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71. 发明授权

US6066324A Carboxyl terminal of papilloma virus L1 region is not required for formation of virus-like particles 失效
标题翻译：乳头瘤病毒L1区的羧基末端不需要形成病毒样颗粒
公开(公告)号：US6066324A
公开(公告)日：2000-05-23
申请号：US817335
申请日：1997-10-02
申请人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
发明人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
IPC分类号： C12N15/09 , A61K38/00 , A61K39/12 , A61P13/02 , A61P15/00 , A61P15/02 , A61P31/12 , C07K14/025 , C07K19/00 , C12N7/00 , C12N7/04 , C12N15/37 , C12N15/62 , C12P21/02 , C12R1/19 , C12R1/92
CPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , A61K2039/5256 , A61K2039/5258 , A61K38/00 , C07K2319/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Recombinant papilloma virus-like particles result from the expression of viral structural protein L1 and/or L2 in which one or several sections of the L1 and/or L2 protein are deleted. The ability to form virus-like particles is at least the same as, preferably higher than, that of native reproduction and/or in vitro production processes.
摘要翻译： PCT No.PCT / EP95 / 03974 371 1997年10月2日第 102（e）1997年10月2日PCT PCT 1995年10月9日PCT公布。公开号WO96 / 11272 日期1996年4月18日重组乳头状瘤病毒样颗粒是由L1和/或L2蛋白的一个或几个部分缺失的病毒结构蛋白L1和/或L2的表达产生的。形成病毒样颗粒的能力至少与天然繁殖和/或体外生产过程相同，优选高于天然繁殖和/或体外生产过程。

72. 发明授权

US5668973A Protection system for critical memory information 失效
标题翻译：关键记忆体信息保护系统
公开(公告)号：US5668973A
公开(公告)日：1997-09-16
申请号：US422435
申请日：1995-04-14
申请人： Peter Stutz , Martin Muller , Daniel Fluckiger
发明人： Peter Stutz , Martin Muller , Daniel Fluckiger
IPC分类号： G06F12/14 , B65G61/00 , G06Q10/00 , G06Q50/00 , G07B17/00 , G06F12/16 , G06F13/00
CPC分类号： G07B17/00193 , G07B2017/00258 , G07B2017/00403 , G07B2017/00967
摘要： A computer system for protecting memory comprising a processor having address outputs and executing a stored program, a memory having a control input, an address-decoder for providing a control signal to the control input of the memory in response to associated address outputs from the processor, and a window circuit. The window circuit comprises a range detector responsive to the address outputs for generating a range-detection signal indicative of an address from the processor being within a protected range, the protected range non-identical to the entirety of the space of addresses within the memory. Access to memory locations within the protected range is permitted only if a request signal is received from the processor. If the request signal is asserted for an unexpectedly long time an error condition is annunciated, for example the processor is reset.
摘要翻译：一种用于保护存储器的计算机系统，包括具有地址输出和执行存储的程序的处理器，具有控制输入的存储器，地址解码器，用于响应于来自处理器的相关联的地址输出向存储器的控制输入提供控制信号，和一个窗口电路。窗口电路包括响应于地址输出的范围检测器，用于产生指示来自处理器的地址在范围检测范围内的范围检测信号，受保护范围与存储器内的地址空间的整体不相同。仅当从处理器接收到请求信号时才允许访问受保护范围内的存储单元。如果请求信号在意外长时间被断言，则报告错误状态，例如处理器被复位。

