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71. 发明授权

US07972378B2 Stents for prosthetic heart valves 有权
标题翻译：假体心脏瓣膜支架
公开(公告)号：US07972378B2
公开(公告)日：2011-07-05
申请号：US12321760
申请日：2009-01-23
申请人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
发明人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/013 , A61F2/07 , A61F2/2433 , A61F2/2436 , A61F2/89 , A61F2/90 , A61F2002/016 , A61F2220/0058 , A61F2220/0075 , A61F2220/0091 , A61F2230/0006 , A61F2230/0054 , A61F2230/008 , A61F2250/0018 , A61F2250/003 , A61F2250/0039
摘要： A stented valve including a stent structure including a generally tubular body portion that has a first end and a second end, wherein an area adjacent the first end has a first stiffness, an area adjacent the second end has a second stiffness, and a central region between the areas at the first and second ends has a third stiffness that is less than the stiffness adjacent the first and second ends, wherein the stent structure can be reconfigured in its central area to match a curved patient anatomical region. The stented valve further includes a valve structure attached within the generally tubular portion.
摘要翻译：一种支架式阀，包括支架结构，其包括具有第一端和第二端的大体管状体部，其中与第一端相邻的区域具有第一刚度，与第二端相邻的区域具有第二刚度，以及中心区域在第一和第二端之间的区域之间具有小于邻近第一和第二端的刚度的第三刚度，其中支架结构可以在其中心区域重新配置以匹配弯曲的患者解剖区域。支架瓣膜还包括附接在大致管状部分内的阀结构。

72. 发明申请

US20100305675A1 LEADS FOR SELECTIVE SENSING AND VIRTUAL ELECTRODES 有权
标题翻译：导电选择感应和虚拟电极
公开(公告)号：US20100305675A1
公开(公告)日：2010-12-02
申请号：US12474645
申请日：2009-05-29
申请人： Timothy G. Laske , Gonzalo Martinez , Mark T. Marshall
发明人： Timothy G. Laske , Gonzalo Martinez , Mark T. Marshall
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61B5/042 , A61N1/0534 , A61N1/0541 , A61N1/056
摘要： Selective sensing implantable medical leads include pulsing and sensing portions and pulsing and not sensing portion. Leads and electrodes may be used in defibrillation and as integrated bipolar defibrillation electrodes. An entire electrode can pass charge while a valve metal or valve metal oxide portion of the electrode prevents the entire electrode from sensing, effectively rejecting unwanted signals. Differential conduction pathways, due to the valve metal and/or oxides thereof, cause the portions of the electrodes to conduct differently when used anodically and cathodically. Complex intracardiac electrical gradient can be formed along with a number of virtual electrodes within the tissue. Reentrant loops can thereby be pinned following defibrillation shock.
摘要翻译：选择性感测可植入医疗引线包括脉冲和感测部分以及脉冲和不感测部分。引线和电极可用于除颤和作为集成的双极除颤电极。整个电极可以通过电荷，同时电极的阀金属或阀金属氧化物部分防止整个电极感测，有效地排除不需要的信号。由于阀门金属和/或其氧化物导致的差动传导路径导致当阳极和阴极使用时，电极的部分不同地传导。可以与组织内的多个虚拟电极一起形成复杂的心内电梯度。因此，除颤休克后可以固定可重入环。

