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71. 发明申请

WO2007005283A2 USE OF DTBZ FOR IMAGING ENDOCRINE PANCREAS AND BETA CELL MASS IN TYPE 1 DIABETES 审中-公开
标题翻译： DTBZ用于在1型糖尿病中成像内皮细胞胰蛋白酶和细胞质量的用途
公开(公告)号：WO2007005283A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/024049
申请日：2006-06-21
申请人： TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , HARRIS, Paul , MAFFEI, Antonella
发明人： HARRIS, Paul , MAFFEI, Antonella
IPC分类号： A61K49/00
CPC分类号： A61K51/0455
摘要： The present invention provides non-invasive methods for determining the beta cell mass in the pancreas of a subject by administering to the subject an effective amount of a vesicular monoamine transporter type 2 (VMAT2)-specific radioligand; obtaining at least one computerized image of at least a portion of the pancreas of the subject; and quantitatively analyzing the computerized image in order to determine the beta cell mass in the pancreas of the subject. The present invention additionally provides methods for diagnosing a metabolic neuroendocrine disorder in a subject including insulinoma, diabetes and preclinical diabetes, as well as methods for determining the efficacy of treatment for a metabolic disorder. The present invention further provides methods for assessing the prognosis of a subject at risk for developing diabetes, and methods for managing the treatment or prevention of diabetes. The present invention also provides kits for use in determining the beta cell mass in the pancreas of a subject, as well as diagnosing metabolic or neuroendocrine disorders in a subject.
摘要翻译：本发明提供了通过向受试者施用有效量的2型（VMAT2）特异性囊泡单体转运蛋白来确定受试者胰腺中的β细胞团的非侵入性方法; 获得所述受试者的胰脏的至少一部分的至少一个计算机化图像; 并定量分析计算机化图像，以确定受试者胰腺中的β细胞量。本发明另外提供了用于诊断包括胰岛素瘤，糖尿病和临床前糖尿病的受试者中的代谢神经内分泌障碍的方法以及用于确定治疗代谢紊乱的功效的方法。本发明还提供了评估患有糖尿病风险的受试者的预后的方法，以及用于治疗或预防糖尿病的方法。本发明还提供了用于确定受试者胰腺中的β细胞群以及诊断受试者中代谢或神经内分泌障碍的试剂盒。

72. 发明申请

WO2003016414A1 COATING COMPOSITION INCLUDING A WATER-BASED COPOLYMER CROSS-LINKING WITH A WATER-DISPERSIBLE CROSS-LINKING AGENT, METHOD OR PREPARING THE SAME, AND A CURED FILM THEREOF 审中-公开
标题翻译：包含水基共聚物的涂料组合物与水分散交联剂，其制备方法或其固化膜的交联连接
公开(公告)号：WO2003016414A1
公开(公告)日：2003-02-27
申请号：PCT/US2002/014984
申请日：2002-05-13
申请人： BASF CORPORATION , RAMESH, Swaminathan , LESSEK, Paul , BREMSER, Wolfgang , HARRIS, Paul
发明人： RAMESH, Swaminathan , LESSEK, Paul , BREMSER, Wolfgang , HARRIS, Paul
IPC分类号： C09D151/00
CPC分类号： C08F212/32 , C08F8/30 , C08F293/005 , C08K5/17 , C08L53/00 , C09D151/003 , C09D153/00 , C08L2666/02
摘要： The present invention is directed to a curable, water-based coating composition utilized in waterborne coating systems. The coating composition is the reaction product of a water-dispersible cross-linking agent and a water-based copolymer prepared by free-radical polymerization. The copolymer is the reaction product of a first block and a second block. The first block is the reaction product of a plurality of monomers including ethylenically unsaturated monomers, acrylic acid and methyl methacrylate and vinylaromatic hydrocarbon monomers. One of the ethylenically unsaturated monomers includes a functional group suitable for reaction with the cross-linking agent. The second block is the reaction product of a non-functional, ethylenically unsaturated monomer. Methods for preparing the coating composition and a cured film are also disclosed.
摘要翻译：本发明涉及用于水性涂料体系中的可固化的水性涂料组合物。涂料组合物是通过自由基聚合制备的水分散性交联剂和水基共聚物的反应产物。共聚物是第一嵌段和第二嵌段的反应产物。第一个嵌段是包括烯属不饱和单体，丙烯酸和甲基丙烯酸甲酯和乙烯基芳烃单体的多种单体的反应产物。烯属不饱和单体之一包括适于与交联剂反应的官能团。第二个嵌段是非官能的烯属不饱和单体的反应产物。还公开了制备涂料组合物和固化膜的方法。

