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71. 发明申请

US20050137516A1 Method and apparatus for collecting and processing blood 有权
标题翻译：用于收集和处理血液的方法和装置
公开(公告)号：US20050137516A1
公开(公告)日：2005-06-23
申请号：US10826420
申请日：2004-04-16
申请人： Kyungyoon Min , Richard Brown
发明人： Kyungyoon Min , Richard Brown
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36 , A61M1/38 , B01D21/26 , A61M37/00
CPC分类号： A61M1/38 , A61M1/0209 , A61M1/302 , A61M1/3693
摘要： Method and apparatus are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and an initial collection chamber in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source; and a quantity of whole blood is collected from the source in the initial collection container. The source is then disconnected from the disposable fluid circuit. The disposable fluid circuit is mounted in association with the reusable controller and the collected blood is processed through the disposable fluid circuit assembly to separate it into the desired components.
摘要翻译：公开了用于收集和分离全血到一个或多个组分中的方法和装置。提供了一种一次性血液分离流体回路，其适于与可重复使用的分离控制器配合。流体回路包括用于与血液源连通的流体流动路径和与流体流动路径流体连通的初始收集室。流体流动路径连接到血液源; 并且在初始收集容器中从源收集一定量的全血。然后将源从一次性流体回路断开。一次性流体回路与可重复使用的控制器相关联地安装，并且收集的血液通过一次性流体回路组件进行处理，以将其分离成所需的组件。

72. 发明授权

US09097631B2 Apparatus and method for processing biological material 有权
公开(公告)号：US09097631B2
公开(公告)日：2015-08-04
申请号：US13616269
申请日：2012-09-14
申请人： Kyungyoon Min , Thomas E. Dudar , James C. Laird
发明人： Kyungyoon Min , Thomas E. Dudar , James C. Laird
IPC分类号： B01D21/00 , B01D21/26 , G01N1/40 , C12N5/07 , C12M1/00 , G01N15/04 , B01L3/00 , G01N21/07 , A61M39/04 , A61M39/26
CPC分类号： G01N1/4077 , A61M39/045 , A61M39/26 , B01D21/26 , B01D21/262 , B01L1/00 , B01L3/502 , B01L3/5021 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/50825 , B01L3/5635 , B01L2200/025 , B01L2200/026 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/10 , B01L2300/044 , B01L2300/046 , B01L2300/049 , B01L2400/0409 , B01L2400/0478 , B01L2400/0481 , B01L2400/0633 , C12M47/02 , G01N1/40 , G01N15/042 , G01N21/03 , G01N21/07 , G01N33/491 , G01N2001/4083 , G01N2015/149 , G01N2035/00495 , G01N2035/1058
摘要： The application discloses an apparatus and method for processing biological material, including a suspension of cells.

73. 发明申请

US20150182682A1 METHOD FOR SIZED-BASED CELL SEPARATION USING SPINNING MEMBRANE FILTRATION 有权
标题翻译：使用旋转膜过滤的基于尺寸的细胞分离方法
公开(公告)号：US20150182682A1
公开(公告)日：2015-07-02
申请号：US14140978
申请日：2013-12-26
申请人： Christopher Wegener , Bret Olson , Kyungyoon Min
发明人： Christopher Wegener , Bret Olson , Kyungyoon Min
IPC分类号： A61M1/34
CPC分类号： A61M1/3496 , A61M1/26 , A61M1/262 , A61M1/265 , A61M1/3633 , A61M2205/3365 , B01D63/16 , B01D2315/02
摘要： A method is provided for separating a suspension of cellular material comprising at least two differently-sized cell types using a spinning membrane separator. The method comprises selecting the cell type to be separated by passing through the membrane; determining a concentration of the selected cell type in the suspension; selecting an inlet flow rate for the suspension; selecting a rotational speed for the spinning membrane separator related to one or more of the concentration and relative size of the selected cell type in the suspension; rotating the spinning membrane separator at the selected rotational speed so that the selected cell type tends to migrate to regions of the shear field adjacent the porous membrane; and flowing the suspension through the spinning membrane separator.
摘要翻译：提供了一种使用纺丝膜分离器分离包含至少两种不同尺寸的细胞类型的细胞材料的悬浮液的方法。该方法包括通过穿过膜选择待分离的细胞类型; 确定悬浮液中所选细胞类型的浓度; 选择悬浮液的入口流量; 选择与悬浮液中所选择的细胞类型的浓度和相对大小中的一种或多种相关的纺丝膜分离器的旋转速度; 以选定的转速旋转纺丝膜分离器，使得所选择的细胞类型倾向于迁移到邻近多孔膜的剪切场的区域; 并使悬浮液流过纺丝膜分离器。

