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71. 发明授权

US06772766B2 Cryogenic method and apparatus for promoting angiogenesis 失效
标题翻译：用于促进血管发生的低温方法和装置
公开(公告)号：US06772766B2
公开(公告)日：2004-08-10
申请号：US10372883
申请日：2003-02-24
申请人： Richard Gallo , Daniel Nahon , Mathieu-Philippe Aubert , Philippe Marchand , Marwan Abboud , Steven G. Arless , Marc Dubuc , Sean Carroll , Dan Wittenberger , John W. Lehmann
发明人： Richard Gallo , Daniel Nahon , Mathieu-Philippe Aubert , Philippe Marchand , Marwan Abboud , Steven G. Arless , Marc Dubuc , Sean Carroll , Dan Wittenberger , John W. Lehmann
IPC分类号： A61B1900
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F2250/0067
摘要： A method of promoting blood vessel growth includes the steps of providing a cryocatheter having a thermally transmission region; placing the cryocatheter proximate an area of tissue to be treated; cooling the thermally transmissive region of the cryocatheter proximate the area of tissue to a temperature sufficient to injure the area of tissue; allowing the area of tissue to warm; and removing the cryocatheter from the area of tissue. Prior, during or after the cooling step, the area of tissue can be mechanically traumatized, and drugs can be injected into the tissue.
摘要翻译：促进血管生长的方法包括提供具有热传递区域的低温摄取机的步骤; 将低温套管放置在待处理组织的一个区域附近; 将靠近组织区域的低温热管的热传导区域冷却到足以损伤组织面积的温度; 允许组织的面积温暖; 并从组织区域移除低温切片机。之前，在冷却步骤期间或之后，组织的面积可以被机械地创伤，药物可以被注射到组织中。

72. 发明授权

US06440126B1 Cryoblation catheter handle 有权
标题翻译：冷冻导管手柄
公开(公告)号：US06440126B1
公开(公告)日：2002-08-27
申请号：US09556042
申请日：2000-04-21
申请人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
发明人： Marwan Abboud , Domenic Santoianni , Philippe Marchand
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61M39/1011
摘要： A cryocatheter system includes a first handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; a second handle portion having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path; and a catheter having a proximal end, a distal end, a first fluid flow path, and a second fluid flow path. The distal end of the first handle portion is matable with the proximal end of the second handle portion to place the respective first and second fluid flow paths of each handle portion in fluid communication; and the distal end of the second handle portion is matable with the proximal end of the catheter to place the respective first and second fluid flow paths of the second handle portion and the catheter in fluid communication.
摘要翻译：一种低温切管系统包括具有近端，远端，第一流体流动路径和第二流体流路的第一手柄部分; 具有近端，远端，第一流体流动路径和第二流体流路的第二手柄部分; 以及具有近端，远端，第一流体流动路径和第二流体流动路径的导管。第一手柄部分的远端可与第二手柄部分的近端配合，以使每个手柄部分的相应的第一和第二流体流动路径流体连通; 并且第二手柄部分的远端可与导管的近端配合，以使第二手柄部分和导管的相应的第一和第二流体流动路径流体连通。

73. 发明授权

US09555223B2 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US09555223B2
公开(公告)日：2017-01-31
申请号：US12238865
申请日：2008-09-26
申请人： Marwan Abboud , Rachid Mahrouche
发明人： Marwan Abboud , Rachid Mahrouche
IPC分类号： A61B18/02 , A61M25/10 , A61B18/14 , A61B17/22 , A61B18/00
CPC分类号： A61M25/10187 , A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/10182 , A61M25/10185 , A61M2025/1013 , A61M2205/15 , A61M2205/3337
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system may include controller that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
摘要翻译：用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括球囊导管，控制台，加压气体或液体充气源，以及将加压冷却剂输送到球囊导管的脐带系统。该系统可以包括监控气囊导管内的压力和体积的量的控制器。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。

