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71. 发明申请

US20100137439A1 USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF 有权
标题翻译：氨基酸及其衍生物的使用
公开(公告)号：US20100137439A1
公开(公告)日：2010-06-03
申请号：US12523048
申请日：2008-01-11
申请人： Hans Christian Wulf , Aslak Godal , Jo Klaveness
发明人： Hans Christian Wulf , Aslak Godal , Jo Klaveness
IPC分类号： A61K31/195 , A61P35/00
CPC分类号： A61K41/0061 , A61K31/221 , A61N5/062
摘要： The invention provides the use of a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a derivative (e.g. an ester) of 5-ALA, or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and wherein side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10% wt (e.g. 0.5 to 8% wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2), (iv) said photoactivation is carried out with sunlight. Preferably, side-effects of PDT are prevented or reduced by using (iii) or (iv) in combination with (i) and/or (ii).
摘要翻译：本发明提供了5-氨基乙酰丙酸（5-ALA）或5-ALA衍生物（例如酯）或其药学上可接受的盐的光敏剂在制备用于光动力疗法（PDT），其中所述PDT包括：（a）向所述动物施用包含所述光敏剂的组合物; 和（b）光活化所述光敏剂，并且其中通过使用（i） - （iv）中的一种或多种来防止或减少所述PDT的副作用（例如疼痛和/或红斑）：（i）所述组合物包含浓度小于10％wt（例如0.5至8％wt）的光敏剂，（ii）所述组合物在所述光活化前施用少于2小时（例如30分钟至90分钟），（iii）所述光活化是用光通量小于50mW / cm2（例如5〜40mW / cm2）的光源进行，（iv）所述的光活化是在太阳光下进行的。优选地，通过使用（iii）或（iv）与（i）和/或（ii）组合来防止或减少PDT的副作用。

72. 发明申请

US20070259889A1 Protein Binding Compounds 审中-公开
标题翻译：蛋白结合化合物
公开(公告)号：US20070259889A1
公开(公告)日：2007-11-08
申请号：US10571890
申请日：2004-09-15
申请人： Jo Klaveness , Bjarne Brudeli
发明人： Jo Klaveness , Bjarne Brudeli
IPC分类号： A61K31/00 , A61K31/4164 , A61K31/513 , A61K31/52 , A61K31/7068 , A61K31/708 , A61K38/38 , A61K47/48 , A61P29/00 , A61P31/00 , A61P35/00
CPC分类号： A61K31/52 , A61K31/4164 , A61K31/513 , A61K31/7068 , A61K31/708 , A61K47/542 , A61K47/543
摘要： The present invention provides a prodrug compound comprising a therapeutically effective moiety coupled via a metabolically cleavable bond to a blood protein binding moiety.
摘要翻译：本发明提供了包含通过代谢可切割键与血液蛋白结合部分偶联的治疗有效部分的前药化合物。

73. 发明授权

US07241460B2 Strontium compound for treatment of sub-dermal soft tissue pain 有权
标题翻译：用于治疗皮肤软组织疼痛的锶化合物
公开(公告)号：US07241460B2
公开(公告)日：2007-07-10
申请号：US10488162
申请日：2002-09-27
申请人： Egil Jellum , Bjørn Jarl Fagerlund , Clas Magne Kjølberg , Jo Klaveness
发明人： Egil Jellum , Bjørn Jarl Fagerlund , Clas Magne Kjølberg , Jo Klaveness
IPC分类号： A61K33/00 , A61K33/14 , A61K33/42 , A61K31/185 , A61K31/19 , A61P21/00 , A61P25/02 , A61P29/00
CPC分类号： A61K33/14 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/198 , A61K31/20 , A61K31/28 , A61K31/375 , A61K31/60 , A61K33/24 , Y10S514/936 , Y10S514/946 , Y10S514/947
摘要： The invention provides a method of treatment of a human or non-human subject to combat sub-dermal soft tissue pain therein, said method comprising administering to a subject in need thereof an effective amount of a physiologically tolerable strontium compound.
摘要翻译：本发明提供一种治疗人或非人受试者的方法，以对抗其中的皮下软组织疼痛，所述方法包括向有需要的受试者施用有效量的生理上可耐受的锶化合物。

