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71. 发明专利

ID24444A 未知
公开(公告)号：ID24444A
公开(公告)日：2000-07-20
申请号：ID20000163
申请日：1998-07-03
申请人： AJINOMOTO KK
发明人： KIMURA EIICHIRO , YAGOSHI CHIZU , NAKAMURA JUN , OSUMI TSUYOSHI , NAKAMATSU TSUYOSHI
IPC分类号： C07K14/345 , C12N1/21 , C12N15/31 , C12P13/08 , C12P13/14

72. 发明专利

AU1687700A Sugar transporter and gene encoding the same 未知
公开(公告)号：AU1687700A
公开(公告)日：2000-07-12
申请号：AU1687700
申请日：1999-12-16
申请人： AJINOMOTO KK
发明人： KANNO SOHEI , KIMURA EIICHIRO , MATSUI KAZUHIKO , NAKAMATSU TSUYOSHI
IPC分类号： C12N15/09 , C07K14/345 , C12N9/88 , C12N15/31

73. 发明专利

PE20000177A1 GEN dtsR TERMOSENSIBLE 未知
公开(公告)号：PE20000177A1
公开(公告)日：2000-02-29
申请号：PE00060598
申请日：1998-07-09
申请人： AJINOMOTO KK
发明人： YAGOSHI CHIZU , NAKAMURA JUN , KIMURA EIICHIRO , NAKAMATSU TSUYOSHI , OSUMI TSUYOSHI
IPC分类号： C07K14/345 , C12N1/21 , C12N15/31 , C12P13/08 , C12P13/14
摘要： SE REFIERE A UN GEN dtsR TERMOSENSIBLE QUE CODIFICA a)UNA SECUENCIA DE AMINOACIDOS (2047), O UNA SECUENCIA DE AMINOACIDOS (543) EN LA QUE EL RESIDUO LEUCINA EN LA POSICION 139 SE CAMBIA CON PROLINA, TENIENDO ESTA PROTEINA UNA ACTIVIDAD DTSR TERMOSENSIBLE; b)UNA SECUENCIA DE AMINOACIDOS DISTINTO QUE COMPRENDE SUSTITUCION, SUPRESION, INSERCION, ADICION O INVERSION DE UNO O VARIOS AMINOACIDOS DISTINTOS AL RESIDUO DE AMINOACIDOS EN LA POSICION 139 EN LA SECUENCIA DE AMINOACIDOS; O EL RESIDUO DE LEUCINA EN LA POSICION 139 SE CAMBIA A UN RESIDUO DE AMINOACIDO DISTINTO AL RESIDUO DE PROLINA, TENIENDO ESTA PROTEINA UNA ACTIVIDAD DTSR TERMOSENSIBLE. TAMBIEN SE REFIERE A UN ADN QUE SE HIBRIDIZA A LA SECUENCIA NUCLEOTIDICA DE NUMEROS DE BASE 359-1987. TAMBIEN SE REFIERE A UNA BACTERIA CORINEFORME QUE NO TIENE UNA PROTEINA DTSR DE TIPO NATURAL Y TENIENDO CAPACIDAD PARA PRODUCIR ACIDO L-GLUTAMICO, ADEMAS TIENE CAPACIDAD PARA PRODUCIR L-LISINA. UN METODO PARA PRODUCIR ACIDO L-GLUTAMICO Y/O L-LISINA QUE COMPRENDE CULTIVAR LA BACTERIA CORINEFORME EN UN MEDIO LIQUIDO PARA PRODUCIR Y ACUMULAR ACIDO L-GLUTAMICO Y/O L-LISINA EN EL MEDIO, RECOLECTAR EL ACIDO L-GLUTAMICO Y/O L-LISINA DESDE EL MEDIO

74. 发明专利

BR9508730A 未知
公开(公告)号：BR9508730A
公开(公告)日：1997-10-21
申请号：BR9508730
申请日：1995-08-09
申请人： AJINOMOTO KK
发明人： KIMURA EIICHIRO , ASAKURA YOKO , UEHARA AKINORI , INOUE SUMIO , KAWAHARA YOSHIO , YOSHIHARA YASUHIKO , NAKAMATSU TSUYOSHI
IPC分类号： C12N1/21 , C12N15/09 , C12P13/08 , C12P13/14