73. 发明授权

US5547846A Immunogenic regions on the E7 protein of human papillomavirus type 16 失效
标题翻译：人类乳头瘤病毒16型E7蛋白上的免疫原性区域
公开(公告)号：US5547846A
公开(公告)日：1996-08-20
申请号：US292169
申请日：1994-08-16
申请人： Dusan Bartsch , Lutz Gissmann , Martin Muller
发明人： Dusan Bartsch , Lutz Gissmann , Martin Muller
IPC分类号： G01N33/569 , A61K39/00 , A61K39/12 , A61K39/395 , A61K39/42 , C07K4/02 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/025 , C07K16/00 , C07K16/08 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , G01N33/577 , C12Q1/00 , C07K7/02 , G01N33/53
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/20022
摘要： The invention describes two immunogenic regions of the E7 protein of human papillomavirus type 16 (HPV 16), one immunoreactive region being located downstream from nucleotide 595 and the other being located downstream from nucleotide 667 of the HPV 16 genome.
摘要翻译：本发明描述了人乳头状瘤病毒16型（HPV16）的E7蛋白的两个免疫原性区域，一个免疫反应区位于核苷酸595的下游，另一个位于HPV16基因组的核苷酸667的下游。

74. 发明授权

US5476031A Hydraulic setting device 失效
标题翻译：液压调节装置
公开(公告)号：US5476031A
公开(公告)日：1995-12-19
申请号：US211330
申请日：1994-05-25
申请人： Helmut Rembold , Martin Muller
发明人： Helmut Rembold , Martin Muller
IPC分类号： F01L1/34 , F01L1/344 , F15B11/024 , F15B11/08 , F15B13/02
CPC分类号： F01L1/344 , F15B11/08 , F15B2211/20538 , F15B2211/20546 , F15B2211/30505 , F15B2211/3051 , F15B2211/30525 , F15B2211/31511 , F15B2211/31529 , F15B2211/31558 , F15B2211/327 , F15B2211/329 , F15B2211/88
摘要： The hydraulic setting device (10) has a differential cylinder (11) whose pressure spaces (14, 18) can each be acted upon by a pump (17). The pressure conduits (15) and (19) between the pump and the two pressure spaces (14) and (18) are connected to a control valve (31) by means of control conduits (29) and (33). A part pressure can be set in the pressure spaces (14) and (18) by spilling pressure medium by corresponding activation of the control valve.
摘要翻译： PCT No.PCT / DE92 / 00747 Sec。 371日期：1994年3月25日 102（e）1994年3月25日PCT提交1992年9月4日PCT公布。公开号WO93 / 07362 日期：1993年04月15日。液压调节装置（10）具有差压缸（11），其压力空间（14,18）可分别由泵（17）作用。泵和两个压力空间（14）和（18）之间的压力管道（15）和（19）通过控制管道（29）和（33）连接到控制阀（31）。部分压力可以通过相应地启动控制阀而使压力介质溢出来设置在压力空间（14）和（18）中。

75. 发明授权

US5305718A Hydraulic control device 失效
标题翻译：液压控制装置
公开(公告)号：US5305718A
公开(公告)日：1994-04-26
申请号：US64163
申请日：1993-05-19
申请人： Martin Muller
发明人： Martin Muller
IPC分类号： F01L1/34 , F01L1/344
CPC分类号： F01L1/34406 , Y10T74/2102
摘要： The hydraulic control device for rotating the camshaft of an internal combustion engine has a couple member constructed as a piston (25) connected with the sprocket wheel of the camshaft via a spiral toothing and with the camshaft via a straight toothing. A hydraulic body is mounted on at the camshaft and receives a radial piston pump which delivers the pressure medium required for the displacement of the piston. The pressure space is closed by a controllable pressure limiting valve. An electromagnetic valve controls a pressure medium flow to the piston bores of the radial piston pump and the pressure medium is delivered by an external pump. The sprocket wheel and camshaft are rotated relative to one another by the displacement of the piston.
摘要翻译： PCT No.PCT / DE92 / 00750 Sec。 371日期：1993年5月19日 102（e）日期1993年5月19日PCT提交1992年9月4日PCT公布。公开号WO93 / 08380 日本1994年4月29日。用于旋转内燃机的凸轮轴的液压控制装置具有构造为通过螺旋齿与凸轮轴的链轮连接的活塞（25）的联接构件，并且通过直线齿。液压体安装在凸轮轴上并且接收径向活塞泵，其输送活塞位移所需的压力介质。压力空间由可控压力限制阀封闭。电磁阀控制到径向活塞泵的活塞孔的压力介质流，并且压力介质由外部泵输送。链轮和凸轮轴通过活塞的位移相对于彼此旋转。

