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71. 发明申请

WO2008048317A1 WATER INSOLUBLE ADDITIVE FOR IMPROVING CONDUCTIVITY OF AN ION EXCHANGE MEMBRANE 审中-公开
标题翻译：用于改善离子交换膜电导率的水不溶性添加剂
公开(公告)号：WO2008048317A1
公开(公告)日：2008-04-24
申请号：PCT/US2006/048913
申请日：2006-12-20
申请人： BALLARD POWER SYSTEMS INC. , BALLARD MATERIAL PRODUCTS INC. , MACKINNON, Sean, M. , MCDERMID, Scott, J. , BONORAND, Lukas, M. , PECKHAM, Timothy, J. , WANG, Keping , LI, Jing
发明人： MACKINNON, Sean, M. , MCDERMID, Scott, J. , BONORAND, Lukas, M. , PECKHAM, Timothy, J. , WANG, Keping , LI, Jing
IPC分类号： C08J5/22 , H01M8/02 , H01M8/10
CPC分类号： C08J5/2231 , C08J2383/02 , H01M8/0289 , H01M8/1007 , H01M8/1023 , H01M8/1037 , H01M8/1039 , H01M8/1044 , H01M8/1074 , Y02P70/56
摘要： A water insoluble additive for improving the performance of an ion- exchange membrane, such as in the context of the high temperature operation of electrochemical fuel cells. The insoluble additive comprises a metal oxide cross-linked matrix having proton conducting groups covalently attached to the matrix through linkers. In one embodiment, the metal is silicon and the cross-linked matrix is a siloxane cross- linked matrix containing silicon atoms cross-linked by multiple disiloxy bonds and having proton conducting groups covalently attached to the silicon atoms through alkanediyl linkers.
摘要翻译：用于改善离子交换膜性能的水不溶性添加剂，例如在电化学燃料电池的高温操作的背景下。不溶性添加剂包括具有质子传导基团的金属氧化物交联基质，其通过接头与基质共价连接。在一个实施方案中，金属是硅，交联基质是含有硅原子的硅氧烷交联基质，所述硅原子通过多个芳氧基键交联并具有通过烷二基接头与硅原子共价连接的质子传导基团。

72. 发明申请

WO2005000897A3 ANTIBODIES AGAINST INTERLEUKIN-22 AND USES THEREFOR 审中-公开
公开(公告)号：WO2005000897A3
公开(公告)日：2005-01-06
申请号：PCT/US2004/020833
申请日：2004-06-22
申请人： GENETICS INSTITUTE, LLC , LI, Jing , TAN, Xiang-Yang , TOMKINSON, Kathleen, N. , PITTMAN, Debra, D. , VELDAN, Geertruida, M. , FOUSER, Lynette
发明人： LI, Jing , TAN, Xiang-Yang , TOMKINSON, Kathleen, N. , PITTMAN, Debra, D. , VELDAN, Geertruida, M. , FOUSER, Lynette
IPC分类号： C07K16/24
摘要： Antibodies and antigen-binding fragments thereof that bind interleukin-22 (IL 22), in particular, human IL-22, and their uses in regulating IL-22-associated immune responses are disclosed. The antibodies disclosed herein are useful in diagnosing, preventing, or treating IL-22-associated immune disorders, e.g., autoimmune disorders (e.g., arthritis).

73. 发明申请

WO2004058175A3 NOVEL USE OF LIVER X RECEPTOR AGONISTS 审中-公开
公开(公告)号：WO2004058175A3
公开(公告)日：2004-07-15
申请号：PCT/US2003/040906
申请日：2003-12-22
申请人： IRM LLC , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAEZ, Enrique , TONTONOZ, Peter , LAFFITTE, Bryan, A. , LI, Jing
发明人： SAEZ, Enrique , TONTONOZ, Peter , LAFFITTE, Bryan, A. , LI, Jing
IPC分类号： A01N41/06
摘要： This invention provides novel methods for modulating expression of glut4 and other genes involved in glucose metabolism, and methods for treating or ameliorating diabetes and related diseases. The methods comprise administering to cells in a subject an effective amount of an LXR agonist and thereby modulating expression of those genes that are important for glucose uptake or gluconeogenesis. The modulation will lead to increased uptake of glucose by cells in the subject and/or reduced glucose output in the liver, and accordingly ameliorate symptoms associated with, e.g., type IIdiabetes.

