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71. 发明授权

US07786080B2 Mutein of a bone morphogenetic protein and use thereof 失效
标题翻译：骨形态发生蛋白的突变蛋白及其用途
公开(公告)号：US07786080B2
公开(公告)日：2010-08-31
申请号：US10591482
申请日：2005-03-04
申请人： Thomas Muller , Walter Sebald
发明人： Thomas Muller , Walter Sebald
IPC分类号： A61K38/18 , C07K14/51
CPC分类号： C07K14/51 , A61K38/00
摘要： The present invention is related to a mutein of a bone morphogenetic protein, whereby the mutein comprises an amino acid substitution compared to the wildtype of the bone morphogenetic protein at the amino acid position corresponding to amino acid position 51 of human BMP-2.
摘要翻译：本发明涉及骨形态发生蛋白的突变蛋白，其中与对应于人BMP-2的氨基酸位置51的氨基酸位置处的骨形态发生蛋白的野生型相比，突变蛋白包含氨基酸取代。

72. 发明申请

US20100010967A1 SYSTEM AND METHOD FOR A LOG-BASED DATA STORAGE 有权
标题翻译：用于基于日志的数据存储的系统和方法
公开(公告)号：US20100010967A1
公开(公告)日：2010-01-14
申请号：US12172971
申请日：2008-07-14
申请人： Thomas Muller
发明人： Thomas Muller
IPC分类号： G06F17/30 , G06F7/06
CPC分类号： G06F17/30587
摘要： Embodiments of the invention provide a high-performance content management system with a log-based data storage. To speed data operations, updates and deletes are appended to log-based data files. Seek operations are not needed as old data is not overwritten or removed at the time of write operations. Instead, the log-based data files are periodically optimized by processes that compact data entries and remove data files containing old data. In addition, an associated index with entries accessible in constant time is used to facilitate the process of locating data entries within the data files. Embodiments of the log-based data storage are implemented in a standard file format for ease of development and maintenance and can be compressed to further improve performance. In one embodiment, the log-based data storage corresponds to a node-based logical data tree that can be adapted to house a variety of data, including data from relational databases.
摘要翻译：本发明的实施例提供了一种具有基于日志的数据存储的高性能内容管理系统。为了加速数据操作，更新和删除将附加到基于日志的数据文件。不需要寻求操作，因为在写入操作时旧数据不会被覆盖或删除。相反，基于日志的数据文件由压缩数据条目和删除包含旧数据的数据文件的进程定期优化。此外，使用具有可在常量时间访问的条目的关联索引来促进在数据文件内定位数据条目的过程。基于日志的数据存储的实施例以标准文件格式实现，以便于开发和维护，并且可以被压缩以进一步提高性能。在一个实施例中，基于日志的数据存储对应于可以适于容纳各种数据（包括来自关系数据库的数据）的基于节点的逻辑数据树。

73. 发明申请

US20080213072A1 Discharge hopper and method of discharging shaft trays filled with rod-shaped products 失效
标题翻译：排料斗和排出装有棒状产品的轴托盘的方法
公开(公告)号：US20080213072A1
公开(公告)日：2008-09-04
申请号：US12068080
申请日：2008-02-01
申请人： Piotr Budny , Thomas Muller , Matthias Horn , Michael Knabe , Arnd Meier
发明人： Piotr Budny , Thomas Muller , Matthias Horn , Michael Knabe , Arnd Meier
IPC分类号： B65G47/04 , B65G65/30 , B65D88/32 , B65G47/74 , B65G3/04
CPC分类号： A24C5/356 , A24C5/358 , B65B19/04
摘要： A discharge hopper for a tray discharge station for serially discharging shaft trays filled with rod-shaped products includes, a conveying element for carrying away the products flowing from the shaft trays and a connecting device for coupling the shaft trays to be emptied to the conveying element. The connecting device is arranged substantially parallel to and spaced apart from the conveying element to form a channel for the product flow and includes an opening for passage of the products from the shaft tray into the channel. In the region of the connecting device there is provided a closure unit to open and close the opening. The closure device is coupled to a movable actuating element so that the closure device can be opened and closed shaft by shaft in relation to the shaft tray to be emptied.
摘要翻译：用于串联排出装有棒状产品的轴托盘的托盘排放站的排出料斗包括用于运送从轴托盘流出的产品的输送元件和用于联接要被排空到输送元件的轴托盘的连接装置。连接装置被布置成基本上与输送元件平行并间隔开，以形成用于产品流动的通道，并且包括用于将产品从轴托盘通入通道的开口。在连接装置的区域中，设置有用于打开和关闭开口的封闭单元。闭合装置联接到可移动的致动元件，使得封闭装置可以相对于要被排空的轴托盘被轴打开和关闭。