74. 发明申请

US20150060363A1 DEVICE AND METHOD FOR PROCESSING AND PRODUCING AUTOLOGOUS PLATELET-RICH PLASMA 有权
标题翻译：用于处理和生产自动化等离子体的装置和方法
公开(公告)号：US20150060363A1
公开(公告)日：2015-03-05
申请号：US14014542
申请日：2013-08-30
申请人： Benjamin E. Kusters , Christopher J. Wegener , Kyungyoon Min
发明人： Benjamin E. Kusters , Christopher J. Wegener , Kyungyoon Min
IPC分类号： A61M1/34
CPC分类号： A61M1/3496 , A61M1/0218 , A61M1/265 , A61M2205/103 , A61M2205/75 , B01D63/16 , B01D2317/02 , B01D2319/02 , B01D2319/06
摘要： A system and method are provided, including an integrated single-use kit, for processing whole blood to produce platelet rich plasma. A two stage spinning membrane separator, has a first stage for receiving whole blood and separating substantially all red blood cells from plasma and platelets, and a second stage for further separating platelet rich plasma from plasma. A first waste container is in fluid communication with the first stage of the separator for receiving separated red blood cells, while a second waste container is in fluid communication with the second stage of the separator for receiving separated plasma. An outlet line is in fluid communication with the second stage of the separator for receiving platelet rich plasma, and a reinfusion container is removably connected to the outlet line for receiving platelet rich plasma from the second stage of the separator.
摘要翻译：提供了一种系统和方法，包括一体化的一次性使用试剂盒，用于处理全血以产生富血小板血浆。两级纺丝膜分离器具有第一阶段，用于接收全血并将血浆和血小板基本上全部红细胞分离，以及用于从血浆中进一步分离富血小板血浆的第二阶段。第一废物容器与分离器的第一级流体连通，用于接收分离的红细胞，而第二废物容器与分离器的第二级流体连通以接收分离的等离子体。出口管线与分离器的第二级流体连通，用于接收富血小板血浆，并且再输注容器可移除地连接到出口管线，用于从分离器的第二级接收富血小板血浆。

75. 发明授权

US08875893B2 Medical containers for use in blood collection and processing and medical systems, methods and apparatus for use in blood collection and processing 有权
标题翻译：用于血液收集和处理的医疗容器和医疗系统，用于采血和加工的方法和装置
公开(公告)号：US08875893B2
公开(公告)日：2014-11-04
申请号：US13021310
申请日：2011-02-04
申请人： Kyungyoon Min
发明人： Kyungyoon Min
IPC分类号： B65D69/00 , B65D71/00 , A61J1/10 , A61M1/02 , A61M1/36
CPC分类号： A61J1/10 , A61M1/0209 , A61M1/0222 , A61M1/3693 , A61M2205/6072
摘要： Medical containers for use in blood collection and processing and medical systems, methods and apparatus for use in blood collection and processing are described. An example medical container to be used during blood collection and processing, the medical container includes an elongated body defining a compartment and a base coupled at a first end of the elongated body. Additionally, the medical container includes a divider extending through the compartment to separate the compartment into a first subcompartment and a second subcompartment, the divider comprising a first material and the elongated body comprising a second material, the first material being relatively more rigid than the second material, the first subcompartment and the subsecond compartment each to accommodate blood pack components.
摘要翻译：描述了用于血液收集和处理的医疗容器以及用于采血和处理的医疗系统，方法和装置。在血液收集和处理期间使用的示例性医疗容器，医疗容器包括限定隔室的细长主体和在细长主体的第一端处联接的基部。另外，医疗容器包括延伸穿过隔室的分隔件，以将隔室分隔成第一子隔室和第二子隔室，分隔件包括第一材料，细长主体包括第二材料，第一材料比第二材料相对更刚性材料，第一个子舱和第二个舱室，每个舱室适合血液包装组件。

