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71. 发明授权

US06803367B2 Substance for inducing apoptosis 失效
标题翻译：诱导凋亡的物质
公开(公告)号：US06803367B2
公开(公告)日：2004-10-12
申请号：US10260356
申请日：2002-10-01
申请人： Tatsuji Enoki , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Tatsuji Enoki , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K3150
CPC分类号： C07D231/12 , C07C45/60 , C07C49/493 , C07C49/707 , C07C49/753 , C07C233/25 , C07D213/65 , C07D233/56 , C07D249/08
摘要： A substance for inducing apoptosis represented by specific formulae. A pharmaceutical composition which can be used for an anticancer agent containing said substance.
摘要翻译：用于诱导特定细胞凋亡的物质。可用于含有所述物质的抗癌剂的药物组合物。

72. 发明授权

US06518317B1 Antiviral agents 失效
标题翻译：抗病毒剂
公开(公告)号：US06518317B1
公开(公告)日：2003-02-11
申请号：US09367185
申请日：1999-08-09
申请人： Hiroaki Sagawa , Nobuto Koyama , Hideto Chono , Kazutoh Takesako , Ikunoshin Kato
发明人： Hiroaki Sagawa , Nobuto Koyama , Hideto Chono , Kazutoh Takesako , Ikunoshin Kato
IPC分类号： A61K31122
CPC分类号： C07C323/58 , A23K20/105 , A23L2/52 , A23L33/10 , A61K31/122 , C07C323/59 , Y10S514/894
摘要： An antiviral agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.
摘要翻译：一种抗病毒剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为有效成分。

73. 发明授权

US06489155B1 Enzymes capable of degrading a sulfated-fucose-containing polysaccharide and their encoding genes 失效
标题翻译：能够降解含硫酸化岩藻糖多糖及其编码基因的酶
公开(公告)号：US06489155B1
公开(公告)日：2002-12-03
申请号：US09486072
申请日：2000-02-22
申请人： Masanori Takayama , Nobuto Koyama , Takeshi Sakai , Ikunoshin Kato
发明人： Masanori Takayama , Nobuto Koyama , Takeshi Sakai , Ikunoshin Kato
IPC分类号： C12N924
CPC分类号： C12N9/00 , C12N9/2402 , C12Y302/01044
摘要： An isolated gene having a DNA sequence coding for the polypeptide having a degrading activity of the sulfated-fucose-containing polysaccharide or having the functionally identical activity as above.
摘要翻译：具有编码具有含硫酸化岩藻糖多糖的降解活性或具有与上述功能相同的活性的多肽的DNA序列的分离基因。

74. 发明授权

US06380262B1 5-membered ring compounds 失效
标题翻译： 5元环化合物
公开(公告)号：US06380262B1
公开(公告)日：2002-04-30
申请号：US09762265
申请日：2001-02-06
申请人： Eiji Kobayashi , Hiromu Ohnogi , Nobuto Koyama , Katsushige Ikai , Hiroaki Sagawa , Ikunoshin Kato
发明人： Eiji Kobayashi , Hiromu Ohnogi , Nobuto Koyama , Katsushige Ikai , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K3112
CPC分类号： C07K5/0215 , A61K38/00
摘要： 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR1, Y is ═O and Z is H, and when it is a cyclopentane ring, X is ═O, Y is OR2 and Z is OR3, (wherein R1 is R4 or —(CO)—R5; R2 is H, —R6 or —(CO)—R7; and R3 is H, R8 or (CO)—R9 (wherein R4, R5, R6, R7, R8 and R9 are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R5, R7 and R9 may be each H), provided that the case where R2═R3═H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.
摘要翻译：由通式（I）表示的5-元环化合物，其旋光异构体或其盐。这些化合物具有包括致癌作用的生理活性。在所述式中，五元环中虚线所示的键表示该5元环可以是具有双键或饱和环戊烷环的环戊烯环，当5元环为环戊烯环时 X为OR 1，Y为= O且Z为H，当为环戊烷环时，X为= O，Y为OR 2，Z为OR 3，（其中R1为R4或 - （CO）-R5; R2为 H，-R6或 - （CO）-R7; R3为H，R8或（CO）-R9（其中R4，R5，R6，R7，R8和R9相同或不同，各自表示脂族，芳族或脂族芳族基团，R 5，R 7和R 9可以各自为H），条件是排除R2 = R3 = H的情况）; W表示通过从含SH化合物中除去SH而得到的残基。

