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71. 发明授权

US3940354A Cephalosporan compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US3940354A
公开(公告)日：1976-02-24
申请号：US436502
申请日：1974-01-25
申请人： Jacques Martel , Rene Heymes , Andre Lutz
发明人： Jacques Martel , Rene Heymes , Andre Lutz
IPC分类号： C07D501/06 , A61K31/545 , C07D303/48 , C07D501/08 , C07D501/22 , C07D501/18
CPC分类号： C07D501/22 , C07D303/48
摘要： Cephalosporon compounds of the formula ##SPC1##In the form of racemic mixtures or optically active isomers or in the form of their cis or trans isomers or mixtures thereof wherein R is selected from the group consisting of phenyl substituted with at least one hydroxyl and sydnone optionally substituted with phenyl, R' is selected from the group consisting of hydrogen and R", R" is an ester group easily removable by acid hydrolysis or hydrogenolysis, R.sub.1 and R.sub.2 are alkyl of 1 to 3 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, Y is selected from the group consisting of amino and Y', Y' is hydrogen and NHCOOZ, Z is straight or branched alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable addition salts with organic and inorganic acids and bases where appropriate with the proviso that when Y is amino, R' is hydrogen and when Y is amino or NHCOOZ, R is phenyl which have antibacterial activity and their preparation.
摘要翻译：式中的头孢菌素化合物在异构混合物或光学活性异构体形式或其独特形式或其异构体或其混合物中，其中R选自被任选被苯基取代的至少一个羟基和硅藻土取代的苯基 R'选自氢和R“，R”是通过酸水解或氢解容易除去的酯基，R 1和R 2是1至3个碳原子的烷基，R 3选自的氢和1至3个碳原子的烷基，Y选自氨基和Y'，Y'是氢和NHCOOZ，Z是1至5个碳原子的直链或支链烷基及其无毒的药学上在适当的情况下，与有机和无机酸和碱可接受的加成盐，条件是当Y为氨基时，R'为氢，当Y为氨基或NHCOOZ时，R为具有抗菌活性的苯基及其制备。

72. 再颁专利

USRE29587E Cyclopentanone derivatives 失效
标题翻译：环戊酮衍生物
公开(公告)号：USRE29587E
公开(公告)日：1978-03-21
申请号：US704846
申请日：1976-07-13
申请人： Jacques Martel , Edmond Toromanoff , Jean Buendia
发明人： Jacques Martel , Edmond Toromanoff , Jean Buendia
IPC分类号： C07C405/00
CPC分类号： C07C405/00
摘要： Novel prostanoic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 7 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen and carbalkoxy of 1 to 7 alkyl carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, carboxy and carbalkoxy of 1 to 7 alkyl carbon atoms, R.sub.3 is selected from the group consisting of hydrogen and .alpha.-tetrahydropyranyl .Iadd.and at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen.Iaddend., m is 3, 4 or 5 and n is 2, 3 or 4 with the proviso that when R.sub.1 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R.sub.2 is hydrogen and R.sub.3 is .alpha.-tetrahydropyranyl; when R.sub.2 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R.sub.1 is hydrogen and R.sub.3 is .alpha.-tetrahydropyranyl and when R.sub.2 is carboxy, R and R.sub.1 are hydrogen and R.sub.3 is .alpha.-tetrahydropyranyl, which possess the physiological activity of prostaglandins .[. , and salts thereof when R, R.sub.1, R.sub.2 and R.sub.3 are hydrogen, with non-toxic, pharmaceutically acceptable bases.]. and their preparation.

73. 发明授权

US4061729A Prostanoic acid derivatives and therapeutic compositions 失效
标题翻译：前列腺酸衍生物和治疗组合物
公开(公告)号：US4061729A
公开(公告)日：1977-12-06
申请号：US587558
申请日：1975-06-17
申请人： Jacques Martel , Jean Buendia , Michel Vivat
发明人： Jacques Martel , Jean Buendia , Michel Vivat
IPC分类号： C07C405/00 , C07C177/00 , A61K31/19 , A61K31/215
CPC分类号： C07C405/00
摘要： Novel prostanoic acid derivatives of the formula ##STR1## wherein R is hydrogen or alkyl having 1 to 4 carbon atoms, m is a whole number from 3, 4 or 5, n is a whole number from 2, 3 or 4, R' is either a linear or branched, saturated or unsaturated aliphatic hydrocarbon having 1 to 4 carbon atoms, or a saturated or mono unsaturated cyclohydrocarbon having 3 to 6 carbon atoms and A is either alkoxy having 1 to 4 carbon atoms or oxygen of a ketonic group, the dotted lines in the pentagonal ring are possible positions of a single double bond where, when A is a ketonic oxygen, the double bond is on the exterior of the ring and when A is alkoxy, the double bond is in one of the two interior positions of the ring, as well as the pharmaceutically compatible salts of mineral or organic bases when R is hydrogen in their .alpha.,.beta. or .beta.,.alpha. forms and mixtures thereof; as well as the process for their preparation, and the therapeutic compositions containing them.
摘要翻译：新颖的式（IMAGE）的前列腺酸衍生物，其中R为氢或具有1至4个碳原子的烷基，m为3,4或5的整数，n为2,3或4的整数，R'为具有1至4个碳原子的直链或支链饱和或不饱和脂族烃，或具有3至6个碳原子的饱和或单不饱和环烃，A为具有1至4个碳原子的烷氧基或酮基氧，五角环中的虚线是单个双键的可能位置，其中当A为酮氧时，双键位于环的外部，当A为烷氧基时，双键位于两个内部位置之一的环，以及当R是其α，β或β，α形式及其混合物中的氢时，矿物或有机碱的药学上相容的盐; 以及它们的制备方法和含有它们的治疗组合物。