76. 发明申请

US20140037750A1 AUTOMATED METHODS AND SYSTEMS FOR PROVIDING PLATELET CONCENTRATES WITH REDUCED RESIDUAL PLASMA VOLUMES AND STORAGE MEDIA FOR SUCH PLATELET CONCENTRATES 有权
标题翻译：用于提供具有减少残留等离子体体积的平板浓度的自动化方法和系统以及用于这些等离子体浓度的储存介质
公开(公告)号：US20140037750A1
公开(公告)日：2014-02-06
申请号：US14110076
申请日：2012-04-06
申请人： Katherine Radwanski , Kyungyoon Min
发明人： Katherine Radwanski , Kyungyoon Min
IPC分类号： A61K35/14
CPC分类号： C12N5/0644 , A01N1/0226 , A61K35/19 , A61M1/0209 , A61M1/0272 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0427
摘要： Automated systems and methods for providing platelet concentrates and synthetic storage media with reduced residual plasma volumes are disclosed. The disclosed systems and methods reduce the residual volume of plasma in platelet concentrate to obtain a platelet product having a volume of plasma that is approximately 5% or less of the total platelet product volume. The disclosed systems and methods also reduce the residual volume of plasma in platelet concentrate to obtain a washed platelet product, wherein the volume of plasma in the washed platelet product is approximately 1% or less of the total washed platelet product volume. Storage media for platelets including less than approximately 10% plasma are also disclosed.
摘要翻译：公开了用于提供具有降低的残留血浆体积的血小板浓缩物和合成储存介质的自动化系统和方法。所公开的系统和方法减少血小板浓缩物中的血浆的剩余体积，以获得血小板体积大约为总血小板产品体积的约5％或更小的血小板产品。所公开的系统和方法还减少血小板浓缩物中的血浆的剩余体积以获得洗涤的血小板产物，其中洗涤的血小板产物中的血浆体积为总洗涤的血小板产物体积的约1％或更少。还公开了包含小于约10％血浆的血小板的储存介质。

77. 发明申请

US20130341291A1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME AND DATA MANAGEMENT SYSTEMS AND METHODS 有权
标题翻译：膜分离装置，系统及其使用方法和数据管理系统及方法
公开(公告)号：US20130341291A1
公开(公告)日：2013-12-26
申请号：US14003281
申请日：2012-03-09
申请人： Christopher J. Wegener , Kyungyoon Min , Laurent Forcioli , Mark J. Brierton , Daniel R. Boggs
发明人： Christopher J. Wegener , Kyungyoon Min , Laurent Forcioli , Mark J. Brierton , Daniel R. Boggs
IPC分类号： A61M1/34
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
摘要翻译：公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。还公开了数据管理系统和方法以及启动方法。

78. 发明申请

US20130052188A1 SYSTEMS AND METHODS FOR OBTAINING IMMUNOGLOBULIN FROM BLOOD 审中-公开
标题翻译：从血液中获取免疫球蛋白的系统和方法
公开(公告)号：US20130052188A1
公开(公告)日：2013-02-28
申请号：US13618772
申请日：2012-09-14
申请人： Kyungyoon Min , Larry Backes , Francisco M. Rausa, III , Shawn F. Bairstow , Sindhu Ramachandran , Sharon Pokropinski
发明人： Kyungyoon Min , Larry Backes , Francisco M. Rausa, III , Shawn F. Bairstow , Sindhu Ramachandran , Sharon Pokropinski
IPC分类号： A61K39/395 , A61P25/28
CPC分类号： A61M1/3472 , A61M1/3486 , A61M1/38 , A61M2202/0419 , A61M2202/0057
摘要： The present disclosure relates generally to systems for obtaining a pharmaceutically acceptable immunoglobulin from blood of a donor comprising a first conduit configured to convey blood from the donor to a substrate, wherein said blood includes at least one first component and at least one second component, said first component of the blood including immunoglobulin, and wherein said substrate is adapted to bind immunoglobulin; and a second conduit configured to convey at least a portion of the second component of the blood from the first conduit to the donor.
摘要翻译：本公开一般涉及用于从供体的血液获得药学上可接受的免疫球蛋白的系统，其包括构建成将血液从供体输送到底物的第一导管，其中所述血液包括至少一种第一组分和至少一种第二组分，所述第一组分包括免疫球蛋白的血液的第一组分，并且其中所述底物适于结合免疫球蛋白; 以及第二导管，其构造成将血液的第二组分的至少一部分从第一导管输送到供体。

