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71. 发明授权

US06169069A Therapeutic/cosmetic compositions comprising CGRP antagonists for treating the eyes or eyelids 失效
标题翻译：包含用于治疗眼睛或眼睑的CGRP拮抗剂的治疗/化妆品组合物
公开(公告)号：US06169069A
公开(公告)日：2001-01-02
申请号：US08623576
申请日：1996-03-28
申请人： Olivier De Lacharriere , Lionel Breton
发明人： Olivier De Lacharriere , Lionel Breton
IPC分类号： A61K3800
CPC分类号： A61K38/225 , A61K39/3955 , Y10S514/844
摘要： Ocular and/or palpebral pruritus and/or ocular and/or palpebral pain and/or ocular and/or palpebral dysaesthesia afflicting a mammalian, notably human patient, are therapeutically treated by administering to such patient a therapeutically/cosmetically effective amount of at least one CGRP antagonist, advantageously in combinatory immixture with at least one antagonist of a neuropeptide other than CGRP, e.g., a substance P antagonist, and/or at least one inflammation mediator antagonist; the subject compositions are also well suited for making up and/or caring for human eyes, eyelashes and/or eyelids, especially sensitive eyes and eyelids.
摘要翻译：影响哺乳动物，特别是人类患者的眼睛和/或睑板瘙痒和/或眼睛和/或睑部疼痛和/或眼睑和/或睑部麻醉感受物通过向该患者施用治疗/化妆有效量的至少一种 CGRP拮抗剂，有利地与除CGRP以外的神经肽的至少一种拮抗剂（例如物质P拮抗剂）和/或至少一种炎症介质拮抗剂的组合性混合物中; 主题组合物也非常适合于补充和/或照顾人眼，睫毛和/或眼睑，特别是敏感的眼睛和眼皮。

72. 发明授权

US6156899A N-aryl-2-hydroxyalkylamido compositions for inducing/stimulating hair growth and/or retarding hair loss and/or for treating hyperseborrhea and/or acne 失效
标题翻译：用于诱导/刺激毛发生长和/或延缓脱发和/或用于治疗过度脂肪和/或痤疮的N-芳基-2-羟基烷基酰氨基组合物
公开(公告)号：US6156899A
公开(公告)日：2000-12-05
申请号：US190300
申请日：1998-11-13
申请人： Jean-Baptiste Galey , Odile Destree , Lionel Breton
发明人： Jean-Baptiste Galey , Odile Destree , Lionel Breton
IPC分类号： C07D295/18 , A61K8/00 , A61K8/40 , A61K8/46 , A61K31/00 , A61K31/17 , A61K31/27 , A61K31/275 , A61K31/445 , A61K31/4453 , A61K31/4465 , A61P17/00 , A61P17/14 , A61Q5/00 , A61Q7/00 , C07C269/04 , C07C271/64 , C07C273/18 , C07C275/50 , C07D295/215 , C07D211/30
CPC分类号： A61K8/44 , A61Q7/00 , C07C271/64 , C07C275/50 , C07D295/215
摘要： Novel N-aryl-2-hydroxyalkylamido compounds having the formula (I): ##STR1## are well suited for inducing/stimulating hair growth and/or retarding hair loss and/or for therapeutically treating hyperseborrhea and/or acne.
摘要翻译：具有式（I）的新型N-芳基-2-羟基烷基酰氨基化合物：非常适合于诱导/刺激毛发生长和/或延缓脱发和/或用于治疗性治疗高脂肪和/或痤疮。

73. 发明授权

US5858024A Composition for dyeing keratin fibres containing a substance P antagonist 失效
标题翻译：用于染色含有P物质拮抗剂的角蛋白纤维的组合物
公开(公告)号：US5858024A
公开(公告)日：1999-01-12
申请号：US716534
申请日：1996-09-19
申请人： Olivier De Lacharriere , Lionel Breton , Genevieve Loussouarn
发明人： Olivier De Lacharriere , Lionel Breton , Genevieve Loussouarn
IPC分类号： A61K8/00 , A61K8/19 , A61K8/20 , A61K8/31 , A61K8/33 , A61K8/41 , A61K8/49 , A61K8/64 , A61K8/97 , A61K8/99 , A61Q5/00 , A61Q5/10 , A61K7/13
CPC分类号： A61K8/20 , A61K8/64 , A61K8/97 , A61K8/99 , A61Q5/10 , A61K2800/70
摘要： The invention relates to a composition, in particular a cosmetic composition, and more particularly one for dyeing keratin fibers, this composition containing at least one substance P antagonist in order to reduce or even eliminate the irritant effects of the dyes and/or pigments and/or dye precursors used during this dyeing. The substance P antagonist may form part of the dye composition itself or may be contained in a composition which is applied prior to the application of the dye composition.
摘要翻译：本发明涉及一种组合物，特别是化妆品组合物，更特别地涉及用于染色角蛋白纤维的组合物，该组合物含有至少一种物质P拮抗剂，以减少或甚至消除染料和/或颜料的刺激性影响和/ 或在染色期间使用的染料前体。物质P拮抗剂可以形成染料组合物本身的一部分，或者可以包含在施用染料组合物之前施用的组合物中。

