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71. 发明授权

US07512440B2 Ventricular pacing 有权
标题翻译：心室起搏
公开(公告)号：US07512440B2
公开(公告)日：2009-03-31
申请号：US11300611
申请日：2005-12-13
申请人： Daniel Felipe Ortega , Alberto German Giniger , Qingsheng Zhu , J. Edward Shapland
发明人： Daniel Felipe Ortega , Alberto German Giniger , Qingsheng Zhu , J. Edward Shapland
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61N1/362 , A61N1/3627 , A61N1/3962
摘要： A method and apparatus are disclosed for treating a condition of a patient's heart includes placing a first electrode and a second electrode in a right ventricle of the heart. A reference electrode is placed within the patient and internal or external to the heart. A pacing signal is generated including a first signal component, a second signal component and a reference component with the first and second signal components having opposite polarity and with both of the first and second components having a potential relative to the reference component. The first component is transmitted to the first electrode. The second component is transmitted to the second electrode. The reference electrode is connected to the reference component which may be an electrical ground. The pacing signal and the placement of the electrodes are selected to alter a contraction of a left ventricle of the heart.
摘要翻译：公开了一种用于治疗患者心脏状况的方法和装置，包括将第一电极和第二电极放置在心脏的右心室中。参考电极放置在患者体内并在心脏内部或外部。生成包括第一信号分量，第二信号分量和参考分量的起搏信号，其中第一和第二信号分量具有相反的极性，并且第一和第二分量都具有相对于参考分量的电势。第一部件被传输到第一电极。第二部件被传送到第二电极。参考电极连接到可以是电接地的参考部件。选择起搏信号和放置电极以改变心脏左心室的收缩。

72. 发明授权

US07479107B2 Core body temperature monitoring in heart failure patients 有权
标题翻译：核心体温监测心力衰竭患者
公开(公告)号：US07479107B2
公开(公告)日：2009-01-20
申请号：US11258432
申请日：2005-10-25
申请人： Qingsheng Zhu , Julio Spinelli
发明人： Qingsheng Zhu , Julio Spinelli
IPC分类号： A61B5/00
CPC分类号： A61B5/14539 , A61B5/0008 , A61B5/024 , A61B5/076 , A61B5/145
摘要： An implanted heart monitor includes sensors that measure various aspects of the heart failure patient's heart. A remote heart monitoring system connects the implanted heart monitor to a care provider, such as a physician. The data provided by the implanted heart monitor permits the care provider to obtain valuable data on the heart in order to make health care decisions affecting the heart failure patient's treatment. In many cases, the measurement of core body temperature and other patient data will enable the care provider to alter the patient's treatment to address the patient's condition. The implanted heart monitor can communicate over a wireless communication link with an external monitor. The implanted heart monitor may be implemented as part of a pacing device (i.e., pace maker) or may be a separate unit devoted to monitoring functions. The external monitor communicates with a monitoring station over a communication link. The monitoring station can operate as a centralized data collection unit, collecting data from multiple external monitors and multiple implanted heart monitors. Various other aspects of a heart failure patient's heart and/or body can be monitored, such as heart rate, blood pH levels, blood CO2 levels, and any other indications of the heart failure patient's activity. Various predetermined thresholds may be set to trigger alarms and/or data reports.
摘要翻译：植入心脏监测器包括测量心力衰竭患者心脏的各个方面的传感器。远程心脏监测系统将植入的心脏监测器连接到护理提供者，例如医师。由植入式心脏监测器提供的数据允许护理提供者在心脏上获得有价值的数据，以便使医疗保健决定影响心力衰竭患者的治疗。在许多情况下，核心体温和其他患者数据的测量将使护理人员能够改变患者的治疗以解决病人的状况。植入的心脏监测器可以通过无线通信链路与外部监视器进行通信。植入心脏监视器可以被实现为起搏装置（即，起搏器）的一部分，或者可以是专用于监视功能的单独单元。外部监视器通过通信链路与监控站进行通信。监控站可以作为集中数据采集单元运行，从多个外部监视器和多个植入心脏监视器收集数据。可以监测心力衰竭患者的心脏和/或身体的各种其他方面，例如心率，血液pH值，血液二氧化碳水平以及心力衰竭患者活动的任何其他指征。可以设置各种预定阈值以触发报警和/或数据报告。