74. 发明申请

US20080181754A1 Discharge hopper and method of discharing trays, in particular shaft trays, filled with rod-shaped articles 审中-公开
标题翻译：排料斗和排料托盘的方法，特别是装有杆状制品的轴托盘
公开(公告)号：US20080181754A1
公开(公告)日：2008-07-31
申请号：US12010992
申请日：2008-01-31
申请人： Piotr Budny , Thomas Muller , Matthias Horn , Michael Knabe , Arnd Meier
发明人： Piotr Budny , Thomas Muller , Matthias Horn , Michael Knabe , Arnd Meier
IPC分类号： B65G65/00
CPC分类号： A24C5/356 , B65G43/08 , B65G47/19
摘要： A discharge hopper for a tray discharge station discharges a tray filled with rod-shaped products. A receiving chamber for the products flowing from the tray is open at the top in the direction of the tray and at the bottom is defined by a channel formed by a conveying element that carries away the products. Flow regulating elements within the receiving chamber control the flow of products within the discharge hopper. A monitoring unit is arranged and constructed for detecting the level of products within the tray. The monitoring unit is operatively connected to the flow regulating elements for individual control of the flow regulating elements.
摘要翻译：用于托盘排出站的排出料斗排出填充有棒状产品的托盘。用于从托盘流出的产品的接收室在托盘的顶部处是敞开的，并且底部由通过输送元件形成的通道限定，该输送元件带走产品。接收室内的流量调节元件控制排出料斗内的产品流。布置和构造监测单元以检测托盘内的产品的水平。监测单元可操作地连接到流量调节元件，用于单独控制流量调节元件。

75. 发明申请

US20080039121A1 Methods and Systems for Establishing Relationships Between Mobile Communication Device Users 审中-公开
标题翻译：建立移动通信设备用户关系的方法与系统
公开(公告)号：US20080039121A1
公开(公告)日：2008-02-14
申请号：US11831959
申请日：2007-08-01
申请人： Thomas Muller , Jan Schulz , Lars Henrik Grau , Marhus Juhr-De Benedetti
发明人： Thomas Muller , Jan Schulz , Lars Henrik Grau , Marhus Juhr-De Benedetti
IPC分类号： H04M3/42 , G06F7/00
CPC分类号： H04M7/0036 , H04M2203/655
摘要： A method of establishing a community including a first mobile communication device user and a second mobile communication device user is disclosed. The method includes receiving a first message from the first mobile communication device user and receiving a second message from the second mobile communication device user. The method further includes parsing the first message and the second message to determine a first user identifier and a first user-generated key and a second user identifier and a second user-generated key respectively. Furthermore, the method includes calculating a matching probability between the first mobile communication device user and the second mobile communication device user based on at least one of a proximity of distance, a proximity of time of the receipt of messages, and matching of the user-generated keys.
摘要翻译：公开了一种建立包括第一移动通信设备用户和第二移动通信设备用户的社区的方法。该方法包括从第一移动通信设备用户接收第一消息并从第二移动通信设备用户接收第二消息。该方法还包括分析第一消息和第二消息以分别确定第一用户标识符和第一用户生成的密钥以及第二用户标识符和第二用户生成的密钥。此外，该方法包括基于距离的接近度，接收消息的时间的接近度以及用户级别的匹配中的至少一个来计算第一移动通信设备用户和第二移动通信设备用户之间的匹配概率，生成的键。

76. 发明申请

US20070293425A1 Mutein of a Bone Morphogenetic Protein and Use Thereof 失效
标题翻译：骨形态发生蛋白的突变蛋白及其用途
公开(公告)号：US20070293425A1
公开(公告)日：2007-12-20
申请号：US10591482
申请日：2005-03-04
申请人： Thomas Muller , Walter Sebald
发明人： Thomas Muller , Walter Sebald
IPC分类号： A61K38/18 , A01K67/027 , A61P19/00 , C07H21/00 , C07K16/22 , C12N15/63 , C12P21/00 , C12N5/10 , C12N15/12 , C07K14/51 , A61P43/00 , A61K31/7052
CPC分类号： C07K14/51 , A61K38/00
摘要： The present invention is related to a mutein of a bone morphogenetic protein, whereby the mutein comprises an amino acid substitution compared to the wildtype of the bone morphogenetic protein at the amino acid position corresponding to amino acid position 51 of human BMP-2.
摘要翻译：本发明涉及骨形态发生蛋白的突变蛋白，其中与对应于人BMP-2的氨基酸位置51的氨基酸位置处的骨形态发生蛋白的野生型相比，突变蛋白包含氨基酸取代。

