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71. 发明授权

US07963149B2 Method and device for determining hydraulic leakage rate in liquid-conveying sections, in particular, injection valves of internal combustion engines 有权
标题翻译：用于确定液体输送部分，特别是内燃机的喷射阀中的液压泄漏率的方法和装置
公开(公告)号：US07963149B2
公开(公告)日：2011-06-21
申请号：US12090516
申请日：2006-10-12
申请人： Martin Maier , Frank Mozer , Eberhard Waibler
发明人： Martin Maier , Frank Mozer , Eberhard Waibler
IPC分类号： G01M3/02 , G01M3/16
CPC分类号： G01M3/2876 , F02M65/00 , F02M65/006
摘要： A method and device for determining the hydraulic leakage rate of liquid-conveying parts, in particular injection valves for internal combustion engines, place the liquid-conveying part into a test body, and the liquid-conveying part is charged with a test liquid under a particular pressure, and a carrier gas stream is provided in a flow duct of the test body, and a vapor mixture behind the liquid-conveying part is conducted to an analyzer, and a measurement and analysis are carried out, using the analyzer, of the hydraulic leakage rate of the liquid-conveying part via the concentration of test liquid in the vapor mixture, the carrier gas stream being brought in via a nozzle element close to the leakage point of the liquid-conveying part, and/or a heating of the vapor mixture being provided behind the liquid-conveying part for complete conversion into the gas phase. The testing device is particularly suitable for leakage measurement in fuel injection valves used in fuel injection systems of mixture-compressing externally ignited internal combustion engines.
摘要翻译：一种用于确定液体输送部件，特别是用于内燃机的喷射阀的液压泄漏率的方法和装置，将液体输送部件放入测试体中，并且在液体输送部件的下面装入测试液体特定的压力，并且在测试体的流动管道中设置载气流，并且将液体输送部件后面的蒸汽混合物传导到分析器，并且使用分析仪进行测量和分析，通过蒸汽混合物中的测试液体的浓度，液体输送部分的液压泄漏速率，载气流经由靠近液体输送部分的泄漏点的喷嘴元件引入，和/或蒸气混合物设置在液体输送部分的后面，以完全转化为气相。该测试装置特别适用于在混合压缩外部点燃的内燃机的燃料喷射系统中使用的燃料喷射阀中的泄漏测量。

72. 发明申请

US20090239814A1 Carbohydrate Conjugates as Delivery Agents for Oligonucleotides 有权
标题翻译：碳水化合物缀合物作为寡核苷酸的递送剂
公开(公告)号：US20090239814A1
公开(公告)日：2009-09-24
申请号：US12328528
申请日：2008-12-04
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Narayanannair , Martin Maier
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Jayaprakash K. Narayanannair , Martin Maier
IPC分类号： A61K31/715 , C07H17/02 , C12N5/06
CPC分类号： A61K47/28 , A61K31/70 , A61K31/7004 , A61K31/7052 , A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/22 , A61K47/543 , A61K47/549 , A61K47/60 , A61K48/00 , C07H21/02 , Y02A50/385 , Y02A50/411 , Y02A50/467 , Y02P20/55
摘要： The present invention provides iRNA agents comprising at least one subunit of the formula (I): wherein: A and B are each independently for each occurrence O, N(RN) or S; X and Y are each independently for each occurrence H, OH, a hydroxyl protecting group, a phosphate group, a phosphodiester group, an activated phosphate group, an activated phosphite group, a phosphoramidite, a solid support, —P(Z′)(Z″)O-nucleoside, —P(Z′)(Z″)O-oligonucleotide, a lipid, a PEG, a steroid, a lipophile, a polymer, —P(Z′)(Z″)O-Linker-OP(Z′″)(Z″″)O-oligonucleotide, a nucleotide, an oligonucleotide, —P(Z′)(Z″)-formula (I), —P(Z′)(Z″)— or -Linker-R; R is LG, -Linker-LG, or has the structure shown below: LG is independently for each occurrence a carbohydrate, e.g., monosaccharide, disaccharide, trisaccharide, tetrasaccharide, oligosaccharide, polysaccharide; RN is independently for each occurrence H, methyl, ethyl, propyl, isopropyl, butyl, or benzyl; and Z′, Z″, Z′″ and Z″″ are each independently for each occurrence O or S.
摘要翻译：本发明提供包含至少一个式（I）亚基的iRNA试剂：其中：A和B各自独立地为O，N（RN）或S; X和Y各自独立地为H，OH，羟基保护基，磷酸基，磷酸二酯基，活化磷酸酯基，活化亚磷酸酯基，亚磷酰胺，固体载体，-P（Z'）（ Z'）（Z“）O - 寡核苷酸，脂质，PEG，类固醇，亲脂体，聚合物，-P（Z'）（Z”）O （Z'）（Z“） - （Z”）（Z“）（Z”）（Z“）（Z”）（Z“） - 或-Linker-R; R是LG，-Linker-LG，或具有如下结构：每次出现LG独立为碳水化合物，例如单糖，二糖，三糖，四糖，寡糖，多糖; 乙烯基，丙基，异丙基，丁基或苄基各自独立地为N， Z'，Z“，Z”“和Z”“各自独立地为O或S.