74. 发明授权

US4016158A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US4016158A
公开(公告)日：1977-04-05
申请号：US538189
申请日：1975-01-02
申请人： Jacques Martel , Rene Heymes
发明人： Jacques Martel , Rene Heymes
IPC分类号： C07D209/48 , C07D501/22 , C07D501/60
CPC分类号： C07D209/48
摘要： Novel desacetoxycephalosporin derivatives of the formula ##STR1## in racemic or optically active form or cis and trans forms and mixtures thereof wherein R is selected from the group consisting of aminophenyl and R', R' is selected from the group consisting of phenyl optionally substituted with at least one member of the group consisting of halogen and nitro and a 5 to 6 member heterocyclic group, Y is selected from the group consisting of amino, NHCOOR" where R" is alkyl of 1 to 5 carbon atoms, hydrogen and hydroxy, A is selected from the group consisting of ##STR2## in which at least 2 of R.sub.2, R.sub.3 and R.sub.4 are alkyl of 1 to 3 carbon atoms and the third is hydrogen or alkyl of 1 to 3 carbon atoms with the total number of carbon atoms being not greater than 5 and cycloalkyl of 3 to 7 carbon atoms optionally containing a heteroatom and R.sub.1 is selected from the group consisting of hydrogen, easily acid hydrolyzable group and easily hydrogenolysis removable group, with the proviso that when R is aminophenyl Y is other than amino and NHCOOR" and R.sub.1 is hydrogen and when Y is amino, R.sub.1 is hydrogen and the non-toxic, pharmaceutically acceptable addition salts with organic and inorganic bases and acids where appropriate which have antibacterial activity.
摘要翻译：式I的新型脱乙酰氧基头孢菌素衍生物以外消旋或旋光形式或顺式和反式形式及其混合物，其中R选自氨基苯基和R'，R'选自任选取代的苯基其中至少一个由卤素和硝基组成的组和5至6个杂环基，Y选自氨基，NHCOOR“，其中R”是1至5个碳原子的烷基，氢和羟基，A选自其中R 2，R 3和R 4中的至少2个为1至3个碳原子的烷基和第3个为氢或1至3个碳原子的烷基的，其总数为碳原子数不超过5个，任选含有杂原子的3至7个碳原子的环烷基，R 1选自氢，易酸性可水解基团和易氢解脱除基团，条件是当 R是氨基苯基，Y不是氨基，NHCOOR“，R 1是氢，当Y是氨基时，R 1是氢，并且与适当的有机和无机碱和酸的无毒的，药学上可接受的加成盐具有抗菌活性。

75. 发明授权

US4826874A Use of pyrethroids in a pour-on parasitic method 失效
标题翻译：在喷洒寄生方法中使用拟除虫菊酯
公开(公告)号：US4826874A
公开(公告)日：1989-05-02
申请号：US574551
申请日：1984-01-27
申请人： Werner Bonin , Jacques Martel
发明人： Werner Bonin , Jacques Martel
IPC分类号： A01N53/00 , A61K31/215 , A61K31/275 , A61K31/34 , A61K31/38 , A61K31/40 , A01N37/34
CPC分类号： A61K31/40 , A01N53/00 , A61K31/215 , A61K31/275 , A61K31/34 , A61K31/38
摘要： The invention is directed to combatting parasites of warm-blooded animals use cyclopropylcarboxylate exterior surface of the animal.
摘要翻译：本发明涉及对抗温血动物的寄生虫使用动物的环丙基羧酸酯外表面。

