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71. 发明授权

US06472160B2 Immunoassay device and immunoassay method using the same 有权
标题翻译：免疫测定装置及免疫测定方法采用该方法
公开(公告)号：US06472160B2
公开(公告)日：2002-10-29
申请号：US09492191
申请日：2000-01-27
申请人： Hiroko Saruta , Akira Hasegawa , Yoshihiro Ashihara , Yuko Ishioka , Mitsuo Isomura
发明人： Hiroko Saruta , Akira Hasegawa , Yoshihiro Ashihara , Yuko Ishioka , Mitsuo Isomura
IPC分类号： G01N33543
CPC分类号： G01N33/558 , G01N33/571 , Y10S435/962 , Y10S435/97 , Y10S435/975 , Y10S436/81 , Y10S436/814 , Y10S436/817 , Y10S436/818 , Y10S436/906
摘要： Disclosed are an immunoassay device which comprises a labeled substance dotting portion and a specimen dotting portion provided thereon, and an immunoassay method using the device.
摘要翻译：公开了一种免疫测定装置，其包括标记物质点状部分和设置在其上的标本点部分，以及使用该装置的免疫测定方法。

72. 发明授权

US6139175A Light source for endoscopes, having different numerical-aperture light collection system 有权
标题翻译：内窥镜光源，具有不同的数值孔径光采集系统
公开(公告)号：US6139175A
公开(公告)日：2000-10-31
申请号：US395743
申请日：1999-09-14
申请人： Makoto Tomioka , Akira Hasegawa , Takayuki Suzuki , Yumi Ikeda
发明人： Makoto Tomioka , Akira Hasegawa , Takayuki Suzuki , Yumi Ikeda
IPC分类号： G02B23/26 , A61B1/06 , F21V8/00 , G02B6/42 , H04N5/225
CPC分类号： G02B6/0006 , G02B6/4206 , G02B6/4298
摘要： A light source device for endoscopes includes a light source; a condenser lens unit for collecting light beams from the light source; a light guide for receiving the light beams collected through the condenser lens unit into its entrance end face to transmit them to its exit end face; and a reflecting mirror located on the opposite side of the condenser lens unit with respect to the light source. The light source device is designed so that a position where the light beams emitted from the light source are collected directly through the condenser lens unit does not coincide with a position where the light beams emitted from the light source and reflected back to the light source by the reflecting mirror are collected through the condenser lens unit. In an embodiment, an arc axis of the light source is substantially parallel to the optical axis of the condenser lens unit. In another embodiment, direct light and reflected light each enter an entrance face of a forked light guide. In another embodiment, an infra-red removing filter is interposed between a front lens and a rear lens of the condenser unit.
摘要翻译：一种内窥镜用光源装置，具备：光源; 聚光透镜单元，用于收集来自光源的光束; 用于将通过聚光透镜单元收集的光束接收到其入口端面以将其传送到其出射端面的光导; 以及位于聚光透镜单元相对于光源的相反侧的反射镜。光源装置被设计成使得从光源发射的光束直接通过聚光透镜单元收集的位置与从光源发射并从光源发射并反射回光源的位置不一致，该位置通过反射镜通过聚光透镜单元收集。在一个实施例中，光源的弧轴基本上平行于聚光透镜单元的光轴。在另一个实施例中，直射光和反射光各自进入叉形光导的入射面。在另一个实施例中，红外去除滤光片插入在聚光单元的前透镜和后透镜之间。

73. 发明授权

US6022123A Light source device 失效
标题翻译：光源装置
公开(公告)号：US6022123A
公开(公告)日：2000-02-08
申请号：US880799
申请日：1997-06-23
申请人： Makoto Tomioka , Akira Hasegawa , Takayuki Suzuki , Yumi Ikeda
发明人： Makoto Tomioka , Akira Hasegawa , Takayuki Suzuki , Yumi Ikeda
IPC分类号： G02B23/26 , A61B1/06 , F21V8/00 , G02B6/42 , F21V5/04
CPC分类号： G02B6/0006 , G02B6/4298 , F21Y2113/00
摘要： A light source device formed of two or more light emitting components and a collector optical component or system which collects light that is emitted from light emitting regions of the light emitting components. Light from the light emitting regions is spatially combined along a common optical axis and formed into an output beam. The light source device positions respective light emitting regions of two or more light emitting components at conjugate foci of a light collector component or system, thus providing a spatially combined output beam from the two or more light emitting regions. Thus, the intensity (i.e., brightness) of the combined output beam exceeds that produced by any individual light emitting region. Further, the light source device of the invention enables a much higher intensity, combined output beam to be produced than previously obtainable from conventional, non-laser light sources.
摘要翻译：由两个或更多个发光部件形成的光源装置和收集从发光部件的发光区域发射的光的收集光学部件或系统。来自发光区域的光沿共同的光轴空间地组合并形成输出光束。光源装置将两个或更多个发光部件的发光区域定位在集光器部件或系统的共轭焦点处，从而提供来自两个或更多个发光区域的空间结合的输出光束。因此，组合的输出光束的强度（即，亮度）超过由任何单个发光区域产生的强度（即亮度）。此外，本发明的光源装置能够比以前从常规的非激光光源获得的更高强度的组合输出光束产生。