73. 发明申请

US20100198346A1 Method for Guiding a Medical Device 有权
标题翻译：引导医疗器械的方法
公开(公告)号：US20100198346A1
公开(公告)日：2010-08-05
申请号：US12570888
申请日：2009-09-30
申请人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
发明人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
IPC分类号： A61F2/24
CPC分类号： A61F2/2496 , A61B5/0044 , A61B5/1076 , A61B5/6853 , A61B8/445 , A61B18/1442 , A61B34/20 , A61B90/37 , A61B90/39 , A61B2017/00243 , A61B2018/00291 , A61B2018/00351 , A61B2018/00577 , A61B2034/2051 , A61B2034/2063 , A61B2090/378 , A61B2090/397 , A61F2/2433 , A61F2210/009 , A61F2250/0096 , A61N7/02
摘要： A device and method for valve replacement or valve repair is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding a valve replacement delivery member or a valve repair delivery member within the patient while tracking the position of the delivery member in the patient, positioning the valve replacement member or valve repair member in a desired position to place a valve or repair valve and removing the delivery member from the patient. In one aspect of the invention, a delivery system is provided for percutaneous delivery of a heart valve to a predetermined position in the heart of a patient, where the delivery system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a delivery system is provided for percutaneous repair of a heart valve in the heart of a patient, where the repair system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a method and device are provided that involve imaging a native root using an interoperative technique, then introducing a device that is easily visualized in a chosen imaging modality.
摘要翻译：公开了一种用于瓣膜置换或瓣膜修复的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪位置的同时引导患者内的瓣膜置换输送构件或瓣膜修复递送构件的患者中的输送构件，将瓣膜置换构件或瓣膜修复构件定位在期望的位置以放置瓣膜或修复瓣膜并从患者移除输送构件。在本发明的一个方面，提供一种用于将心脏瓣膜经皮递送到患者心脏中的预定位置的递送系统，其中递送系统本身包括允许其准确地定位在心脏中的特征。在本发明的另一方面，提供一种用于经皮修复患者心脏中的心脏瓣膜的递送系统，其中所述修复系统本身包括允许其准确地定位在心脏中的特征。在本发明的另一方面，提供了一种方法和装置，其涉及使用手术技术对本地根进行成像，然后引入在选择的成像模式中容易可视化的装置。

74. 发明申请

US20100179641A1 MULTI-LAYERED STENTS AND METHODS OF IMPLANTING 审中-公开
标题翻译：多层手术和植入方法
公开(公告)号：US20100179641A1
公开(公告)日：2010-07-15
申请号：US12732329
申请日：2010-03-26
申请人： Timothy R. Ryan , Timothy G. Laske , Philipp Bonhoeffer , Silvia Schievano
发明人： Timothy R. Ryan , Timothy G. Laske , Philipp Bonhoeffer , Silvia Schievano
IPC分类号： A61F2/82
CPC分类号： A61F2/852 , A61F2/2418 , A61F2/2475 , A61F2/90 , A61F2/915 , A61F2/958 , A61F2002/826 , A61F2002/828 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0058 , A61F2230/0054 , A61F2240/001 , A61F2250/0015 , A61F2250/0018 , A61F2250/006 , Y10T29/49
摘要： A method of percutaneously delivering a multi-layered stent assembly to a desired implantation location of a patient including the steps of radially compressing a multi-layered stent assembly to a compressed size for implantation in a patient, the multi-layered stent assembly including a first stent, a second stent coaxially positioned within at least a portion of a length of the first stent, and a valve, wherein the first stent comprises at least one different material property than the second stent. The method further includes delivering the multi-layered stent assembly to the desired implantation location of the patient using a delivery system and substantially simultaneously expanding the first stent and the second stent of the multi-layered stent assembly at the desired implantation location to a radially expanded size that is larger than the compressed size.
摘要翻译：一种将多层支架组件经皮递送到患者期望的植入位置的方法，包括将多层支架组件径向压缩至压缩尺寸以便植入患者的步骤，所述多层支架组件包括第一支架，同轴地定位在第一支架的长度的至少一部分中的第二支架和阀，其中第一支架包括与第二支架相比的至少一种不同的材料特性。该方法还包括使用递送系统将多层支架组件递送到患者的期望植入位置，并且将所述多层支架组件的第一支架和第二支架基本上同时地扩展到期望的植入位置，以径向扩张尺寸大于压缩尺寸。

