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71. 发明授权

US08197770B2 Fluid handling cassette having a spectroscopic sample cell 有权
标题翻译：具有光谱样品池的流体处理盒
公开(公告)号：US08197770B2
公开(公告)日：2012-06-12
申请号：US12359874
申请日：2009-01-26
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： B01L3/00
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module includes a module housing and a first fluid passageway extending from the module housing. The first fluid passageway has a patient end remote from the housing. The first fluid passageway is configured to provide fluid communication with a bodily fluid in a patient. A fluid component separator is in fluid communication with the first fluid passageway. The fluid component separator is configured to separate at least one component from a portion of the bodily fluid drawn from the patient. A spectroscopic sample cell is configured to hold at least a portion of the first component.
摘要翻译：流体处理模块被配置为可移除地与可重复使用的主流体处理装置接合。模块包括模块壳体和从模块壳体延伸的第一流体通道。第一流体通道具有远离壳体的患者端。第一流体通道被配置为提供与患者体内的体液的流体连通。流体组分分离器与第一流体通道流体连通。流体组分分离器构造成将至少一种组分与从患者抽出的体液的一部分分离。光谱样品池被配置为保持第一组分的至少一部分。

72. 发明授权

US08034015B2 Anti-clotting apparatus and methods for fluid handling system 有权
标题翻译：用于流体处理系统的抗凝装置和方法
公开(公告)号：US08034015B2
公开(公告)日：2011-10-11
申请号：US12111109
申请日：2008-04-28
申请人： James R. Braig , Richard Keenan
发明人： James R. Braig , Richard Keenan
IPC分类号： A61M37/00
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61M5/14212 , A61M2230/20 , G01N21/35
摘要： A method for maintaining clear passageways in an extracorporeal blood flow system. The method comprises intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system. Also disclosed is an extracorporeal blood flow system. The system comprises a passageway, and a device operatively connected to provide one or more anti-clotting agents to a least a portion of said passageway.
摘要翻译：一种用于在体外血液流动系统中保持清晰通道的方法。该方法包括间歇地向体外血液流通系统的通道提供一种或多种抗凝血剂。还公开了一种体外血液流动系统。该系统包括通道和可操作地连接以向所述通道的至少一部分提供一种或多种抗凝血剂的装置。

73. 发明申请

US20110218411A1 FLUID HANDLING CASSETTE SYSTEM FOR BODY FLUID ANALYZER 有权
标题翻译：液体流动分析仪的流体处理系统
公开(公告)号：US20110218411A1
公开(公告)日：2011-09-08
申请号：US12986112
申请日：2011-01-06
申请人： Richard Keenan , Jeff Chiou , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James R. Braig
发明人： Richard Keenan , Jeff Chiou , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James R. Braig
IPC分类号： A61B5/157 , G01N33/50
CPC分类号： A61B5/157 , G01N33/50
摘要： A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module configured to interface with a main instrument. The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.
摘要翻译：用于体液分析的流体处理系统。该系统包括被配置为与主仪器接口的第一流体处理模块。第一流体处理模块具有第一流体处理网络，并且第一流体处理网络包括适于在输注通道内移动流体的输注通道和输液流体压力构件。流体处理系统还具有与第一模块分离的第二流体处理模块，第一模块被配置为与主仪器相接触。第二流体处理模块具有第二流体处理网络和可经由第二流体处理网络访问的至少一个样品分析单元。第一和第二模块被配置为在第一和第二流体处理网络和样品池之间互连并提供流体连通。

74. 发明授权

US07907985B2 Fluid handling cassette with a fluid control interface and sample separator 有权
标题翻译：流体处理盒带有流体控制界面和样品分离器
公开(公告)号：US07907985B2
公开(公告)日：2011-03-15
申请号：US11316676
申请日：2005-12-21
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/00 , A61M1/00 , G01N35/00 , G01N9/30
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.
摘要翻译：提供了可移除地与体液分析器接合的流体处理模块。模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。流体处理元件可以具有至少一个控制元件接口。

