专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US07253156B2 Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists 有权
标题翻译：碳酸酯和氨基甲酸酯修饰形式的糖皮质激素与B2肾上腺素能激动剂组合
公开(公告)号：US07253156B2
公开(公告)日：2007-08-07
申请号：US11364659
申请日：2006-02-28
申请人： Mark G. Currie , Steve Jones , Paul Grover , Chris H. Senanayake , Q. Kevin Fang
发明人： Mark G. Currie , Steve Jones , Paul Grover , Chris H. Senanayake , Q. Kevin Fang
IPC分类号： A61K31/56
CPC分类号： A61K45/06 , A61K31/137 , A61K31/56 , A61K31/573 , A61K31/58 , Y10S514/87 , A61K2300/00
摘要： Compositions containing β2 adrenergic agonists in combination with carbonates and carbamates of the formula and in combination with related steroid carbonates and carbamates are disclosed. The compositions are useful for treating bronchospasm, for inducing bronchodilation and for treating rhinitis, asthma, and chronic obstructive pulmonary disease (COPD) and inflammatory diseases, particularly by inhalation.
摘要翻译：公开了含有β2肾上腺素能激动剂与下式的碳酸酯和氨基甲酸酯并与相关的类固醇碳酸酯和氨基甲酸酯组合的组合物。该组合物可用于治疗支气管痉挛，用于诱发支气管扩张和治疗鼻炎，哮喘和慢性阻塞性肺疾病（COPD）和炎性疾病，特别是通过吸入治疗。

72. 发明授权

US07087785B2 Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide 有权
标题翻译：用反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺及其甲酰胺处理CNS病症
公开(公告)号：US07087785B2
公开(公告)日：2006-08-08
申请号：US10663173
申请日：2003-09-16
申请人： Thomas P. Jerussi , Qun Kevin Fang , Mark G. Currie
发明人： Thomas P. Jerussi , Qun Kevin Fang , Mark G. Currie
IPC分类号： C07C211/45 , C07C233/15 , A61K31/135 , A61K31/03 , A61K31/165
CPC分类号： C07C211/42 , C07B2200/07 , C07C2602/10 , C07C2602/28
摘要： Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.
摘要翻译：用（1R，4S） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症; 和（1S，4R） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺。还公开了制备4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的方法。该方法包括制备N- [4-（3,4-二氯苯基）-1,2,3,4-四氢萘-1-基]甲酰胺的全部四种异构体，它们也是有用的。

73. 发明授权

US06586437B2 (S)-hydroxynefazodone antipsychotic therapy 失效
标题翻译：（S） - 羟基吗啡酮抗精神病药治疗
公开(公告)号：US06586437B2
公开(公告)日：2003-07-01
申请号：US09993130
申请日：2001-11-14
申请人： Mark G. Currie , Thomas P. Jerussi , Paul D. Rubin
发明人： Mark G. Currie , Thomas P. Jerussi , Paul D. Rubin
IPC分类号： A61K31525
CPC分类号： C07D249/12 , A61K31/496
摘要： Treatment of psychoses with (S)-hydroxynefazodone is disclosed.
摘要翻译：公开了用（S） - 羟基吗啡酮治疗精神病。

74. 发明授权

US5140102A Pentadecapeptide, guanylin, which stimulates intestinal guanylate cyclase 失效
标题翻译：五肽，鸟苷蛋白，刺激肠道鸟苷酸环化酶
公开(公告)号：US5140102A
公开(公告)日：1992-08-18
申请号：US764461
申请日：1991-09-23
申请人： Mark G. Currie
发明人： Mark G. Currie
IPC分类号： A61K38/00 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00
摘要： A novel pentadecapeptide is disclosed which is useful for the control of intestinal fluid absorption and that has the following amino acid sequence ##STR1##
摘要翻译：公开了一种新颖的十五肽，其可用于控制肠液吸收并且具有以下氨基酸序列

75. 发明申请

US20140342996A1 Treatments for Gastrointestinal Disorders 有权
标题翻译：胃肠道疾病治疗
公开(公告)号：US20140342996A1
公开(公告)日：2014-11-20
申请号：US14124282
申请日：2012-06-08
申请人： Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
发明人： Mark G. Currie , Daniel P. Zimmer , Angelika Fretzen , Marco Kessler , Brian M. Cali
IPC分类号： C07K7/08 , A61K45/06 , A61K38/10
CPC分类号： C07K7/08 , A61K38/10 , A61K45/06
摘要： The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.
摘要翻译：本发明提供了治疗较低胃肠道疾病（包括肠易激综合征和便秘）的药物组合物和方法。