75. 发明授权

US5962326A Hyperthermostable .beta.-galactosidase gene, enzyme encoded thereby, and process for production 失效
标题翻译：超热稳定性β-半乳糖苷酶基因，由此编码的酶，以及生产方法
公开(公告)号：US5962326A
公开(公告)日：1999-10-05
申请号：US993581
申请日：1997-12-18
申请人： Atsushi Shimada , Miki Odate , Nobuto Koyama , Kimikazu Hashino , Kiyozo Asada , Ikunoshin Kato
发明人： Atsushi Shimada , Miki Odate , Nobuto Koyama , Kimikazu Hashino , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12N9/38 , C12N15/56 , C12N15/10 , C12N15/63
CPC分类号： C12Y302/01023 , C12N9/2471
摘要： An isolated SDS-resistant hyperthermostable .beta.-galactosidase gene derived from Pyrococcus furiosus. Examples thereof include genes respectively shown in SEQ ID NO: 1 and SEQ ID NO: 2 and genes each hybridizable with the above gene shown in SEQ ID NO: 1. A method of cloning the hyperthermostable .beta.-galactosidase gene in which each of the above genes or pacts thereof is used as a probe or primer. A process for producing a hyperthermostable .beta.-galactosidase by culturing a transformant into which a plasmid containing each of the above gene has been introduced.
摘要翻译：来自激烈热球菌的分离的耐SDS耐热超β-半乳糖苷酶基因。其实例包括分别显示在SEQ ID NO：1和SEQ ID NO：2中的基因以及各自可与SEQ ID NO：1所示的上述基因杂交的基因。一种克隆其中每个上述的高热稳定性β-半乳糖苷酶基因的方法基因或其结合物用作探针或引物。通过培养引入含有上述每种基因的质粒的转化体来生产超热稳定性β-半乳糖苷酶的方法。

76. 发明授权

US07572617B2 Thermostable ribonuclease H obtained from Archeoglobus profundus 有权
标题翻译：从Archeoglobus profundus获得的热稳定性核糖核酸酶H
公开(公告)号：US07572617B2
公开(公告)日：2009-08-11
申请号：US10526073
申请日：2003-08-26
申请人： Shigekazu Hokazono , Takashi Uemori , Tetsuki Tanaka , Ikunoshin Kato
发明人： Shigekazu Hokazono , Takashi Uemori , Tetsuki Tanaka , Ikunoshin Kato
IPC分类号： C07K14/00 , C12N9/16 , C12Q1/14 , C12N15/00 , C12N5/10 , C12N1/21 , C12P21/00 , C07H21/00
CPC分类号： C12N9/22
摘要： An isolated polypeptide having a thermostable ribonuclease H activity from Archaeoglobus profundus is highly useful in genetic engineering, as well as a gene encoding this polypeptide and a genetic engineering process for producing the polypeptide.
摘要翻译：具有来自古细丝虫的热稳定核糖核酸酶H活性的分离的多肽在遗传工程中是非常有用的，以及编码该多肽的基因和用于产生多肽的基因工程方法。

77. 发明授权

US5189144A Human calpastatin-like polypeptide 失效
标题翻译：人类钙蛋白酶抑制素样多肽
公开(公告)号：US5189144A
公开(公告)日：1993-02-23
申请号：US852343
申请日：1992-03-17
申请人： Kiyozo Asada , Takashi Uemori , Masahiro Endo , Fusao Kimizuka , Ikunoshin Kato
发明人： Kiyozo Asada , Takashi Uemori , Masahiro Endo , Fusao Kimizuka , Ikunoshin Kato
IPC分类号： C07K7/08 , C07K14/81
CPC分类号： C07K7/08 , C07K14/8139
摘要： Polypeptides are provided which have a calpain inhibitory activity. The polypeptides have an activity like that of natural human calpastatin but are significantly shorter in length than natural human calpastatin. The polypeptides are suited for synthetic manufacture.
摘要翻译：提供具有钙蛋白酶抑制活性的多肽。多肽具有类似于天然人钙蛋白酶抑制剂的活性，但其长度明显短于天然人钙蛋白酶抑制剂。该多肽适用于合成制造。

