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71. 发明申请

WO2009048527A1 SUBSTITUTED BIPHENYL GPR40 MODULATORS 审中-公开
标题翻译：取代的BIPHENYL GPR40调节器
公开(公告)号：WO2009048527A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/011422
申请日：2008-10-03
申请人： AMGEN INC. , KIM, Yong-Jae , BROWN, Sean, P. , CAO, Qiong , DRANSFIELD, Paul, J. , DU, Xiaohui , HOUZE, Jonathan , JIAO, Xian Yun , KOHN, Todd, J. , LAI, Sujen , LI, An-Rong , LIN, Daniel , LUO, Jian , MEDINA, Julio, C. , REAGAN, Jeffrey, D. , PATTAROPONG, Vatee , SCHWARZ, Margrit , SHEN, Wang , SU, Yongli , SWAMINATH, Gayathri , VIMOLRATANA, Marc , WANG, Xiang , XIONG, Yumei , YANG, Li , YU, Ming , ZHANG, Jie , ZHU, Liusheng
发明人： KIM, Yong-Jae , BROWN, Sean, P. , CAO, Qiong , DRANSFIELD, Paul, J. , DU, Xiaohui , HOUZE, Jonathan , JIAO, Xian Yun , KOHN, Todd, J. , LAI, Sujen , LI, An-Rong , LIN, Daniel , LUO, Jian , MEDINA, Julio, C. , REAGAN, Jeffrey, D. , PATTAROPONG, Vatee , SCHWARZ, Margrit , SHEN, Wang , SU, Yongli , SWAMINATH, Gayathri , VIMOLRATANA, Marc , WANG, Xiang , XIONG, Yumei , YANG, Li , YU, Ming , ZHANG, Jie , ZHU, Liusheng
IPC分类号： C07C59/68 , C07C217/54 , C07C323/19 , C07D213/64 , A61K31/192 , A61K31/4415 , A61P3/10
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

72. 发明申请

WO2008013737A3 COMPOSITIONS FOR REPROGRAMMING A CELL AND USES THEREFOR 审中-公开
标题翻译：用于重新编程细胞的组合物及其用途
公开(公告)号：WO2008013737A3
公开(公告)日：2008-11-06
申请号：PCT/US2007016402
申请日：2007-07-19
申请人： UNIV FLORIDA , YANG LI-JUN
发明人： YANG LI-JUN
IPC分类号： A61K39/00 , C07K1/00 , C12N5/00 , C12N5/02 , C12N5/071
CPC分类号： C07K14/82 , A61K48/005 , C07K14/4702 , C07K2319/10 , C07K2319/21 , C07K2319/71 , C12N5/0676 , C12N2506/14 , C12N2510/00 , C12N2750/14143 , C12N2750/14171 , C12Q1/6897
摘要： The present invention generally provides therapeutic compositions and methods for treating a disease, disorder, or injury characterized by a deficiency in the number or biological activity of a cell of interest. The method provides compositions for generating reprogrammed cells or for increasing regeneration in a cell, tissue, or organ of interest. Such methods are useful for treating subjects having a deficiency in a particular cell type or in a polypeptide produced by that cell type. In particular, the invention provides prophylactic and therapeutic methods and compositions for ameliorating or preventing hyperglycemia associated with type 1 and type II diabetes and related complications.
摘要翻译：本发明一般提供治疗组合物和方法，用于治疗以感兴趣的细胞的数量或生物学活性缺乏为特征的疾病，病症或损伤。该方法提供了用于产生重编程细胞或用于增加感兴趣的细胞，组织或器官中的再生的组合物。这样的方法对于治疗具有特定细胞类型缺陷的受试者或由该细胞类型产生的多肽是有用的。具体而言，本发明提供用于改善或预防与1型和II型糖尿病及相关并发症相关的高血糖的预防和治疗方法和组合物。