75. 发明专利

ES2335828T3 BACTERIAS CORINEFORMES PARA PRODUCIR L-GLU. 未知
公开(公告)号：ES2335828T3
公开(公告)日：2010-04-05
申请号：ES99944770
申请日：1999-09-22
申请人： AJINOMOTO KK
发明人： ASAKURA YOKO , NAKAMURA JUN , KANNO SOHEI , SUGA MIKIKO , KIMURA EIICHIRO , ITO HISAO
IPC分类号： C12N15/37 , C12P13/14 , C12N1/21 , C12N15/67 , C12P13/04
摘要： Un método de producción de ácido L-glutámico, que comprende la etapa de cultivar una bacteria corineforme que expresa una enzima codificada por un gen que biosintetiza ácido L-glutámico, seleccionada entre el grupo que consiste en glutamato deshidrogenasa (GDH), citrato sintasa (CS), isocitrato deshidrogenasa (ICDH), piruvato deshidrogenasa (PDH) y aconitasa (ACO), y en el que una secuencia del promotor de dicho gen que biosintetiza ácido L-glutámico, situada sobre un cromosoma de la bacteria, contiene por lo menos una secuencia seleccionada entre el grupo que consiste en i) una secuencia TTGTCA, TTGACA o TTGCCA en la región -35 de la secuencia del promotor; ii) la secuencia TATAAT en la región -10 de la secuencia del promotor; y iii) una combinación de (i) y (ii).

76. 发明专利

DE60043464D1 未知
公开(公告)号：DE60043464D1
公开(公告)日：2010-01-14
申请号：DE60043464
申请日：2000-10-04
申请人： AJINOMOTO KK
发明人： HIRANO SEIKO , NONAKA GEN , MATSUZAKI YUMI , AKIYOSHI NAOKI , NAKAMURA KANAE , KIMURA EIICHIRO , OSUMI TSUYOSHI , MATSUI KAZUHIKO , KAWAHARA YOSHIO , KURAHASHI OSAMU , NAKAMATSU TSUYOSHI , SUGIMOTO SHINICHI
IPC分类号： C12N15/60 , C07K14/34 , C12N9/02 , C12N9/04 , C12N9/12 , C12N9/26 , C12N9/88 , C12N15/31 , C12N15/53 , C12N15/54 , C12N15/56
摘要： A plurality of primer sets are designed based on a region where conservation at the amino acid level is observed among various microorganisms for known gene sequences corresponding to a gene coding for an enzyme of the L-amino acid biosynthetic pathway derived from Corynebacterium thermoaminogenes, preferably an enzyme that functions at a higher temperature compared with that of Corynebacterium glutamicum. PCR is performed by using the primers and chromosomal DNA of Corynebacterium thermoaminogenes as a template. The primers with which an amplification fragment has been obtained are used as primers for screening to select a clone containing a target DNA fragment from a plasmid library of chromosomal DNA of Corynebacterium thermoaminogenes.

77. 发明专利

DE69941594D1 未知
公开(公告)号：DE69941594D1
公开(公告)日：2009-12-10
申请号：DE69941594
申请日：1999-09-22
申请人： AJINOMOTO KK
发明人： ASAKURA YOKO , NAKAMURA JUN , KANNO SOHEI , SUGA MIKIKO , KIMURA EIICHIRO , ITO HISAO , MATSUI KAZUHIKO , OHSUMI TSUYOSHI , NAKAMATSU TSUYOSHI , KURAHASHI OSAMU
IPC分类号： C12N15/37 , C12N15/67 , C12N1/21 , C12P13/04 , C12P13/14
摘要： A method of producing coryneform bacteria having an improved amino acid-or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on a chromosome of a coryneform bacterium to make it dose to a consensus sequence or introducing a change in a promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on a chromosome of a coryneform bacterium by gene recombination to make it close to a consensus sequence, to obtain mutants of the coryneform amino acid- or nucleic acid-producing microorganism, culturing the mutants and select a mutant capable of producing the intended amino acid or nucleic acid in a large amount. This method can construct a mutant capable of suitably enriching or controling the expression of an intended gene without using a plasmid and also capable of producing amino acids in a high yield, by the recombination or mutation.