78. 发明授权

US07932071B2 Thermostable ribonuclease H from Archaeoglobus profundus 有权
标题翻译：来自Archaeoglobus profundus的热稳定性核糖核酸酶H
公开(公告)号：US07932071B2
公开(公告)日：2011-04-26
申请号：US12493428
申请日：2009-06-29
申请人： Shigekazu Hokazono , Takashi Uemori , Tetsuki Tanaka , Ikunoshin Kato
发明人： Shigekazu Hokazono , Takashi Uemori , Tetsuki Tanaka , Ikunoshin Kato
IPC分类号： C07H21/00 , C12N15/00 , C12N1/21 , C12N5/10 , C12P21/00 , C07K14/00 , C12Q1/44 , C12N9/16
CPC分类号： C12N9/22
摘要： A polypeptide having an RNaseH activity from Archaeoglobus profundus and being highly useful in gene engineering; a gene encoding this polypeptide; and a genetic engineering process for producing the polypeptide.
摘要翻译：具有来自古细菌球菌的RNaseH活性并且在基因工程中非常有用的多肽; 编码该多肽的基因; 以及用于产生多肽的遗传工程方法。

79. 发明申请

US20090269809A1 THERMOSTABLE RIBONUCLEASE H 有权
标题翻译：热稳定的RIBONUCLEASE H
公开(公告)号：US20090269809A1
公开(公告)日：2009-10-29
申请号：US12493428
申请日：2009-06-29
申请人： Shigekazu Hokazono , Takashi Uemori , Tetsuki Tanaka , Ikunoshin Kato
发明人： Shigekazu Hokazono , Takashi Uemori , Tetsuki Tanaka , Ikunoshin Kato
IPC分类号： C12P21/02 , C12N15/11 , C12N15/00 , C12N1/21
CPC分类号： C12N9/22
摘要： A polypeptide having an RNaseH activity and being highly useful in gene engineering; a gene encoding this polypeptide; and a genetic engineering process for producing the polypeptide.
摘要翻译：具有RNaseH活性并且在基因工程中非常有用的多肽; 编码该多肽的基因; 以及用于产生多肽的遗传工程方法。

80. 发明申请

US20070298415A1 Method of Amplifying Nucleic Acid 审中-公开
标题翻译：核酸扩增方法
公开(公告)号：US20070298415A1
公开(公告)日：2007-12-27
申请号：US10582345
申请日：2004-12-06
申请人： Takashi Uemori , Osamu Takeda , Junko Yamamoto , Hiroyuki Mukai , Kiyozo Asada , Ikunoshin Kato
发明人： Takashi Uemori , Osamu Takeda , Junko Yamamoto , Hiroyuki Mukai , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12P19/34 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6844 , C12Q2531/119 , C12Q2525/185 , C12Q2537/143 , C12Q2525/161
摘要： In the case where a template nucleic acid has sequences substantially the same as each other, a primer is designed in a region between these sequences so as to give a product in a ladder structure in which a target region is polymerized in a single sequence via the same sequences in the ICAN reaction. By using a chimeric oligonucleotide primer and a ladder-forming oligonucleotide primer containing a specific base sequence, an amplification product having a ladder structure can be positively formed and thus the sensitivity, amplification efficiency and reaction speed in the ICAN reaction can be elevated.
摘要翻译：在模板核酸具有彼此基本相同的序列的情况下，在这些序列之间的区域中设计引物，以便产生梯形结构中的产物，其中靶区域通过经由在ICAN反应中相同的序列。通过使用嵌合寡核苷酸引物和含有特定碱基序列的梯形寡核苷酸引物，可以积极地形成具有梯形结构的扩增产物，从而可以提高ICAN反应中的灵敏度，扩增效率和反应速度。

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