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71. 发明申请

US20080084553A1 Method And Apparatus For Multimodal Detection 有权
标题翻译：多模态检测方法与装置
公开(公告)号：US20080084553A1
公开(公告)日：2008-04-10
申请号：US11632471
申请日：2005-07-14
申请人： Jason H. Neiss , Robert Schweitzer , Patrick J. Treado
发明人： Jason H. Neiss , Robert Schweitzer , Patrick J. Treado
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01J3/44 , G01J3/28 , G01J3/2823 , G01N21/6486 , G01N21/65 , G01N2201/1293
摘要： In one embodiment, the disclosure relates to a method for detecting and classifying an unknown substance in a sample. The method including the steps of (a) providing a spectrum for each of a predetermined number of reference substances; (b) detecting an area of interest on said unknown substance; (c) targeting said area of interest; (d) determining a spectrum from said area of interest; (e) comparing the determined spectrum with the spectrum of one of the reference substances; and (f) classifying said unknown substance based on the comparison of spectra.
摘要翻译：在一个实施方案中，本公开涉及用于检测和分类样品中未知物质的方法。该方法包括以下步骤：（a）为预定数量的参考物质中的每一个提供光谱; （b）检测所述未知物质的感兴趣区域; （c）针对该地区的目标; （d）从所述感兴趣区域确定频谱; （e）将所确定的光谱与参考物质之一的光谱进行比较; 和（f）基于光谱的比较对所述未知物质进行分类。

72. 发明授权

US07283241B2 Method and apparatus for a microscope image selector 有权
标题翻译：显微镜图像选择器的方法和装置
公开(公告)号：US07283241B2
公开(公告)日：2007-10-16
申请号：US11045080
申请日：2005-01-31
申请人： Xinghua Wang , Thomas C. Voigt , David Tuschel , Chenhui Wang , Patrick J. Treado
发明人： Xinghua Wang , Thomas C. Voigt , David Tuschel , Chenhui Wang , Patrick J. Treado
IPC分类号： G01N21/25
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.
摘要翻译：本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

73. 发明授权

US07268862B2 Near infrared chemical imaging microscope 有权
公开(公告)号：US07268862B2
公开(公告)日：2007-09-11
申请号：US11366887
申请日：2006-03-02
申请人： Patrick J. Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick J. Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01N21/00 , G01J3/40
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

74. 发明申请

US20070201022A1 System and method for spectral unmixing in a fiber array spectral translator based polymorph screening system 有权
标题翻译：基于光纤阵列光谱变换器的多态性筛选系统中光谱解混合的系统和方法
公开(公告)号：US20070201022A1
公开(公告)日：2007-08-30
申请号：US11679112
申请日：2007-02-26
申请人： Jason H. Neiss , Patrick J. Treado , Robert Schweitzer
发明人： Jason H. Neiss , Patrick J. Treado , Robert Schweitzer
IPC分类号： G01J3/00
CPC分类号： G01J3/2803 , G01J3/02 , G01J3/0218 , G01J3/0221 , G01J3/024 , G01J3/0291 , G01J3/0294 , G01J3/04 , G01J3/2823 , G01J3/44 , G01N21/65 , G01N2201/0833 , G01N2201/1293
摘要： The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for performing spectral unmixing of a mixture containing multiple polymorphs. In an embodiment, a first spectrum of a mixture containing polymorphs of a compound is obtained using a photon detector and a fiber array spectral translator having plural fibers. A set of second spectra is provided where each spectrum of the set of second spectra may be representative of a different polymorph of the compound. The first spectrum and the set of second spectra may be compared, and based on the comparison, the presence of one or more polymorphs in the mixture may be determined.
摘要翻译：本公开总体上涉及使用用于执行含有多个多晶型物的混合物的光谱解混合的光纤阵列光谱转换器（“FAST”）光谱系统的方法和装置。在一个实施方案中，使用具有多个纤维的光子检测器和光纤阵列光谱转换器获得含有化合物多晶型物的混合物的第一光谱。提供了一组第二光谱，其中该组第二光谱的每个光谱可以代表该化合物的不同多晶型物。可以比较第一光谱和第二光谱集，并且基于比较，可以确定混合物中一个或多个多晶型物的存在。