73. 发明申请

WO2008101311A1 PROCESS FOR PURIFICATION OF WATER SOLUBLE POLYMERS 审中-公开
标题翻译：水溶性聚合物的纯化方法
公开(公告)号：WO2008101311A1
公开(公告)日：2008-08-28
申请号：PCT/CA2007/000272
申请日：2007-02-22
申请人： BIOVECTRA INC. , MONTHONY, James, F. , YANG, Li , KERSHAW, Kurt, E. , WINSLOW, Christopher, D. , RILEY, John, G.
发明人： MONTHONY, James, F. , YANG, Li , KERSHAW, Kurt, E. , WINSLOW, Christopher, D. , RILEY, John, G.
IPC分类号： C08L29/02 , B01D59/30 , C08F6/12 , C08G65/30 , G01N33/44
CPC分类号： C08F8/44 , B01D15/361 , B01J47/12 , C08F6/003 , C08G65/30 , C08G65/3326 , C08G65/3346 , G01N30/02 , Y10T436/255
摘要： A process for purification of water soluble polymers is provided. A polymer of interest can be separated from a mixture of polymers, provided the polymer of interest differs from other polymers in the mixture in the number of reactive terminal groups. The process involves derivatizing polymers at the reactive terminal groups with a derivatizing molecule, bearing either (i) two or three cationic or anionic ionizable groups, and a group capable of covalent bonding to the reactive terminal groups or (ii) three or four ionizable groups, at least one of which is capable of covalent bonding to the reactive terminal groups; followed by ion exchange. The process allows removal of PEG from MPEG, and can be used for polymers having an average size greater than 9,000 Da Derivatization may be reversible in order to allow re-use of recovered contaminant polymers.
摘要翻译：提供了一种用于纯化水溶性聚合物的方法。感兴趣的聚合物可以从聚合物的混合物中分离出来，只要所关心的聚合物与反应性末端基团数目的混合物中的其它聚合物不同。该方法包括用衍生化分子衍生化反应性末端基团的聚合物，该衍生化分子带有（i）两个或三个阳离子或阴离子可离子基团，以及能够与反应性末端基团共价结合的基团，或（ii）三个或四个可离子化基团，其中至少一个能够与反应性末端基团共价结合; 然后进行离子交换。该方法允许从MPEG去除PEG，并且可以用于平均尺寸大于9,000Da的聚合物。衍生化可以是可逆的，以便允许再利用回收的污染物聚合物。

74. 发明申请

WO2008019006A2 SERUM DNA METHYLATION SCREENING FOR CANCER 审中-公开
标题翻译：用于癌症的血清DNA甲基化筛选
公开(公告)号：WO2008019006A2
公开(公告)日：2008-02-14
申请号：PCT/US2007016970
申请日：2007-07-30
申请人： REGENTS TH E UNIVERSITY OF TEX , BABAIAN RICHARD , FRITSCHE HERBERT , YANG LI-YING
发明人： BABAIAN RICHARD , FRITSCHE HERBERT , YANG LI-YING
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q1/6886
摘要： We disclose a method of screening a mammal for a cancer associated with methylation of promoters of tumor-suppressor genes by collecting a sample of a body fluid or tissue of the mammal containing free DNA; isolating the free DNA from the sample; amplifying at least a portion of the promoter of each of a plurality of turner-suppressor genes associated with the cancer from the free DNA, to yield a plurality of amplified promoters; and quantifying methylation of each of the plurality of amplified promoters, to yield a methylation quantity. The method can have a high sensitivity and high specificity and can thus reduce the proportion of unneeded biopsies. It can also be performed with minimal invasiveness and discomfort to a patient.
摘要翻译：我们公开了通过收集含有游离DNA的哺乳动物的体液或组织的样品来筛选哺乳动物与肿瘤抑制基因启动子的甲基化相关的方法; 从样品中分离游离DNA; 从游离DNA扩增与癌症相关的多个转移抑制基因中的每一个的至少一部分启动子，以产生多个扩增的启动子; 并定量多个扩增的启动子中的每一个的甲基化，以产生甲基化量。该方法可以具有高灵敏度和高特异性，因此可以减少不需要的活组织检查的比例。它也可以以最小的入侵和对患者的不适进行。

75. 发明申请

WO2007104058A3 METHOD AND APPARATUS FOR TARGET DETECTION USING ELECTRODE-BOUND VIRUSES 审中-公开
公开(公告)号：WO2007104058A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/063723
申请日：2007-03-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , WEISS, Gregory A. , PENNER, Reginald M. , TAM, Phillip Y. , YANG, Li-mei , BRIGHAM, Tyler
发明人： WEISS, Gregory A. , PENNER, Reginald M. , TAM, Phillip Y. , YANG, Li-mei , BRIGHAM, Tyler
IPC分类号： C12Q1/70 , G01N33/554 , G01N33/569 , C12M1/34
摘要： A biosensor capable of detecting the presence and/or concentration of an analyte or biomarker includes at least one electrically conductive electrode operatively coupled to an impedance analyzer for measuring the change in the resistive impedance of the electrode in response to an applied alternating current at a plurality of frequencies. In one embodiment, at least one electrode is covered with a self-assembled monolayer that is chemically bonded to a surface. A plurality of virus particles such as phage viruses are immobilized on the self-assembled monolayer and may be exposed to a test or sample solution. The virus particles may be obtained from phage-displayed libraries to detect a wide variety of targets including, for example, DNA, RNA, small molecules, and proteins or polypeptides. In another embodiment, the virus particles are electrostatically bound to a substrate in between a pair of elongated electrodes disposed on a substrate.