74. 发明授权

US5971576A Light source device for endoscopes 失效
标题翻译：内窥镜用光源装置
公开(公告)号：US5971576A
公开(公告)日：1999-10-26
申请号：US854944
申请日：1997-05-14
申请人： Makoto Tomioka , Akira Hasegawa , Takayuki Suzuki , Yumi Ikeda
发明人： Makoto Tomioka , Akira Hasegawa , Takayuki Suzuki , Yumi Ikeda
IPC分类号： G02B23/26 , A61B1/06 , F21V8/00 , G02B6/42 , H04N5/225 , F21V7/04
CPC分类号： G02B6/0006 , G02B6/4206 , G02B6/4298
摘要： A light source device for endoscopes includes a light source; a condenser lens unit for collecting light beams from the light source; a light guide for receiving the light beams collected through the condenser lens unit into its entrance end face to transmit them to its exit end face; and a reflecting mirror located on the opposite side of the condenser lens unit with respect to the light source. The light source device is designed so that a position where the light beams emitted from the light source are collected directly through the condenser lens unit does not coincide with a position where the light beams emitted from the light source and reflected back to the light source by the reflecting mirror are collected through the condenser lens unit.
摘要翻译：一种内窥镜用光源装置，具备：光源; 聚光透镜单元，用于收集来自光源的光束; 用于将通过聚光透镜单元收集的光束接收到其入口端面以将其传送到其出射端面的光导; 以及位于聚光透镜单元相对于光源的相反侧的反射镜。光源装置被设计成使得从光源发射的光束直接通过聚光透镜单元收集的位置与从光源发射并从光源发射并反射回光源的位置不一致，该位置通过反射镜通过聚光透镜单元收集。

75. 发明授权

US5869460A Sulfated and phosphated saccharide derivatives, process for the preparation of the same and use thereof 失效
标题翻译：硫酸化和磷酸化的糖衍生物，其制备方法和用途
公开(公告)号：US5869460A
公开(公告)日：1999-02-09
申请号：US739423
申请日：1996-10-29
申请人： Toshinao Usui , Takao Igami , Takuji Kakigami , Hitoshi Hamashima , Takahito Jomori , Akira Tashita , Yoshiro Ishiwatari , Shoji Yokochi , Takahiko Mitani , Yasuo Suzuki , Akira Hasegawa
发明人： Toshinao Usui , Takao Igami , Takuji Kakigami , Hitoshi Hamashima , Takahito Jomori , Akira Tashita , Yoshiro Ishiwatari , Shoji Yokochi , Takahiko Mitani , Yasuo Suzuki , Akira Hasegawa
IPC分类号： C07H1/00 , A61K31/70 , A61K31/7028 , A61P29/00 , A61P43/00 , C07H1/02 , C07H3/06 , C07H5/08 , C07H11/04 , C07H15/04 , C07H15/00
CPC分类号： A61K31/7024 , C07H11/04 , C07H3/06 , C07H5/08 , Y02P20/55
摘要： There are described sulfated and phosphated saccharide erivatives of the Formula ##STR1## wherein R.sub.1 is hydrogen atom or a residue of sulfate, phosphate or L-fucose; R.sub.2, R.sub.3 and R.sub.4 are hydrogen atom or a residue of sulfate or phosphate, respectively; 1 is an integer of 0 or 1;m is an integer of 0-15; and n is an integer of 0-21, or pharmaceutically acceptable salts thereof, a process for the preparation of the derivatives and salts as well as use thereof, as an anti-inflammatory agent.
摘要翻译：其中R1表示氢原子或硫酸盐，磷酸盐或L-岩藻糖残基;硫酸盐，磷酸盐或L-岩藻糖残基; R2，R3和R4分别是氢原子或硫酸盐或磷酸盐的残基; 1是0或1的整数; m为0-15的整数; n为0-21的整数，或其药学上可接受的盐，作为抗炎剂的衍生物和盐的制备方法及其用途。

