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71. 发明申请

US20060270679A1 Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 审中-公开
公开(公告)号：US20060270679A1
公开(公告)日：2006-11-30
申请号：US11500252
申请日：2006-08-07
申请人： Scott Edmondson , Michael Fisher , Dooseop Kim , Malcolm Maccoss , Emma Parmee , Ann Weber , Jinyou Xu
发明人： Scott Edmondson , Michael Fisher , Dooseop Kim , Malcolm Maccoss , Emma Parmee , Ann Weber , Jinyou Xu
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

72. 发明申请

US20060087813A1 System for airflow management in electronic enclosures 有权
标题翻译：电子机柜气流管理系统
公开(公告)号：US20060087813A1
公开(公告)日：2006-04-27
申请号：US10972868
申请日：2004-10-25
申请人： Wiren Becker , Joseph Corrado , Ethan Cruz , Michael Fisher , Gary Goth
发明人： Wiren Becker , Joseph Corrado , Ethan Cruz , Michael Fisher , Gary Goth
IPC分类号： H05K1/00
CPC分类号： H05K7/20563 , G06F1/183 , G06F1/20
摘要： A system for airflow management in an electronic enclosure includes a backplane assembly having at least one backplane connector, at least one daughter card, and components disposed on the daughter card oriented to facilitate front-to-back airflow, wherein inlet cooling air impinges on the backplane assembly and splits into at least two flow portions flowing in different directions along a surface defining the backplane assembly
摘要翻译：一种用于电子外壳中的气流管理的系统包括背板组件，该背板组件具有至少一个背板连接器，至少一个子卡，以及设置在子卡上的部件，其定向成便于前后气流，其中入口冷却空气冲击底板组件，并分成沿着限定背板组件的表面沿不同方向流动的至少两个流动部分

73. 发明申请

US20050177170A1 Dynamic knee balancer with pressure sensing 有权
标题翻译：带压力感应的动态膝盖平衡器
公开(公告)号：US20050177170A1
公开(公告)日：2005-08-11
申请号：US10973936
申请日：2004-10-25
申请人： Michael Fisher , Anthony Hedley , Michael Howard , Kevin Cordes , Toshinobu Katsuya
发明人： Michael Fisher , Anthony Hedley , Michael Howard , Kevin Cordes , Toshinobu Katsuya
IPC分类号： A61B17/00 , A61B17/02 , A61B17/15 , A61B17/58 , A61B17/90 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/38 , A61F2/46
CPC分类号： A61B17/02 , A61B17/025 , A61B17/155 , A61B2017/0268 , A61B2090/064 , A61F2/38 , A61F2/4657 , A61F2/4684 , A61F2002/30092 , A61F2002/30428 , A61F2002/30507 , A61F2002/30538 , A61F2002/30553 , A61F2002/30566 , A61F2210/0014 , A61F2220/0025 , A61F2250/0006 , A61F2250/0008 , G06F19/00
摘要： A device for performing a surgical procedure on a knee includes an adjustable femoral portion, a tibial portion and at least one sensor coupled with the femoral and/or tibial portions to sense pressure exerted by the femoral and tibial portions against one another. The femoral portion is adapted for removably coupling with a distal end of a femur to adjust tension in soft tissue adjacent the knee and has at least one positioning feature adapted to move relative to the distal end of the femur as the femoral portion is adjusted, thus helping position a femoral prosthetic on the distal end of the femur. The sensor(s) may be adapted to sense pressure at medial and lateral sides of the knee, and relative pressures may be displayed as data on a visual display. Adjustments to the femoral member may be made to balance pressure at flexion and extension of the knee.
摘要翻译：用于在膝盖上执行外科手术的装置包括可调整的股骨部分，胫骨部分和与股骨和/或胫骨部分联接的至少一个传感器，以感测由股骨和胫骨部分彼此抵抗的压力。股骨部分适于与股骨的远端可移动地联接以调节邻近膝盖的软组织中的张力，并且具有适于在调节股骨部分时相对于股骨的远端移动的至少一个定位特征，因此帮助股骨假体位于股骨远端。传感器可以适于感测膝盖的内侧和外侧的压力，并且相对压力可以作为数据显示在视觉显示器上。可以对股骨构件进行调整，以平衡膝盖弯曲和伸展时的压力。