78. 发明专利

DE60038967D1 GEN FÜR EIN THERMOPHILES ENZYM DES AMINOSÄUREBIOSYNTHESE-SYSTEMS UND THERMOTOLERANTES CORYNEFORMES BAKTERIUM 未知
公开(公告)号：DE60038967D1
公开(公告)日：2008-07-03
申请号：DE60038967
申请日：2000-10-04
申请人： AJINOMOTO KK
发明人： HIRANO SEIKO , NONAKA GEN , MATSUZAKI YUMI , AKIYOSHI NAOKI , NAKAMURA KANAE , KIMURA EIICHIRO , OSUMI TSUYOSHI , MATSUI KAZUHIKO , KAWAHARA YOSHIO , KURAHASHI OSAMU , NAKAMATSU TSUYOSHI , SUGIMOTO SHINICHI
IPC分类号： C12N15/60 , C07K14/34 , C12N9/02 , C12N9/04 , C12N9/12 , C12N9/26 , C12N9/88 , C12N15/31 , C12N15/53 , C12N15/54 , C12N15/56 , C12P13/04
摘要： A plurality of primer sets are designed based on a region where conservation at the amino acid level is observed among various microorganisms for known gene sequences corresponding to a gene coding for an enzyme of the L-amino acid biosynthetic pathway derived from Corynebacterium thermoaminogenes, preferably an enzyme that functions at a higher temperature compared with that of Corynebacterium glutamicum. PCR is performed by using the primers and chromosomal DNA of Corynebacterium thermoaminogenes as a template. The primers with which an amplification fragment has been obtained are used as primers for screening to select a clone containing a target DNA fragment from a plasmid library of chromosomal DNA of Corynebacterium thermoaminogenes.

79. 发明专利

HU225541B1 PROCESS FOR PRODUCING L-AMINO ACIDS BY FERMENTATION AND AMINO ACID-PRODUCING BACTERIUM STRAINS 未知
公开(公告)号：HU225541B1
公开(公告)日：2007-03-28
申请号：HU0100045
申请日：1999-09-22
申请人： AJINOMOTO KK
发明人： ASAKURA YOKO , NAKAMURA JUN , KANNO SOHEI , SUGA MIKIKO , KIMURA EIICHIRO , ITO HISAO , MATSUI KAZUHIKO , NAKAMATSU TSUYOSHI , KURAHASHI OSAMU , OHSUMI TSUYOSHI
IPC分类号： C12N15/37 , C12N15/67 , C12N1/21 , C12N9/02 , C12N9/10 , C12N15/52 , C12P13/04 , C12P13/14 , C12P19/38
摘要： A method of producing coryneform bacteria having an improved amino acid-or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on a chromosome of a coryneform bacterium to make it dose to a consensus sequence or introducing a change in a promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on a chromosome of a coryneform bacterium by gene recombination to make it close to a consensus sequence, to obtain mutants of the coryneform amino acid- or nucleic acid-producing microorganism, culturing the mutants and select a mutant capable of producing the intended amino acid or nucleic acid in a large amount. This method can construct a mutant capable of suitably enriching or controling the expression of an intended gene without using a plasmid and also capable of producing amino acids in a high yield, by the recombination or mutation.

80. 发明专利

AT346948T 未知
公开(公告)号：AT346948T
公开(公告)日：2006-12-15
申请号：AT00105968
申请日：2000-03-24
申请人： AJINOMOTO KK
发明人： KIMURA EIICHIRO , NAKAMATSU TSUYOSHI , KURAHASHI OSAMU , OHTAKI HIROMI
IPC分类号： C12N15/09 , C07K14/345 , C12N1/21 , C12P13/14 , C12R1/13 , C12N15/31

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