74. 发明授权

US08992515B2 Coolant injection tube 有权
标题翻译：冷却液注射管
公开(公告)号：US08992515B2
公开(公告)日：2015-03-31
申请号：US12269493
申请日：2008-11-12
申请人： Jean-Pierre Lalonde , Marwan Abboud , Teresa Ann Mihalik , Jean-Pierre Desmarais , Dan Wittenberger
发明人： Jean-Pierre Lalonde , Marwan Abboud , Teresa Ann Mihalik , Jean-Pierre Desmarais , Dan Wittenberger
IPC分类号： A61B18/18 , A61B18/02 , A61B17/22 , A61B18/00
CPC分类号： A61B18/02 , A61B2017/00318 , A61B2017/22038 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device includes a steering element defining a passage for a guide wire. A fluid injection tube defining a proximal and a distal end is also included, wherein a portion of the fluid injection tube is contoured about a portion of the steering element. A plurality of injection ports may be disposed in the portion of the fluid injection tube contoured about the steering element.
摘要翻译：医疗装置包括限定用于导丝的通道的操纵元件。还包括限定近端和远端的流体注入管，其中流体注入管的一部分围绕转向元件的一部分成形。多个注射口可以设置在围绕转向元件成形的流体注射管的部分中。

75. 发明授权

US08475440B2 Wide area ablation of myocardial tissue 有权
标题翻译：广泛消融心肌组织
公开(公告)号：US08475440B2
公开(公告)日：2013-07-02
申请号：US11953189
申请日：2007-12-10
申请人： Marwan Abboud , Fredric L. Milder , George Klein
发明人： Marwan Abboud , Fredric L. Milder , George Klein
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body having a substantially fixed diameter, a proximal end and a distal end; a first lumen for permitting passage of a cooling fluid from the proximal end to the distal end; a second lumen permitting return of the cooling fluid from the distal end to the proximal end; and an ablation element expandable from a first diameter that is substantially the same as the diameter of the catheter body to a second diameter that is at least twice the diameter of the catheter body, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more balloon and/or a flexible element that is deformed by moving the distal end of the catheter toward the proximal end of the catheter. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method a tissue ablation device is provided and tissue in the antrum of the left atrium is ablated with the device. In an exemplary method, only tissue in the antrum is ablated, and the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括具有基本上固定的直径，近端和远端的导管主体; 用于允许冷却流体从近端通向远端的第一腔; 允许冷却流体从远端返回到近端的第二管腔; 以及可从第一直径扩张的消融元件，所述第一直径基本上与所述导管主体的直径相同至所述导管主体直径的至少两倍的第二直径，所述消融元件具有与所述不平坦表面一致的表面部分心脏组织的形貌。消融元件可以包括通过将导管的远端朝向导管的近端移动而变形的一个或多个气囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用装置消融左心房窦内的组织。在示例性方法中，只有窦中的组织被消融，并且通过冷冻组织产生消融。

76. 发明授权

US07951140B2 Catheter with cryogenic and electrical heating ablation 有权
标题翻译：导管用低温和电加热消融
公开(公告)号：US07951140B2
公开(公告)日：2011-05-31
申请号：US11971582
申请日：2008-01-09
申请人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
发明人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/1492 , A61B18/18 , A61B2017/00243 , A61B2018/0212 , A61B2018/0268
摘要： A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion re-treatment cycles.
摘要翻译：导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。 RF电极可以被操作以加热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织，从而允许操作的更大的通用性和增强病变大小，速度或放置多病变治疗或单次病变再治疗周期。

77. 发明授权

US07780657B2 Cooling system 有权
标题翻译：冷却系统
公开(公告)号：US07780657B2
公开(公告)日：2010-08-24
申请号：US11709964
申请日：2007-02-23
申请人： Marwan Abboud , Rachid Mahrouche , Jean-Pierre Lalonde , Dan Wittenberger
发明人： Marwan Abboud , Rachid Mahrouche , Jean-Pierre Lalonde , Dan Wittenberger
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A cryogenic medical system includes a medical device and a console connectable to the medical device at a connection point. The console controls the temperature of the medical device. The console includes a first cooling system directing coolant to the medical device at a first temperature along a coolant supply line and a second cooling system chilling the coolant within the coolant supply line to a temperature below the first temperature before the coolant reaches the connection point.
摘要翻译：低温医疗系统包括在连接点处可连接到医疗装置的医疗装置和控制台。控制台控制医疗设备的温度。所述控制台包括第一冷却系统，所述第一冷却系统沿着冷却剂供应管线在第一温度下将冷却剂引导至所述医疗设备;以及第二冷却系统，在所述冷却剂到达所述连接点之前将所述冷却剂供应管线内的冷却剂冷却至低于所述第一温度的温度。