74. 发明申请

WO2003100000A3 AMPLIFICATION AND OVEREXPRESSION OF ONCOGENES 审中-公开
公开(公告)号：WO2003100000A3
公开(公告)日：2003-12-04
申请号：PCT/US2003/016049
申请日：2003-05-22
申请人： TULARIK INC. , LI, Jing , MU, David , YANG, Jianxin
发明人： LI, Jing , MU, David , YANG, Jianxin
IPC分类号： C12Q1/70
摘要： There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the RecQL5, CTXL, USP13, MCL1, and Pellino1 genes, which are amplified in many types of cancer. The RecQL5, CTXL, USP13, MCL1, and Pellino1 genes, their expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or as vaccines; they also are used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.

75. 发明申请

WO2003079982A2 GENE AMPLIFICATION IN CANCER 审中-公开
标题翻译：癌基因扩增
公开(公告)号：WO2003079982A2
公开(公告)日：2003-10-02
申请号：PCT/US2003/008305
申请日：2003-03-18
申请人： TULARIK INC. , LI, Jing , POWERS, Scott , YANG, Jianxin
发明人： LI, Jing , POWERS, Scott , YANG, Jianxin
IPC分类号： A61K
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , Y10T436/143333
摘要： There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the CTSZ and CD24 genes, which are amplified colon cancer and/or ovarian cancer and/or breast cancer genes. The CTSZ and CD24 genes, their expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or vaccine; they also are used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.
摘要翻译：公开了利用扩增的结肠癌和/或卵巢癌和/或乳腺癌基因的CTSZ和CD24基因来诊断，预防和治疗哺乳动物（例如人）中的肿瘤和癌症的方法和组合物。 CTSZ和CD24基因，其表达的蛋白质产物和抗体用于诊断或作为癌症治疗或疫苗的靶标; 它们也用于鉴定可用于癌症诊断，预防和治疗的化合物和试剂。

76. 发明申请

WO2003018043A1 COMPOSITIONS AND METHODS FOR TREATING SUBJECTS WITH HYPERGLYCEMIA 审中-公开
标题翻译：用高效液相色谱法处理物质的组合物和方法
公开(公告)号：WO2003018043A1
公开(公告)日：2003-03-06
申请号：PCT/US2002/027996
申请日：2002-09-03
申请人： OHIO UNIVERSITY , CHEN, Xiaozhuo , LIU, Fang , LI, Yungsheng , LI, Jing
发明人： CHEN, Xiaozhuo , LIU, Fang , LI, Yungsheng , LI, Jing
IPC分类号： A61K35/78
CPC分类号： C07H13/08 , A61K36/185
摘要： A partially purified plant extract for treating subjects who are hyperglycemic is provided. The partially-purified plant extract comprises a plurality of water soluble compounds having a molecular weight greater than 800 and less than 1500 grams/mole. One of the compounds in the partially-purified plant extract is the hydrolysable gallotannin known as penta-O-galloyl-D-glucose. The partially-purified plant extract is substantially free of triterpenoids, including corosolic acid and high molecular weight ellagitannins, i.e., ellagitannins having a molecular weight of greater than 1500 grams/mole. In a highly preferred embodiment, the partially purified plant extract is derived from the tropical plant Lagerstroemia Speciosa. L , which is also known as banaba. The present invention also relates to a method of using the present partially-purified extract to treat subjects who are hyperglycemic.
摘要翻译：提供了用于治疗高血糖患者的部分纯化的植物提取物。部分纯化的植物提取物包含分子量大于800且小于1500克/摩尔的多种水溶性化合物。部分纯化的植物提取物中的一种化合物是称为五-O-酰基-D-葡萄糖的可水解的gal单宁。部分纯化的植物提取物基本上不含三萜类化合物，包括科罗索酸和高分子量鞣花素，即分子量大于1500克/摩尔的鞣花素。在非常优选的实施方案中，部分纯化的植物提取物衍生自热带植物紫薇。 L，也被称为banaba。本发明还涉及使用本发明部分纯化的提取物来治疗高血糖患者的方法。

77. 发明申请

WO2018103688A1 IMIDAZO [1,5-A] PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS 审中-公开
公开(公告)号：WO2018103688A1
公开(公告)日：2018-06-14
申请号：PCT/CN2017/114970
申请日：2017-12-07
申请人： BEIGENE, LTD. , LI, Jing
发明人： LI, Jing , ZHAO, Haibo , WANG, Zhiwei
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00 , A61P37/00
摘要： Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3Kδ related disorders or diseases by using the compound disclosed herein.