74. 发明申请

US20050149599A1 Policy based system management 有权
标题翻译：基于策略的系统管理
公开(公告)号：US20050149599A1
公开(公告)日：2005-07-07
申请号：US10507902
申请日：2003-03-27
申请人： Sohail Rana , Paul McKee , Michael Fisher
发明人： Sohail Rana , Paul McKee , Michael Fisher
IPC分类号： G06F9/46 , H04L12/24 , G06F15/16
CPC分类号： H04L41/046 , G06F9/465 , G06Q20/203 , H04L41/0893
摘要： A computer network is managed by policies. This allows selections to be made from a range of control options and optionally to be based on locally available system information. Policy-based management is distributed across the system and is handled locally by management agents (70) allowing control of a sub-network (72). As a result a distributed policy-based management system is provided which allows additional flexibility of control.
摘要翻译：计算机网络由策略管理。这允许从一系列控制选项进行选择，并且可选地基于本地可用的系统信息。基于策略的管理被分布在整个系统中并且由允许对子网络（72）的控制的管理代理（70）在本地处理。因此，提供了一种分布式的基于策略的管理系统，允许更多的控制灵活性。

75. 发明申请

US20050126420A1 Wall breaching apparatus and method 审中-公开
标题翻译：墙体破坏装置及方法
公开(公告)号：US20050126420A1
公开(公告)日：2005-06-16
申请号：US10938199
申请日：2004-09-10
申请人： Richard Givens , Michael Fisher , Thomas Burky , Jerome Klein , Graham Alexander , Jason Paugh
发明人： Richard Givens , Michael Fisher , Thomas Burky , Jerome Klein , Graham Alexander , Jason Paugh
IPC分类号： F42B3/08 , F42D3/00 , F42B1/00
CPC分类号： F42B1/02 , F42B3/02 , F42B3/08 , F42D3/00
摘要： Wall breaching apparatus and methods utilizing shaped charges for penetration of walls of buildings and other structures for rescue, escape, or military operations.
摘要翻译：墙体破坏装置和方法利用成形装置对建筑物和其他结构的墙壁进行穿透以进行救援，逃生或军事行动。

76. 发明申请

US20050119261A1 Biaryl substituted triazoles as sodium channnel blockers 有权
标题翻译：二芳基取代三唑作为钠通道阻断剂
公开(公告)号：US20050119261A1
公开(公告)日：2005-06-02
申请号：US10799230
申请日：2004-03-12
申请人： Prasun Chakravarty , Michael Fisher , Jeffrey Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
发明人： Prasun Chakravarty , Michael Fisher , Jeffrey Fisher , Brenda Palucki , Min Park , William Parsons , Bishan Zhou , James Carey , Douglas Frantz , Michael Kress , Damian Weaver
IPC分类号： A61K31/4196 , A61P25/00 , C07D249/08 , C07D249/10 , C07D413/02 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D417/02 , C07D43/02
CPC分类号： C07D249/08 , C07D249/10
摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
摘要翻译：由式I，II或III表示的二芳基取代的三唑化合物或其药学上可接受的盐，以及其制备方法。药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

77. 发明授权

US5374275A Surgical suturing device and method of use 失效
标题翻译：手术缝合装置及使用方法
公开(公告)号：US5374275A
公开(公告)日：1994-12-20
申请号：US37572
申请日：1993-03-25
申请人： James G. Bradley , Michael Fisher
发明人： James G. Bradley , Michael Fisher
IPC分类号： A61B17/00 , A61B17/04 , A61M23/00
CPC分类号： A61B17/0469 , A61B17/0057 , A61B2017/047 , A61B2017/0472
摘要： A surgical device for closing an incision created by a trocar or similar surgical device is disclosed. The surgical device comprises a support member within which are disposed a first and second needle positioning means. Each of these means carries a suture needle in retrorse configuration relative to the distal end of the support member. The needles can be retracted or deployed relative to the support member in a plurality of desired positions. In operation, the needles are deployed at a desired distance from the edge of the incision. The surgeon then pulls the device out of the body of the patient, thereby capturing and pulling the needles through first the peritoneum followed by the fascia. Needle capture means are provided which retain and remove the needles after the peritoneum and fascia are sutured, leaving the loose ends of the suture thread which can then be tied off below skin level to close the incision.
摘要翻译：公开了一种用于封闭由套管针或类似手术装置产生的切口的手术装置。手术装置包括支撑构件，在支撑构件内设置有第一和第二针定位装置。这些装置中的每个装置相对于支撑构件的远端携带以反向构造的缝合针。针可以相对于支撑构件在多个期望位置中缩回或展开。在操作中，针从切口的边缘以期望的距离展开。外科医生然后将装置从患者的身体拉出，从而首先将针头收紧并拉出腹膜，然后是筋膜。提供针捕获装置，其在腹膜和筋膜缝合之后保留和移除针，留下缝合线的松散端，然后将其缝合在皮肤层下方以封闭切口。