74. 发明授权

US5851556A Use of a salt of an alkaline-earth metal as TNF-A or substance P inhibitor in a topical composition and composition obtained 失效
标题翻译：在局部组合物和组合物中使用碱土金属盐作为TNF-A或物质P抑制剂
公开(公告)号：US5851556A
公开(公告)日：1998-12-22
申请号：US630326
申请日：1996-04-10
申请人： Lionel Breton , Olivier De Lacharriere
发明人： Lionel Breton , Olivier De Lacharriere
IPC分类号： A61K8/19 , A61K8/36 , A61K8/365 , A61K8/44 , A61K33/00 , A61K33/06 , A61K33/14 , A61Q19/00 , A61K33/32
CPC分类号： A61Q19/005 , A61K33/00 , A61K33/06 , A61K33/14 , A61K8/19 , A61K8/36 , A61K8/365 , A61K8/44 , A61Q19/00
摘要： The invention relates to the use of a salt of an alkaline-earth metal in a cosmetic, pharmaceutical, veterinary and/or dermatological composition for treating, in particular, sensitive skins. It relates, in addition, to the use of a salt of an alkaline-earth metal for preventing and/or combating rosacea and/or skin irritation and/or dartre and/or pudic erythema and/or dysesthetic sensation and/or sensation of inflammation and/or pruritus of the skin and/or of the mucous membranes. The salt is in particular strontium nitrate or chloride.
摘要翻译：本发明涉及在化妆品，药物，兽医和/或皮肤病学组合物中用于治疗特别是敏感皮肤的碱土金属盐的用途。此外，还涉及使用碱土金属的盐来预防和/或防治酒渣鼻和/或皮肤刺激和/或呕吐和/或红斑和/或躁动症和/或炎症感觉和/或皮肤和/或粘膜的瘙痒。该盐特别是硝酸锶或氯化锶。

75. 发明授权

US5788956A Antiperspirant compositions comprising substance P antagonists 失效
标题翻译：包含P物质拮抗剂的止汗剂组合物
公开(公告)号：US5788956A
公开(公告)日：1998-08-04
申请号：US738910
申请日：1996-10-28
申请人： Olivier De Lacharriere , Lionel Breton
发明人： Olivier De Lacharriere , Lionel Breton
IPC分类号： A61K8/19 , A61K8/20 , A61K8/64 , A61Q15/00 , A61K7/32 , A61K7/00
CPC分类号： A61K8/64 , A61K8/19 , A61K8/20 , A61Q15/00 , A61K2800/70
摘要： Cutaneous perspiration in a human subject is prevented and/or controlled by topically applying to the skin of an individual in need of such treatment, an effective antiperspirant amount of at least one substance P antagonist.
摘要翻译：通过局部施用于需要这种治疗的个体的皮肤，有效的止汗剂量的至少一种P物质拮抗剂来防止和/或控制人类受试者的皮肤出汗。

76. 发明授权

US5714155A Ethylenediamine derivative in a cosmetic or dermatological composition, and composition containing in particular a product having an irritant side effect 失效
标题翻译：化妆品或皮肤病学组合物中的乙二胺衍生物，特别是含有刺激性副作用的产品的组合物
公开(公告)号：US5714155A
公开(公告)日：1998-02-03
申请号：US575089
申请日：1995-12-19
申请人： Olivier De Lacharriere , Jean-Baptiste Galey , Lionel Breton , Jacqueline Dumats
发明人： Olivier De Lacharriere , Jean-Baptiste Galey , Lionel Breton , Jacqueline Dumats
IPC分类号： A61K9/06 , A61K8/00 , A61K8/04 , A61K8/30 , A61K8/41 , A61K8/49 , A61K9/08 , A61K9/107 , A61K9/127 , A61K31/135 , A61K31/137 , A61K31/275 , A61P17/00 , A61P43/00 , A61Q1/14 , A61Q5/02 , A61Q5/04 , A61Q5/08 , A61Q5/10 , A61Q9/04 , A61Q19/00 , A61Q19/08 , A61K7/48
CPC分类号： A61K31/137 , A61K8/41 , A61Q19/00 , A61K2800/75 , A61Q1/14 , A61Q19/004 , A61Q19/08 , A61Q5/02 , Y10S514/844 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/944
摘要： The invention relates to the use of an ethylenediamine derivative as a substance P antagonist and/or as a local analgesic in, or for the preparation of, a cosmetic or dermatological composition for treating sensitive skin-types. The invention relates in particular to the use of this derivative for preventing and/or combating skin irritations and/or dartres and/or erythema and/or dysaesthesic sensations and/or sensations of inflammation and/or pruritus of the skin and/or the mucous membranes including the eyes. The invention also relates to a composition containing a product having an irritant side effect and this derivative, so as to reduce this irritant effect or even to remove it altogether.
摘要翻译：本发明涉及乙二胺衍生物作为物质P拮抗剂和/或局部止痛剂在制备化妆品或皮肤病学组合物中用于治疗敏感性皮肤类型的用途。本发明特别涉及用于预防和/或防治皮肤刺激和/或眩晕和/或皮肤和/或粘液的炎症和/或瘙痒的红斑和/或呼吸困难感和/或感觉的用途。膜包括眼睛。本发明还涉及含有具有刺激性副作用的产品和该衍生物的组合物，以减少这种刺激性的影响，甚至完全去除它。