73. 发明申请

WO2013169292A1 FREE-FLOATING PROTECTIVE GLOVE 审中-公开
标题翻译：自由浮动保护手套
公开(公告)号：WO2013169292A1
公开(公告)日：2013-11-14
申请号：PCT/US2012/066527
申请日：2012-11-26
申请人： BATT, Michael, J. , EINESSON, Erik , HARRIS, Paul
发明人： EINESSON, Erik , HARRIS, Paul
IPC分类号： A41D13/08 , A41D19/015
CPC分类号： A41D19/01511 , A41D31/0061
摘要： A free-floating mesh protective glove is disclosed. The glove has palm-side inner and outer fabric layers joined along their peripheries, and a top-side outer fabric layer attached to the palm-side layers along their peripheries, except in a cuff region. Protection against stabbing and cutting is provided by two metallic-meshes layers shaped to fit inside the palm-side layers and held in place by being sandwiched between, but not attached to, them. The metal meshes slide past each other when the glove is clenched, improving flexibility and reducing crinkling. The woven mesh layers have stainless steel fibers with a diameter of 0.2 mm or less and apertures of 0.45 mm or less. The meshes are layered together with a warp-fiber direction in one mesh oriented at an angle of approximately 22.5 degrees with respect to the warp-fiber direction of the adjacent mesh.
摘要翻译：公开了一种自由浮动的网状防护手套。手套具有沿着它们的周边连接的棕榈侧内外层和外围织物层，除了在袖带区域之外，它们沿其周边附着到手掌侧层。通过两个金属网格层提供防止刺伤和切割的保护，这两个金属网格层被形成为装配在手掌层内部并且通过夹在它们之间但未附着在其上而保持在适当的位置。当手套紧握时，金属网格彼此滑过，提高柔韧性并减少皱纹。编织网层具有直径为0.2mm以下且0.45mm以下的孔的不锈钢纤维。网格以一根相对于相邻网格的经纤维方向以大约22.5度的角度取向的一个网格中的经向纤维方向层叠在一起。

74. 发明申请

WO2006102341A1 PIGMENT DISPERSANT, METHOD OF MAKING COATING COMPOSITIONS, AND COATING COMPOSITIONS 审中-公开
标题翻译：颜料分散剂，涂料组合物的制备方法和涂料组合物
公开(公告)号：WO2006102341A1
公开(公告)日：2006-09-28
申请号：PCT/US2006/010267
申请日：2006-03-21
申请人： BASF CORPORATION , OHRBOM, Walter , CAIOZZO, Nicholas , BALATAN, Sergio , CZORNIJ, Zenon Paul , CERTO, Clair , ECHOLS, Janice , HARRIS, Paul
发明人： OHRBOM, Walter , CAIOZZO, Nicholas , BALATAN, Sergio , CZORNIJ, Zenon Paul , CERTO, Clair , ECHOLS, Janice , HARRIS, Paul
IPC分类号： C09D7/00 , C09D7/12
CPC分类号： C09D5/027
摘要： A coating composition comprises at least one material dispersed in a vinyl or acrylic polymer, wherein the vinyl or acrylic polymer comprises (a) one or more anchor group monomer units (a) having an ionizable or active hydrogen functionality or a functionality that forms a covalent bond with the dispersed material, wherein the ionizable functionality is other than a carboxylic acid group in which the carbonyl carbon is separated from the closest ethylenically unsaturated carbon by at least four atoms and the anchor group monomer units (a) are other than those having polyoxyalkylene groups; (b) about 5% to about 45% by weight of one or more stabilizer monomer units (b) having a carboxylic acid group in which the carbonyl carbon is separated from the closest ethylenically unsaturated carbon by at least four atoms, having polyoxyalkylene groups, having gamma-hydroxy carbamate or beta-hydroxy carbamate groups, and combinations thereof; and (c) up to about 50 percent by weight of aromatic monomer units.
摘要翻译：涂料组合物包含分散在乙烯基或丙烯酸类聚合物中的至少一种材料，其中乙烯基或丙烯酸类聚合物包含（a）具有可离子化或活性氢官能团的一个或多个锚定单体单元（a）或形成共价的官能团与分散的材料结合，其中可电离的官能团不同于其中羰基碳与最接近的烯属不饱和碳分开至少四个原子的羧酸基团，锚定基团单体单元（a）不同于具有聚氧化烯的那些组; （b）约5重量％至约45重量％的一种或多种具有羧酸基团的稳定剂单体单元（b），其中羰基碳与最接近烯属不饱和碳的至少四个原子分离，具有聚氧化烯基团，具有γ-羟基氨基甲酸酯或β-羟基氨基甲酸酯基团，及其组合; 和（c）至多约50重量％的芳族单体单元。