75. 发明授权

US07061606B2 Near infrared chemical imaging microscope 有权
公开(公告)号：US07061606B2
公开(公告)日：2006-06-13
申请号：US10773077
申请日：2004-02-05
申请人： Patrick J. Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick J. Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01J3/44 , G01J3/28
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

76. 发明授权

US08269174B2 Method and apparatus for compact spectrometer for multipoint sampling of an object 有权
标题翻译：用于多物体采样的紧凑型光谱仪的方法和装置
公开(公告)号：US08269174B2
公开(公告)日：2012-09-18
申请号：US12719904
申请日：2010-03-09
申请人： Charles W. Gardner , Patrick J. Treado , Matthew Nelson , Robert Schweitzer
发明人： Charles W. Gardner , Patrick J. Treado , Matthew Nelson , Robert Schweitzer
IPC分类号： G01J5/02
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0256 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/6456 , G01N21/6486 , G01N21/65
摘要： A method and a portable device for assessing the occurrence of an agent in a sample. A sample is illuminated with photons emanating from a portable device to produce photons reflected, emitted, or absorbed from a set of multiple points in the sample having a defined geometric relationship. The portable device is used to simultaneously illuminate the sample and analyze the photons reflected, emitted, or absorbed from the set of multiple points using spectroscopic methods, including infrared, fluorescence, and UV/visible. The agent assessed may include a hazardous agent, a chemical agent, a biological agent, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof.
摘要翻译：一种用于评估样品中的试剂的发生的方法和便携式装置。用便携式设备发出的光子照射样品，以产生从具有确定的几何关系的样品中的一组多个点反射，发射或吸收的光子。便携式设备用于同时照亮样品并使用包括红外，荧光和紫外/可见光在内的光谱方法分析从该组多个点反射，发射或吸收的光子。所评估的试剂可以包括危险剂，化学试剂，生物制剂，微生物，细菌，原生动物，病毒及其组合。

77. 发明申请

US20120072122A1 Forensic Integrated Search Technology 审中-公开
标题翻译：法医综合搜索技术
公开(公告)号：US20120072122A1
公开(公告)日：2012-03-22
申请号：US13246906
申请日：2011-09-28
申请人： Robert Schweitzer , Patrick J. Treado , Jason Neiss
发明人： Robert Schweitzer , Patrick J. Treado , Jason Neiss
IPC分类号： G06F19/00
CPC分类号： G06F16/2462 , G16C20/20 , G16C20/90
摘要： A system and method to search spectral databases and to identify unknown materials. A library comprising sublibraries is provided, each sublibrary containing a plurality of reference data sets corresponding to known materials. Test data sets are provided, characteristic of an unknown material. Each test data set is generated by one or more spectroscopic data generating instruments. Each sublibrary is searched and a corresponding set of scores is produced, indicating a likelihood of a match. Relative probability values are calculated for each searched sublibrary. All relative probability values are fused producing a set of final probability values, used to determine whether the unknown material is represented through a known material in the library. A highest final probability value is selected compared to a minimum confidence value. If the probability value is greater than or equal to the minimum confidence value, the known material is reported.
摘要翻译：搜索光谱数据库并识别未知材料的系统和方法。提供了包括子库的库，每个子库包含对应于已知材料的多个参考数据集。提供测试数据集，是未知材料的特征。每个测试数据集由一个或多个光谱数据产生装置产生。搜索每个子图书馆，并产生相应的一组分数，指示匹配的可能性。对于每个搜索的子图库计算相对概率值。所有相对概率值被融合，产生一组最终概率值，用于确定未知材料是否通过库中的已知材料表示。与最小置信度值相比，选择最高最终概率值。如果概率值大于或等于最小置信度值，则报告已知材料。

78. 发明申请

US20110299071A1 MULTIPOINT METHOD FOR IDENTIFYING HAZARDOUS AGENTS 有权
标题翻译：用于识别危险剂的多点方法
公开(公告)号：US20110299071A1
公开(公告)日：2011-12-08
申请号：US12422360
申请日：2009-04-13
申请人： Patrick J. Treado , Joseph E. Demuth , Robert Schweitzer
发明人： Patrick J. Treado , Joseph E. Demuth , Robert Schweitzer
IPC分类号： G01J3/44 , G01J1/42 , G01J5/02 , G01N21/64 , G01T1/105
CPC分类号： G01N21/65 , G01N21/64 , G01N21/6402 , G01N21/8483 , G01N2021/6417
摘要： The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
摘要翻译：本发明涉及通过对样品进行多点光谱分析来评估样品中危险剂的发生的装置和方法。公开了采用拉曼光谱法和其他分光光度法的方法。还公开了适于执行这种多点方法的设备和系统。