77. 发明授权

US09770474B2 Bacterial extracts cultured in thermal waters comprising anti-redness agents 有权
公开(公告)号：US09770474B2
公开(公告)日：2017-09-26
申请号：US12175108
申请日：2008-07-17
申请人： Audrey Gueniche , Lionel Breton
发明人： Audrey Gueniche , Lionel Breton
IPC分类号： A01N65/00 , A61K35/74 , A61K8/99 , A61K35/08 , A61Q1/02 , A61Q19/00
CPC分类号： A61K35/74 , A61K8/99 , A61K35/08 , A61Q1/02 , A61Q19/004
摘要： Red blotches on the skin such as those associated with environmental stresses, or red blotches associated with a skin disorder, for example those occurring during rosacea, are treated/reduced by administering to individuals afflicted therewith, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.

78. 发明授权

US09326927B2 Use of cannabinoid compounds for stimulating melanogenesis 有权
标题翻译：使用大麻素化合物刺激黑素生成
公开(公告)号：US09326927B2
公开(公告)日：2016-05-03
申请号：US14237015
申请日：2012-08-03
申请人： Michela Zuccolo , Roland Jourdain , Lionel Breton , Mauro Maccarrone
发明人： Michela Zuccolo , Roland Jourdain , Lionel Breton , Mauro Maccarrone
IPC分类号： A61K8/42 , A61Q5/10 , A61Q19/04 , A61K31/164 , A61K31/16 , A61Q5/00 , A61Q19/00
CPC分类号： A61K8/42 , A61K31/16 , A61K31/164 , A61Q5/00 , A61Q5/10 , A61Q19/00 , A61Q19/04
摘要： The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R1 represents a hydrogen atom or a C1-C30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C1-C6 alkyl groups; R3 and R4 form, together with the carbon atom which bears them, an oxo group or else R3 and R4 represent a hydrogen atom; R5 represents a hydrogen atom or a C1-C6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group —N(R6)—, with R6 representing a hydrogen atom or a C1-C6 alkyl group; represents a single or double bond; n is 1, 2 or 3, preferentially 1 or 2; it being understood that, when R3 and R4 together form an oxo group with the carbon atom which bears them and X represents an oxygen atom, then R1 cannot represent a hydroxymethyl group, as an agent for coloring keratin materials. It also relates to one of these specific cannabinoid compounds for use thereof in the treatment of vitiligo or pityriasis versicolor, to nontherapeutic cosmetic processes for coloring the skin or for treating canities, comprising the topical application to the skin and/or head hair, or the oral administration, of a composition comprising, in a physiologically acceptable medium, one of these cannabinoid compounds, and to a process for selecting an active agent which promotes the pigmentation of keratin materials.
摘要翻译：本发明涉及至少一种选自对应于通式（I）的化合物的大麻素化合物及其几何异构体和旋光异构体，其美容上可接受的酸或碱盐及其水合物的非治疗性美容用途; 其中式（I）化合物：R 1表示氢原子或C 1 -C 30烷基; 所述烷基可以任选被羟基（OH）基团取代; R2表示卤素原子或选自羟基，硫醇（SH）和任选被一个或两个C 1 -C 6烷基取代的氨基的基团; R3和R4与带有它们的碳原子一起形成氧代基，或者R3和R4表示氢原子; R5表示氢原子或C1-C6烷基; X表示选自氧和硫原子的杂原子和二价基团-N（R 6） - ，其中R 6表示氢原子或C 1 -C 6烷基; 代表单键或双键; n为1,2或3，优选1或2; 应当理解，当R3和R4一起形成具有带有碳原子的氧代基并且X表示氧原子时，则R1不能代表作为角蛋白材料着色剂的羟甲基。它还涉及这些特定的大麻素化合物之一，用于治疗白癜风或疣状糠疹，用于对皮肤着色或用于治疗阴茎的非治疗性美容方法，包括局部应用于皮肤和/或头发，或在生理上可接受的介质中包含这些大麻素化合物之一的组合物的口服给药，以及用于选择促进角蛋白材料着色的活性剂的方法。