77. 发明申请

US20050156366A1 Arrangement with a height-adjustable component 有权
标题翻译：具有高度可调组件的布置
公开(公告)号：US20050156366A1
公开(公告)日：2005-07-21
申请号：US10760791
申请日：2004-01-19
申请人： Thomas Muller
发明人： Thomas Muller
IPC分类号： A47B9/10 , F16F9/02 , F16F5/00
CPC分类号： F16F9/0227 , A47B9/10 , F16F9/0272
摘要： An arrangement with a height-adjustable component includes an approximately vertically extending upright which bears the component, the upright including a pneumatic spring. The pneumatic spring has a cylinder having a bottom end connected to a fixed part of the arrangement. A piston displaceably arranged in the cylinder subdivides the cylinder into a bottom cylinder chamber and a top cylinder chamber and has a piston rod at one end. The piston rod projects through the top cylinder chamber and is guided out of the top end of the cylinder and bears the component at its free end. The top and bottom cylinder chambers are filled with a gas filling, under positive pressure, which subjects the piston to an upwardly directed push-out force corresponding approximately to the opposing weight-induced force of the component. A valve allows a gas flow from the top into the bottom cylinder chamber and blocks the same in the opposite flow direction. A manually actuable connecting valve selectively connects the bottom and the top chambers.
摘要翻译：具有高度可调部件的装置包括大致垂直延伸的直立部件，其支撑部件，直立件包括气动弹簧。气动弹簧具有连接到该装置的固定部分的底端的气缸。可移动地布置在气缸中的活塞将气缸细分为底缸室和顶缸室，并且在一端具有活塞杆。活塞杆通过顶部气缸室突出，并被引导出气缸的顶端，并在其自由端承载部件。顶部和底部气缸室在正压力下填充有气体填充物，其使活塞受到大致对应于组件的相对的重量引起的力的向上指向的推出力。阀门允许气体从顶部进入底部气缸室，并在相反的流动方向阻挡气体。手动致动的连接阀选择性地连接底部和顶部腔室。

78. 发明申请

US20050020558A1 Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics 失效
标题翻译：使用HSP90抑制剂与抗虚型药物组合治疗疾病的方法
公开(公告)号：US20050020558A1
公开(公告)日：2005-01-27
申请号：US10856742
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K31/427 , A61K31/535 , A61K45/06
CPC分类号： A61K45/06 , A61K31/427
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimitotic, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimitotic in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimitotic. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimitotic and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和抗有丝分裂剂，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一个步骤中一种抗有丝分裂剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用受试者的HSP90抑制剂治疗并随后用剂量的抗有丝分裂剂治疗。在本发明的另一方面，提供一种治疗癌症的方法，其中首先用一种抗有丝分裂的剂量治疗受试者，随后用剂量的HSP90抑制剂治疗。

79. 发明申请

US20050020557A1 Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors 审中-公开
标题翻译：使用HSP90抑制剂与酶抑制剂组合治疗疾病的方法
公开(公告)号：US20050020557A1
公开(公告)日：2005-01-27
申请号：US10856696
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/19 , A61K31/33
CPC分类号： A61K31/165 , A61K31/395 , A61K31/517
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an enzyme inhibitor, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an enzyme inhibitor in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an enzyme inhibitor. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an enzyme inhibitor and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和酶抑制剂，其中组合给药提供协同效应。在本发明的一个方面，提供一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量和另一步骤中的酶抑制剂的剂量来治疗受试者。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一种剂量的HSP90抑制剂治疗受试者，并随后用一定剂量的酶抑制剂治疗。在本发明的另一方面，提供一种治疗癌症的方法，其中首先用一定剂量的酶抑制剂处理受试者，随后用一定剂量的HSP90抑制剂处理。

80. 发明授权

US6157969A Device for connecting DMA request signals to a selected one of DMA input lines 失效
标题翻译：将DMA请求信号连接到选定的一条DMA输入线的装置
公开(公告)号：US6157969A
公开(公告)日：2000-12-05
申请号：US91197
申请日：1998-06-10
申请人： Thomas Muller
发明人： Thomas Muller
IPC分类号： G06F13/28 , G06F13/14 , G06F13/40
CPC分类号： G06F13/28
摘要： A computer with module slots which can be connected to one another pith address lines, data lines and control lines, the control lines comprising DMA request lines, and with a DMA controller to which DMA request signals can be sent by plug-in functional units over the DMA request lines and setting means. The computer is provided with means to simplify a selection of DMA request lines for transmitting DMA request signals.This may be used in personal computers and in automation computers.
摘要翻译： PCT No.PCT / DE96 / 02197 Sec。 371日期：1998年6月10日 102（e）1998年6月10日PCT PCT 1996年11月18日PCT公布。公开号WO97 / 22043 日期：1997年6月19日具有模块插槽的计算机，可以连接到另一个地址线，数据线和控制线，控制线包括DMA请求线，以及可通过插头向其发送DMA请求信号的DMA控制器 - 在DMA请求线和设置装置上的功能单元。计算机具有简化用于发送DMA请求信号的DMA请求线的选择的装置。这可以用于个人计算机和自动化计算机中。

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