75. 发明申请

US20090326343A1 FLUID HANDLING CASSETTE HAVING A SPECTROSCOPIC SAMPLE CELL 有权
标题翻译：具有光谱样品池的流体处理箱
公开(公告)号：US20090326343A1
公开(公告)日：2009-12-31
申请号：US12359874
申请日：2009-01-26
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/15
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module includes a module housing and a first fluid passageway extending from the module housing. The first fluid passageway has a patient end remote from the housing. The first fluid passageway is configured to provide fluid communication with a bodily fluid in a patient. A fluid component separator is in fluid communication with the first fluid passageway. The fluid component separator is configured to separate at least one component from a portion of the bodily fluid drawn from the patient. A spectroscopic sample cell is configured to hold at least a portion of the first component.
摘要翻译：流体处理模块被配置为可移除地与可重复使用的主流体处理装置接合。模块包括模块壳体和从模块壳体延伸的第一流体通道。第一流体通道具有远离壳体的患者端。第一流体通道被配置为提供与患者体内的体液的流体连通。流体组分分离器与第一流体通道流体连通。流体部件分离器构造成将至少一个部件与从患者抽出的体液的一部分分离。光谱样品池被配置为保持第一组分的至少一部分。

76. 发明授权

US06884222B1 Method and apparatus for estimation of resting respiratory quotient 失效
公开(公告)号：US06884222B1
公开(公告)日：2005-04-26
申请号：US10718075
申请日：2003-11-20
申请人： James R. Braig
发明人： James R. Braig
IPC分类号： A61B5/083 , A61B5/08
CPC分类号： A61B5/083
摘要： A method and apparatus for determining a user's Respiratory Quotient (RQ) using just measured O2 and CO2 concentrations without use of a flow meter. The RQ is determined by measuring the user's real-time inspired O2 concentration (INS O2) and end tidal O2 concentration (ETO2) and measuring the user's real-time inspired CO2 concentration (INS CO2) and end tidal CO2 concentration (ETCO2), and then determining the user's RQ from the measured INS O2, ETO2, INS CO2, and ETCO2 values in accordance with the following equation: RQ=(ETCO2−INS CO2)/(INS O2−ETO2). In order to avoid error introduced by the flow rate, the measurement steps are preferably performed while the user is in a resting condition. Also, ETCO2 is preferably measured as the maximum CO2 value in a breath cycle of the user, while INS CO2 is preferably measured as the minimum CO2 value in a breath cycle of the user. Similarly, ETO2 is preferably measured as the minimum O2 value within a breath cycle of the user, while INS O2 is measured as the maximum O2 value within a breath cycle of the user. On the other hand, the values of INS CO2 and ETCO2 also may be determined in accordance with the invention by analysis of a CO2 waveform of a breath cycle of the user and the values of INS O2 and ETO2 determined by synchronizing timing of the O2 waveform of a breath cycle of the user with the CO2 waveform and sampling INS O2 and ETO2 values simultaneously with sampling of complementary CO2 values determined by analysis of the CO2 wavefomm. The RQ measuring device may include the oxygen and CO2 sensors in a mainstream or sidestream configuration.

77. 发明授权

US06731961B2 Method for transforming phase spectra to absorption spectra 失效
公开(公告)号：US06731961B2
公开(公告)日：2004-05-04
申请号：US10291912
申请日：2002-11-08
申请人： James R. Braig , W. Dale Hall , Casper W. Barnes , Peng Zheng , Jennifer H. Gable
发明人： James R. Braig , W. Dale Hall , Casper W. Barnes , Peng Zheng , Jennifer H. Gable
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/1491 , G01N21/1717 , G01N21/35 , G01N21/3577 , G01N21/71
摘要： A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. One embodiment provides a transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation. Phase and magnitude differences in the transfer function are detected in the presence of the sought-after analyte. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. Another embodiment provides a method for transforming thermal phase spectra to absorption spectra for consistent determination of analyte concentration within the sample.

78. 发明授权

US06196046B1 Devices and methods for calibration of a thermal gradient spectrometer 失效
标题翻译：用于校准热梯度光谱仪的设备和方法
公开(公告)号：US06196046B1
公开(公告)日：2001-03-06
申请号：US09382273
申请日：1999-08-25
申请人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Kamrava Azizi , David J. Correia , Charles E. Kramer
发明人： James R. Braig , Bernhard B. Sterling , Daniel S. Goldberger , Joan C. Godfrey , Kamrava Azizi , David J. Correia , Charles E. Kramer
IPC分类号： G01N100
CPC分类号： A61B5/1495 , A61B5/14532 , A61B2560/0233 , A61B2560/0271
摘要： A calibration standard for calibrating a thermal gradient spectrometer. The calibration standard is a structure having a particular glucose concentration which a thermal gradient spectrometer reads for determining whether the spectrometer is in calibration. The structure of the calibration standard properly mimics the physiology of human tissue. A number of such standards, each containing a different concentration of glucose are provided in kit form with a thermal gradient spectrometer for use in calibrating the spectrometer. The spectrometer is provided with a display and internal circuitry for performing self-calibrating adjustments and a communications port for electronically coupling to a remote computer and database for supplying external calibration commands to said spectrometer.
摘要翻译：用于校准热梯度光谱仪的校准标准。校准标准是具有特定葡萄糖浓度的结构，热梯度光谱仪读取以确定光谱仪是否在校准中。校准标准的结构恰当地模拟了人体组织的生理。提供了许多这样的标准，每种含有不同浓度的葡萄糖的试剂盒形式与用于校准光谱仪的热梯度光谱仪一起提供。光谱仪具有用于执行自校准调节的显示器和内部电路，以及用于电子耦合到远程计算机和数据库的通信端口，用于向所述光谱仪提供外部校准命令。