73. 发明申请

US20080314120A1 Method and Device for Determining Hydraulic Leakage Rate in Liquid-Conveying Sections, in Particular, Injection Valves of Internal Combustion Engines 有权
标题翻译：确定液体输送段液压泄漏率的方法和装置，特别是内燃机喷油阀
公开(公告)号：US20080314120A1
公开(公告)日：2008-12-25
申请号：US12090516
申请日：2006-10-12
申请人： Martin Maier , Frank Mozer , Eberhard Waibler
发明人： Martin Maier , Frank Mozer , Eberhard Waibler
IPC分类号： G01M3/02
CPC分类号： G01M3/2876 , F02M65/00 , F02M65/006
摘要： A method and device for determining the hydraulic leakage rate of liquid-conveying parts, in particular injection valves for internal combustion engines, place the liquid-conveying part into a test body, and the liquid-conveying part is charged with a test liquid under a particular pressure, and a carrier gas stream is provided in a flow duct of the test body, and a vapor mixture behind the liquid-conveying part is conducted to an analyzer, and a measurement and analysis are carried out, using the analyzer, of the hydraulic leakage rate of the liquid-conveying part via the concentration of test liquid in the vapor mixture, the carrier gas stream being brought in via a nozzle element close to the leakage point of the liquid-conveying part, and/or a heating of the vapor mixture being provided behind the liquid-conveying part for complete conversion into the gas phase. The testing device is particularly suitable for leakage measurement in fuel injection valves used in fuel injection systems of mixture-compressing externally ignited internal combustion engines.
摘要翻译：一种用于确定液体输送部件，特别是用于内燃机的喷射阀的液压泄漏率的方法和装置，将液体输送部件放入测试体中，并且在液体输送部件的下面装入测试液体特定的压力，并且在测试体的流动管道中设置载气流，并且将液体输送部件后面的蒸汽混合物传导到分析器，并且使用分析仪进行测量和分析，通过蒸汽混合物中的测试液体的浓度，液体输送部分的液压泄漏速率，载气流经由靠近液体输送部分的泄漏点的喷嘴元件引入，和/或蒸气混合物设置在液体输送部分的后面，以完全转化为气相。该测试装置特别适用于在混合压缩外部点燃的内燃机的燃料喷射系统中使用的燃料喷射阀中的泄漏测量。

74. 发明申请

US20080312268A1 Substituted tricyclic piperidone compounds 审中-公开
标题翻译：取代三环哌啶酮化合物
公开(公告)号：US20080312268A1
公开(公告)日：2008-12-18
申请号：US12143614
申请日：2008-06-20
申请人： Stefan Schunk , Stefan Oberboersch , Hagen-Heinrich Hennies , Martin Maier , Anton Khartulyari
发明人： Stefan Schunk , Stefan Oberboersch , Hagen-Heinrich Hennies , Martin Maier , Anton Khartulyari
IPC分类号： A61K31/439 , C07D221/22 , A61P25/32 , A61P25/30 , A61P25/00
CPC分类号： C07D471/08
摘要： Substituted tricyclic piperidone derivatives corresponding to Formula I: a method for producing such compounds; pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhea, pruritus, alcohol and drug abuse, drug dependency, lethargy and/or anxiety.
摘要翻译：对应于式I的取代的三环哌啶酮衍生物：这种化合物的制备方法; 含有这些化合物的药物组合物，以及这些化合物用于治疗疼痛，抑郁症，尿失禁，腹泻，瘙痒，酒精和药物滥用，药物依赖性，嗜睡和/或焦虑症的用途。