76. 发明授权

US4501687A Cyclopentanols 失效
标题翻译：环戊醇
公开(公告)号：US4501687A
公开(公告)日：1985-02-26
申请号：US325992
申请日：1981-11-30
申请人： Jacques Martel , Jean Buendia , Francois Nezot
发明人： Jacques Martel , Jean Buendia , Francois Nezot
IPC分类号： C07C69/003 , A61K8/34 , A61Q13/00 , C07C27/00 , C07C29/38 , C07C29/40 , C07C29/60 , C07C35/06 , C07C41/00 , C07C43/188 , C07C45/00 , C07C45/60 , C07C47/267 , C07C49/203 , C07C49/242 , C07C49/255 , C07C67/00 , C07C253/00 , C07C255/31 , C11B9/00 , A61K7/46
CPC分类号： C11B9/003 , C07C29/38 , C07C29/40 , C07C29/60 , C07C35/06 , C07C45/60 , C07C47/267 , C07C49/242 , C07C49/255 , C07B2200/07 , C07C2101/08
摘要： Novel cyclopentanols of the formula ##STR1## wherein R.sub.1 and R.sub.2 are identical and are selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R.sub.3 is selected from the group consisting of --OH, alkoxy of 1 to 8 carbon atoms and acyloxy of an organic carboxylic acid of 1 to 18 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms, R.sub.5 and R.sub.8 are individually selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms and R.sub.6 and R.sub.7 are individually selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, --CN, --COCH.sub.3 and --COOAlK.sub.2 and AlK.sub.2 is alkyl of 1 to 8 carbon atoms useful as perfumery agents and their preparation and novel intermediates.
摘要翻译：新颖的式（I）的环戊醇，其中R 1和R 2相同并且选自氢和1至4个碳原子的烷基，R 3选自-OH，1至8个碳的烷氧基 1至18个碳原子的有机羧酸的原子和酰氧基，R 4选自氢和1至8个碳原子的烷基，R 5和R 8分别选自氢，1至 8个碳原子，2〜8个碳原子的链烯基和炔基，R6和R7分别选自氢，1〜8个碳原子的烷基，2〜8个碳原子的链烯基和炔基，-CN，-COCH3 -COOAlK2和AlK2是可用作香料剂的1至8个碳原子的烷基及其制备和新型中间体。

77. 发明授权

US4357583A Passive electromagnetic wave limiter and duplexer formed by means of such a limiter 失效
标题翻译：被动电磁波限制器和双工器通过这种限制器形成
公开(公告)号：US4357583A
公开(公告)日：1982-11-02
申请号：US153781
申请日：1980-05-27
申请人： Jacques Martel , Gilles Sillard
发明人： Jacques Martel , Gilles Sillard
IPC分类号： H01P1/15 , H03G11/02
CPC分类号： H01P1/15 , H03G11/025
摘要： A passive limiter formed as a wave-guide, in at least one cross-section of the guide, by means of one or more resonating windows in which is shunt-mounted at least head-to-tail one pair of diodes having the same polarity and being disposed in the same plane. One or more such limiters may be contemplated for forming duplexers.
摘要翻译：无源限制器通过一个或多个共振窗口在导向器的至少一个横截面中形成为波导，其中分流安装至少头对端一对具有相同极性的二极管并设置在同一平面上。可以考虑一个或多个这样的限制器来形成双工器。

78. 发明授权

US4053597A Hydroxy-phenylacetamido cephalosporin compositions and method of use 失效
标题翻译：羟基苯乙酮胺CEPHALOSPORIN组合物及其使用方法
公开(公告)号：US4053597A
公开(公告)日：1977-10-11
申请号：US635383
申请日：1975-11-25
申请人： Jacques Martel , Rene Heymes , Andre Lutz
发明人： Jacques Martel , Rene Heymes , Andre Lutz
IPC分类号： A61K31/545 , C07D501/22
CPC分类号： C07D501/22
摘要： Cephalosporan compounds of the formula ##STR1## in the form of racemic mixtures or optically active isomers or in the form of their cis or trans isomers or mixtures thereof wherein R is selected from the group consisting of phenyl substituted with at least one hydroxyl and sydnone optionally substituted with phenyl, R' is selected from the group consisting of hydrogen and R", R" is an ester group easily removable by acid hydrolysis or hydrogenolysis, R.sub.1 and R.sub.2 are alkyl of 1 to 3 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, Y is selected from the group consisting of amino and Y', Y' is hydrogen and NHCOOZ, Z is straight or branched alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable addition salts with organic and inorganic acids and bases where appropriate with the proviso that when Y is amino, R' is hydrogen and when Y is amino or NHCOOZ, R is phenyl which have antibacterial activity and their preparation.