74. 发明申请

US20070116646A1 Optical imaging of endometriosis 审中-公开
标题翻译：子宫内膜异位症的光学成像
公开(公告)号：US20070116646A1
公开(公告)日：2007-05-24
申请号：US10573604
申请日：2004-09-28
申请人： Jo Klaveness , Edvin Johannesen , Helge Tolleshaug
发明人： Jo Klaveness , Edvin Johannesen , Helge Tolleshaug
IPC分类号： A61K49/00 , C07K16/46
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0043 , A61K49/0052
摘要： The invention provides contrast agents for optical imaging of endometriosis in patients. The contrast agent may be used in diagnosis of endometriosis, for follow-up of progress in disease development, and for follow-up of treatment of endometriosis. Further, the invention provides methods for optical imaging of endometriosis. The contrast agent has affinity for an abnormally expressed target associated with endometriosis. By abnormally expressed, is meant that the target is either overexpressed or downregulated. Endometriotic tissue containing a downregulated target may be identified by a low amount of bound contrast agent compared to normal tissue. In this situation, the amount of contrast agent should be less than 50% of that in normal tissue, preferably less than 10%.
摘要翻译：本发明提供了用于患者子宫内膜异位症的光学成像的造影剂。造影剂可用于诊断子宫内膜异位症，用于随访疾病发展进展，以及随访子宫内膜异位症的治疗。此外，本发明提供了用于子宫内膜异位症的光学成像的方法。造影剂对与子宫内膜异位症相关的异常表达的靶标具有亲和力。通过异常表达意味着靶标过表达或下调。与正常组织相比，含有下调靶的子宫内膜异位组织可以通过少量结合的造影剂来鉴定。在这种情况下，造影剂的量应小于正常组织的50％，优选小于10％。

75. 发明申请

US20050013877A1 Strontium compound for treatment of sub-dermal soft tissue pain 有权
标题翻译：用于治疗皮肤软组织疼痛的锶化合物
公开(公告)号：US20050013877A1
公开(公告)日：2005-01-20
申请号：US10488162
申请日：2002-09-27
申请人： Egil Jellum , Bjorn Fagerlund , Clas Kjolberg , Jo Klaveness
发明人： Egil Jellum , Bjorn Fagerlund , Clas Kjolberg , Jo Klaveness
IPC分类号： A61K47/18 , A61K33/24 , A61K45/00 , A61K47/20 , A61P17/00 , A61P25/02 , A61K33/14 , A61K33/00
CPC分类号： A61K33/14 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/198 , A61K31/20 , A61K31/28 , A61K31/375 , A61K31/60 , A61K33/24 , Y10S514/936 , Y10S514/946 , Y10S514/947
摘要： The invention provides a method of treatment of a human or non-human subject to combat sub-dermal soft tissue pain therein, said method comprising administering to a subject in need thereof an effective amount of a physiologically tolerable strontium compound.
摘要翻译：本发明提供一种治疗人或非人受试者的方法，以对抗其中的皮下软组织疼痛，所述方法包括向有需要的受试者施用有效量的生理上可耐受的锶化合物。

76. 发明授权

US06264917B1 Targeted ultrasound contrast agents 失效
标题翻译：靶向超声造影剂
公开(公告)号：US06264917B1
公开(公告)日：2001-07-24
申请号：US08958993
申请日：1997-10-28
申请人： Jo Klaveness , Pål Rongved , Dagfinn Løvhaug
发明人： Jo Klaveness , Pål Rongved , Dagfinn Løvhaug
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0043 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , Y10S977/929
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，具有包含通过成膜表面活性剂的单层稳定的充气微泡的记者，所述报告基团与至少一个载体偶联或连接。

77. 发明授权

US5817289A Non-cluster type bismuth compounds 失效
标题翻译：非簇型铋化合物
公开(公告)号：US5817289A
公开(公告)日：1998-10-06
申请号：US486225
申请日：1995-06-07
申请人： Jo Klaveness , Arne Berg , Torsten Almen , Klaes Golman , Michael Droege , S. B. Yu
发明人： Jo Klaveness , Arne Berg , Torsten Almen , Klaes Golman , Michael Droege , S. B. Yu
IPC分类号： A61K49/00 , A61K49/04 , C07F9/94 , A61K51/00 , A61M36/14
CPC分类号： A61K49/04 , A61K49/0433 , C07F9/94
摘要： The use in diagnostic imaging, in particular X-ray, MRI, ultrasound and scintigraphy, of contrast agents comprising bismuth clusters and/or organic bismuth compounds, and contrast media containing such bismuth compounds. The bismuth compounds are also useful in therapy, in particular as antimicrobial agents and antiulcer agents. Novel bismuth compounds are also disclosed.
摘要翻译：用于包含铋簇和/或有机铋化合物的造影剂的诊断成像，特别是X射线，MRI，超声和闪烁扫描，以及含有这种铋化合物的造影剂。铋化合物也可用于治疗，特别是抗微生物剂和抗溃疡剂。还公开了新颖的铋化合物。