76. 发明申请

WO2007104058A2 METHOD AND APPARATUS FOR TARGET DETECTION USING ELECTRODE-BOUND VIRUSES 审中-公开
标题翻译：使用电极病毒检测目标的方法和装置
公开(公告)号：WO2007104058A2
公开(公告)日：2007-09-13
申请号：PCT/US2007063723
申请日：2007-03-09
申请人： UNIV CALIFORNIA , WEISS GREGORY A , PENNER REGINALD M , TAM PHILLIP Y , YANG LI-MEI , BRIGHAM TYLER
发明人： WEISS GREGORY A , PENNER REGINALD M , TAM PHILLIP Y , YANG LI-MEI , BRIGHAM TYLER
IPC分类号： C12Q1/70
CPC分类号： G01N27/327 , G01N27/3277
摘要： A biosensor capable of detecting the presence and/or concentration of an analyte or biomarker includes at least one electrically conductive electrode operatively coupled to an impedance analyzer for measuring the change in the resistive impedance of the electrode in response to an applied alternating current at a plurality of frequencies. In one embodiment, at least one electrode is covered with a self-assembled monolayer that is chemically bonded to a surface. A plurality of virus particles such as phage viruses are immobilized on the self-assembled monolayer and may be exposed to a test or sample solution. The virus particles may be obtained from phage-displayed libraries to detect a wide variety of targets including, for example, DNA, RNA, small molecules, and proteins or polypeptides. In another embodiment, the virus particles are electrostatically bound to a substrate in between a pair of elongated electrodes disposed on a substrate.
摘要翻译：能够检测分析物或生物标志物的存在和/或浓度的生物传感器包括可操作地耦合到阻抗分析器的至少一个导电电极，用于响应于多个施加的交流电流来测量电极的电阻阻抗的变化的频率。在一个实施方案中，至少一个电极被化学键合到表面的自组装单层覆盖。多个病毒颗粒如噬菌体病毒固定在自组装单层上，并可暴露于测试或样品溶液中。病毒颗粒可以从噬菌体展示的文库中获得，以检测多种靶，包括例如DNA，RNA，小分子和蛋白质或多肽。在另一个实施方案中，病毒颗粒在布置在基底上的一对细长电极之间静电结合到基底上。

77. 发明申请

WO2005034410A3 METHOD AND APPARATUS OF INTEGRATING LINK LAYER SECURITY INTO A PHYSICAL LAYER TRANSCEIVER 审中-公开
标题翻译：将连接层安全集成到物理层收发器中的方法和装置
公开(公告)号：WO2005034410A3
公开(公告)日：2006-03-30
申请号：PCT/US2004032555
申请日：2004-09-30
申请人： CISCO TECH IND , BIEDERMAN DANIEL C , YANG LI-JAU
发明人： BIEDERMAN DANIEL C , YANG LI-JAU
IPC分类号： H04K1/00 , H04L9/00 , H04J3/12 , G06F15/16 , H03M7/00 , H03M7/34 , H04J3/16 , H04L12/56 , H04L12/66
CPC分类号： H04L9/00 , H04K1/00
摘要： An apparatus for providing link layer security link layer security in a Physical Layer Transcevier (PHY) is disclosed. In one embodiment, the apparatus may comprise analog circuitry configured to interface with a data transmission medium, digital circuitry configured to interface with a Media Access Controller (MAC); and a crypto engine coupled to the digital circuitry.
摘要翻译：公开了一种用于在物理层收发器（PHY）中提供链路层安全链路层安全性的装置。在一个实施例中，该装置可以包括配置成与数据传输介质接口的模拟电路，配置成与介质访问控制器（MAC）接口的数字电路; 以及耦合到数字电路的密码引擎。