79. 发明授权

US07486395B2 System and method for a chemical imaging threat assessor with a probe 有权
标题翻译：具有探针的化学成像威胁评估者的系统和方法
公开(公告)号：US07486395B2
公开(公告)日：2009-02-03
申请号：US11544648
申请日：2006-10-10
申请人： Patrick J. Treado , Thomas C. Voigt , Wesley H. Hutchison
发明人： Patrick J. Treado , Thomas C. Voigt , Wesley H. Hutchison
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0227 , G01J3/0256 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0286 , G01J3/0289 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/2803 , G01J3/2823 , G01J3/44 , G01J3/4406 , G01J3/447 , G01N2021/656 , G01N2201/0846
摘要： The disclosure relates to a portable and/or handheld bioagent detector and methodology described herein that is based in part on advanced Raman Chemical Imaging (“RCI”) technology. According to one embodiment of the present disclosure, the detection system may include a fiber array spectral translator (“FAST”) and may also include a probe which may include a complementary metal oxide semiconductor (CMOS) camera. The probe alleviates the need to place the main instrument close to an unconfined release of a potentially hazardous material and facilitates analysis of a sample that is situated in a hard-to-reach location while minimizing contamination of the detector and operator.
摘要翻译：本公开涉及部分基于先进的拉曼化学成像（“RCI”）技术的本文描述的便携式和/或手持式生物代谢检测器和方法。根据本公开的一个实施例，检测系统可以包括光纤阵列光谱转换器（“FAST”），并且还可以包括可以包括互补金属氧化物半导体（CMOS）照相机的探针。探头减轻了将主仪器置于非限制性释放潜在危险物质的需要，并有助于分析位于难以到达的位置的样品，同时最大限度地减少检测器和操作者的污染。

80. 发明申请

US20080300826A1 FORENSIC INTEGRATED SEARCH TECHNOLOGY WITH INSTRUMENT WEIGHT FACTOR DETERMINATION 有权
标题翻译：威信集成搜索技术与仪器重量因子确定
公开(公告)号：US20080300826A1
公开(公告)日：2008-12-04
申请号：US12017445
申请日：2008-01-22
申请人： Robert C. SCHWEITZER , Patrick J. Treado
发明人： Robert C. SCHWEITZER , Patrick J. Treado
IPC分类号： G06F17/18
CPC分类号： G06K9/00536 , G06F19/703 , G06F19/709 , H01J49/0036
摘要： A system and method to search spectral databases and to identify unknown materials from multiple spectroscopic data in the databases. The methodology may be substantially automated and is configurable to determine weights to be accorded to spectroscopic data from different spectroscopic data generating instruments for improved identification of unknown materials. Library spectra from known materials are divided into training and validation sets. Initial, instrument-specific weighting factors are determined using a weight grid or weight scale. The training and validation spectra are weighted with the weighting factors and indicator probabilities for various sets of “coarse” weighting factors are determined through an iterative process. The finally-selected set of coarse weighting factors is further “fine tuned” using a weight grid with finer values of weights. The instrument-specific finer weight values may be applied to test data sets (or spectra) of an unknown material as well as to the library spectra from corresponding spectroscopic instruments. Instrument-specific weights for each class of samples may also be computed for additional customization and accuracy.
摘要翻译：一种用于搜索光谱数据库并从数据库中的多个光谱数据中识别未知物质的系统和方法。该方法可以基本上是自动化的，并且可配置为确定要与来自不同光谱数据生成装置的光谱数据一致的权重，以改进未知材料的识别。已知材料的谱图谱分为训练和验证集。使用权重网格或权重量表确定初始的仪器特定加权因子。训练和验证光谱通过加权因子加权，并且通过迭代过程确定各组“粗”加权因子的指标概率。最终选择的粗加权系数集合使用具有更精确的权重值的权重网格进一步“精细调整”。仪器特定的更精细的重量值可以应用于未知材料的测试数据集（或光谱）以及来自相应光谱仪的文库光谱。也可以计算每类样品的仪器特定重量，以获得额外的定制和准确性。

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