75. 发明申请

US20080262593A1 Multi-layered stents and methods of implanting 审中-公开
标题翻译：多层支架和植入方法
公开(公告)号：US20080262593A1
公开(公告)日：2008-10-23
申请号：US12070208
申请日：2008-02-15
申请人： Timothy R. Ryan , Timothy G. Laske , Philipp Bonhoeffer , Silvia Schievano
发明人： Timothy R. Ryan , Timothy G. Laske , Philipp Bonhoeffer , Silvia Schievano
IPC分类号： A61F2/84
CPC分类号： A61F2/852 , A61F2/2418 , A61F2/2475 , A61F2/90 , A61F2/915 , A61F2/958 , A61F2002/826 , A61F2002/828 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0058 , A61F2230/0054 , A61F2240/001 , A61F2250/0015 , A61F2250/0018 , A61F2250/006 , Y10T29/49
摘要： A method of percutaneously delivering a multi-layered stent assembly to a desired implantation location of a patient including the steps of radially compressing a multi-layered stent assembly to a compressed size for implantation in a patient, the multi-layered stent assembly including a first stent, a second stent coaxially positioned within at least a portion of a length of the first stent, and a valve, wherein the first stent comprises at least one different material property than the second stent. The method further includes delivering the multi-layered stent assembly to the desired implantation location of the patient using a delivery system and substantially simultaneously expanding the first stent and the second stent of the multi-layered stent assembly at the desired implantation location to a radially expanded size that is larger than the compressed size.
摘要翻译：一种将多层支架组件经皮递送到患者期望的植入位置的方法，包括将多层支架组件径向压缩至压缩尺寸以便植入患者的步骤，所述多层支架组件包括第一支架，同轴地定位在第一支架的长度的至少一部分中的第二支架和阀，其中第一支架包括与第二支架相比的至少一种不同的材料特性。该方法还包括使用递送系统将多层支架组件递送到患者的期望植入位置，并且将所述多层支架组件的第一支架和第二支架基本上同时地扩展到期望的植入位置，以径向扩张尺寸大于压缩尺寸。

76. 发明授权

US07413564B2 Slit valve catheters 有权
标题翻译：狭缝阀导管
公开(公告)号：US07413564B2
公开(公告)日：2008-08-19
申请号：US10382948
申请日：2003-03-06
申请人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar
发明人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas-Bejar
IPC分类号： A61M25/16 , A61M25/18
CPC分类号： A61M25/0075
摘要： An external surface of a catheter body includes a pressure responsive slit formed in an indentation wherein a wall thickness of the catheter body within the indentation is less than a wall thickness of a major portion of the catheter body. Material exits a lumen of the catheter body, via the pressure responsive slit, when a pressure inside the lumen exceeds an external pressure.
摘要翻译：导管体的外表面包括形成在凹陷中的压力响应狭缝，其中压痕内导管体的壁厚小于导管主体的主要部分的壁厚。当内腔内的压力超过外部压力时，材料通过压力响应狭缝离开导管主体的内腔。

77. 发明申请

US20080183273A1 Stented heart valve devices and methods for atrioventricular valve replacement 有权
标题翻译：心脏瓣膜瓣膜置换装置及房室瓣置换方法
公开(公告)号：US20080183273A1
公开(公告)日：2008-07-31
申请号：US12009323
申请日：2008-01-17
申请人： Thierry Mesana , Timothy G. Laske , Allen Tower , Alexander J. Hill , Timothy R. Ryan
发明人： Thierry Mesana , Timothy G. Laske , Allen Tower , Alexander J. Hill , Timothy R. Ryan
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61F2/2418 , A61F2/2433 , A61F2/82 , A61F2/852 , A61F2/958 , A61F2002/065 , A61F2002/8486 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/005 , A61F2230/0054 , A61F2250/0018 , A61F2250/0036 , A61F2250/0037 , A61F2250/0039 , A61F2250/0064 , A61F2250/0069
摘要： A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.
摘要翻译：一种用于植入体腔（例如二尖瓣）的可压缩和可扩展的支架组件，所述支架组件包括至少一个成形和尺寸使其允许相邻心脏结构的正常操作的支架筒。一个或多个支架套筒可以包括在支架组件中，其中一个或多个支架套筒可以包括具有锥形边缘的圆柱体。