79. 发明授权

US06095986A Disposable anti-fog airway adapter 失效
标题翻译：一次性防雾气道适配器
公开(公告)号：US06095986A
公开(公告)日：2000-08-01
申请号：US123232
申请日：1998-07-28
申请人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
发明人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
IPC分类号： A61B5/097 , A61B5/08
CPC分类号： A61B5/097
摘要： A disposable anti-fog airway adapter for use with a mainstream respiratory gas analyzer which provides a measurement of a patient's inhaled and exhaled gases. The airway adapter includes windows that are constructed of a thin, low heat capacity plastic that rapidly equilibrates to the temperature of the warm moist gases in the patient breathing circuit. In addition, the inside of the windows is also coated with an anti-fog surfactant either by laminating an anti-fog film with the window plastic prior to attaching the window to the airway adapter body or by first attaching the window to the airway adapter body and then applying the surfactant to the airway adapter after the window film is bonded in place so that the surfactant coats the entire inside of the adapter. The surfactant functions to increase the critical wetting tension of the surface it covers so that water on the window spreads into a uniform thin layer which does not absorb very much infrared energy and thus does not significantly reduce the signal strength. "Instant on" operation is accomplished because no heater and the like is necessary to warm up the windows to maintain them at an elevated temperature to prevent fogging. Numerous techniques are also provided for adhering the windows to the airway adapter body so that a substantially airtight seal may be obtained.
摘要翻译：用于主流呼吸气体分析仪的一次性防雾气道适配器，其提供对患者的吸入和呼出气体的测量。气道适配器包括由能够快速平衡到患者呼吸回路中的温湿润气体的温度的薄的低热容塑料构成的窗户。此外，窗户的内部还通过在将窗口附接到气道适配器主体之前层叠防雾膜与窗户塑料，或者通过首先将窗口附接到气道适配器本体上来涂覆防雾表面活性剂然后在将窗膜粘合就位后将表面活性剂施用于气道适配器，使得表面活性剂涂覆在适配器的整个内部。表面活性剂用于增加其覆盖的表面的临界润湿张力，使得窗户上的水扩散到不吸收非常多的红外能量的均匀薄层，因此不显着降低信号强度。实现“即时打开”操作，因为不需要加热器等来预热窗户以将其保持在高温以防止起雾。还提供了许多技术用于将窗口粘附到气道适配器主体，使得可以获得基本上气密的密封。

80. 发明授权

US5515847A Self-emission noninvasive infrared spectrophotometer 失效
标题翻译：自发式无创红外分光光度计
公开(公告)号：US5515847A
公开(公告)日：1996-05-14
申请号：US247311
申请日：1994-05-23
申请人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Bernhard B. Sterling
发明人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Bernhard B. Sterling
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/6826 , G01N21/35 , G01N21/3581
摘要： A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy emitted by the person as heat is monitored and the infrared absorption of particular constituents in the blood (such as glucose or blood alcohol) is measured at characteristic infrared absorption wavelengths for those constituents. The measurements are preferably synchronized with systole and diastole of the cardiac cycle so that the signal contribution caused by veins and tissues (which do not pulse) may be cancelled when a ratio of the detected signals is taken. The concentration of the blood constituents are then determined in accordance with a polynomial equation.
摘要翻译：一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。通过监测血液成分具有强烈且可区分的吸收光谱的长红外波长范围内的所需血液成分的红外吸收来进行测量。监测由人发射的长波长红外能量作为热，并且对于那些成分在特征红外吸收波长处测量血液中特定成分（如葡萄糖或血液酒精）的红外吸收。所述测量优选与心动周期的收缩和心律舒张同步，使得当检测到的信号的比率被采取时，可以消除由静脉和组织引起的信号贡献（其不脉冲）。然后根据多项式方程确定血液成分的浓度。

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