyi Min
发明人： Jong Gill , Xiaoyi Min
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61N1/3627 , A61N1/36521
摘要： Techniques are provided for detecting left ventricular end diastolic pressure (LV EDP) using a pressure sensor implanted within the heart of a patient and for detecting and evaluating heart failure and pulmonary edema based on LV EDP. Briefly, the peak of the R-wave of an intracardiac electrogram (IEGM) is used to trigger the measurement of a pressure value within the left ventricle. This pressure value is deemed to be representative of LV EDP. In this manner, LV EDP is easily detected merely by measuring pressure at one point within the heartbeat—thereby eliminating any need to track ventricular pressure throughout the heartbeat. Techniques for detecting and evaluating heart failure and pulmonary edema based on the R-wave triggered LV EDP measurements are also set forth herein.
摘要翻译：提供了使用植入患者心脏内的压力传感器来检测左心室舒张压（LV EDP）的技术，并且用于基于LV EDP检测和评估心脏衰竭和肺水肿。简而言之，使用心内电描记图（IEGM）的R波的峰值来触发左心室内的压力值的测量。该压力值被认为是LV EDP的代表。以这种方式，仅通过测量心跳内的一点的压力来容易地检测LV EDP，从而消除了跟踪整个心跳期间的心室压力的任何需要。本文还介绍了基于R波触发的LV EDP测量来检测和评估心脏衰竭和肺水肿的技术。

79. 发明申请

US20080215127A1 Medical Electrical Lead Providing Far-Field Signal Attenuation 审中-公开
标题翻译：医疗电气铅提供远场信号衰减
公开(公告)号：US20080215127A1
公开(公告)日：2008-09-04
申请号：US12122458
申请日：2008-05-16
申请人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
发明人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573
摘要： A bipolar pacing and sensing lead incorporates a range of active surface areas for each of the anode and cathode electrodes, and a range of inter-electrode spacings between the anode and cathode electrodes which, in combination, provide acceptable near-field signal amplitudes and attenuate the amplitudes of unwanted signals, such as far-field R-waves, far-field P-waves, and T-waves.
摘要翻译：双极起搏和感测引线包括用于阳极和阴极电极中的每一个的一系列活性表面积，以及阳极和阴极电极之间的一系列电极间间隔，其组合提供可接受的近场信号幅度并衰减不想要的信号的幅度，例如远场R波，远场P波和T波。

80. 发明申请

US20080086177A1 System and Related Methods for Monitoring Cardiac Disease Using Pacing Latency Measurements 审中-公开
标题翻译：使用起搏延迟测量监测心脏疾病的系统和相关方法
公开(公告)号：US20080086177A1
公开(公告)日：2008-04-10
申请号：US11539824
申请日：2006-10-09
申请人： Xiaoyi Min , Paul A. Levine , Jong Gill
发明人： Xiaoyi Min , Paul A. Levine , Jong Gill
IPC分类号： A61N1/365
CPC分类号： A61N1/37 , A61B5/0452 , A61B5/0809 , A61B5/091 , A61B5/11 , A61N1/3621 , A61N1/3627
摘要： A system and related methods for monitoring cardiac disease. The system includes an implantable medical device having a microcontroller that is configured to measure a pacing latency value for a region of a heart, compare the measured pacing latency value to a previously measured pacing latency value for the region of the heart, and determine a change in an amount of cardiac disease in the region of the heart based on the comparison of the measured pacing latency values.
摘要翻译：用于监测心脏病的系统和相关方法。该系统包括具有微控制器的可植入医疗装置，微控制器被配置为测量心脏区域的起搏延迟值，将测量的起搏延迟值与心脏区域的先前测量的起搏延迟值进行比较，并确定改变基于测量的起搏延迟值的比较，在心脏区域中的心脏病的量。

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