78. 发明授权

US09550157B2 Single-use mixing and bioreactor systems 有权
标题翻译：一次性混合和生物反应器系统
公开(公告)号：US09550157B2
公开(公告)日：2017-01-24
申请号：US14345256
申请日：2012-09-13
申请人： Thomas Erdenberger , Richard L. Damren , Colin R. Tuohey , Michael Fisher , Parrish M. Galliher , Jonathan A. Kenney
发明人： Thomas Erdenberger , Richard L. Damren , Colin R. Tuohey , Michael Fisher , Parrish M. Galliher , Jonathan A. Kenney
IPC分类号： B01F13/08 , B01F7/00 , B01F7/16 , B01F15/00 , B01F3/04 , C12M1/06 , C12M1/00
CPC分类号： B01F13/0818 , B01F3/04106 , B01F3/04531 , B01F7/0025 , B01F7/00633 , B01F7/162 , B01F13/0872 , B01F15/00714 , B01F15/0085 , B01F2003/04673 , B01F2015/0011 , B01F2215/0073 , C12M23/14 , C12M23/26 , C12M27/02
摘要： Disclosed are magnetic agitation mixing systems for use with flexible container reaction vessels. In one aspect of the invention, the orientation of magnetic coupling between the impeller magnets and the external driver magnets is modified such that the coupling is neither strictly axial nor strictly radial. Also disclosed are “receiver-less” retainer configurations whereby the single-use container need not have a rigid base that defines a cup or post to engage of rotatable agitator.
摘要翻译：公开了用于柔性容器反应容器的磁力搅拌混合系统。在本发明的一个方面中，叶轮磁体和外部驱动磁体之间的磁耦合的取向被改变，使得联接器既不是严格的轴向也不是严格的径向。还公开了“无接收器”保持器构造，由此一次性容器不需要具有限定杯或柱以接合可旋转搅拌器的刚性基座。

79. 发明授权

US08894756B2 Collapsible bag vessel with antifoaming device 有权
标题翻译：具有消泡装置的可折叠袋式容器
公开(公告)号：US08894756B2
公开(公告)日：2014-11-25
申请号：US13276087
申请日：2011-10-18
申请人： Parrish M. Galliher , Geoffrey L. Hodge , Michael Fisher
发明人： Parrish M. Galliher , Geoffrey L. Hodge , Michael Fisher
IPC分类号： B01D19/00 , C12M1/00 , B01F13/08 , B01F15/00 , B01F3/04
CPC分类号： B65D33/02 , B01F3/04106 , B01F13/0827 , B01F15/00831 , B01F15/0085 , B01F2215/0073 , B29C45/16 , B29K2023/0633 , B29L2031/7128 , C12M23/14 , C12M29/06 , C12M41/02
摘要： Disclosed herein are fluid containment systems such as gas delivery configurations, foam control systems and bag molding methods and articles for supported collapsible bag vessels and bioreactors. A vessel may include a device which can reduce the foam produced or contained within the vessel. Sensors and/or controllers may optionally be used to monitor and/or control foaming.
摘要翻译：本文公开了流体容纳系统，例如气体输送配置，泡沫控制系统和袋成型方法以及用于支撑的可折叠袋容器和生物反应器的制品。容器可以包括可以减少容器内产生或容纳的泡沫的装置。传感器和/或控制器可以可选地用于监测和/或控制发泡。

80. 发明授权

US08440668B2 Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of type 2 diabetes 有权
标题翻译： β-氨基杂环二肽基肽酶抑制剂用于治疗2型糖尿病
公开(公告)号：US08440668B2
公开(公告)日：2013-05-14
申请号：US13086563
申请日：2011-04-14
申请人： Scott D. Edmondson , Michael Fisher , Dooseop Kim , Malcolm MacCoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Michael Fisher , Dooseop Kim , Malcolm MacCoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： A61K31/495 , A61K31/40
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

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