75. 发明申请

WO2005052885A1 METHOD AND SYSTEM FOR ASSISTING THE PASSAGE OF AN ENTITY THROUGH SUCCESSIVE ZONES TO A DESTINATION 审中-公开
标题翻译：方法和系统，用于辅助实体通过成功地区到达目的地
公开(公告)号：WO2005052885A1
公开(公告)日：2005-06-09
申请号：PCT/GB2004/004948
申请日：2004-11-24
申请人： ROLLS-ROYCE PLC , WINAND, Henri, Michel, Andre , OLIVER, Richard , HARRIS, Paul
发明人： WINAND, Henri, Michel, Andre , OLIVER, Richard , HARRIS, Paul
IPC分类号： G08G1/123
CPC分类号： G07C9/00111 , B64F1/366 , G08G1/20
摘要： A method and a corresponding system for assisting the passage of an entity (10) through successive zones (Zn to Z1) to a destination (40) are provided. The method includes the steps of: associating an identifier with the entity; creating a plurality of required incidents for the entity, each required incident having a place reference and a time reference associated with it, the required incidents including a final incident for which the place reference is the destination and the time reference is a predetermined time; at intervals, detecting the presence of the entity in one of said zones and the time of said presence, thereby generating a match; registering correspondences between the matches thus-generated and said required incidents; and generating an alert for the entity when the time reference for a required incident is reached and that incident does not have a corresponding match. The method operates on a pull system whereby earlier events are driven by the requirements of future events. The method allows preventative action to be taken before delays occur and can adjust to deal with variations in local conditions. A preferred embodiment is implemented in a transport hub, where the entities may be passengers, crew or luggage.
摘要翻译：提供了一种辅助将实体（10）通过连续区（Zn至Z1）到目的地（40）的方法和对应系统。该方法包括以下步骤：将标识符与实体相关联; 为实体创建多个所需的事件，每个所需事件具有与之相关联的地点参考和时间参考，所需事件包括地点参考是目的地的最终事件，并且时间参考是预定时间; 间隔地检测在所述区域之一中的实体的存在和所述存在的时间，从而产生匹配; 记录由此产生的匹配和所需事件之间的对应关系; 并且当达到所需事件的时间基准并且该事件没有相应匹配时，为该实体生成警报。该方法在拉动系统上操作，其中较早的事件由未来事件的要求驱动。该方法允许在延迟发生之前采取预防措施，并且可以调整以处理局部条件的变化。优选实施例在运输枢纽中实现，其中实体可以是乘客，船员或行李箱。

76. 发明申请

WO2006116682A2 POLYPEPTIDES HAVING ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有内切酶活性的多肽和编码其的多核苷酸
公开(公告)号：WO2006116682A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/016244
申请日：2006-04-27
申请人： NOVOZYMES, INC.
发明人： HARRIS, Paul , LOPEZ DE LEON, Alfredo , REY, Micheal , DING, Hanshu , VLASENKO, Elena
IPC分类号： C12N9/42 , C12N9/24 , C12N15/00 , C11D3/386
CPC分类号： C12N9/2437 , C11D3/38636 , C12N15/8246 , C12Y302/01004
摘要： The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有内切葡聚糖酶活性的分离多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

77. 发明申请

WO2005074647A3 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：WO2005074647A3
公开(公告)日：2005-08-18
申请号：PCT/US2005/003525
申请日：2005-01-28
申请人： NOVOZYMES INC.
发明人： BROWN, Kimberly , HARRIS, Paul , ZARETSKY, Elizabeth , RE, Edward , VLASENKO, Elena , MCFARLAND, Keith , LOPEZ DE LEON, Alfredo
IPC分类号： C07K14/37
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

78. 发明申请

WO2006005032A2 POLYPEPTIDES HAVING ALPHA-GLUCOSIDASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有α-葡糖苷酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：WO2006005032A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/023678
申请日：2005-06-29
申请人： NOVOZYMES, INC.
发明人： OTANI, Suzanne , GE, Haiyan , HARRIS, Paul , YAVER, Debbie , BLINKOVSKY, Alexander
IPC分类号： C12N9/42 , C07H21/04 , C12P21/06
CPC分类号： C12N9/2408 , C12C5/004 , C12C7/04 , C12C7/20 , C12C11/00 , C12C12/02 , C12N9/2411 , C12N15/8245 , C12Y302/0102
摘要： The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有α-葡糖苷酶活性的分离的多肽和编码所述多肽的分离的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

79. 发明申请

WO2006074435A2 POLYPEPTIDES HAVING CELLOBIOHYDRLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有细胞毒素活性的多肽和编码其的多核苷酸
公开(公告)号：WO2006074435A2
公开(公告)日：2006-07-13
申请号：PCT/US2006/000659
申请日：2006-01-06
申请人： NOVOZYMES, INC.
发明人： BROWN, Kimberly , HARRIS, Paul , LOPEZ DE LEON, Alfredo , MERINO, Sandra
IPC分类号： C12N9/42
CPC分类号： C12Y302/01091 , C11D3/38636 , C12N9/2437
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

80. 发明申请

WO2006078256A2 POLYPEPTIDES HAVING XYLANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有XYLANASE活性的多肽和编码其的多核苷酸
公开(公告)号：WO2006078256A2
公开(公告)日：2006-07-27
申请号：PCT/US2005/004386
申请日：2005-02-09
申请人： NOVOZYMES, INC.
发明人： YAVER, Debbie , HARRIS, Paul , OTANI, Suzanne , LIN, Janine , HAIYAN, Ge
IPC分类号： A01H1/00
CPC分类号： C12N9/2482 , C12N9/248 , C12Y302/01008
摘要： The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有木聚糖酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

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