76. 发明授权

US5800982A Antigenic peptides for growing hepatitis C virus, kit comprising the same and methods for its grouping using the same 失效
标题翻译：用于生长丙型肝炎病毒的抗原肽，包含其的试剂盒以及使用其组合的方法
公开(公告)号：US5800982A
公开(公告)日：1998-09-01
申请号：US685764
申请日：1996-07-24
申请人： Akira Hasegawa , Noboru Maki , Shintaro Yagi , Tomiko Kashiwakuma , Kenjiro Yamaguchi , Naoko Ikeguchi , Tomoko Kobayashi , Chiaki Senoo
发明人： Akira Hasegawa , Noboru Maki , Shintaro Yagi , Tomiko Kashiwakuma , Kenjiro Yamaguchi , Naoko Ikeguchi , Tomoko Kobayashi , Chiaki Senoo
IPC分类号： C07K14/18 , C12N15/51 , C12Q1/70 , A61K39/29
CPC分类号： C07K14/005 , C12N2770/24222
摘要： The present invention relates to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group I of hepatitis C virus (HCV); to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group II of HCV; to a kit for identifying HCV Groups I or II which comprises said peptides in separate sections; and to methods for grouping HCV. The peptides of the present invention can be used to detect HCV Groups I or II specifically as well as the detection of patients having the mixed infection, by which HCV Group II-infected patients can receive early interferon treatment effectively. The peptides are also useful for diagnosis of HCV infection.
摘要翻译：本发明涉及能够特异性地针对丙型肝炎病毒（HCV）I组抗体的NS4相关抗原肽; 涉及能够与针对HCV II组的抗体特异性反应的NS4相关抗原肽; 用于鉴定HCV组I或II的试剂盒，其包含分开部分中的所述肽; 以及HCV分组方法。本发明的肽可用于特异性检测HCV组I或II，以及检测具有混合感染的患者，由此可以有效地接受HCV II类感染患者的早期干扰素治疗。这些肽也可用于诊断HCV感染。

77. 发明授权

US5528801A Stringer tape and slide fastener incorporating the same 失效
标题翻译：包括其的带钢带和拉链
公开(公告)号：US5528801A
公开(公告)日：1996-06-25
申请号：US298174
申请日：1994-08-30
申请人： Akira Hasegawa
发明人： Akira Hasegawa
IPC分类号： A44B19/02 , A44B19/34 , A44B19/40 , A44B19/00
CPC分类号： A44B19/346 , Y10T24/2523 , Y10T24/2525 , Y10T24/2539
摘要： A slide fastener comprising a pair of stranger tapes, each including an elongated tape body including a plurality of warp threads and a beaded longitudinal edge portion provided on one longitudinal edge of the elongated tape body, the beaded marginal portion including a tube formed integrally with the elongated tape body and a plurality of filler threads inserted through the tube in such a way not to be intertwined with each other, the filler threads being identical in denier with the warp thread; and two rows of coupling elements extruded from plastics and each mounted on the respective beaded edge, each element comprising a coupling head and a pair of clamping legs extending rearward from the coupling head, each row of coupling elements being connected with two connecting rods embedded in the legs, each element clamp-mounted on the beaded edge with the legs sewn to the beaded edge by sewn stitches.
摘要翻译：一种拉链，包括一对陌生的带子，每条带子包括细长的带体，该带状体包括多根经线，以及设置在细长带体的一个纵向边缘上的串珠的纵向边缘部分，珠状边缘部分包括与细长的带体和多个填充线，其以不相互缠绕的方式插入管中，填充线的旦数与经线相同; 和两排由塑料挤出并且各自安装在相应的珠缘边缘上的每个连接元件，每个元件包括联接头和从联接头向后延伸的一对夹持腿，每排联接元件与嵌入在其中的两个连接杆连接腿部，每个元件夹紧安装在串珠边缘上，腿部通过缝合缝合缝合到串珠边缘。