73. 发明申请

US20090005832A1 Circuit-Based Devices and Methods for Pulse Control of Endocardial Pacing in Cardiac Rhythm Management 有权
标题翻译：基于电路的心脏节律管理心内膜起搏脉搏控制装置及方法
公开(公告)号：US20090005832A1
公开(公告)日：2009-01-01
申请号：US12147356
申请日：2008-06-26
申请人： Qingsheng Zhu , Daniel Felipe Ortega
发明人： Qingsheng Zhu , Daniel Felipe Ortega
IPC分类号： A61N1/37
CPC分类号： A61N1/3627
摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by generating pulses for delivery to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, an implantable pulse generator includes circuitry for generating pacing profiles, with signals of opposite polarities, specifically selected for delivery on electrodes at a site near the septal wall of a right ventricle of the heart.
摘要翻译：工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。某些方面涉及起搏和/或作图，通过产生用于递送到心脏部位的脉搏，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/ 压力或其组合。在一个实施例中，可植入脉冲发生器包括用于产生具有相反极性的信号的起搏曲线的电路，其具体选择用于在靠近心脏右心室隔壁的位置处的电极上传送。

74. 发明授权

US07468032B2 Advanced patient management for identifying, displaying and assisting with correlating health-related data 有权
标题翻译：高级患者管理，用于识别，显示和协助健康相关数据的关联
公开(公告)号：US07468032B2
公开(公告)日：2008-12-23
申请号：US10323713
申请日：2002-12-18
申请人： Jeffrey E. Stahmann , John Hatlestad , Qingsheng Zhu
发明人： Jeffrey E. Stahmann , John Hatlestad , Qingsheng Zhu
IPC分类号： A61B5/00
CPC分类号： A61B5/02405 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/0464 , A61B5/0809 , A61B5/0816 , A61B5/0833 , A61B5/16 , A61B5/205 , A61B5/743 , A61B5/7435 , A61B5/7475 , A61B7/00 , A61B2560/0242 , A61B2560/0271 , G06F19/00
摘要： Systems, devices and methods for identifying, displaying and assisting in correlating health-related data. One aspect is a programmable device having machine executable instructions for performing a method for use in correlating data to manage a patient's health. In various embodiments, data related to the patient's health is acquired. The acquired data includes one or more trended health-related parameters, and at least one of one or more predetermined health-related events and one or more health-related alerts. Correlations are identified. The one or more trended health-related parameters and the at least one of the one or more predetermined health-related events and the one or more health-related alerts establish a causal relationship between the acquired data and the patient's health.
摘要翻译：用于识别，显示和协助关联健康相关数据的系统，设备和方法。一个方面是具有机器可执行指令的可编程设备，用于执行用于关联数据以管理患者健康的方法。在各种实施例中，获得与患者健康有关的数据。所获取的数据包括一个或多个趋势健康相关参数，以及一个或多个预定健康相关事件和一个或多个健康相关警报中的至少一个。确定相关性。所述一个或多个趋势健康相关参数以及所述一个或多个预定健康相关事件和所述一个或多个健康相关警报中的至少一个建立所获取的数据与所述患者健康之间的因果关系。

75. 发明申请

US20080215108A1 Cardiac rhythm management system for edema 有权
标题翻译：水肿心律管理系统
公开(公告)号：US20080215108A1
公开(公告)日：2008-09-04
申请号：US12152099
申请日：2008-05-12
申请人： Qingsheng Zhu , Julio C. Spinelli
发明人： Qingsheng Zhu , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A cardiac rhythm management system detects edema. In response to an episode of detected edema, it initiates or adjusts a cardiac resynchronization therapy and/or a cardiac contractility modulation (CCM) therapy.
摘要翻译：心律管理系统检测水肿。响应于检测到的水肿发作，其启动或调整心脏再同步治疗和/或心脏收缩调节（CCM）治疗。

76. 发明授权

US07366567B2 Method for treating myocardial infarction 有权
公开(公告)号：US07366567B2
公开(公告)日：2008-04-29
申请号：US11088231
申请日：2005-03-23
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

77. 发明申请

US20080077031A1 System and method for remote expert-system medical device programming 有权
标题翻译：远程专家系统医疗设备编程的系统和方法
公开(公告)号：US20080077031A1
公开(公告)日：2008-03-27
申请号：US11985995
申请日：2007-11-19
申请人： Julio Spinelli , Qingsheng Zhu
发明人： Julio Spinelli , Qingsheng Zhu
IPC分类号： A61B5/0452
CPC分类号： A61N1/37282 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06Q50/22 , G16H40/40
摘要： One embodiment includes a system for prescribing therapeutic treatment for a patient via communications over a network, including an implantable medical device (IMD) to be implanted in the patient to record a patient characteristic, the implantable medical device being programmable and configured to communicate via wireless communications with the IMD and to communicate securely over the network, the medical device programming computer including a user interface. The embodiment includes a server to communicate securely over the network with the medical device programming computer, the server including at least a first expert prescription system comprising at least one physician's prescription and at least one expert-system to compare the at least one patient characteristic to the at least one physician's prescription to issue a parameter to be programmed into the IMD based on the comparison.
摘要翻译：一个实施例包括一种用于通过网络进行通信来对患者进行治疗性治疗的系统，包括要植入患者中的可植入医疗装置（IMD）以记录患者特征，所述可植入医疗装置是可编程的并且经配置以经由无线与IMD的通信并且通过网络安全地通信，医疗设备编程计算机包括用户界面。该实施例包括通过网络与医疗设备编程计算机安全地通信的服务器，该服务器至少包括第一专家处方系统，该第一专家处方系统包括至少一个医师的处方和至少一个专家系统，以将至少一个患者特征与所述至少一位医生处方根据比较发布要编程到IMD中的参数。