78. 发明授权

US07740627B2 Surgical method and apparatus for treating atrial fibrillation 有权
标题翻译：用于治疗房颤的手术方法和装置
公开(公告)号：US07740627B2
公开(公告)日：2010-06-22
申请号：US11184045
申请日：2006-01-06
申请人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
发明人： James Gammie , Randy Jordan , Marwan Abboud , Allan Zingeler , Saqib Masroor
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body, a proximal end and a distal end; a first lumen; a second lumen; and an ablation element expandable from a first diameter to a second diameter, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more deformable balloon and/or flexible elements. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method, a tissue ablation device is provided and tissue in the left atrium is ablated with the device, whereby the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括导管主体，近端和远端; 第一个管腔第二个管腔以及可从第一直径扩展到第二直径的消融元件，所述消融元件具有与心脏组织的不平坦表面形貌一致的表面部分。消融元件可以包括一个或多个可变形的球囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用该装置消除左心房中的组织，由此通过冷冻组织产生消融。

79. 发明授权

US07591814B2 Extended treatment zone catheter 有权
标题翻译：扩展治疗区导管
公开(公告)号：US07591814B2
公开(公告)日：2009-09-22
申请号：US11093179
申请日：2005-03-29
申请人： Domenic Santoianni , Marwan Abboud , Sean Carroll
发明人： Domenic Santoianni , Marwan Abboud , Sean Carroll
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00053 , A61B2017/00243 , A61B2017/00973 , A61B2018/00095 , A61B2018/0212 , A61B2018/0262
摘要： A catheter having an extended treatment zone for cooling tissue is provided. The catheter includes an elongate catheter body having a distal tip, and a fluid injection conduit disposed inside the catheter body defining a return lumen therein. The fluid injection conduit further defines two or more injection orifices including a first distal orifice near the distal tip, and a second orifice longitudinally offset along the fluid injection conduit to be less proximate the distal tip than the first orifice. Fluid cryogen flowing through the orifices creates an extended tissue cooling contour about the distal end portion of the catheter. At least one ECG ring electrode is provided about the catheter body near the second orifice. The catheter may thus provide for electrocardiographic mapping of tissue nodes lying transversely between the distal tip and the ECG ring electrode.
摘要翻译：提供了一种具有用于冷却组织的延伸处理区的导管。导管包括具有远侧末端的细长导管主体和设置在导管主体内部的流体注入导管，其在其中限定回流腔。流体注射导管还限定两个或更多个注射孔，其包括靠近远侧末端的第一远端孔，以及沿着流体注射导管纵向偏移的第二孔，以比第一孔更靠近远端。流经孔的流体冷冻剂围绕导管的远端部分产生延长的组织冷却轮廓。在第二孔周围的导管本体周围设置至少一个ECG环形电极。因此，导管可以提供横向位于远端尖端和ECG环形电极之间的组织结节的心电图。

80. 发明授权

US07347856B2 Minimally invasive surgical clamp having treatment elements 有权
标题翻译：具有治疗元件的微创手术夹具
公开(公告)号：US07347856B2
公开(公告)日：2008-03-25
申请号：US10890364
申请日：2004-07-13
申请人： Dan Wittenberger , Cristian Petre , Daniel Nahon , Réal Ste-Marie , Marwan Abboud
发明人： Dan Wittenberger , Cristian Petre , Daniel Nahon , Réal Ste-Marie , Marwan Abboud
IPC分类号： A61B18/18
CPC分类号： A61B17/29 , A61B5/0408 , A61B17/122 , A61B17/2812 , A61B17/282 , A61B18/02 , A61B18/0218 , A61B18/1492 , A61B2017/00026 , A61B2017/00084 , A61B2017/00243 , A61B2017/00738 , A61B2017/2905 , A61B2017/2931 , A61B2017/2944 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/1465
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation tool is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.
摘要翻译：提供了具有用于致动一对相对的钳口构件的装置的医疗装置。钳口构件可从第一位置相对于彼此移动，其中钳口构件相对于彼此以间隔开的关系设置到第二位置，其中钳口构件协作以在其间抓握组织。消融工具连接到至少一个夹爪构件，使得钳口构件能够通过夹在其间夹持的组织进行消融能量。

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