75. 发明申请

US20080075156A1 PHASE SHIFT ADJUSTING METHOD AND CIRCUIT 有权
标题翻译：相移调整方法与电路
公开(公告)号：US20080075156A1
公开(公告)日：2008-03-27
申请号：US11535968
申请日：2006-09-27
申请人： Otto Schumacher , Martin Maier , Thomas Hein , Aaron John Nygren
发明人： Otto Schumacher , Martin Maier , Thomas Hein , Aaron John Nygren
IPC分类号： H04B3/46 , H04L7/00
CPC分类号： H04L7/048 , G01R31/31725 , G01R31/31937 , G06F1/10 , G06F11/073 , G06F11/1004 , G06F11/18 , G06F11/186 , G06F11/263 , G11C7/1078 , G11C7/1084 , G11C7/22 , G11C11/4076 , G11C11/4093 , G11C29/02 , G11C29/023 , G11C29/025 , G11C29/028 , G11C29/50012 , G11C2207/2254 , H03M13/33 , H04L7/0008 , H04L7/0037 , H04L7/0091
摘要： Method and system of adjusting a first phase shift between a first data signal and a clock signal at a sending device. First and second test signals representing firs and second test data, respectively, are transmitted to a receiving device. The test signals have respective phase shifts relative to the clock signal. An error detection code is calculated from first and second received data carried by the transmitted signals. The error detection code is transmitted from the receiving device to the sending device. An estimated first received data is calculated from the error detection code, wherein the estimated first received data are calculated under the assumption that the second received data are identical to the second test data. The first phase shift is adjusted on the basis of a comparison of the estimated first received data and the first test data.
摘要翻译：在发送设备处调整第一数据信号和时钟信号之间的第一相移的方法和系统。分别表示第一测试数据和第二测试数据的第一和第二测试信号被发送到接收设备。测试信号相对于时钟信号具有相应的相移。由发送的信号承载的第一和第二接收数据计算错误检测码。错误检测码从接收设备发送到发送设备。从错误检测码计算估计的第一接收数据，其中在第二接收数据与第二测试数据相同的假设下计算估计的第一接收数据。基于估计的第一接收数据和第一测试数据的比较来调整第一相移。

76. 发明授权

US06974865B2 C3′ -methylene hydrogen phosphonate oligomers and related compounds 失效
标题翻译： C3'-亚甲基膦酸低聚物和相关化合物
公开(公告)号：US06974865B2
公开(公告)日：2005-12-13
申请号：US10322242
申请日：2002-12-18
申请人： Phillip Dan Cook , Muthiah Manoharan , Martin Maier , Haoyun An
发明人： Phillip Dan Cook , Muthiah Manoharan , Martin Maier , Haoyun An
IPC分类号： A61K49/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H21/00 , A61K49/0006 , C07B2200/11 , C07H19/06 , C07H19/10
摘要： The present invention is directed to nucleoside monomers wherein the 3′-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylene phosphonate linkages. Further, methods of preparing monomers and oligomers according to the present invention are provided.
摘要翻译：本发明涉及其中3'-O原子被亚甲基代替的核苷单体。本发明还提供了包含多个这样的单体的低聚物，其通过亚甲基膦酸酯键连接。此外，提供了制备根据本发明的单体和低聚物的方法。

77. 发明授权

US06971364B2 Fuel injection system for internal combustion engines with gasoline direct injection, which includes optional injection into the intake tube, and method for operating it 有权
标题翻译：具有汽油直喷式的内燃机燃油喷射系统，其中包括可选择地注入进气管，以及操作它的方法
公开(公告)号：US06971364B2
公开(公告)日：2005-12-06
申请号：US10229068
申请日：2002-08-28
申请人： Guido Pilgram , Martin Maier
发明人： Guido Pilgram , Martin Maier
IPC分类号： F02B23/08 , F02B23/10 , F02B75/12 , F02D17/00 , F02D41/00 , F02D41/04 , F02D41/06 , F02D41/08 , F02D41/34 , F02M26/50 , F02M61/14 , F02M63/00 , F02M69/00 , F02M69/04 , F02B3/00
CPC分类号： F02B23/101 , F02B23/08 , F02B2075/125 , F02D41/0065 , F02D41/042 , F02D41/068 , F02D41/3094 , F02D2041/389 , F02D2200/0406 , F02M26/13 , F02M26/50 , Y02T10/123 , Y02T10/125
摘要： A fuel injection system for GDI internal combustion engines, which has a second injection valve in the intake tube, and a method for operating this fuel injection system. By injecting fuel into the intake tube at intervals by means of the second injection valve, the formation of deposits in the intake tube and on the inlet valve, which are produced due to the recirculation of exhaust gas through the exhaust recirculation tube, can be prevented and possibly existing deposits can be broken down.
摘要翻译：一种用于GDI内燃机的燃料喷射系统，其在进气管中具有第二喷射阀，以及用于操作该燃料喷射系统的方法。通过借助于第二喷射阀间歇地将燃料喷射到进气管中，可以防止由于废气通过排气再循环管再循环而产生的进气管和入口阀中的沉积物的形成并且可能存在现有的存款。