78. 发明申请

US20080045852A1 DETECTION OF CONGESTION FROM MONITORING PATIENT RESPONSE TO A RECUMBENT POSITION 有权
标题翻译：检测患者对重要位置的反应
公开(公告)号：US20080045852A1
公开(公告)日：2008-02-21
申请号：US11926425
申请日：2007-10-29
申请人： John Hatlestsad , Qingsheng Zhu , Jeffrey Stahmann
发明人： John Hatlestsad , Qingsheng Zhu , Jeffrey Stahmann
IPC分类号： A61B5/08
CPC分类号： A61B5/0809 , A61B5/0816 , A61B5/1071 , A61B5/1116 , A61B5/1135 , A61B5/4806 , A61B5/6831 , A61B5/6846 , A61B5/686 , A61N1/36542
摘要： Systems and methods obtain information that allows detection of whether a patient suffers from congestion by monitoring a response of the patient to a recumbent position of the patient's body. The patient may be monitored to determine a respiration pattern for a non-recumbent position such as standing and a respiration pattern for a recumbent position such as lying down. The two patterns may be compared, either by a processing device or a physician, to determine a difference in the two respiration patterns. Furthermore, the congestion may be inferred from detecting an amount of time that the patient spends in a recumbent position or from detecting the recumbent angle that the patient obtains, either of which is presumed to indicate whether a recumbent position presents discomfort to the patient due to the presence of congestion.
摘要翻译：系统和方法获得允许通过监视患者对患者身体的卧位的反应来检测患者是否患有拥塞的信息。可以监测患者以确定用于躺卧位置的无卧位的呼吸模式，例如躺卧和躺卧位置的呼吸模式。可以通过处理装置或医师来比较两种模式，以确定两种呼吸模式的差异。此外，可以通过检测患者在躺卧位置中花费的时间量或从检测患者获得的躺卧角度来推断拥塞，其中任何一个被推定为指示躺卧位置是否由于患者的不适而给患者带来不适拥堵的存在。

79. 发明申请

US20080015653A1 METHOD AND APPARATUS FOR PHONOCARDIOGRAPHIC IMAGE ACQUISITION AND PRESENTATION 有权
标题翻译：用于图像摄影和呈现的方法和装置
公开(公告)号：US20080015653A1
公开(公告)日：2008-01-17
申请号：US11780405
申请日：2007-07-19
申请人： Krzysztof Siejko , Gerrard Carlson , William Lincoln , Qingsheng Zhu
发明人： Krzysztof Siejko , Gerrard Carlson , William Lincoln , Qingsheng Zhu
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/36578 , A61N1/3682 , A61N1/3702
摘要： A cardiac rhythm management system provides a phonocardiographic image indicative of a heart's mechanical events related to hemodynamic performance. The phonocardiographic image includes a stack of acoustic sensor signal segments representing multiple cardiac cycles. Each acoustic sensor signal segment includes heart sounds indicative of the heart's mechanical events and representations of the heart's electrical events. The stack of acoustic sensor signal segments are aligned by a selected type of the heart's mechanical or electrical events and are grouped by a cardiac timing parameter for presentation.
摘要翻译：心律管理系统提供指示与血液动力学性能相关的心脏的机械事件的心音图像。心音图像包括表示多个心动周期的一组声传感器信号段。每个声学传感器信号段包括指示心脏的机械事件和心脏电气事件的表示的心脏声音。声学传感器信号段的堆叠通过所选择的心脏的机械或电气事件的类型对准，并且通过心脏定时参数分组以进行呈现。

80. 发明授权

US07225024B2 Sensors having protective eluting coating and method therefor 有权
标题翻译：具有保护性洗脱涂层的传感器及其方法
公开(公告)号：US07225024B2
公开(公告)日：2007-05-29
申请号：US10677144
申请日：2003-09-30
申请人： Qingsheng Zhu , Ronald W. Heil, Jr. , Mudit Jain
发明人： Qingsheng Zhu , Ronald W. Heil, Jr. , Mudit Jain
IPC分类号： A61N1/365 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61N1/0568
摘要： A cardiac management implantable device that has an intravascular device body, and one or more chemical sensors coupled with the intravascular device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.
摘要翻译：一种具有血管内装置体的心脏管理可植入装置，以及与血管内装置本体结合的一个或多个化学传感器。药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

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