79. 发明申请

US20120273416A1 SYSTEMS AND METHODS OF CONTROLLING FOULING DURING A FILTRATION PROCEDURE 有权
标题翻译：在过滤过程中控制排料的系统和方法
公开(公告)号：US20120273416A1
公开(公告)日：2012-11-01
申请号：US13095633
申请日：2011-04-27
申请人： Christopher J. Wegener , Marc N. Weasler , Benjamin E. Kusters , Daniel R. Boggs , Kyungyoon Min
发明人： Christopher J. Wegener , Marc N. Weasler , Benjamin E. Kusters , Daniel R. Boggs , Kyungyoon Min
IPC分类号： B01D61/32
CPC分类号： B01D65/02 , A61M1/3496 , B01D61/22 , B01D61/32 , B01D2311/14 , B01D2311/16 , B01D2311/165 , B01D2321/40
摘要： Systems and methods of controlling fouling during a filtration procedure are described. A plasmapheresis method includes accepting a selection of a plasma flow rate and predicting an estimated procedure end time based at least partially on a plasma collection target volume. The method also includes flowing blood past a membrane and changing a plasma flow rate until the selected plasma flow rate through the membrane is achieved. The method also includes determining an acceptable rate of pressure change with time for respective times to the estimated procedure end time, the acceptable fouling rate limit being associated with a system pressure and adjusting the plasma flow rate based on the determined acceptable rate of pressure change with time.
摘要翻译：描述了在过滤过程中控制结垢的系统和方法。血浆置换法包括接受血浆流速的选择并且至少部分地基于等离子体收集目标体积来预测估计的过程结束时间。该方法还包括使血液流过膜并改变等离子体流速，直到达到所选择的通过膜的等离子体流速。该方法还包括在相应时间内估计可接受的压力变化速率到估计的程序结束时间，可接受的结垢速率极限与系统压力相关联并且基于所确定的可接受的压力变化速率来调节等离子体流速时间。

80. 发明授权

US08211049B2 Blood processing system for single or double access draw and return 有权
标题翻译：血液处理系统可单程或双程进行抽取和归还
公开(公告)号：US08211049B2
公开(公告)日：2012-07-03
申请号：US12392193
申请日：2009-02-25
申请人： Kyungyoon Min
发明人： Kyungyoon Min
IPC分类号： A61M37/00 , A61M1/00
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/3616 , A61M1/3627
摘要： A blood processing system is disclosed which is adapted for single or double access draw and return. The blood processing system includes a blood processor for separating blood (or blood components) into one or more components or other components. In one embodiment the blood processor includes an inlet for receiving blood from blood source and an outlet for returning at least one blood component to the source. The processing system includes a first flow path in communication with the inlet, a second flow path in communication with the outlet, a third flow path in communication with a second flow path at two spaced apart locations, a reservoir communicates with the third flow path between the two spaced apart locations, and a flow communication site associated with the second flow path downstream of the spaced apart locations which communication site is adapted to permit communication with the first flow path.
摘要翻译：公开了一种血液处理系统，其适用于单次或双次存取和返回。血液处理系统包括用于将血液（或血液成分）分离成一个或多个组分或其它组分的血液处理器。在一个实施例中，血液处理器包括用于从血液源接收血液的入口和用于将至少一个血液成分返回到源的出口。处理系统包括与入口连通的第一流动路径，与出口连通的第二流动路径，在两个间隔开的位置处与第二流动路径连通的第三流动路径，储存器与第二流动路径在第二流动路径之间连通，两个间隔开的位置，以及与间隔开的位置下游的第二流动路径相关联的流动通信站点，该通信站点适于允许与第一流动路径的通信。

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