78. 发明申请

US20050179571A1 Method and apparatus for determining a frequency for the sampling of an analog signal 有权
标题翻译：用于确定模拟信号采样频率的方法和装置
公开(公告)号：US20050179571A1
公开(公告)日：2005-08-18
申请号：US11098743
申请日：2005-04-04
申请人： Martin Maier
发明人： Martin Maier
IPC分类号： G09G3/20 , G09G3/36 , G09G5/00 , G09G5/18 , H03M7/00
CPC分类号： G09G5/008
摘要： In a method and an apparatus for determining a frequency for the sampling of an analog signal, which is provided to a digital screen for representing an image on the same, at least two areas succeeding in line direction will be established in the image to be displayed. In each of the established areas, a sample phase will be determined, for which a contrast in the established area is maximum or a minimum. Subsequently, a local course of the sample phase will be determined in the line direction based on the determined sample phases. The sampling frequency will be determined based on a base value and a modification value, which is derived from the local course of the sample phase.
摘要翻译：在用于确定模拟信号采样的频率的方法和装置中，其提供给用于表示其上的图像的数字屏幕，将在要显示的图像中建立至少两个沿行方向的区域。在每个已建立的区域中，将确定一个采样阶段，对于该阶段，建立区域的对比度最大或最小。随后，将基于确定的样本相位在线方向上确定样本相位的局部路线。采样频率将根据从样本相位的局部过程导出的基值和修正值来确定。

79. 发明授权

US06869032B2 Fuel injection valve 失效
标题翻译：燃油喷射阀
公开(公告)号：US06869032B2
公开(公告)日：2005-03-22
申请号：US10297155
申请日：2002-03-27
申请人： Martin Maier , Guenter Dantes , Detlef Nowak , Joerg Heyse
发明人： Martin Maier , Guenter Dantes , Detlef Nowak , Joerg Heyse
IPC分类号： F02M51/06 , F02M51/08 , F02M61/16 , F02M61/18 , F02M69/04 , F02M61/00
CPC分类号： F02M69/045 , F02M61/162 , F02M61/163 , F02M61/1853 , F02M2051/08
摘要： A fuel injector, in particular for a high-pressure injector for direct injection of fuel into a combustion chamber of an internal combustion engine, has compression of a fuel/air mixture with spark ignition. On the downstream end of the valve a valve seat element is provided, to which a perforated disk acting as a flow restrictor is connected downstream. A swirl element is situated upstream from the valve seat which imparts an atomization-promoting rotational motion to the fuel to be injected. In the valve seat element downstream from the valve seat, an elongated outlet orifice is provided which opens directly into an orifice in the perforated disk attached to the valve seat element. The width of the outlet orifice is greater than the width of the orifice in the perforated disk, at least at its narrowest location, so that it is possible to adjust the steady-state flow rate of the valve at the orifice.
摘要翻译：燃料喷射器，特别是用于将燃料直接喷射到内燃机的燃烧室中的高压喷射器，具有用火花点火的燃料/空气混合物的压缩。在阀的下游端设置有阀座元件，作为流量限制器的多孔盘连接到下游。涡流元件位于阀座的上游，其向喷射的燃料施加雾化促进旋转运动。在阀座下游的阀座元件中，设置有细长的出口孔，其直接打开在连接到阀座元件的多孔盘中的孔中。出口孔的宽度至少在其最窄的位置处大于多孔板中孔口的宽度，使得可以调节阀在孔处的稳态流速。

80. 发明授权

US06817635B2 Fuel injector and corresponding production method 失效
标题翻译：燃油喷射器及相应的生产方式
公开(公告)号：US06817635B2
公开(公告)日：2004-11-16
申请号：US10182410
申请日：2002-10-29
申请人： Martin Maier , Guenther Hohl , Guenter Dantes , Detlef Nowak
发明人： Martin Maier , Guenther Hohl , Guenter Dantes , Detlef Nowak
IPC分类号： B05B130
CPC分类号： F02M61/168 , F02M51/0671 , F02M61/162 , F02M61/18 , F02M61/1806 , Y10S239/90
摘要： A fuel injector for fuel injection systems of internal combustion engines and a method of manufacturing same are described. The fuel injector includes a valve seat body into which a valve seat face is introduced, which cooperates with a valve closing body to form a sealing seat, and a nozzle body to which the valve seat body is fixedly connected. The valve seat body is insertable into the interior of the nozzle body and on its downstream side it has a partially spherical outside geometry, which rests on a bearing surface of a seat body recess in the nozzle body. Valve seat body is mounted so it can rotate relative to the nozzle body on the bearing surface until its position is finally secured, and it may be aligned by a centering mandrel.
摘要翻译：描述了一种用于内燃机燃料喷射系统的燃料喷射器及其制造方法。燃料喷射器包括阀座体，阀座面被引入其中，阀座面与阀关闭体配合形成密封座，以及与阀座体固定连接的喷嘴体。阀座体可插入喷嘴体的内部，并且在其下游侧具有部分球形的外部几何形状，其位于喷嘴体中的座椅主体凹部的支承表面上。安装阀座体，使得其可以相对于支承表面上的喷嘴体旋转，直到其位置最终被固定，并且其可以通过定心心轴对准。

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