78. 发明申请

WO2013028585A1 SOLID-STATE COMPOSITIONS AND METHODS FOR GENERATING WHITE LIGHT 审中-公开
标题翻译：固体状态组合物和生成白光的方法
公开(公告)号：WO2013028585A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051516
申请日：2012-08-19
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , LI, Jing , ROUSHAN, Mojgan
发明人： LI, Jing , ROUSHAN, Mojgan
IPC分类号： H01L31/00
CPC分类号： H01L51/5036 , C09K11/883 , H01L33/502 , Y02B20/181
摘要： This application discloses a new family of inorganic-organic hybrid semiconductor bulk materials built on periodic nanostructured 2D layers of ZnS that emit bright white light with high quantum efficiency. These ZnS-based crystalline inorganic-organic hybrid semiconductors have well defined and precisely controllable crystal structure and composition. Their optical emission properties, including intensity, quantum yield, and color quality, can be systematically tuned by varying the composition of both inorganic and organic components. Methods for preparing these materials, use of these materials as a new type of single-phased white light emitting phosphors, and their applications in making WLED devices are also disclosed.
摘要翻译：该申请公开了一种新型的无机 - 有机杂化半导体体材料系列，它们建立在发射具有高量子效率的亮白光的ZnS的周期性纳米结构2D层上。这些ZnS基结晶无机 - 有机杂化半导体具有良好的定义和精确控制的晶体结构和组成。可以通过改变无机组分和有机组分的组成来系统地调节它们的光学发射性质，包括强度，量子产率和颜色质量。还公开了制备这些材料的方法，使用这些材料作为新型的单相白色发光荧光体，以及它们在制备WLED器件中的应用。

79. 发明申请

WO2013019224A1 METHOD AND APPARATUS TO DETECT A CONDUCTIVE BODY 审中-公开
标题翻译：检测导电体的方法和装置
公开(公告)号：WO2013019224A1
公开(公告)日：2013-02-07
申请号：PCT/US2011/046394
申请日：2011-08-03
申请人： HALLIBURTON ENERGY SERVICES, INC. , BITTAR, Michael S. , LI, Jing
发明人： BITTAR, Michael S. , LI, Jing
IPC分类号： E21B47/022 , G01V3/26
CPC分类号： G01V3/26 , E21B47/02216 , G06F17/00
摘要： Various embodiments include apparatus and methods to detect and locate conductive bodies and/or provide steam-assisted gravity drainage (SAGD) steering operation. Tools can be configured with receiving sensors (310) arranged to cancel substantially a primary signal associated with a probe signal without rotating the receiving sensors to cancel the primary signal and to capture a secondary signal generated from a conductive body (301) below the earth's surface. Additional apparatus, systems, and methods are disclosed.
摘要翻译：各种实施例包括用于检测和定位导电体的设备和方法和/或提供蒸汽辅助重力排水（SAGD）转向操作。工具可以配置有接收传感器（310），其布置成基本消除与探测信号相关联的主要信号，而不旋转接收传感器以抵消主信号并且捕获从地球表面下方的导电体（301）产生的辅助信号。公开了附加装置，系统和方法。

80. 发明申请

WO2012145021A1 DIELECTRIC TOOL-BASED FORMATION POROSITY LOGGING SYSTEMS AND METHODS 审中-公开
标题翻译：基于电介质工艺的成孔测井系统及方法
公开(公告)号：WO2012145021A1
公开(公告)日：2012-10-26
申请号：PCT/US2011/053215
申请日：2011-09-26
申请人： HALLIBURTON ENERGY SERVICES, INC. , LI, Jing , KAINER, Gary , ROURKE, Marvin , BITTAR, Michael
发明人： LI, Jing , KAINER, Gary , ROURKE, Marvin , BITTAR, Michael
IPC分类号： G01V3/30
CPC分类号： G01V3/08 , G01V3/30 , G06F1/28 , G06F1/3203 , Y02D10/126
摘要： A method and system for calculating formation porosity is presented. The method includes calculating formation porosity of a borehole by obtaining complex dielectric constant measurements with a high frequency dielectric tool. Next, a dielectric constant of formation water is derived from the complex dielectric constant measurements. Finally, a formation porosity is determined based at least in part on the measured complex dielectric constant and the derived dielectric constant formation water.
摘要翻译：提出了一种计算地层孔隙度的方法和系统。该方法包括通过用高频电介质工具获得复杂的介电常数测量来计算井眼的地层孔隙度。接下来，从复介电常数测量得出地层水的介电常数。最后，至少部分地基于测量的复介电常数和衍生的介电常数形成水来确定地层孔隙度。

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