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    • 72. 发明授权
    • Sensor for microscopy
    • US10353190B2
    • 2019-07-16
    • US13519360
    • 2010-12-22
    • Bas HulskenSjoerd Stallinga
    • Bas HulskenSjoerd Stallinga
    • H04N7/18G02B21/36G02B21/24
    • This invention pertains to a method for microscopically imaging a sample, with a digital scanner comprising a sensor including a 2D array of pixels and to a digital scanning microscope carrying out this method. It is notably provided a method for microscopically imaging a sample with a scanner comprising a sensor including a 2D array of pixels in an XY coordinate system, the axis Y being substantially perpendicular to the scan direction, wherein the scanner is arranged such that the sensor can image an oblique cross section of the sample, and wherein the method comprises the steps of: • activating a first sub-array of the 2D array of pixels, the first sub-array extending mainly along the Y axis at a first X coordinate (X1), • creating a first image by imaging a first area of the sample by means of the first sub-array of pixels. According to aspects of the invention, it is further proposed a scanner carryout this method and using the same 2D array sensor for imaging and auto-focusing purpose.
    • 75. 发明申请
    • SENSOR FOR MICROSCOPY
    • 传感器用于显微镜
    • US20120287256A1
    • 2012-11-15
    • US13519360
    • 2010-12-22
    • Bas HulskenSjoerd Stallinga
    • Bas HulskenSjoerd Stallinga
    • H04N7/18
    • G02B21/367G02B21/241G02B21/361
    • This invention pertains to a method for microscopically imaging a sample, with a digital scanner comprising a sensor including a 2D array of pixels and to a digital scanning microscope carrying out this method. It is notably provided a method for microscopically imaging a sample with a scanner comprising a sensor including a 2D array of pixels in an XY coordinate system, the axis Y being substantially perpendicular to the scan direction, wherein the scanner is arranged such that the sensor can image an oblique cross section of the sample, and wherein the method comprises the steps of: • activating a first sub-array of the 2D array of pixels, the first sub-array extending mainly along the Y axis at a first X coordinate (X1), • creating a first image by imaging a first area of the sample by means of the first sub-array of pixels. According to aspects of the invention, it is further proposed a scanner carryout this method and using the same 2D array sensor for imaging and auto-focusing purpose.
    • 本发明涉及一种用于对样品进行微观成像的方法,数字扫描器包括包含2D阵列像素的传感器和执行该方法的数字扫描显微镜。 特别提供了一种用于使用扫描仪对样品进行显微成像的方法,所述扫描器包括在XY坐标系中包括像素的2D阵列的传感器,所述轴线Y基本上垂直于扫描方向,其中扫描器被布置成使得传感器可 对样本的倾斜横截面进行成像,并且其中所述方法包括以下步骤:•激活所述2D阵列的第一子阵列,所述第一子阵列主要沿着所述Y轴在第一X坐标(X1 ),•通过借助于第一像素子阵列对样本的第一区域进行成像来创建第一图像。 根据本发明的方面,进一步提出扫描器执行该方法并使用相同的2D阵列传感器用于成像和自动聚焦目的。
    • 76. 发明申请
    • MULTI-FOCAL SPOT GENERATOR AND MULTI-FOCAL MULTI-SPOT SCANNING MICROSCOPE
    • 多焦点发生器和多焦点多点扫描显微镜
    • US20100264294A1
    • 2010-10-21
    • US12742985
    • 2008-11-19
    • Sjoerd StallingaLevinus P. BakkerDirk L.J. Vossen
    • Sjoerd StallingaLevinus P. BakkerDirk L.J. Vossen
    • G02B27/64G02B26/08H01L27/14
    • G02B27/0087G02B3/0006G02B21/004
    • The invention relates to a spot-generator (10) having: an entrance surface (12) for receiving an incident light beam (20) and an exit surface (14) for transmitting the light beam, the entrance surface defining an entrance side (16) and the exit surface defining an exit side (18), wherein the spot generator is designed to modulate the incident light beam to generate on the exit side a plurality of separate light spots. According to the invention, the plurality of light spots comprises a first light spot (22) generated in a first focal plane (24) and a second light spot (26) generated in a second focal plane (28), the first focal plane and the second focal plane being essentially perpendicular to the mean propagation direction of the exit light beam, and wherein the first light spot (22) differs from every other light spot generated on the exit side by the spot generator in the projection of its position on a plane essentially perpendicular to the mean propagation direction of the exit light beam. Advantageously, the light spots of the plurality of separate light spots have identical spectra. The invention further relates to a multi-spot scanning microscope and to a method of generating an image of a microscopic sample. Advantageously, the method comprises the step of generating a three-dimensional image of the sample.