78. 发明授权

US5481918A Acoustic lens system 失效
标题翻译：声透镜系统
公开(公告)号：US5481918A
公开(公告)日：1996-01-09
申请号：US258814
申请日：1994-06-13
申请人： Akira Hasegawa , Masayoshi Omura , Shinichi Imade , Eishi Ikuta
发明人： Akira Hasegawa , Masayoshi Omura , Shinichi Imade , Eishi Ikuta
IPC分类号： G03B42/06 , G01N29/04 , G10K11/30 , G01N29/06 , G01N29/24
CPC分类号： G10K11/30
摘要： An acoustic lens system is constructed so that at least one surface of acoustic lenses constituting the acoustic lens system is an aspherical surface, which has such a shape that curvature moderates progressively in separating from the axis of the acoustic lens system, and an acoustic beam stop is provided therein. As a result, aberrations can be favorably corrected even when the angle of view and the numerical aperture are increased and this brings about the acoustic lens system suitable for an objective lens of an acoustic system for securing an image of an object having a two-dimensional size in particular.
摘要翻译：声透镜系统被构造成使得构成声透镜系统的声透镜的至少一个表面是非球面，其具有在与声透镜系统的轴分离的同时逐渐缓和的形状和声束停止在其中。结果，即使当视角和数值孔径增加时，也可以有利地校正像差，并且这导致适合用于声学系统的物镜的声透镜系统，用于固定具有二维的物体的图像特别是大小。

79. 发明授权

US5365024A Acoustic lens system 失效
标题翻译：声透镜系统
公开(公告)号：US5365024A
公开(公告)日：1994-11-15
申请号：US15303
申请日：1993-02-09
申请人： Akira Hasegawa , Masayoshi Omura , Shinichi Imade , Eishi Ikuta
发明人： Akira Hasegawa , Masayoshi Omura , Shinichi Imade , Eishi Ikuta
IPC分类号： G01N29/22 , A61B8/00 , G10K11/30 , H04R1/34 , G10K11/00 , G01S15/00
CPC分类号： G10K11/30
摘要： The acoustic lens system is used for ultrasonic imaging in an ultrasonic system which displays an image of an object while transmitting ultrasonic waves and receiving the ultrasonic waves reflected from the object, and has a half field angle .omega. expressed as follows: ##EQU1## wherein the reference symbol v.sub.0 represents the velocity of sound in the medium located on the incidence side of the first lens surface and the reference symbol v.sub.1 designates the velocity of sound in the medium located on the emergence side of the first lens surface. Accordingly, the acoustic lens system according to the present invention is remarkably excellent in the performance thereof in respect of field angles, aberrations, aperture angles, attenuation, etc., and has an advantage to permits further reducing acoustic attenuation and preventing spurious images from being formed due to multiple reflections by arranging antireflection films on the lens surfaces.
摘要翻译：声透镜系统用于在超声波系统中进行超声波成像，该超声波系统在发送超声波并接收从物体反射的超声波的同时显示物体的图像，并且具有如下表示的半场角ω：其中附图标记v0表示位于第一透镜表面的入射侧的介质中的声速，附图标记v1表示位于第一透镜表面的出射侧的介质中的声速。因此，根据本发明的声透镜系统在场角，像差，孔径角，衰减等方面的性能非常优异，并且具有进一步降低声衰减和防止杂散图像的优点通过在透镜表面上布置防反射膜而导致多次反射而形成。

80. 发明授权

US5270825A Imaging optical system having a moire elimination effect 失效
标题翻译：具有莫尔纹消除效果的成像光学系统
公开(公告)号：US5270825A
公开(公告)日：1993-12-14
申请号：US596074
申请日：1990-10-11
申请人： Yoshiharu Takasugi , Akira Hasegawa
发明人： Yoshiharu Takasugi , Akira Hasegawa
IPC分类号： A61B1/04 , G02B27/60 , H04N5/225 , H04N5/30
CPC分类号： G02B27/60 , A61B1/042 , H04N2005/2255
摘要： An imaging optical system for forming images of objects on an image surface. The optical system includes an aspherical surface that functions to reduce spatial frequency response of the optical system when aperture size of the optical system is reduced within a variable range and adapted so as to eliminate spurious signal by the aspherical surface.
摘要翻译：一种用于在图像表面上形成物体的图像的成像光学系统。该光学系统包括一个非球面，当光学系统的孔径尺寸在可变范围内减小时，其功能可以减小光学系统的空间频率响应，并适用于消除非球面的杂散信号。

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