79. 发明授权

US09125934B2 Bacterial extracts cultured in thermal waters for treating sensitive skin, mucous membranes and scalps 有权
标题翻译：在热水中培养的细菌提取物用于治疗敏感性皮肤，粘膜和头皮
公开(公告)号：US09125934B2
公开(公告)日：2015-09-08
申请号：US12175129
申请日：2008-07-17
申请人： Lionel Breton , Yann Mahe , Richard Martin
发明人： Lionel Breton , Yann Mahe , Richard Martin
IPC分类号： A61K8/00 , A61K35/74 , A61Q19/00 , A61K8/99 , A61K35/08
CPC分类号： A61K35/74 , A61K8/99 , A61K35/08 , A61K2800/75 , A61Q19/005
摘要： Sensitive skin, mucous membranes and scalps are treated by administering to individuals in need of such treatment, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.
摘要翻译：通过对需要这种治疗的个体施用敏感性皮肤，粘膜和头皮，从而有效量的至少一种非光合和非果皮丝状细菌提取物在包括至少一种非亚硫酸盐的培养基中培养矿物质和/或热水，例如衍生自细菌透明丝杆菌丝状丝菌的提取物，特别是菌株ATCC15551，在来自La Roche Posay的富含水的培养基中培养。

80. 发明申请

US20140193349A1 USE OF CANNABINOID COMPOUNDS FOR STIMULATING MELANOGENESIS 有权
标题翻译：使用CANNABINOID化合物刺激造血细胞
公开(公告)号：US20140193349A1
公开(公告)日：2014-07-10
申请号：US14237015
申请日：2012-08-03
申请人： Michela Zuccolo , Roland Jourdain , Lionel Breton , Mauro Maccarrone
发明人： Michela Zuccolo , Roland Jourdain , Lionel Breton , Mauro Maccarrone
IPC分类号： A61K8/42 , A61Q5/00 , A61Q19/00
CPC分类号： A61K8/42 , A61K31/16 , A61K31/164 , A61Q5/00 , A61Q5/10 , A61Q19/00 , A61Q19/04
摘要： The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R1 represents a hydrogen atom or a C1-C30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C1-C6 alkyl groups; R3 and R4 form, together with the carbon atom which bears them, an oxo group or else R3 and R4 represent a hydrogen atom; R5 represents a hydrogen atom or a C1-C6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group —N(R6)—, with R6 representing a hydrogen atom or a C1-C6 alkyl group; represents a single or double bond; n is 1, 2 or 3, preferentially 1 or 2; it being understood that, when R3 and R4 together form an oxo group with the carbon atom which bears them and X represents an oxygen atom, then R1 cannot represent a hydroxymethyl group, as an agent for coloring keratin materials. It also relates to one of these specific cannabinoid compounds for use thereof in the treatment of vitiligo or pityriasis versicolor, to nontherapeutic cosmetic processes for coloring the skin or for treating canities, comprising the topical application to the skin and/or head hair, or the oral administration, of a composition comprising, in a physiologically acceptable medium, one of these cannabinoid compounds, and to a process for selecting an active agent which promotes the pigmentation of keratin materials.
摘要翻译：本发明涉及至少一种选自对应于通式（I）的化合物的大麻素化合物及其几何异构体和旋光异构体，其美容上可接受的酸或碱盐及其水合物的非治疗性美容用途; 其中式（I）化合物：R 1表示氢原子或C 1 -C 30烷基; 所述烷基可以任选被羟基（OH）基团取代; R2表示卤素原子或选自羟基，硫醇（SH）和任选被一个或两个C 1 -C 6烷基取代的氨基的基团; R3和R4与带有它们的碳原子一起形成氧代基，或者R3和R4表示氢原子; R5表示氢原子或C1-C6烷基; X表示选自氧和硫原子的杂原子和二价基团-N（R 6） - ，其中R 6表示氢原子或C 1 -C 6烷基; 代表单键或双键; n为1,2或3，优选1或2; 应当理解，当R3和R4一起形成具有带有碳原子的氧代基并且X表示氧原子时，则R1不能代表作为角蛋白材料着色剂的羟甲基。它还涉及这些特定的大麻素化合物之一，用于治疗白癜风或疣状糠疹，用于对皮肤着色或用于治疗阴茎的非治疗性美容方法，包括局部应用于皮肤和/或头发，或在生理上可接受的介质中包含这些大麻素化合物之一的组合物的口服给药，以及用于选择促进角蛋白材料着色的活性剂的方法。

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