    • 本发明涉及点光发生器(10),其具有:用于接收入射光束(20)的入射表面(12)和用于透射光束的出射表面(14),入射面限定入射侧(16 )和所述出射表面限定出射侧(18),其中所述光斑发生器被设计成调制所述入射光束,以在所述出射侧产生多个单独的光斑。 根据本发明,多个光点包括在第一焦平面(24)中产生的第一光点(22)和在第二焦平面(28)中产生的第二光点(26),第一焦平面和 所述第二焦平面基本上垂直于所述出射光束的平均传播方向,并且其中所述第一光点(22)在其位置的投影中由所述光点发生器在出射侧产生的每隔一个光点不同 平面基本上垂直于出射光束的平均传播方向。 有利地,多个分开的光点中的光点具有相同的光谱。 本发明还涉及多点扫描显微镜和产生微观样品图像的方法。 有利地,该方法包括产生样本的三维图像的步骤。
    • 79. 发明授权
    • Method and apparatus for detection of a speckle based physically unclonable function
    • 用于检测基于散斑的物理不可克隆功能的方法和装置
    • US07432485B2
    • 2008-10-07
    • US10582383
    • 2004-11-24
    • Sjoerd StallingaBoris SkoricPim Theo TuylsWillem Gerard OpheyAntonius Hermanus Maria Akkermans
    • Sjoerd StallingaBoris SkoricPim Theo TuylsWillem Gerard OpheyAntonius Hermanus Maria Akkermans
    • G02B7/04H01L27/00
    • G02B27/48H04L9/3278
    • An optical arrangement of at least a coherent light source (1), a strongly scattering object (5) (the PUF), and a pixe-lated photo-detector (6), wherein the pixels are comparable in size with the bright and dark patches of the speckle pattern produced by coherent radiation traversing the scattering object (5). Quantitively, the pixel size should be roughly λ/NA, where λ is the wave-length, and (i) NA=a/z for free-space geometry, with a being the beam radius and z being the distance between the exit surface of the PUF (5) and the pixelated detector (6), or (ii) NA is the numerical aperture of a lens (7) in an imaging geometry. In a preferred embodiment of the invention, there are tentative requirements that the pixels should be at least smaller than ηmaxλNA and preferably larger than ηmaxλ/NA, where (in an exemplary embodiment) ηmax=5 and ηmin=0.05, say. It will be understood by a person skilled in the art that the present invention is concerned with the optical arrangement of the PUF (5) and the photo-detector (6), rather than the photo -detector (6) per se.
    • 至少相干光源(1),强散射物体(5)(PUF)和像素照片检测器(6)的光学布置,其中像素在尺寸上与明暗相当 通过穿过散射物体(5)的相干辐射产生的斑点图案的斑块。 数量上,像素尺寸应该大致为λ/ NA,其中λ是波长,和(i)NA =自由空间几何的a / z,其中光束半径和z是出射表面之间的距离 的PUF(5)和像素化检测器(6),或者(ii)NA是成像几何形状中的透镜(7)的数值孔径。 在本发明的优选实施例中,暂时要求像素应该至少小于λmaxλNA,并且优选地大于等于λmax /λ,其中( 在一个示例性实施例中),例如,max = 5和eta分钟= 0.05。 本领域技术人员将理解,本发明涉及PUF(5)和光电检测器(6)的光学布置,而不是光电检测器(6)本身。