79. 发明授权

US3962223A Substituted cephene-4-carboxylates and their method of preparation 失效
标题翻译：取代的CEPHENE-4-羧酸酯及其制备方法
公开(公告)号：US3962223A
公开(公告)日：1976-06-08
申请号：US320493
申请日：1973-01-02
申请人： Jacques Martel , Rene Heymes
发明人： Jacques Martel , Rene Heymes
IPC分类号： A61K31/545 , B01J23/44 , C07D209/48 , C07D303/48 , C07D501/08 , C07D501/18 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/06
CPC分类号： C07D209/48 , B01J23/44 , C07C255/00 , C07D303/48
摘要： Novel desacetoxycephalosporin derivatives of the formula ##EQU1## in racemic or optically active form or cis and trans forms and mixtures thereof wherein R is selected from the group consisting of aminophenyl and R', R' is selected from the group consisting of phenyl optionally substituted with at least one member of the group consisting of halogen and nitro and a 5 to 6 member heterocyclic group, Y is selected from the group consisting of amino, NHCOOR" where R" is alkyl of 1 to 5 carbon atoms, hydrogen and hydroxy, A is selected from the group consisting of alkyl of 2 to 5 carbon atoms and cycloalkyl of 3 to 7 carbon atoms optionally containing a heteroatom and R.sub.1 is selected from the group consisting of hydrogen, easily acid hydrolyzable group and easily hydrogenolysis removable group, with the proviso that when R is aminophenyl Y is other than amino and NHCOOR" and R.sub.1 is hydrogen and when Y is amino, R.sub.1 is hydrogen and the non-toxic pharmaceutically acceptable addition salts of with organic and inorganic bases and acids where appropriate which have antibacterial activity and a novel process for their preparation and novel intermediates therefor.

80. 发明授权

US4521331A Method of imparting a pleasant odor 失效
标题翻译：赋予气味的方法
公开(公告)号：US4521331A
公开(公告)日：1985-06-04
申请号：US438486
申请日：1982-11-02
申请人： Jacques Martel , Jean Buendia , Francois Nezot
发明人： Jacques Martel , Jean Buendia , Francois Nezot
IPC分类号： C07C69/003 , A61K8/37 , A61Q13/00 , C07C67/00 , C07C69/007 , C07C253/00 , C07C255/17 , C07C255/46 , C07C255/57 , C07D207/00 , C07D213/79 , C07D213/80 , C07D307/54 , C07D307/64 , C07D307/68 , C07D333/24 , C07D333/32 , C11B9/00 , A61K7/16 , C11D3/50
CPC分类号： C11B9/003 , C07D333/32
摘要： All possible isomeric forms and mixtures thereof of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of alkyl of 1 to 8 carbon atoms and alkenyl of 2 to 8 carbon atoms and R is selected from the group consisting of (a) hydrogen, (b) alkyl of 1 to 12 carbon atoms and alkenyl and alkynyl of 2 to 12 carbon atoms optionally substituted with cyano, saturated or unsaturated cycloalkyl or bicycloalkyl of 3 to 12 carbon atoms also optionally substituted, and optionally interrupted by an oxygen atom or containing a keto group, (c) cycloalkyl of 3 to 12 carbon atoms optionally having at least one double bond and at least one alkyl substituent of 1 to 4 carbon atoms, (d) aryl, arylalkyl, aralkenyl and aralkynyl of 6 to 20 carbon atoms optionally substituted on the aryl ring and the alkyl, alkenyl or alkynyl being optionally interrupted with an oxygen or containing a ketone group and (e) heteroaryl, heteroaralkyl, heteroaralkenyl and heteroaralkynyl optionally substituted on the heteroaryl ring and the alkyl, alkenyl and alkynyl being optionally interrupted with an oxygen atom or having a keto group with the proviso that R is not methyl when R.sub.1 is 2-methyl-1-propenyl, useful as perfume agents.
摘要翻译：式Ⅰ化合物的所有可能的异构体形式及其混合物，其中R 1选自1至8个碳原子的烷基和2至8个碳原子的链烯基，R选自（a）氢，（b）1至12个碳原子的烷基和2至12个碳原子的烯基和炔基，其任选被氰基，3至12个碳原子的饱和或不饱和环烷基或双环烷基取代，也可任选地被氧原子或含有酮基，（c）任选具有至少一个双键和至少一个碳原子数为1至4的烷基取代基的碳原子数为3至12的环烷基，（d）芳基，芳基烷基，芳烯基和芳炔基任选在芳基环上被取代的碳原子数6〜20个，烷基，链烯基或炔基任选被氧或含有酮基中断，和（e）杂芳基，杂芳烷基，杂链烯基和杂炔基任选地在杂芳基环上被取代，并且烷基，烯基和炔基任选被氧原子中断或具有酮基，条件是当R 1是2-甲基-1-丙烯基时，R不是甲基，可用作香料剂。

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