78. 发明申请

WO2005034410A2 METHOD AND APPARATUS OF INTEGRATING LINK LAYER SECURITY INTO A PHYSICAL LAYER TRANSCEIVER 审中-公开
标题翻译：将连接层安全集成到物理层收发器中的方法和装置
公开(公告)号：WO2005034410A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/032555
申请日：2004-09-30
申请人： CISCO TECHNOLOGY, INC. , BIEDERMAN, Daniel, C. , YANG, Li-Jau
发明人： BIEDERMAN, Daniel, C. , YANG, Li-Jau
IPC分类号： H04L
CPC分类号： H04L9/00 , H04K1/00
摘要： An apparatus for providing link layer security link layer security in a Physical Layer Transcevier (PHY) is disclosed. In one embodiment, the apparatus may comprise analog circuitry configured to interface with a data transmission medium, digital circuitry configured to interface with a Media Access Controller (MAC); and a crypto engine coupled to the digital circuitry.
摘要翻译：公开了一种用于在物理层收发器（PHY）中提供链路层安全链路层安全性的装置。在一个实施例中，该装置可以包括被配置为与数据传输介质接口的模拟电路，被配置为与介质访问控制器（MAC）接口的数字电路; 以及耦合到数字电路的密码引擎。

79. 发明申请

WO2012134446A1 EPIANDROSTERONE AND/OR ANDROSTERONE DERIVATIVES AND METHOD OF USE THEREOF 审中-公开
标题翻译：肾上腺皮质激素和/或安慰剂衍生物及其使用方法
公开(公告)号：WO2012134446A1
公开(公告)日：2012-10-04
申请号：PCT/US2011/030306
申请日：2011-03-29
申请人： SUTTER WEST BAY HOSPITALS doing business as CALIFORNIA PACIFIC MEDICAL CENTER , CATHOLIC HEALTCARE WEST , YANG, Li-Xi
发明人： YANG, Li-Xi
IPC分类号： C07J1/00 , C07D471/04 , A61K31/565 , A61P35/00 , A61P5/00
CPC分类号： C07J43/003 , C07J1/0011
摘要： Disclosed herein are epiandrosterone and androsterone derivatives of Formula (II), process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译：本文公开了式（II）的表雄酮和雄酮衍生物，其制备方法，其药物组合物及其使用方法。

80. 发明申请

WO2011082263A1 STANDING SEAM PROFILE FOR THERMOPLASTIC ROOF ORNAMENTATION AND ATTACHMENT METHOD 审中-公开
标题翻译：用于热塑性屋顶结构和附着方法的标准焊缝轮廓
公开(公告)号：WO2011082263A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062423
申请日：2010-12-29
申请人： BUILDING MATERIALS INVESTMENT CORPORATION , YANG, Li-ying , TAYLOR, Thomas, J. , RAILKAR, Sudhir
发明人： YANG, Li-ying , TAYLOR, Thomas, J. , RAILKAR, Sudhir
IPC分类号： E04B7/00
CPC分类号： E04D5/06 , B29C65/103 , B29C65/4815 , B29C65/4825 , B29C65/5057 , B29C65/5092 , B29C66/1122 , B29C66/474 , B29C66/524 , B29C66/71 , B29C66/73921 , B29C66/836 , B29C66/8432 , B29C66/86533 , B29L2031/003 , B29L2031/108 , E04D15/00 , E04D15/04 , Y10T156/10 , Y10T428/14 , Y10T428/1476 , Y10T428/24017 , Y10T428/24182 , B29K2027/06 , B29K2023/00
摘要： In accordance with the disclosed principles, a novel thermoplastic profile roofing strip and an apparatus for welding the thermoplastic profile roofing strip to a thermoplastic roofing membrane is disclosed. In one embodiment, the thermoplastic profile roofing strip may comprise a horizontal base extending longitudinally and having a notched profile. In addition, the thermoplastic profile strip may comprise a vertical central portion laterally connected at one edge and normal to the horizontal base. In such embodiments, the vertical central portion extends longitudinally along the horizontal base to provide the improved profile. Related methods of welding a thermoplastic strip to a thermoplastic membrane are also disclosed.
摘要翻译：根据所公开的原理，公开了一种新型热塑性轮廓屋顶条和用于将热塑性轮廓屋顶条焊接到热塑性屋顶膜的设备。在一个实施例中，热塑性轮廓屋顶条可以包括纵向延伸并具有凹口轮廓的水平基部。此外，热塑性型材条可以包括在一个边缘处横向连接并垂直于水平基部的垂直中心部分。在这样的实施例中，垂直中心部分沿水平底座纵向延伸以提供改进的轮廓。还公开了将热塑性带焊接到热塑性膜的相关方法。

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