76. 发明授权

US5179120A Porphycene compounds for photodynamic therapy 失效
标题翻译：磷光化合物用于光动力疗法
公开(公告)号：US5179120A
公开(公告)日：1993-01-12
申请号：US723394
申请日：1991-06-28
申请人： Emanuel Vogel , Clemens Richert , Thomas Benninghaus , Martin Muller , Alexander D. Cross
发明人： Emanuel Vogel , Clemens Richert , Thomas Benninghaus , Martin Muller , Alexander D. Cross
IPC分类号： A61K31/40 , A61K41/00 , A61K49/00 , A61P7/00 , A61P17/00 , A61P35/00 , C07D20060101 , C07D209/56 , C07D487/22
CPC分类号： C07D487/22 , A61K41/0057
摘要： A porphycene having the structure ##STR1## wherein each R.sup.1 is, independently, (a) --(CH.sub.2).sub.n --X, where n=1-4, X is OR.sup.2 and R.sup.2 is C.sub.1-6 alkyl, aralkyl or aryl; CN; OH; OSO.sub.2 R.sup.2 ; NH.sub.2 ; NHR.sup.2 ; NR.sub.2.sup.2 ; SH; SR.sup.2 ; S(O).sub.1-2 R.sup.2 ; COOH; CO.sub.2 R.sup.2 ; C(O)NH.sub.2 ; C(O)NHR.sup.2 ; C(O)NR.sub.2.sup.2 ; halogen; or CHO;(b) --(CH.sub.2).sub.m CH.dbd.CH.sub.2 where m is 0-2; or(c) --(CH.sub.2).sub.n --O--G where G is a mono- or oligosaccharide;(d) --(CH.sub.2).sub.2n --X, where X is an amino acid, oligopeptide covalently bonded by an ether-, ester- or amine-bond or --Y--(CH.sub.2).sub.n -porphycene.sup.2 (porphycene.sup.2 being a compound of the same structure and Y is a direct bond; --O--; or --CH.dbd.CH.sub.2); or(e) where one, two or three of the substituents R.sup.1 are C.sub.1-6 alkyl or aryl and the remaining substituents are as above under (a)-(d), and salts and metal complexes thereof. The porphycene compounds and pharmaceutical compositions containing the compounds are useful in photodynamic therapy treatment of tumors and psoriasis.
摘要翻译：具有结构的卟菲烯，其中每个R 1独立地为（a） - （CH 2）n -X，其中n = 1-4，X为OR 2，R 2为C 1-6烷基，芳烷基或芳基; CN; 哦; OSO2R2; NH2; NHR2; NR22; SH; SR2; S（O）1-2R2; COOH; CO2R2; C（O）NH 2; C（O）NHR 2; C（O）NR22; 卤素; 或CHO; （b） - （CH 2）m CH = CH 2，其中m是0-2; 或（c） - （CH 2）n -O-G，其中G是单糖或寡糖; （d） - （CH2）2n-X，其中X是氨基酸，通过醚 - ，酯 - 或胺键共价结合的寡肽或-Y-（CH 2）n - 卟吩二（卟吩2是相同的化合物）结构，Y是直接键; -O-;或-CH = CH 2）; 或（e）其中一个，两个或三个取代基R 1为C 1-6烷基或芳基，其余取代基如上述（a） - （d）所述，及其盐和金属络合物。含有这些化合物的卟吩化合物和药物组合物可用于肿瘤和牛皮癣的光动力疗法治疗。