76. 发明申请

US20130338063A9 Methods and Compositions for the Treatment of Gastrointestinal Disorders 审中-公开
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20130338063A9
公开(公告)日：2013-12-19
申请号：US13427431
申请日：2012-03-22
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Li Jing Sun
IPC分类号： A61K38/10 , A61P1/00 , C12P21/02 , A61P29/00 , A61P3/04 , C07K7/08 , A61P1/04
CPC分类号： C07K7/08 , A61K38/00
摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘描述了其它条件和病症，组合物具有激活鸟苷酸环化酶C（GC-C）受体的肽。

77. 发明申请

US20130156720A1 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLIC SYNDROME AND RELATED DISEASES AND DISORDERS 审中-公开
标题翻译：治疗或预防代谢综合征及相关疾病和疾病的组合物和方法
公开(公告)号：US20130156720A1
公开(公告)日：2013-06-20
申请号：US13819243
申请日：2011-08-23
申请人： Mark G. Currie
发明人： Mark G. Currie
IPC分类号： A61K31/785 , A61K31/155 , A61K31/787 , A61K45/06 , A61K31/4439 , A61K31/721 , A61K31/575
CPC分类号： A61K31/785 , A61K31/155 , A61K31/198 , A61K31/403 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/4453 , A61K31/4985 , A61K31/517 , A61K31/575 , A61K31/64 , A61K31/702 , A61K31/721 , A61K31/787 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are novel compositions and methods for treating or preventing metabolic syndromes. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a combination of at least one antidiabetic agent, at least one proton pump inhibitor and at least one bile acid sequestrant, and, optionally, at least one active agent, including, but not limited to, dyslipidemia agents, histamine H2 receptor blockers, antacids, γ-aminobutyricacid-b (GABA-B) agonists, prodrugs of GABA-B agonists, protease inhibitors and combinations of two or more thereof.
摘要翻译：本文公开了用于治疗或预防代谢综合征的新型组合物和方法。所述方法通常包括向有需要的患者施用治疗有效量的药物组合物，其包含至少一种抗糖尿病药物，至少一种质子泵抑制剂和至少一种胆汁酸螯合剂的组合，以及任选地至少一种活性剂，包括但不限于血脂异常药，组胺H2受体阻断剂，抗酸剂，γ-氨基丁酸-B（GABA-B）激动剂，GABA-B激动剂的前药，蛋白酶抑制剂及其两种或更多种的组合。

78. 发明申请

US20120172325A1 Methods and Compositions for the Treatment of Gastrointestinal Disorders 审中-公开
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20120172325A1
公开(公告)日：2012-07-05
申请号：US13175127
申请日：2011-07-01
申请人： Mark G. Currie
发明人： Mark G. Currie
IPC分类号： A61K31/708 , A61P29/00 , A61P1/04 , A61P1/00 , A61P1/10
CPC分类号： A61K31/708 , A61K31/194 , A61K31/215 , A61K45/06 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis employing. The methods and compositions employ guanosine 3′,5′-cyclic monophosphate pharmaceutically acceptable salt thereof.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），使用胃轻瘫。该方法和组合物使用鸟苷3'，5'-环状单磷酸酯其药学上可接受的盐。

79. 发明授权

US08110553B2 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US08110553B2
公开(公告)日：2012-02-07
申请号：US12788979
申请日：2010-05-27
申请人： Mark G. Currie , Shalina Mahajan-Miklos , G. Todd Milne , Thea Norman
发明人： Mark G. Currie , Shalina Mahajan-Miklos , G. Todd Milne , Thea Norman
IPC分类号： A61K38/10
CPC分类号： C07K7/08 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其他病症和病症。

80. 发明申请

US20110118195A1 Methods and Compositions for the Treatment of Gastrointestinal Disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20110118195A1
公开(公告)日：2011-05-19
申请号：US12788979
申请日：2010-05-27
申请人： Mark G. Currie , Shalina Mahajan-Miklos
发明人： Mark G. Currie , Shalina Mahajan-Miklos
IPC分类号： A61K38/10 , C07K1/14 , C07K1/20 , A61P1/04 , A61P1/10 , A61P1/00
CPC分类号： C07K7/08 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其他病症和病症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式