78. 发明授权

US5735279A SQUID magnetometry using ferro-, ferri- are paramagnetic particles 失效
标题翻译：使用铁，铁的SQUID磁力计是顺磁性颗粒
公开(公告)号：US5735279A
公开(公告)日：1998-04-07
申请号：US483168
申请日：1995-06-07
申请人： Jo Klaveness , Thorfinn Ege , Scott M. Rocklage
发明人： Jo Klaveness , Thorfinn Ege , Scott M. Rocklage
IPC分类号： A61B5/05 , A61K49/00 , A61K49/06 , A61K49/18 , A61B5/055
CPC分类号： A61K49/1887 , A61K49/18 , A61K49/1857 , Y10T436/24
摘要： The invention provides for the use of a physiologically tolerable, particulate, free or matrix-borne, ferromagnetic, ferrimagnetic or paramagnetic material for the manufacture of a diagnostic agent for magnetometric imaging of a human or non-human animal body.
摘要翻译：本发明提供了生理上可耐受的，颗粒状的，游离的或基质载体的铁磁性，亚铁磁性或顺磁性材料用于制造用于人或非人动物体的磁积分成像的诊断剂。

79. 发明授权

US5733525A Method of EII using a water insoluble particulate agent 失效
标题翻译：使用水不溶性颗粒剂的EII方法
公开(公告)号：US5733525A
公开(公告)日：1998-03-31
申请号：US828530
申请日：1997-03-31
申请人： Jo Klaveness
发明人： Jo Klaveness
IPC分类号： A61B5/05 , A61B5/053 , A61K49/00 , A61B5/055
CPC分类号： A61B5/0536 , A61K49/0002 , Y10S514/974 , Y10T436/24
摘要： The invention relates to a method of electrical impedance imaging of a human or animal subject which method comprises parenterally administering to the subject an EII contrast agent and generating an electrical impedance image of at least part of said subject. The contrast agent may be optionally dissolved or dispersed in a physiologically tolerable liquid carrier medium. The contrast agent is capable on dispersion in water of yielding a fluid having an electrical impedance different to that of water and being a water-insoluble particulate material.
摘要翻译：本发明涉及一种人或动物对象的电阻抗成像方法，该方法包括向对象肠胃外施用EII造影剂并产生所述受试者的至少一部分的电阻抗图像。造影剂可以任选地溶解或分散在生理上可耐受的液体载体介质中。造影剂能够在水中分散，产生具有与水不同的电阻抗的流体，并且是水不溶性颗粒材料。

80. 发明授权

US5718884A Microbubble-based contrast agents with crosslinked and reduced proteinaceous shells 失效
标题翻译：具有交联和还原蛋白质壳的基于微泡的造影剂
公开(公告)号：US5718884A
公开(公告)日：1998-02-17
申请号：US397065
申请日：1995-05-04
申请人： Jo Klaveness , Pal Rongved , John Henrik Johansen , Per Antonius Foss , Anders H.o slashed.gset , Anne Marie Hvoslef
发明人： Jo Klaveness , Pal Rongved , John Henrik Johansen , Per Antonius Foss , Anders H.o slashed.gset , Anne Marie Hvoslef
IPC分类号： A61K49/00 , A61K49/18 , A61K49/22 , A61K49/04
CPC分类号： A61K49/1821 , A61K49/18 , A61K49/223
摘要： The present invention pertains to proteinaceous gas- or gas precursor-containing microbubble contrast agents for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g., a dialdehyde such as glutaraldehyde or an .alpha.,.beta.-unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH. The contrast agents exhibit improved in vivo and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution.
摘要翻译： PCT No.PCT / GB93 / 01861 Sec。 371日期：1995年5月4日 102（e）日期1995年5月4日PCT提交1993年9月3日PCT公布。出版物WO94 / 06477 日期：1994年3月31日本发明涉及用于超声和/或MR成像的含蛋白质气体或气体前体的微泡造影剂，其中蛋白质基质通过与双官能醛反应而交联（例如，二醛如作为戊二醛或α，β-不饱和醛如丙烯醛）在水性介质中基本上为中性pH。造影剂表现出改善的体内和储存稳定性，特别是如果基质也与席夫碱还原剂如硼氢化钠反应。这种交联的含蛋白质气体的造影剂的尺寸分布的修改，例如，为了减少微泡的平均尺寸，进一步提高了它们的稳定性并且允许制备具有特别窄的微泡尺寸分布的新型造影剂。

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