77. 发明授权

US5053658A Electrical machine, such as rotary current generator, having improved cooling 失效
标题翻译：电动机，如旋转电流发生器，具有改善的冷却
公开(公告)号：US5053658A
公开(公告)日：1991-10-01
申请号：US527086
申请日：1990-05-21
申请人： Bernhard Fakler , Martin Muller , Pfluger , Klaus-Georg Burger , Kurt Weisserth
发明人： Bernhard Fakler , Martin Muller , Pfluger , Klaus-Georg Burger , Kurt Weisserth
IPC分类号： H02K3/38 , H02K5/04 , H02K9/22 , H02K19/24
CPC分类号： H02K19/24 , H02K3/38 , H02K5/04 , H02K9/22
摘要： An electrical machine, particularly a rotary current generator, has a stator, a claw pole rotor, a stator winding having winding heads extending outwardly beyond ends of the surface-cooled stator, a metal housing surrounding the stator and serving for withdrawal of heat from an interior to an exterior of the housing, a zinc die cast alloy in which the winding heads are electrically insulatingly embedded and which conduct heat to the metal housing, and an electrically insulating layer completely coating each of the winding heads and located between each of the winding heads and the zinc die cast alloy.
摘要翻译：一种电机，特别是一种旋转电流发生器，具有一个定子，一个爪极转子，一个定子绕组，其具有向外延伸超过表面冷却定子的端部的绕组头，围绕定子并用于将热量从内部到壳体的外部，锌压铸合金，其中绕组头电绝缘地嵌入并且向金属壳体传导热量;以及电绝缘层，其完全涂覆每个绕组头并位于每个绕组之间头和锌压铸合金。

78. 发明授权

US5041715A Gas spring, a method of filling a gas spring with pressurized gas and an installation for performing the method 失效
标题翻译：气弹簧，用加压气体填充气弹簧的方法和用于执行该方法的装置
公开(公告)号：US5041715A
公开(公告)日：1991-08-20
申请号：US551489
申请日：1990-07-11
申请人： Martin Muller
发明人： Martin Muller
IPC分类号： B23B41/08 , B23K26/12 , B23K26/382 , B23K26/40 , F16F9/02 , F16F9/43 , F17C5/06
CPC分类号： B23K26/123 , B23K26/12 , B23K26/127 , B23K26/382 , B23K26/40 , F16F9/0281 , F16F9/435 , F17C5/06 , B23K2203/50 , F17C2209/2109 , F17C2209/221 , F17C2223/0123 , F17C2227/04 , F17C2260/013 , F17C2270/0563
摘要： A gas spring must be filled with pressurized gas through an opening. This opening must be closed after the filling operation while maintaining the gas pressure within the gas spring. According to an illustrative example of the invention, the filling opening is bored by a laser beam, while the location of the opening to be bored is confined within a filling chamber. After such laser boring of the opening, pressurized gas is admitted to the filling chamber and flows from the filling chamber into the gas spring. Hereinafter, the opening is closed again by directing the laser beam against an annular zone surrounding the opening.