78. 发明授权

US07207988B2 Method and apparatus for providing intra-pericardial access 有权
标题翻译：用于提供心包内通路的方法和装置
公开(公告)号：US07207988B2
公开(公告)日：2007-04-24
申请号：US10606908
申请日：2003-06-26
申请人： Michael E. Leckrone , Timothy G. Laske , Michael Ujhelyi
发明人： Michael E. Leckrone , Timothy G. Laske , Michael Ujhelyi
IPC分类号： A61B18/14
CPC分类号： A61B17/3478 , A61B17/3417 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2017/3443 , A61B2017/3484 , A61B2017/3488 , A61B2017/349 , A61B2018/00291 , A61B2018/00357 , A61B2018/00392
摘要： A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially. The tubular member may be passed through the wall of the heart or the pericardium in its extended configuration and thereafter, the distal-most portion of the tubular member may be moved proximally, causing its diameter enlarge, anchoring the distal end of the catheter or cannula to the pericardium or to the wall of a heart chamber. In these embodiments, the device is preferably provided with a shoulder or flange located proximal to the extendible tubular member, for location on the opposite side of the heart wall or pericardium from the distal end of the catheter or cannula.
摘要翻译：一种用于进入心包空间的方法和装置，其提供其最远端位于心包空间中的输送导管或插管的稳定的短期或长期放置。导管或插管可以通过穿透胸壁和心包而经心脏穿过心室的壁或经胸腔引入心包空间。一些实施例设置有用于稳定导管或插管的远端的机构，该机构可以使用位于导管或插管的远端处的可伸展的弹性大体管状构件。该装置可以设置有用于纵向延伸管状构件的机构，从而使其直径基本上减小。管状构件可以以其延伸构型穿过心脏壁或心包，此后，管状构件的最远端部分可以向近侧移动，导致其直径增大，将导管或套管的远端固定到心包室或心室的壁。在这些实施例中，装置优选地设置有位于可伸缩管状构件的近侧的肩部或凸缘，用于位于与导管或插管远端的心脏壁或心包相反的一侧。

79. 发明授权

US07184842B2 Medical electrical lead anchoring 有权
标题翻译：医用电气导线锚定
公开(公告)号：US07184842B2
公开(公告)日：2007-02-27
申请号：US10664995
申请日：2003-09-17
申请人： Kevin R. Seifert , Timothy G. Laske
发明人： Kevin R. Seifert , Timothy G. Laske
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N1/059 , A61N2001/0578
摘要： A lead body of a medical electrical lead includes a distal end, a first elongated insulated conductor extending toward the distal end and a first electrode coupled to the conductor. A second elongated insulated conductor includes a first portion extending within the lead body to the distal end and a second portion extending distally from the distal end of the lead body where it is terminated by a tissue anchor on which a second electrode is mounted; the tissue anchor includes a surface for receiving a push force from an insertion tool, which is adapted to insert the anchor within a segment of tissue such that the first electrode of the lead body is in close proximity to the segment of tissue.
摘要翻译：医疗电线的引线体包括远端，朝向远端延伸的第一细长绝缘导体和耦合到导体的第一电极。第二细长绝缘导体包括在引线主体内延伸到远端的第一部分和从引线主体的远端向远端延伸的第二部分，其中第二部分由其上安装有第二电极的组织锚固件终止; 组织锚固件包括用于接收来自插入工具的推力的表面，其适于将锚固件插入组织段内，使得引线主体的第一电极紧邻组织段。

80. 发明授权

US07103418B2 Active fluid delivery catheter 有权
标题翻译：主动流体输送导管
公开(公告)号：US07103418B2
公开(公告)日：2006-09-05
申请号：US10262046
申请日：2002-10-02
申请人： Timothy G. Laske , Daniel C. Sigg , John L. Sommer
发明人： Timothy G. Laske , Daniel C. Sigg , John L. Sommer
IPC分类号： A61N1/05 , A61M31/00
CPC分类号： A61M25/0082 , A61M25/0026 , A61M25/0084 , A61M2025/0089 , A61M2025/0095 , A61N1/05 , A61N1/0575 , A61N1/0587
摘要： A medical system incorporating fluid delivery and lead delivery lumens dispense fluid into a volume of tissue. The fluid comprises or contains a pharmacologic, genetic, or biologic agent. The fluid may be dispensed initially during implantation or later using a minimally invasive medical procedure.
摘要翻译：包含流体输送和引流输送腔的医疗系统将流体分配到一定体积的组织中。流体包含或含有药理学，遗传学或生物学药剂。流体可以在植入期间或之后使用微创医疗程序最初分配。

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