79. 发明授权

US4306054A Process for the production of epoxide resins 失效
标题翻译：环氧树脂生产工艺
公开(公告)号：US4306054A
公开(公告)日：1981-12-15
申请号：US91654
申请日：1979-11-05
申请人： Ferdinand Alber , Wolfgang Bohm , Manfred Gaikowski , Christian Gunther , Herbert Hecker , Walter Horingklee , Lothar Kaiser , Helmut Kopp , Erna Lange , Gotthold May , Martin Muller , Wieland Schafer , Jurgen Schillgalies , Manfred Scholz , Gunter Seidel
发明人： Ferdinand Alber , Wolfgang Bohm , Manfred Gaikowski , Christian Gunther , Herbert Hecker , Walter Horingklee , Lothar Kaiser , Helmut Kopp , Erna Lange , Gotthold May , Martin Muller , Wieland Schafer , Jurgen Schillgalies , Manfred Scholz , Gunter Seidel
IPC分类号： C08G59/00 , C08G59/06 , C08G59/24
CPC分类号： C08G59/00 , C08G59/063 , C08G59/245
摘要： The invention relates to the continuous production of epoxide resins of low, medium and high molecular weight, and also to their purification and to that of the waste water. No raw materials are required in addition to epichlorohydrin, 2,2-bis-(4-hydroxyphenyl)-propane, alkali hydroxide and water. The raw materials are fed at a shear rate of 7.5-50.times.10.sup.4 sec.sup.-1 (at a peripheral speed of the rotor of 15 to 50 m/sec and a distance of the rotor elements from the stator elements of 0.01 to 0.02 cm) continuously into a reactor and mixed in such a way that by the concentration of high kinetic energy in a very limited space the interfaces of the phases of the heterogeneous reaction mixture are increased to an extreme extent and the reagents are caused to react with one another within 5 sec. at the latest.The reaction proceeds very evenly in the reactor. By conversion of the kinetic energy and reaction heat of the chemical reaction the necessary reaction temperature is maintained for the reaction system within the reactor. The resins obtained and also their waste water are extracted in a pulsation unit in a counterflow, by means of water or organic solvents. This process enables epoxide resins of superior quality to be economically produced. The contamination of the waste water can be thus reduced to a minimum.
摘要翻译：本发明涉及连续生产低，中，高分子量的环氧树脂，以及它们的净化和废水的环氧树脂。除表氯醇，2,2-双 - （4-羟基苯基） - 丙烷，碱金属氢氧化物和水外，不需要任何原料。原料以7.5-50×104秒-1的转速（转子的圆周速度为15〜50m /秒，转子元件与定子元件的距离为0.01〜0.02cm）连续进入反应器并以这样的方式混合，即通过在非常有限的空间中浓缩高动能，将非均相反应混合物的相的界面增加到极端程度，并使试剂在5秒内彼此反应。最新的该反应在反应器中非常均匀地进行。通过转化化学反应的动能和反应热，维持反应器内的反应体系所需的反应温度。所获得的树脂及其废水通过水或有机溶剂在逆流中以脉动单元提取。该方法能够经济地生产出优质的环氧树脂。废水的污染因此可以降至最低。

80. 发明申请

US20120115207A1 ENHANCED PRODUCTION OF PAPILLOMAVIRUS-LIKE PARTICLES WITH A MODIFIED BACULOVIRUS EXPRESSION SYSTEM 审中-公开
标题翻译：用改良的巴氏杆菌表达系统增强具有类似芽胞杆菌的颗粒的生产
公开(公告)号：US20120115207A1
公开(公告)日：2012-05-10
申请号：US13257248
申请日：2010-03-30
申请人： Tilo Senger , Martin Muller , Lutz Gissmann
发明人： Tilo Senger , Martin Muller , Lutz Gissmann
IPC分类号： C12N7/02 , C12N15/85 , C12N5/10
CPC分类号： C12N15/86 , A61K39/00 , A61K2039/5258 , C12N7/00 , C12N2710/14143 , C12N2710/20023
摘要： The present invention is concerned with the provision of a method for manufacturing papillomavirus like particles (PV-VLP), comprising the steps of a) culturing a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises at least one polynucleotide encoding a PV L1 polypeptide, and b) obtaining VLPs from the host cell. Also proposed is a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises a polynucleotide encoding at least one PV L1 polypeptide. Furthermore, a method for the manufacture of a pharmaceutical composition for the treatment or prevention of PV-related disease comprising the steps of manufacturing PV-VLPs and the further step of formulating the VLPs as a pharmaceutical composition is proposed as well as an expression vector comprising at least one polynucleotide encoding a PV L1 polypeptide but lacking a functional gene for a v-cath protease.
摘要翻译：本发明涉及制备乳头瘤病毒样颗粒（PV-VLP）的方法，其包括以下步骤：a）培养缺乏蛋白酶活性的宿主细胞并包含表达载体，其中所述表达载体包含至少一种多核苷酸编码PV L1多肽，和b）从宿主细胞获得VLP。还提出了缺乏蛋白酶活性并包含表达载体的宿主细胞，其中所述表达载体包含编码至少一种PV L1多肽的多核苷酸。此外，提出了制备用于治疗或预防PV相关疾病的药物组合物的方法，其包括制备PV-VLP的步骤和配制作为药物组合物的VLP的进一步步骤以及包含编码PV L1多肽的至少一种多核苷酸，但缺乏v-cath蛋白酶的功能基因。

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